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Conserved domains on  [gi|225735619|ref|NP_001139585|]
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mesoderm induction early response protein 1 isoform i [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 225-269 7.02e-23

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


:

Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 89.98  E-value: 7.02e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 225735619 225 WTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKK 269
Cdd:cd11661    2 WSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
MIER1_3_C super family cl44847
Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the ...
 279-344 1.21e-13

Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the C-terminal of MIER1 and MIER3. MIER1 is a transcriptional repressor that regulates the expression of a number of genes including SP1 target genes, recruiting histone deacetylase 1 (HDAC1) through its ELM2 domain. It has two isoforms, alpha and beta, which differ in their C-terminal domains, both of them being able to interact with HDAC1. The gene encoding MIER3 has been identified as a candidate cancer susceptibility gene. MIER1 and 3 share two regions of high homology, one at the N-terminal and the second at the C-terminal, represented in this entry, which includes a short region located immediately downstream of the SANT extension that is 84% identical.


The actual alignment was detected with superfamily member pfam19426:

Pssm-ID: 437258  Cd Length: 217  Bit Score: 69.55  E-value: 1.21e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225735619  279 QTRFGKKKYNLHPGVTDYMDRLLDESESAASSrAPSPPPTASNSSNSQSEKEDGTVSTANQNGVSS 344
Cdd:pfam19426   1 QTRFGKKKYNHHPGVTDYMDRLVDEAEGLGVD-VSSSAVCSASRLEPVPDQQLSILNSITASDLTA 65
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 119-168 2.11e-10

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


:

Pssm-ID: 460214  Cd Length: 53  Bit Score: 55.70  E-value: 2.11e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 225735619  119 IMVGSMFQAEIPVgICRYKENEKVYENDDQ-LLWDPE-YLPEDKVIIFLKDA 168
Cdd:pfam01448   1 IRVGPRYQAEIPE-LLPPSEEEDRYEEEDElLVWDPNhNLPDRKLDEYLVVA 51
 
Name Accession Description Interval E-value
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 225-269 7.02e-23

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 89.98  E-value: 7.02e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 225735619 225 WTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKK 269
Cdd:cd11661    2 WSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
MIER1_3_C pfam19426
Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the ...
 279-344 1.21e-13

Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the C-terminal of MIER1 and MIER3. MIER1 is a transcriptional repressor that regulates the expression of a number of genes including SP1 target genes, recruiting histone deacetylase 1 (HDAC1) through its ELM2 domain. It has two isoforms, alpha and beta, which differ in their C-terminal domains, both of them being able to interact with HDAC1. The gene encoding MIER3 has been identified as a candidate cancer susceptibility gene. MIER1 and 3 share two regions of high homology, one at the N-terminal and the second at the C-terminal, represented in this entry, which includes a short region located immediately downstream of the SANT extension that is 84% identical.


Pssm-ID: 437258  Cd Length: 217  Bit Score: 69.55  E-value: 1.21e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225735619  279 QTRFGKKKYNLHPGVTDYMDRLLDESESAASSrAPSPPPTASNSSNSQSEKEDGTVSTANQNGVSS 344
Cdd:pfam19426   1 QTRFGKKKYNHHPGVTDYMDRLVDEAEGLGVD-VSSSAVCSASRLEPVPDQQLSILNSITASDLTA 65
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 119-168 2.11e-10

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 55.70  E-value: 2.11e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 225735619  119 IMVGSMFQAEIPVgICRYKENEKVYENDDQ-LLWDPE-YLPEDKVIIFLKDA 168
Cdd:pfam01448   1 IRVGPRYQAEIPE-LLPPSEEEDRYEEEDElLVWDPNhNLPDRKLDEYLVVA 51
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
225-270 4.60e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.06  E-value: 4.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 225735619   225 WTEEECRNFEQGLKAYG-KDFHLIqANKVRTRSVGECVAFYYMWKKS 270
Cdd:smart00717   4 WTEEEDELLIELVKKYGkNNWEKI-AKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 225-268 6.02e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.18  E-value: 6.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 225735619  225 WTEEECRNFEQGLKAYGKDFHLIqANKVRTRSVGECVAFYYMWK 268
Cdd:pfam00249   4 WTPEEDELLLEAVEKLGNRWKKI-AKLLPGRTDNQCKNRWQNYL 46
 
Name Accession Description Interval E-value
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 225-269 7.02e-23

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 89.98  E-value: 7.02e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 225735619 225 WTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKK 269
Cdd:cd11661    2 WSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
MIER1_3_C pfam19426
Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the ...
 279-344 1.21e-13

Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the C-terminal of MIER1 and MIER3. MIER1 is a transcriptional repressor that regulates the expression of a number of genes including SP1 target genes, recruiting histone deacetylase 1 (HDAC1) through its ELM2 domain. It has two isoforms, alpha and beta, which differ in their C-terminal domains, both of them being able to interact with HDAC1. The gene encoding MIER3 has been identified as a candidate cancer susceptibility gene. MIER1 and 3 share two regions of high homology, one at the N-terminal and the second at the C-terminal, represented in this entry, which includes a short region located immediately downstream of the SANT extension that is 84% identical.


Pssm-ID: 437258  Cd Length: 217  Bit Score: 69.55  E-value: 1.21e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 225735619  279 QTRFGKKKYNLHPGVTDYMDRLLDESESAASSrAPSPPPTASNSSNSQSEKEDGTVSTANQNGVSS 344
Cdd:pfam19426   1 QTRFGKKKYNHHPGVTDYMDRLVDEAEGLGVD-VSSSAVCSASRLEPVPDQQLSILNSITASDLTA 65
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 119-168 2.11e-10

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 55.70  E-value: 2.11e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 225735619  119 IMVGSMFQAEIPVgICRYKENEKVYENDDQ-LLWDPE-YLPEDKVIIFLKDA 168
Cdd:pfam01448   1 IRVGPRYQAEIPE-LLPPSEEEDRYEEEDElLVWDPNhNLPDRKLDEYLVVA 51
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 225-268 8.36e-08

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 47.96  E-value: 8.36e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 225735619 225 WTEEECRNFEQGLKAYG-KDFHLIqANKVRTRSVGECVAFYYMWK 268
Cdd:cd00167    2 WTEEEDELLLEAVKKYGkNNWEKI-AKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
225-270 4.60e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.06  E-value: 4.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 225735619   225 WTEEECRNFEQGLKAYG-KDFHLIqANKVRTRSVGECVAFYYMWKKS 270
Cdd:smart00717   4 WTEEEDELLIELVKKYGkNNWEKI-AKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 225-268 6.02e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.18  E-value: 6.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 225735619  225 WTEEECRNFEQGLKAYGKDFHLIqANKVRTRSVGECVAFYYMWK 268
Cdd:pfam00249   4 WTPEEDELLLEAVEKLGNRWKKI-AKLLPGRTDNQCKNRWQNYL 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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