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Conserved domains on  [gi|229091322|ref|NP_001153199|]
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putative phospholipase B-like 2 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Phospholip_B super family cl20281
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
38-552 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


The actual alignment was detected with superfamily member pfam04916:

Pssm-ID: 398535  Cd Length: 536  Bit Score: 540.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322   38 LAGAIPAPGGRWARDGQVPPASRSRSVLLDVSAGQ-----LLMVDGRHPDAVAWANLTNAIRETGWAFLELGTSGQYNDS 112
Cdd:pfam04916   2 LLAAVLAFSASFASHSESKTQFGTYCATVYWSAAQdsftvGLVLDKSGRNDVARAYFNDSVNTTGWGFLEIETNSVYSDT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  113 LQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEyevGYC-ERLKSFLEANLEWMQEEMESNPDSPYWHQVRLTLLQLKG 191
Cdd:pfam04916  82 LQAYAAGFLEGYLTAELIYDHYSNTFPQYCKNST---GFCdPKLRAFLEENLKWMRKQVKENPDDPYWRQVGLVYAQLDG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  192 LEDSYEGRVSFPAGKfTIKPLGFLLLQLSGDLEDLELALNKTKIKPS------LGSGSCSALIKLLPGQSDLLVAHNTWN 265
Cdd:pfam04916 159 LVAGYNARAASDKRK-PLTFFQILLLNLAGDLEDLVPALSPPKNSSQqakflmKEPGHCSALIKLLPGFEDLLFGHTTWS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  266 NYQHMLRVIKKYWLQFregpwGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVRPRGcVLE 345
Cdd:pfam04916 238 SYSAMLRIYKHYDFPV-----SDRAVVPGTTVSFSSYPGLLSSLDDFYITSSGLAVMETTNGIFNQTLYKLVKPSS-VLT 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  346 WVRNIVANRLASDGATWADIFKRFNSGT-------------------------------GMVVVADKTSELYQKTYWASY 394
Cdd:pfam04916 312 WQRVMVANRLAHSGREWAEIFSRYNSGTynnqwmvldyklftpgqelpdgtfwvveqipGYIEASDVTAVLNRTGYWPSY 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  395 NIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLMRYNDFLHDPLSLCKACnpqpngeNAIS 474
Cdd:pfam04916 392 NIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKALMRYNNYKKDPLSKGSPE-------NAIS 464
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 229091322  475 ARSDLNPANGsypfqalrQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPPFQWSTSP-FSGLLHMGQPDLWKFAPV 552
Cdd:pfam04916 465 ARGDLNPSGG--------HRAFGAIDTKVTNYALVLSLQARAISGPTTDTQPPFDWSSSPfFNVTRHQGHPDVWNFDFV 535
 
Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
38-552 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


Pssm-ID: 398535  Cd Length: 536  Bit Score: 540.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322   38 LAGAIPAPGGRWARDGQVPPASRSRSVLLDVSAGQ-----LLMVDGRHPDAVAWANLTNAIRETGWAFLELGTSGQYNDS 112
Cdd:pfam04916   2 LLAAVLAFSASFASHSESKTQFGTYCATVYWSAAQdsftvGLVLDKSGRNDVARAYFNDSVNTTGWGFLEIETNSVYSDT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  113 LQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEyevGYC-ERLKSFLEANLEWMQEEMESNPDSPYWHQVRLTLLQLKG 191
Cdd:pfam04916  82 LQAYAAGFLEGYLTAELIYDHYSNTFPQYCKNST---GFCdPKLRAFLEENLKWMRKQVKENPDDPYWRQVGLVYAQLDG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  192 LEDSYEGRVSFPAGKfTIKPLGFLLLQLSGDLEDLELALNKTKIKPS------LGSGSCSALIKLLPGQSDLLVAHNTWN 265
Cdd:pfam04916 159 LVAGYNARAASDKRK-PLTFFQILLLNLAGDLEDLVPALSPPKNSSQqakflmKEPGHCSALIKLLPGFEDLLFGHTTWS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  266 NYQHMLRVIKKYWLQFregpwGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVRPRGcVLE 345
Cdd:pfam04916 238 SYSAMLRIYKHYDFPV-----SDRAVVPGTTVSFSSYPGLLSSLDDFYITSSGLAVMETTNGIFNQTLYKLVKPSS-VLT 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  346 WVRNIVANRLASDGATWADIFKRFNSGT-------------------------------GMVVVADKTSELYQKTYWASY 394
Cdd:pfam04916 312 WQRVMVANRLAHSGREWAEIFSRYNSGTynnqwmvldyklftpgqelpdgtfwvveqipGYIEASDVTAVLNRTGYWPSY 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  395 NIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLMRYNDFLHDPLSLCKACnpqpngeNAIS 474
Cdd:pfam04916 392 NIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKALMRYNNYKKDPLSKGSPE-------NAIS 464
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 229091322  475 ARSDLNPANGsypfqalrQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPPFQWSTSP-FSGLLHMGQPDLWKFAPV 552
Cdd:pfam04916 465 ARGDLNPSGG--------HRAFGAIDTKVTNYALVLSLQARAISGPTTDTQPPFDWSSSPfFNVTRHQGHPDVWNFDFV 535
 
Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
38-552 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


Pssm-ID: 398535  Cd Length: 536  Bit Score: 540.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322   38 LAGAIPAPGGRWARDGQVPPASRSRSVLLDVSAGQ-----LLMVDGRHPDAVAWANLTNAIRETGWAFLELGTSGQYNDS 112
Cdd:pfam04916   2 LLAAVLAFSASFASHSESKTQFGTYCATVYWSAAQdsftvGLVLDKSGRNDVARAYFNDSVNTTGWGFLEIETNSVYSDT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  113 LQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEyevGYC-ERLKSFLEANLEWMQEEMESNPDSPYWHQVRLTLLQLKG 191
Cdd:pfam04916  82 LQAYAAGFLEGYLTAELIYDHYSNTFPQYCKNST---GFCdPKLRAFLEENLKWMRKQVKENPDDPYWRQVGLVYAQLDG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  192 LEDSYEGRVSFPAGKfTIKPLGFLLLQLSGDLEDLELALNKTKIKPS------LGSGSCSALIKLLPGQSDLLVAHNTWN 265
Cdd:pfam04916 159 LVAGYNARAASDKRK-PLTFFQILLLNLAGDLEDLVPALSPPKNSSQqakflmKEPGHCSALIKLLPGFEDLLFGHTTWS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  266 NYQHMLRVIKKYWLQFregpwGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVRPRGcVLE 345
Cdd:pfam04916 238 SYSAMLRIYKHYDFPV-----SDRAVVPGTTVSFSSYPGLLSSLDDFYITSSGLAVMETTNGIFNQTLYKLVKPSS-VLT 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  346 WVRNIVANRLASDGATWADIFKRFNSGT-------------------------------GMVVVADKTSELYQKTYWASY 394
Cdd:pfam04916 312 WQRVMVANRLAHSGREWAEIFSRYNSGTynnqwmvldyklftpgqelpdgtfwvveqipGYIEASDVTAVLNRTGYWPSY 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  395 NIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLMRYNDFLHDPLSLCKACnpqpngeNAIS 474
Cdd:pfam04916 392 NIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKALMRYNNYKKDPLSKGSPE-------NAIS 464
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 229091322  475 ARSDLNPANGsypfqalrQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPPFQWSTSP-FSGLLHMGQPDLWKFAPV 552
Cdd:pfam04916 465 ARGDLNPSGG--------HRAFGAIDTKVTNYALVLSLQARAISGPTTDTQPPFDWSSSPfFNVTRHQGHPDVWNFDFV 535
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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