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Conserved domains on  [gi|229576892|ref|NP_001153398|]
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paired box protein Pax-4 isoform 3 [Mus musculus]

Protein Classification

paired box protein( domain architecture ID 11265415)

paired box protein similar to mammalian Pax6, a transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas, and Drosophila gooseberry, which is involved in defining the polarity of embryonic segments

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
5-129 2.74e-76

Paired Box domain;


:

Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 229.90  E-value: 2.74e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229576892     5 GLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAV 84
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 229576892    85 VARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLR 129
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
172-227 1.96e-23

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 91.41  E-value: 1.96e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 229576892  172 RNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRR 227
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
5-129 2.74e-76

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 229.90  E-value: 2.74e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229576892     5 GLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAV 84
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 229576892    85 VARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLR 129
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
5-131 4.52e-62

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 193.79  E-value: 4.52e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229576892   5 GLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAV 84
Cdd:cd00131    1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 229576892  85 VARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLRAL 131
Cdd:cd00131   81 VKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX pfam00292
'Paired box' domain;
5-129 2.86e-58

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 183.92  E-value: 2.86e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229576892    5 GLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAV 84
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 229576892   85 VARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLR 129
Cdd:pfam00292  81 VTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
172-227 1.96e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 91.41  E-value: 1.96e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 229576892  172 RNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRR 227
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
172-226 3.14e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 82.68  E-value: 3.14e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 229576892   172 RNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWR 226
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
172-229 4.03e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 82.29  E-value: 4.03e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 229576892 172 RNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQE 229
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
167-238 1.36e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.68  E-value: 1.36e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 229576892 167 PGTSHRNRTifSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWEAQLP 238
Cdd:COG5576   50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPG 119
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
27-131 2.17e-07

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 51.78  E-value: 2.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229576892  27 RQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGV--LEPKCIGGSKPRLaTPAVVARIAQL-KDEYPALFAWEI 103
Cdd:COG3415   28 RLRAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGLagLKDRPRGGRPSKL-SDEQRERLLELlREKSPDQGSRWT 106
                         90       100
                 ....*....|....*....|....*...
gi 229576892 104 QHQLCTEGLCTQDKAPSVSSINRVLRAL 131
Cdd:COG3415  107 LAELAELLEEEFGVEVSPSTVRRLLKRL 134
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
5-129 2.74e-76

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 229.90  E-value: 2.74e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229576892     5 GLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAV 84
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 229576892    85 VARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLR 129
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
5-131 4.52e-62

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 193.79  E-value: 4.52e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229576892   5 GLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAV 84
Cdd:cd00131    1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 229576892  85 VARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLRAL 131
Cdd:cd00131   81 VKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX pfam00292
'Paired box' domain;
5-129 2.86e-58

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 183.92  E-value: 2.86e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229576892    5 GLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAV 84
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 229576892   85 VARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLR 129
Cdd:pfam00292  81 VTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
172-227 1.96e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 91.41  E-value: 1.96e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 229576892  172 RNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRR 227
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
172-226 3.14e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 82.68  E-value: 3.14e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 229576892   172 RNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWR 226
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
172-229 4.03e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 82.29  E-value: 4.03e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 229576892 172 RNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQE 229
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
167-238 1.36e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.68  E-value: 1.36e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 229576892 167 PGTSHRNRTifSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWEAQLP 238
Cdd:COG5576   50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPG 119
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
27-131 2.17e-07

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 51.78  E-value: 2.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229576892  27 RQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGV--LEPKCIGGSKPRLaTPAVVARIAQL-KDEYPALFAWEI 103
Cdd:COG3415   28 RLRAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGLagLKDRPRGGRPSKL-SDEQRERLLELlREKSPDQGSRWT 106
                         90       100
                 ....*....|....*....|....*...
gi 229576892 104 QHQLCTEGLCTQDKAPSVSSINRVLRAL 131
Cdd:COG3415  107 LAELAELLEEEFGVEVSPSTVRRLLKRL 134
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
19-68 1.91e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.59  E-value: 1.91e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 229576892  19 GRPLPLDTRQQIVQ-LAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLE 68
Cdd:cd00090    1 LKALSDPTRLRILRlLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVE 51
HTH_32 pfam13565
Homeodomain-like domain;
54-128 9.70e-04

Homeodomain-like domain;


Pssm-ID: 463923 [Multi-domain]  Cd Length: 73  Bit Score: 37.28  E-value: 9.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 229576892   54 VSKILGRYYRTGV--LEPKCIGGSKPRLaTPAVVARIAQLKDEYPALFAWEIQHQLCTEGlctqDKAPSVSSINRVL 128
Cdd:pfam13565   2 VYRWRKRYNEEGLegLEDRPRRGRPRKL-TDEQEARLLALLCEEPRWSPRLLAERLEEEF----GVKVSRSTVRRIL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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