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Conserved domains on  [gi|237757297|ref|NP_001153772|]
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pannexin-2 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Innexin super family cl03000
Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans ...
 58-150 1.83e-08

Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.


The actual alignment was detected with superfamily member pfam00876:

Pssm-ID: 470716  Cd Length: 330  Bit Score: 56.43  E-value: 1.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237757297   58 TVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTE------LRDALPGVDASLWPSLFEHKF---LPYaL 128
Cdd:pfam00876  11 TVVILLFFALLVTAKQYVGDPIDCWVPAEFTGSWEEYINTYCWIEntytvpFEEDIPDEALNGERERKYISYyqwVPF-I 89

                          90       100
                  ....*....|....*....|...
gi 237757297  129 LAFAAIM-YVPALGWEFLASTRL 150
Cdd:pfam00876  90 LFFQAILfYLPRLLWKFLEGGRI 112
PRK11633 super family cl25866
cell division protein DedD; Provisional
 387-468 3.18e-03

cell division protein DedD; Provisional


The actual alignment was detected with superfamily member PRK11633:

Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237757297 387 AQSNHDATPTVR--DSGVQTVDPSANPAEPDG-AAEPPVVKRPRKKmkwiPTSNPLPQPfKEPLAIMRVENSKAEKPKPA 463
Cdd:PRK11633  65 TQPPEGAAEAVRagDAAAPSLDPATVAPPNTPvEPEPAPVEPPKPK----PVEKPKPKP-KPQQKVEAPPAPKPEPKPVV 139


                 ....*
gi 237757297 464 RRKTA 468
Cdd:PRK11633 140 EEKAA 144
 
Name Accession Description Interval E-value
Innexin pfam00876
Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans ...
 58-150 1.83e-08

Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.


Pssm-ID: 459975  Cd Length: 330  Bit Score: 56.43  E-value: 1.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237757297   58 TVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTE------LRDALPGVDASLWPSLFEHKF---LPYaL 128
Cdd:pfam00876  11 TVVILLFFALLVTAKQYVGDPIDCWVPAEFTGSWEEYINTYCWIEntytvpFEEDIPDEALNGERERKYISYyqwVPF-I 89

                          90       100
                  ....*....|....*....|...
gi 237757297  129 LAFAAIM-YVPALGWEFLASTRL 150
Cdd:pfam00876  90 LFFQAILfYLPRLLWKFLEGGRI 112
PRK11633 PRK11633
cell division protein DedD; Provisional
 387-468 3.18e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237757297 387 AQSNHDATPTVR--DSGVQTVDPSANPAEPDG-AAEPPVVKRPRKKmkwiPTSNPLPQPfKEPLAIMRVENSKAEKPKPA 463
Cdd:PRK11633  65 TQPPEGAAEAVRagDAAAPSLDPATVAPPNTPvEPEPAPVEPPKPK----PVEKPKPKP-KPQQKVEAPPAPKPEPKPVV 139


                 ....*
gi 237757297 464 RRKTA 468
Cdd:PRK11633 140 EEKAA 144
 
Name Accession Description Interval E-value
Innexin pfam00876
Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans ...
 58-150 1.83e-08

Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.


Pssm-ID: 459975  Cd Length: 330  Bit Score: 56.43  E-value: 1.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237757297   58 TVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTE------LRDALPGVDASLWPSLFEHKF---LPYaL 128
Cdd:pfam00876  11 TVVILLFFALLVTAKQYVGDPIDCWVPAEFTGSWEEYINTYCWIEntytvpFEEDIPDEALNGERERKYISYyqwVPF-I 89

                          90       100
                  ....*....|....*....|...
gi 237757297  129 LAFAAIM-YVPALGWEFLASTRL 150
Cdd:pfam00876  90 LFFQAILfYLPRLLWKFLEGGRI 112
PRK11633 PRK11633
cell division protein DedD; Provisional
 387-468 3.18e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237757297 387 AQSNHDATPTVR--DSGVQTVDPSANPAEPDG-AAEPPVVKRPRKKmkwiPTSNPLPQPfKEPLAIMRVENSKAEKPKPA 463
Cdd:PRK11633  65 TQPPEGAAEAVRagDAAAPSLDPATVAPPNTPvEPEPAPVEPPKPK----PVEKPKPKP-KPQQKVEAPPAPKPEPKPVV 139


                 ....*
gi 237757297 464 RRKTA 468
Cdd:PRK11633 140 EEKAA 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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