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Conserved domains on  [gi|223972623|ref|NP_001138862|]
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sulfotransferase family 6B, member 2 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
37-276 4.47e-70

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 217.21  E-value: 4.47e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623   37 EDDIFLVSYPKSGTHWLAEVIERIPD--AGITLTSP-----------IEL-------GDISKFEELKRIPKRRAIPTHLN 96
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNrgDFEKSEEPhlfnnhnrspfLEWypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623   97 YEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHYYRDNPNLPSTETWAAFLELFLKGDVVYGSWFDHVLSWEEHKNDKNVLF 176
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623  177 IFYEEMKKDFVKSLKKITAFLGIDVNDSEMAKIARSTSFSEMKSNAAKencdpNHVicALTSDRNLVFRKGVVGDWINYF 256
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCL-----NYS--KLPKEVSPFFRKGLVGDWKNYF 233

                         250       260
                  ....*....|....*....|
gi 223972623  257 TPKQNRVFDELFTEKMRNSD 276
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
37-276 4.47e-70

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 217.21  E-value: 4.47e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623   37 EDDIFLVSYPKSGTHWLAEVIERIPD--AGITLTSP-----------IEL-------GDISKFEELKRIPKRRAIPTHLN 96
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNrgDFEKSEEPhlfnnhnrspfLEWypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623   97 YEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHYYRDNPNLPSTETWAAFLELFLKGDVVYGSWFDHVLSWEEHKNDKNVLF 176
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623  177 IFYEEMKKDFVKSLKKITAFLGIDVNDSEMAKIARSTSFSEMKSNAAKencdpNHVicALTSDRNLVFRKGVVGDWINYF 256
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCL-----NYS--KLPKEVSPFFRKGLVGDWKNYF 233

                         250       260
                  ....*....|....*....|
gi 223972623  257 TPKQNRVFDELFTEKMRNSD 276
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 10-275 5.39e-32

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 121.18  E-value: 5.39e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623  10 LHKYMGIFFSTMSSEELLGSLDSFDAREDDIFLVSYPKSGTHWLAEVI------ERIPDAGITL--TSPIEL-----GDI 76
Cdd:PLN02164  52 LIEYGGHWWLQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTfaianrSRFDDSSNPLlkRNPHEFvpyieIDF 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623  77 SKFEELKRIPKRR--AIPTHLNYEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHY-YRDNPNLPSTETWAAFLELFLKGDV 153
Cdd:PLN02164 132 PFFPSVDVLKDKGntLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLS 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623 154 VYGSWFDHVLS-WEEHK-NDKNVLFIFYEEMKKDFVKSLKKITAFLGIDVNDSE-----MAKIARSTSFSEMKSNAAKEN 226
Cdd:PLN02164 212 VYGPYLDHVLGyWKAYQeNPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKG 291

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 223972623 227 CDPNHVICALTSDrNLVFRKGVVGDWINYFTPKQNRVFDELFTEKMRNS 275
Cdd:PLN02164 292 EKDREDRPAVYAN-SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGT 339
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
37-276 4.47e-70

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 217.21  E-value: 4.47e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623   37 EDDIFLVSYPKSGTHWLAEVIERIPD--AGITLTSP-----------IEL-------GDISKFEELKRIPKRRAIPTHLN 96
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNrgDFEKSEEPhlfnnhnrspfLEWypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623   97 YEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHYYRDNPNLPSTETWAAFLELFLKGDVVYGSWFDHVLSWEEHKNDKNVLF 176
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623  177 IFYEEMKKDFVKSLKKITAFLGIDVNDSEMAKIARSTSFSEMKSNAAKencdpNHVicALTSDRNLVFRKGVVGDWINYF 256
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCL-----NYS--KLPKEVSPFFRKGLVGDWKNYF 233

                         250       260
                  ....*....|....*....|
gi 223972623  257 TPKQNRVFDELFTEKMRNSD 276
Cdd:pfam00685 234 TPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 10-275 5.39e-32

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 121.18  E-value: 5.39e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623  10 LHKYMGIFFSTMSSEELLGSLDSFDAREDDIFLVSYPKSGTHWLAEVI------ERIPDAGITL--TSPIEL-----GDI 76
Cdd:PLN02164  52 LIEYGGHWWLQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTfaianrSRFDDSSNPLlkRNPHEFvpyieIDF 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623  77 SKFEELKRIPKRR--AIPTHLNYEMLPVTVKQKQCKIIYIVRNPKDTAVSMFHY-YRDNPNLPSTETWAAFLELFLKGDV 153
Cdd:PLN02164 132 PFFPSVDVLKDKGntLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLS 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623 154 VYGSWFDHVLS-WEEHK-NDKNVLFIFYEEMKKDFVKSLKKITAFLGIDVNDSE-----MAKIARSTSFSEMKSNAAKEN 226
Cdd:PLN02164 212 VYGPYLDHVLGyWKAYQeNPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKG 291

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 223972623 227 CDPNHVICALTSDrNLVFRKGVVGDWINYFTPKQNRVFDELFTEKMRNS 275
Cdd:PLN02164 292 EKDREDRPAVYAN-SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGT 339
Sulfotransfer_3 pfam13469
Sulfotransferase family;
40-203 3.56e-09

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 54.99  E-value: 3.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623   40 IFLVSYPKSGT-------------HWLAEVIERIPDAGITLTSPIELgdiskFEELKRIPK--RRAI---PTHLNY---- 97
Cdd:pfam13469   1 IFIVGLPRSGTtllhrllaahpdvRPPEETWFVIPRILALLQAWGKS-----LEALARVPSyaRWLCdksPSHLFHldll 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223972623   98 -EMLPvtvkqkQCKIIYIVRNPKDTAV-SMFHYYRDNpnlpsTETWAAFLELFLKGDVVYgsWFDHVLSWEEHK---NDK 172
Cdd:pfam13469  76 lKAFP------DAKFIHLHRDPVDTVIsSYCSLFGFT-----LSSYSTAFLRDIGLALAR--WSRAYERLMAARarvPPG 142

                         170       180       190
                  ....*....|....*....|....*....|.
gi 223972623  173 NVLFIFYEEMKKDFVKSLKKITAFLGIDVND 203
Cdd:pfam13469 143 RFLDVRYEDLVADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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