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Conserved domains on  [gi|236461846|ref|NP_001153468|]
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pro-neuregulin-1, membrane-bound isoform isoform ndf43c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Neuregulin super family cl20026
Neuregulin intracellular region;
113-270 1.59e-85

Neuregulin intracellular region;


The actual alignment was detected with superfamily member pfam02158:

Pssm-ID: 426627  Cd Length: 360  Bit Score: 260.92  E-value: 1.59e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236461846  113 TKKQRKKLHDRLRQSLRSERNNMmNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236461846  193 VTQTPSH---SWSNGHTESILSESHSVIVMSSVENSRHSSPTG-GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 268
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158


                  ..
gi 236461846  269 RH 270
Cdd:pfam02158 159 RY 160
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 36-66 2.55e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 236461846   36 CVNGGECFMVkdlsnPSRYLCKCQPGFTGAR 66
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
PHA03099 super family cl31525
epidermal growth factor-like protein (EGF-like protein); Provisional
 28-120 8.74e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


The actual alignment was detected with superfamily member PHA03099:

Pssm-ID: 165381  Cd Length: 139  Bit Score: 36.15  E-value: 8.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236461846  28 CAEKEKTFCVNGgECFMVKDLSNpsrYLCKCQPGFTGARCTENVPMKVQNQEKAEElyQKRVLTITGICIALLVVGIMCV 107
Cdd:PHA03099  45 CGPEGDGYCLHG-DCIHARDIDG---MYCRCSHGYTGIRCQHVVLVDYQRSEKPNT--TTSYIPSPGIVLVLVGIIITCC 118

                         90
                 ....*....|...
gi 236461846 108 VAYCKTKKQRKKL 120
Cdd:PHA03099 119 LLSVYRFTRRTKL 131
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
113-270 1.59e-85

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 260.92  E-value: 1.59e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236461846  113 TKKQRKKLHDRLRQSLRSERNNMmNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236461846  193 VTQTPSH---SWSNGHTESILSESHSVIVMSSVENSRHSSPTG-GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 268
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158


                  ..
gi 236461846  269 RH 270
Cdd:pfam02158 159 RY 160
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 36-66 2.55e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 236461846   36 CVNGGECFMVkdlsnPSRYLCKCQPGFTGAR 66
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 36-68 3.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 3.03e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 236461846  36 CVNGGECFMVkdlsnPSRYLCKCQPGFTGARCT 68
Cdd:cd00054   11 CQNGGTCVNT-----VGSYRCSCPPGYTGRNCE 38
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 28-120 8.74e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 36.15  E-value: 8.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236461846  28 CAEKEKTFCVNGgECFMVKDLSNpsrYLCKCQPGFTGARCTENVPMKVQNQEKAEElyQKRVLTITGICIALLVVGIMCV 107
Cdd:PHA03099  45 CGPEGDGYCLHG-DCIHARDIDG---MYCRCSHGYTGIRCQHVVLVDYQRSEKPNT--TTSYIPSPGIVLVLVGIIITCC 118

                         90
                 ....*....|...
gi 236461846 108 VAYCKTKKQRKKL 120
Cdd:PHA03099 119 LLSVYRFTRRTKL 131
 
Name Accession Description Interval E-value
Neuregulin pfam02158
Neuregulin intracellular region;
113-270 1.59e-85

Neuregulin intracellular region;


Pssm-ID: 426627  Cd Length: 360  Bit Score: 260.92  E-value: 1.59e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236461846  113 TKKQRKKLHDRLRQSLRSERNNMmNIANGPHHPNPPPENVQLVNqYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
Cdd:pfam02158   1 TKKQRKKMHDHLRQNLRSERNNR-NLANGPNHPNPPPEEIQMVN-YISKNVPATEHVIRHEAETSFSGSHYTSTSHHSTT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236461846  193 VTQTPSH---SWSNGHTESILSESHSVIVMSSVENSRHSSPTG-GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSE 268
Cdd:pfam02158  79 VTHTSSHeerTWSNERTESVTSDSQSGIMSSSVETSKCSSPACmEARGRRNAAGGPRDPNSYLRQYRDSPDSLRDSPHSE 158


                  ..
gi 236461846  269 RH 270
Cdd:pfam02158 159 RY 160
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 36-66 2.55e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 236461846   36 CVNGGECFMVkdlsnPSRYLCKCQPGFTGAR 66
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 36-68 3.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 3.03e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 236461846  36 CVNGGECFMVkdlsnPSRYLCKCQPGFTGARCT 68
Cdd:cd00054   11 CQNGGTCVNT-----VGSYRCSCPPGYTGRNCE 38
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 28-120 8.74e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 36.15  E-value: 8.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236461846  28 CAEKEKTFCVNGgECFMVKDLSNpsrYLCKCQPGFTGARCTENVPMKVQNQEKAEElyQKRVLTITGICIALLVVGIMCV 107
Cdd:PHA03099  45 CGPEGDGYCLHG-DCIHARDIDG---MYCRCSHGYTGIRCQHVVLVDYQRSEKPNT--TTSYIPSPGIVLVLVGIIITCC 118

                         90
                 ....*....|...
gi 236461846 108 VAYCKTKKQRKKL 120
Cdd:PHA03099 119 LLSVYRFTRRTKL 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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