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Conserved domains on  [gi|236467215|ref|NP_001153621|]
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cell growth regulator with EF hand domain protein 1 precursor [Mus musculus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 184-278 4.74e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.52  E-value: 4.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236467215   184 TKEIRSQVEAKRASLEPEQEAGHQTEGKVDTLSP-------EEEARGQAESEGDVPGPREGAEE-----QVEIKDNEGEA 251
Cdd:TIGR00927  631 SKGDVAEAEHTGERTGEEGERPTEAEGENGEESGgeaeqegETETKGENESEGEIPAERKGEQEgegeiEAKEADHKGET 710

                           90       100
                   ....*....|....*....|....*..
gi 236467215   252 KELLVETLESLNTPNEAEAHSIQLEND 278
Cdd:TIGR00927  711 EAEEVEHEGETEAEGTEDEGEIETGEE 737
EF-hand_7 pfam13499
EF-hand domain pair;
73-136 1.53e-03

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 36.46  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 236467215   73 EQVLLSLFALHDYDQNGQLDGLELLSMLTAAlapgaaHFPINPVILVVDSVLETQDLDGDGLMT 136
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKL------EEGEPLSDEEVEELFKEFDLDKDGRIS 58
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 184-278 4.74e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.52  E-value: 4.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236467215   184 TKEIRSQVEAKRASLEPEQEAGHQTEGKVDTLSP-------EEEARGQAESEGDVPGPREGAEE-----QVEIKDNEGEA 251
Cdd:TIGR00927  631 SKGDVAEAEHTGERTGEEGERPTEAEGENGEESGgeaeqegETETKGENESEGEIPAERKGEQEgegeiEAKEADHKGET 710

                           90       100
                   ....*....|....*....|....*..
gi 236467215   252 KELLVETLESLNTPNEAEAHSIQLEND 278
Cdd:TIGR00927  711 EAEEVEHEGETEAEGTEDEGEIETGEE 737
EF-hand_7 pfam13499
EF-hand domain pair;
73-136 1.53e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 36.46  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 236467215   73 EQVLLSLFALHDYDQNGQLDGLELLSMLTAAlapgaaHFPINPVILVVDSVLETQDLDGDGLMT 136
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKL------EEGEPLSDEEVEELFKEFDLDKDGRIS 58
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 184-278 4.74e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.52  E-value: 4.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 236467215   184 TKEIRSQVEAKRASLEPEQEAGHQTEGKVDTLSP-------EEEARGQAESEGDVPGPREGAEE-----QVEIKDNEGEA 251
Cdd:TIGR00927  631 SKGDVAEAEHTGERTGEEGERPTEAEGENGEESGgeaeqegETETKGENESEGEIPAERKGEQEgegeiEAKEADHKGET 710

                           90       100
                   ....*....|....*....|....*..
gi 236467215   252 KELLVETLESLNTPNEAEAHSIQLEND 278
Cdd:TIGR00927  711 EAEEVEHEGETEAEGTEDEGEIETGEE 737
EF-hand_7 pfam13499
EF-hand domain pair;
73-136 1.53e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 36.46  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 236467215   73 EQVLLSLFALHDYDQNGQLDGLELLSMLTAAlapgaaHFPINPVILVVDSVLETQDLDGDGLMT 136
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKL------EEGEPLSDEEVEELFKEFDLDKDGRIS 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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