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Conserved domains on  [gi|257743044|ref|NP_001158151|]
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anoctamin-8 [Mus musculus]

Protein Classification

anoctamin family protein( domain architecture ID 10518511)

anoctamin family protein similar to anoctamin (anion channel with 8 transmembrane domains), which is a calcium-activated protein and may mediate the calcium-dependent exposure of phospholipids to the extracellular surface, a process called phospholipid scrambling

Gene Ontology:  GO:0005509|GO:0005229
PubMed:  24692353|21607626
SCOP:  4004881
TCDB:  1.A.17

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 237-495 7.27e-80

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 265.60  E-value: 7.27e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   237 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 316
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   317 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLC--LACLICVFILMlgcfqlqelvlsvkglpr 393
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVllLIALLVLGVII------------------ 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   394 lvrFLPKVmlallvsvsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLfqfvnsylslfyigfylkdmDRLKEMLATL 473
Cdd:pfam04547  139 ---YLNFV------------YTKLAKKLTDWENHRTQSEYENSLILKVFL--------------------DRLRIQLAII 183

                          250       260
                   ....*....|....*....|..
gi 257743044   474 LITRQLLQNVREVLQPHLYRRL 495
Cdd:pfam04547  184 MVTKQIINNITEVVLPYLKRKR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 703-872 3.43e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 233.63  E-value: 3.43e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   703 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 782
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   783 CTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHVAIPD 861
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 257743044   862 IPGWVAEEMAK 872
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
917-1057 1.77e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 48.72  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  917 RDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLkqiiPLQTRPPAPTGCAPPPRSPADTRLPAFL 996
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAA----PAAAPAPADDDPPPWEELPPEFASPAPA 512

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 257743044  997 SLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAhRSAGDEPAAAepePRPEDAG 1057
Cdd:PRK12323  513 QPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPR-AAAATEPVVA---PRPPRAS 569
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 237-495 7.27e-80

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 265.60  E-value: 7.27e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   237 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 316
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   317 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLC--LACLICVFILMlgcfqlqelvlsvkglpr 393
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVllLIALLVLGVII------------------ 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   394 lvrFLPKVmlallvsvsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLfqfvnsylslfyigfylkdmDRLKEMLATL 473
Cdd:pfam04547  139 ---YLNFV------------YTKLAKKLTDWENHRTQSEYENSLILKVFL--------------------DRLRIQLAII 183

                          250       260
                   ....*....|....*....|..
gi 257743044   474 LITRQLLQNVREVLQPHLYRRL 495
Cdd:pfam04547  184 MVTKQIINNITEVVLPYLKRKR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 703-872 3.43e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 233.63  E-value: 3.43e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   703 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 782
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   783 CTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHVAIPD 861
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 257743044   862 IPGWVAEEMAK 872
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
917-1057 1.77e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.72  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  917 RDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLkqiiPLQTRPPAPTGCAPPPRSPADTRLPAFL 996
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAA----PAAAPAPADDDPPPWEELPPEFASPAPA 512

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 257743044  997 SLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAhRSAGDEPAAAepePRPEDAG 1057
Cdd:PRK12323  513 QPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPR-AAAATEPVVA---PRPPRAS 569
KLF16_N cd21573
N-terminal domain of Kruppel-like factor 16; Kruppel-like factor 16 (KLF16; also known as ...
 930-1038 4.08e-03

N-terminal domain of Kruppel-like factor 16; Kruppel-like factor 16 (KLF16; also known as Krueppel-like factor 16, Basic transcription element binding protein 4/BTEB4, or Novel Sp1-like zinc finger transcription factor/2NSLP2) is a protein that in humans is encoded by the KLF16 gene. KLF16 functions as a transcription activator. It is thought to modulate dopaminergic transmission in the brain and also regulates the expression of several genes essential for metabolic and endocrine processes in sex steroid-sensitive uterine cells. KLF16 selectively binds three distinct KLF-binding sites (GC, CA, and BTE boxes). KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF16 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF16.


Pssm-ID: 409237 [Multi-domain]  Cd Length: 125  Bit Score: 38.43  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  930 PGPDpvaerGAAKAKGSER--PRRPGAllPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLRFLKAperG 1007
Cdd:cd21573    29 PGPE-----GAGPAAGLDVraPRREAA--PPGTP---------GPPPPPPAPSPPPGGAAAAPHLLAASILADLRG---G 89

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 257743044 1008 PSPPRPGKLFAFS---AREPSANGAPG--GGARAHR 1038
Cdd:cd21573    90 PGAAPGGASPASSssaASSPSSGRAPGaaAAAKSHR 125
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 237-495 7.27e-80

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 265.60  E-value: 7.27e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   237 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 316
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   317 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLC--LACLICVFILMlgcfqlqelvlsvkglpr 393
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVllLIALLVLGVII------------------ 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   394 lvrFLPKVmlallvsvsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLfqfvnsylslfyigfylkdmDRLKEMLATL 473
Cdd:pfam04547  139 ---YLNFV------------YTKLAKKLTDWENHRTQSEYENSLILKVFL--------------------DRLRIQLAII 183

                          250       260
                   ....*....|....*....|..
gi 257743044   474 LITRQLLQNVREVLQPHLYRRL 495
Cdd:pfam04547  184 MVTKQIINNITEVVLPYLKRKR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 703-872 3.43e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 233.63  E-value: 3.43e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   703 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 782
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044   783 CTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHVAIPD 861
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 257743044   862 IPGWVAEEMAK 872
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
917-1057 1.77e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.72  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  917 RDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLkqiiPLQTRPPAPTGCAPPPRSPADTRLPAFL 996
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAA----PAAAPAPADDDPPPWEELPPEFASPAPA 512

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 257743044  997 SLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAhRSAGDEPAAAepePRPEDAG 1057
Cdd:PRK12323  513 QPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPR-AAAATEPVVA---PRPPRAS 569
PHA03379 PHA03379
EBNA-3A; Provisional
 910-1060 2.69e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 48.52  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  910 EQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGA--LLPPGPVLRLKQIIP--LQTRPPAPTgcapPPR 985
Cdd:PHA03379  403 EALEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQVPEPPPvhDLEPGPLHDQHSMAPcpVAQLPPGPL----QDL 478

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 257743044  986 SPADtRLPAFLslrflKAPERGPSP-PRPGKLFAfSAREPSANGAPGGGARAHRSagdEPAAAEPEPRPEDAGHRP 1060
Cdd:PHA03379  479 EPGD-QLPGVV-----QDGRPACAPvPAPAGPIV-RPWEASLSQVPGVAFAPVMP---QPMPVEPVPVPTVALERP 544
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
920-1055 3.56e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.95  E-value: 3.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  920 GGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 999
Cdd:PRK12323  370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 257743044 1000 FLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAePEPRPED 1055
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAA-PAPADDD 495
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 908-1059 7.49e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.90  E-value: 7.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  908 HAEQQARRERDTGGREEARAEAP-GPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRS 986
Cdd:PRK07764  656 HVAVPDASDGGDGWPAKAGGAAPaAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAA 735

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257743044  987 PADTRLPAFLSLRFLKAPERGPSPPRPGklfafsarePSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGHR 1059
Cdd:PRK07764  736 DDPVPLPPEPDDPPDPAGAPAQPPPPPA---------PAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRR 799
PHA03247 PHA03247
large tegument protein UL36; Provisional
 920-1056 8.34e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 8.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  920 GGREEARAEAPGPDPVAERGA--AKAKGSERPRRPgALLPPGPVLRLKQiiplqTRPPAPTGCAPPpRSPADTRlpafls 997
Cdd:PHA03247 2539 GLEELASDDAGDPPPPLPPAAppAAPDRSVPPPRP-APRPSEPAVTSRA-----RRPDAPPQSARP-RAPVDDR------ 2605

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 257743044  998 lrflkAPERGPSPPRPGKLFAFSAREPsangAPGGGARAHRSAGDEPAAAEPEPRPEDA 1056
Cdd:PHA03247 2606 -----GDPRGPAPPSPLPPDTHAPDPP----PPSPSPAANEPDPHPPPTVPPPERPRDD 2655
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 912-1053 1.21e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  912 QARRERdTGGREEARAEApGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiIPLQTRPPAPTGCAPPPRSPADTR 991
Cdd:PRK07764  572 TALAEE-LGGDWQVEAVV-GPAPGAAGGEGPPAPASSGPPEEAARPAAPA------APAAPAAPAPAGAAAAPAEASAAP 643

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 257743044  992 LPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRP 1053
Cdd:PRK07764  644 APGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
PHA03378 PHA03378
EBNA-3B; Provisional
 930-1054 5.47e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.29  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  930 PGPD--PVAERGAAKAKGSERPRRPGALLPPGP-VLRLKQIIPLQTRPP--APTgCAPPPRSPADTRLPAFLSLRFLKAP 1004
Cdd:PHA03378  649 PTPHqpPQVEITPYKPTWTQIGHIPYQPSPTGAnTMLPIQWAPGTMQPPprAPT-PMRPPAAPPGRAQRPAAATGRARPP 727

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 257743044 1005 ERGPSPPRPGKLFAFSAREPSANGA----PGGGARAHRSAGDEPAAAEPEPRPE 1054
Cdd:PHA03378  728 AAAPGRARPPAAAPGRARPPAAAPGrarpPAAAPGRARPPAAAPGAPTPQPPPQ 781
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 922-1057 6.43e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  922 REEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLrlkQIIPLQTRPPAPTGCAPPPRSPADTRLPAflslrfl 1001
Cdd:PRK07764  380 RLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAA---AAPAPAAAPQPAPAPAPAPAPPSPAGNAP------- 449

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 257743044 1002 kaPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAG 1057
Cdd:PRK07764  450 --AGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP 503
PHA03247 PHA03247
large tegument protein UL36; Provisional
 920-1054 7.46e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  920 GGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplqtrPPAPTGCAPPPRSPADTRLPAFLSLR 999
Cdd:PHA03247 2729 RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA------------PPAAPAAGPPRRLTRPAVASLSESRE 2796

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 257743044 1000 FLKAPeRGPSPPRPGKLFAFSAREPSAngAPGGGARAHRSAGDEPAAAEPEPRPE 1054
Cdd:PHA03247 2797 SLPSP-WDPADPPAAVLAPAAALPPAA--SPAGPLPPPTSAQPTAPPPPPGPPPP 2848
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 915-1059 8.72e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 8.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  915 RERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplqtRPPAPTGCAPPPRSPADTRL-- 992
Cdd:PHA03307  790 VRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPA-----------RPPGAAARPPPARSSESSKSkp 858

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  993 PAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEP---RPEDAGHR 1059
Cdd:PHA03307  859 AAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGPMPpggPDPRGGFR 928
PHA03247 PHA03247
large tegument protein UL36; Provisional
 925-1060 1.40e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  925 ARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTRLPaflslrflKAP 1004
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP--------PPP 2843

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 257743044 1005 ERGPSPPRPGKLFA----FSAREPSANGAPGGGARAHRSAGDEPAAA-----EPEPRPEDAGHRP 1060
Cdd:PHA03247 2844 GPPPPSLPLGGSVApggdVRRRPPSRSPAAKPAAPARPPVRRLARPAvsrstESFALPPDQPERP 2908
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 919-1059 1.42e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  919 TGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTRLPAFLS- 997
Cdd:PHA03307   98 ASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLs 177

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257743044  998 ---------------LRFLKAPERG-PSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDepaAAEPEPRPEDAGHR 1059
Cdd:PHA03307  178 speetarapssppaePPPSTPPAAAsPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD---SSSSESSGCGWGPE 252
PHA03247 PHA03247
large tegument protein UL36; Provisional
 917-1053 1.48e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  917 RDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPgalLPPGPVlrlkqiiplqtrPPAPTGCAPPPRSPA----DTRL 992
Cdd:PHA03247 2576 RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGP---APPSPL------------PPDTHAPDPPPPSPSpaanEPDP 2640

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 257743044  993 PAFLSLRFLKAPERGPSPPR---------PGKLFAFSA--REPSANGAPGGGARAHRSAGDEPAAAEPEPRP 1053
Cdd:PHA03247 2641 HPPPTVPPPERPRDDPAPGRvsrprrarrLGRAAQASSppQRPRRRAARPTVGSLTSLADPPPPPPTPEPAP 2712
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
909-1046 1.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  909 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPvlRLKQIIPLQTRPPAPTGCAPPPRSPA 988
Cdd:PRK07003  423 AEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADS--GSASAPASDAPPDAAFEPAPRAAAPS 500

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 257743044  989 DTRLPAFLSLRFLKAPERGPSPPRPgklfafSAREPSANGAPGGGARAHRSAGDEPAA 1046
Cdd:PRK07003  501 AATPAAVPDARAPAAASREDAPAAA------APPAPEARPPTPAAAAPAARAGGAAAA 552
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 909-1056 1.64e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  909 AEQQARRERDTGGREEARAEAPG-----PDPVAERGAAKAKGSERPRRPGAllppgpvlrlkqiiPLQTRPPAPTgcAPP 983
Cdd:PRK07764  378 LERLERRLGVAGGAGAPAAAAPSaaaaaPAAAPAPAAAAPAAAAAPAPAAA--------------PQPAPAPAPA--PAP 441

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 257743044  984 PRSPADTRLPAFLSLRFLKAPE--RGPSPPRPGKLFAFSAREPSANGAPGGGARAhrsagdePAAAEPEPRPEDA 1056
Cdd:PRK07764  442 PSPAGNAPAGGAPSPPPAAAPSaqPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA-------PAAPAAPAGADDA 509
PHA03247 PHA03247
large tegument protein UL36; Provisional
 908-1060 1.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  908 HAEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPlqtrPPAPTGCAPPPRSP 987
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP----PPPTPEPAPHALVS 2717

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 257743044  988 ADTRLPAFLSLR-FLKAPERGPSPPRPgklfafsarePSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGHRP 1060
Cdd:PHA03247 2718 ATPLPPGPAAARqASPALPAAPAPPAV----------PAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 908-1060 2.08e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  908 HAEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPP-------GPVLRLKQIIPLQTRPPAPTGC 980
Cdd:PHA03307   77 TEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPpspapdlSEMLRPVGSPGPPPAASPPAAG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  981 APPPRSPADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSarePSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGHRP 1060
Cdd:PHA03307  157 ASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPS---TPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAG 233
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 916-1026 2.71e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 41.53  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  916 ERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPG--ALLPPG-PVLrlkQIIPLQtrPPAPTGCAPPPRSP----- 987
Cdd:PHA03264  292 VEDGAPGRETGGEGEGPEPAGRDGAAGGEPKPGPPRPApdADRPEGwPSL---EAITFP--PPTPATPAVPRARPvivgt 366

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 257743044  988 -----------ADTRLPAFLSLRFLKAperGPSPPRPGKLFAFSAREPSA 1026
Cdd:PHA03264  367 giaaaaiacvaAAGAVAYFVYTRRRGA---GPLPTKEKKLLAFGNVNYSA 413
KLF16_N cd21573
N-terminal domain of Kruppel-like factor 16; Kruppel-like factor 16 (KLF16; also known as ...
 930-1038 4.08e-03

N-terminal domain of Kruppel-like factor 16; Kruppel-like factor 16 (KLF16; also known as Krueppel-like factor 16, Basic transcription element binding protein 4/BTEB4, or Novel Sp1-like zinc finger transcription factor/2NSLP2) is a protein that in humans is encoded by the KLF16 gene. KLF16 functions as a transcription activator. It is thought to modulate dopaminergic transmission in the brain and also regulates the expression of several genes essential for metabolic and endocrine processes in sex steroid-sensitive uterine cells. KLF16 selectively binds three distinct KLF-binding sites (GC, CA, and BTE boxes). KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF16 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF16.


Pssm-ID: 409237 [Multi-domain]  Cd Length: 125  Bit Score: 38.43  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  930 PGPDpvaerGAAKAKGSER--PRRPGAllPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLRFLKAperG 1007
Cdd:cd21573    29 PGPE-----GAGPAAGLDVraPRREAA--PPGTP---------GPPPPPPAPSPPPGGAAAAPHLLAASILADLRG---G 89

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 257743044 1008 PSPPRPGKLFAFS---AREPSANGAPG--GGARAHR 1038
Cdd:cd21573    90 PGAAPGGASPASSssaASSPSSGRAPGaaAAAKSHR 125
PHA03247 PHA03247
large tegument protein UL36; Provisional
 929-1053 5.84e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  929 APGpDPVAERG---AAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPA--PTGCAPPPRSPADTRLPAFLSLRFLKA 1003
Cdd:PHA03247 2857 APG-GDVRRRPpsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPErpPQPQAPPPPQPQPQPPPPPQPQPPPPP 2935

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 257743044 1004 PERGPSPPRPgklfafsAREPSANGAPGGGARAHRSAGDEPAAAE------PEPRP 1053
Cdd:PHA03247 2936 PPRPQPPLAP-------TTDPAGAGEPSGAVPQPWLGALVPGRVAvprfrvPQPAP 2984
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
924-1056 6.05e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 6.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  924 EARAEAPG---PDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiPLQTRPPAPTGCAPPPrsPADTRLPAFLSLRF 1000
Cdd:PRK12323  417 RAVAAAPArrsPAPEALAAARQASARGPGGAPAPAPAPAAA-------PAAAARPAAAGPRPVA--AAAAAAPARAAPAA 487

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 257743044 1001 LKAPERGPSPP---RPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDA 1056
Cdd:PRK12323  488 APAPADDDPPPweeLPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPA 546
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 909-1013 7.04e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  909 AEQQARRERDTGGREEARAEAPGPDPVAERG----AAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPP 984
Cdd:PRK14951  370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAApapaAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449

                          90       100
                  ....*....|....*....|....*....
gi 257743044  985 RSPADTRlPAFLSLRFLKAPERGPSPPRP 1013
Cdd:PRK14951  450 APPAQAA-PETVAIPVRVAPEPAVASAAP 477
PHA03247 PHA03247
large tegument protein UL36; Provisional
 914-1051 7.33e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  914 RRERDTGGREEARAEAPGPDPVAErgaakakGSERPRRPGALLPPGPVLRLKQIIPLQTRP---PAPTGCAPP------- 983
Cdd:PHA03247 2686 RAARPTVGSLTSLADPPPPPPTPE-------PAPHALVSATPLPPGPAAARQASPALPAAPappAVPAGPATPggparpa 2758

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257743044  984 -PRSPADTRLPAFLSLRFLKAPERGPSPP----RPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEP 1051
Cdd:PHA03247 2759 rPPTTAGPPAPAPPAAPAAGPPRRLTRPAvaslSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP 2831
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 927-1058 8.96e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  927 AEAPGPDPVAERGAAKAKGSERPRRPGALLPPGpvlRLKQIIPLQTRPPAPTGCAPPPRS---PADTRLPAflslrflkA 1003
Cdd:PRK07764  631 GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAS---DGGDGWPAKAGGAAPAAPPPAPAPaapAAPAGAAP--------A 699

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 257743044 1004 PERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGH 1058
Cdd:PRK07764  700 QPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGA 754
PHA03321 PHA03321
tegument protein VP11/12; Provisional
 917-1053 9.50e-03

tegument protein VP11/12; Provisional


Pssm-ID: 223041 [Multi-domain]  Cd Length: 694  Bit Score: 39.94  E-value: 9.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743044  917 RDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLP-PGPVLRLKQIIPL---QTRPPAPTGC-----------A 981
Cdd:PHA03321  428 RQPPGAPAPRRDNDPPPPPRARPGSTPACARRARAQRARDAgPEYVDPLGALRRLpagAAPPPEPAAApspatyytrmgG 507

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 257743044  982 PPPRSPAdtRLPAFLSLRflkaPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRP 1053
Cdd:PHA03321  508 GPPRLPP--RNRATETLR----PDWGPPAAAPPEQMEDPYLEPDDDRFDRRDGAAAAATSHPREAPAPDDDP 573
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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