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Conserved domains on  [gi|257153478|ref|NP_001158019|]
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disrupted in schizophrenia 1 protein isoform i [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG4913 super family cl25907
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
329-488 9.58e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


The actual alignment was detected with superfamily member COG4913:

Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 9.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  329 LLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVE----NDDYDKAETLQQRLEDLEQEK--------------ISL 390
Cdd:COG4913   292 LLEAELEELRAELARLEAELERLEARLDALREELDELEaqirGNGGDRLEQLEREIERLERELeererrrarleallAAL 371
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  391 HFQLPSRQPALSSflghLAAQVQAALRRGATQQASGDDthtplrmeprlleptAQDSLHVSITRrdwLLQEKQQLQKEIE 470
Cdd:COG4913   372 GLPLPASAEEFAA----LRAEAAALLEALEEELEALEE---------------ALAEAEAALRD---LRRELRELEAEIA 429
                         170
                  ....*....|....*...
gi 257153478  471 ALQARMFVLEAKDQQLRR 488
Cdd:COG4913   430 SLERRKSNIPARLLALRD 447
 
Name Accession Description Interval E-value
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
329-488 9.58e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 9.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  329 LLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVE----NDDYDKAETLQQRLEDLEQEK--------------ISL 390
Cdd:COG4913   292 LLEAELEELRAELARLEAELERLEARLDALREELDELEaqirGNGGDRLEQLEREIERLERELeererrrarleallAAL 371
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  391 HFQLPSRQPALSSflghLAAQVQAALRRGATQQASGDDthtplrmeprlleptAQDSLHVSITRrdwLLQEKQQLQKEIE 470
Cdd:COG4913   372 GLPLPASAEEFAA----LRAEAAALLEALEEELEALEE---------------ALAEAEAALRD---LRRELRELEAEIA 429
                         170
                  ....*....|....*...
gi 257153478  471 ALQARMFVLEAKDQQLRR 488
Cdd:COG4913   430 SLERRKSNIPARLLALRD 447
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
336-488 3.03e-03

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 39.37  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  336 VLRDCLLRNRRqmEVISLRLKLQKLQEDAVENDDYDkaetlqQRLEDLEQEKISLHFQLPSR-QPALSSFLghlaaQVQA 414
Cdd:pfam14988  51 ELQTQLLQKEK--EQASLKKELQALRPFAKLKESQE------REIQDLEEEKEKVRAETAEKdREAHLQFL-----KEKA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  415 ALRRGATQQ---ASGDDTHTPLRMEPRLLEPTAQDSLH---VSITRRDWLLQEK-QQLQKEIEALQARMFVLEAKDQQLR 487
Cdd:pfam14988 118 LLEKQLQELrilELGERATRELKRKAQALKLAAKQALSefcRSIKRENRQLQKElLQLIQETQALEAIKSKLENRKQRLK 197

                  .
gi 257153478  488 R 488
Cdd:pfam14988 198 E 198
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
353-531 6.48e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.67  E-value: 6.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478   353 LRLKLQKLQEDAVENDD-YDKAETLQQRLEDLEQEKISL---HFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDD 428
Cdd:TIGR02169  366 LEDLRAELEEVDKEFAEtRDELKDYREKLEKLKREINELkreLDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKED 445
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478   429 THTPLRMEPRLLEPTAQDSLHVSITRRDwLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLV 508
Cdd:TIGR02169  446 KALEIKKQEWKLEQLAADLSKYEQELYD-LKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVH 524
                          170       180
                   ....*....|....*....|...
gi 257153478   509 GQLSlgQLQEVSKALQDTLASAG 531
Cdd:TIGR02169  525 GTVA--QLGSVGERYATAIEVAA 545
PRK11281 PRK11281
mechanosensitive channel MscK;
357-474 9.36e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 39.12  E-value: 9.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  357 LQKLQEDAVE--NDDYDKA--ETLQQRLEDLEQekislhfQLPSRQPALSSFLGHLAAQ------VQAALRRGAT--QQ- 423
Cdd:PRK11281  103 LEALKDDNDEetRETLSTLslRQLESRLAQTLD-------QLQNAQNDLAEYNSQLVSLqtqperAQAALYANSQrlQQi 175
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257153478  424 ----ASGDDTHTPLRMEPRLLEPTAQDSLHVSI------------------TRRDWLLQEKQQLQKEIEALQA 474
Cdd:PRK11281  176 rnllKGGKVGGKALRPSQRVLLQAEQALLNAQNdlqrkslegntqlqdllqKQRDYLTARIQRLEHQLQLLQE 248
 
Name Accession Description Interval E-value
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
329-488 9.58e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 9.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  329 LLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVE----NDDYDKAETLQQRLEDLEQEK--------------ISL 390
Cdd:COG4913   292 LLEAELEELRAELARLEAELERLEARLDALREELDELEaqirGNGGDRLEQLEREIERLERELeererrrarleallAAL 371
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  391 HFQLPSRQPALSSflghLAAQVQAALRRGATQQASGDDthtplrmeprlleptAQDSLHVSITRrdwLLQEKQQLQKEIE 470
Cdd:COG4913   372 GLPLPASAEEFAA----LRAEAAALLEALEEELEALEE---------------ALAEAEAALRD---LRRELRELEAEIA 429
                         170
                  ....*....|....*...
gi 257153478  471 ALQARMFVLEAKDQQLRR 488
Cdd:COG4913   430 SLERRKSNIPARLLALRD 447
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
337-488 1.95e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478 337 LRDCLLRNRRQMEviSLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKIslhfQLPSRQPALSSFLghlaAQVQAAL 416
Cdd:COG4717   93 LQEELEELEEELE--ELEAELEELREELEKLEKLLQLLPLYQELEALEAELA----ELPERLEELEERL----EELRELE 162
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 257153478 417 RRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARmfvLEAKDQQLRR 488
Cdd:COG4717  163 EELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEE---LEELEEELEQ 231
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
336-488 3.03e-03

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 39.37  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  336 VLRDCLLRNRRqmEVISLRLKLQKLQEDAVENDDYDkaetlqQRLEDLEQEKISLHFQLPSR-QPALSSFLghlaaQVQA 414
Cdd:pfam14988  51 ELQTQLLQKEK--EQASLKKELQALRPFAKLKESQE------REIQDLEEEKEKVRAETAEKdREAHLQFL-----KEKA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  415 ALRRGATQQ---ASGDDTHTPLRMEPRLLEPTAQDSLH---VSITRRDWLLQEK-QQLQKEIEALQARMFVLEAKDQQLR 487
Cdd:pfam14988 118 LLEKQLQELrilELGERATRELKRKAQALKLAAKQALSefcRSIKRENRQLQKElLQLIQETQALEAIKSKLENRKQRLK 197

                  .
gi 257153478  488 R 488
Cdd:pfam14988 198 E 198
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
353-531 6.48e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.67  E-value: 6.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478   353 LRLKLQKLQEDAVENDD-YDKAETLQQRLEDLEQEKISL---HFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDD 428
Cdd:TIGR02169  366 LEDLRAELEEVDKEFAEtRDELKDYREKLEKLKREINELkreLDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKED 445
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478   429 THTPLRMEPRLLEPTAQDSLHVSITRRDwLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLV 508
Cdd:TIGR02169  446 KALEIKKQEWKLEQLAADLSKYEQELYD-LKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVH 524
                          170       180
                   ....*....|....*....|...
gi 257153478   509 GQLSlgQLQEVSKALQDTLASAG 531
Cdd:TIGR02169  525 GTVA--QLGSVGERYATAIEVAA 545
PRK11281 PRK11281
mechanosensitive channel MscK;
357-474 9.36e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 39.12  E-value: 9.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257153478  357 LQKLQEDAVE--NDDYDKA--ETLQQRLEDLEQekislhfQLPSRQPALSSFLGHLAAQ------VQAALRRGAT--QQ- 423
Cdd:PRK11281  103 LEALKDDNDEetRETLSTLslRQLESRLAQTLD-------QLQNAQNDLAEYNSQLVSLqtqperAQAALYANSQrlQQi 175
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257153478  424 ----ASGDDTHTPLRMEPRLLEPTAQDSLHVSI------------------TRRDWLLQEKQQLQKEIEALQA 474
Cdd:PRK11281  176 rnllKGGKVGGKALRPSQRVLLQAEQALLNAQNdlqrkslegntqlqdllqKQRDYLTARIQRLEHQLQLLQE 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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