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Conserved domains on  [gi|259013354|ref|NP_001158277|]
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thrombospondin type-1 domain-containing protein 7A precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 184-235 3.41e-18

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 79.63  E-value: 3.41e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 259013354   184 CIVSEFSPWSECSRTCGSGLQHRTRHVVAPPQYGGSGCPNLTEFQVCQSNPC 235
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1276-1329 5.87e-15

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 70.39  E-value: 5.87e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 259013354  1276 CQLSDWSSWSQCSQTCGlTGKMIRKRTVTQPFQGDGRPCPSLmEQSKPCPVKPC 1329
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-GGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 350-404 1.25e-12

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 63.84  E-value: 1.25e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259013354   350 CQVSEWLEWSPCSKTCHdvtspTGTRVRTRTITQFPIGSEKECPALEEKEPCVSQ 404
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-----GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLP 50
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1025-1065 2.68e-11

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 59.99  E-value: 2.68e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 259013354  1025 CKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKL 1065
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL 41
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 761-817 9.43e-10

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 55.75  E-value: 9.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 259013354   761 CVVTPYSDWTPCPSSCREGdsgarKQSRQRVIIQLPANGGKECSdPLYEEKACEAPP 817
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGG-----VQTRTRTVIVEPQNGGRPCP-ELLERRPCNLPP 51
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1404-1463 2.10e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 51.90  E-value: 2.10e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013354  1404 CYLNDWSSWSLCQLTCvngedlgFGGIQVRSRAVIIQELENQHLCPEQmLETKSCDDGQC 1463
Cdd:pfam19028    1 CVVSEWSEWSECSVTC-------GGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1155-1206 2.58e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 51.51  E-value: 2.58e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 259013354  1155 CVISEWGPWTQCALPCNPsGSRQRSADPIRQPADEGRACPDAVEKEPCSLNK 1206
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGG-GVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1088-1150 8.20e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.75  E-value: 8.20e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 259013354  1088 WVTEPWSVCKVTfvdmrdnCGEGVQTRKVRCMQntADGPSEhVEDYLCDPEDMPLGSRECKLP 1150
Cdd:pfam19030    1 WVAGPWGECSVT-------CGGGVQTRLVQCVQ--KGGGSI-VPDSECSAQKKPPETQSCNLK 53
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 502-562 9.54e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 44.19  E-value: 9.54e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 259013354   502 CEVSPWSAWGPCTYEnCNdqqgkKGFKLRKRRITNEPTGGSGAtgnCPHLLEAIPCEEPSC 562
Cdd:pfam19028    1 CVVSEWSEWSECSVT-CG-----GGVQTRTRTVIVEPQNGGRP---CPELLERRPCNLPPC 52
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 688-756 2.39e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 2.39e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013354   688 WQTGPWGQCiedtsvssfnttttwngEASCSVGMQTRKVICVRVNVGQ-VGPKKCPESLRPETVRPCLLP 756
Cdd:pfam19030    1 WVAGPWGEC-----------------SVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLK 53
 
Name Accession Description Interval E-value
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 184-235 3.41e-18

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 79.63  E-value: 3.41e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 259013354   184 CIVSEFSPWSECSRTCGSGLQHRTRHVVAPPQYGGSGCPNLTEFQVCQSNPC 235
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1276-1329 5.87e-15

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 70.39  E-value: 5.87e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 259013354  1276 CQLSDWSSWSQCSQTCGlTGKMIRKRTVTQPFQGDGRPCPSLmEQSKPCPVKPC 1329
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-GGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 350-404 1.25e-12

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 63.84  E-value: 1.25e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259013354   350 CQVSEWLEWSPCSKTCHdvtspTGTRVRTRTITQFPIGSEKECPALEEKEPCVSQ 404
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-----GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLP 50
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1025-1065 2.68e-11

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 59.99  E-value: 2.68e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 259013354  1025 CKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKL 1065
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL 41
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 761-817 9.43e-10

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 55.75  E-value: 9.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 259013354   761 CVVTPYSDWTPCPSSCREGdsgarKQSRQRVIIQLPANGGKECSdPLYEEKACEAPP 817
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGG-----VQTRTRTVIVEPQNGGRPCP-ELLERRPCNLPP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 186-236 5.07e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.74  E-value: 5.07e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 259013354    186 VSEFSPWSECSRTCGSGLQHRTRHVV-APPQYGGSGCP-NLTEFQVCQSNPCE 236
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCsPPPQNGGGPCTgEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1404-1463 2.10e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 51.90  E-value: 2.10e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013354  1404 CYLNDWSSWSLCQLTCvngedlgFGGIQVRSRAVIIQELENQHLCPEQmLETKSCDDGQC 1463
Cdd:pfam19028    1 CVVSEWSEWSECSVTC-------GGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1155-1206 2.58e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 51.51  E-value: 2.58e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 259013354  1155 CVISEWGPWTQCALPCNPsGSRQRSADPIRQPADEGRACPDAVEKEPCSLNK 1206
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGG-GVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1279-1329 4.38e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.35  E-value: 4.38e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 259013354   1279 SDWSSWSQCSQTCGlTGKMIRKRTVT-QPFQGDGRPCPSLMEQSKPCPVKPC 1329
Cdd:smart00209    2 SEWSEWSPCSVTCG-GGVQTRTRSCCsPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1088-1150 8.20e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.75  E-value: 8.20e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 259013354  1088 WVTEPWSVCKVTfvdmrdnCGEGVQTRKVRCMQntADGPSEhVEDYLCDPEDMPLGSRECKLP 1150
Cdd:pfam19030    1 WVAGPWGECSVT-------CGGGVQTRLVQCVQ--KGGGSI-VPDSECSAQKKPPETQSCNLK 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 502-562 9.54e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.19  E-value: 9.54e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 259013354   502 CEVSPWSAWGPCTYEnCNdqqgkKGFKLRKRRITNEPTGGSGAtgnCPHLLEAIPCEEPSC 562
Cdd:pfam19028    1 CVVSEWSEWSECSVT-CG-----GGVQTRTRTVIVEPQNGGRP---CPELLERRPCNLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 688-756 2.39e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 2.39e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013354   688 WQTGPWGQCiedtsvssfnttttwngEASCSVGMQTRKVICVRVNVGQ-VGPKKCPESLRPETVRPCLLP 756
Cdd:pfam19030    1 WVAGPWGEC-----------------SVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLK 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1028-1066 1.07e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 1.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 259013354   1028 SEWSNWSRCSKSCGSGVKVRSKW-LREKPYNGGRPCPKLD 1066
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRScCSPPPQNGGGPCTGED 41
 
Name Accession Description Interval E-value
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 184-235 3.41e-18

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 79.63  E-value: 3.41e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 259013354   184 CIVSEFSPWSECSRTCGSGLQHRTRHVVAPPQYGGSGCPNLTEFQVCQSNPC 235
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1276-1329 5.87e-15

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 70.39  E-value: 5.87e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 259013354  1276 CQLSDWSSWSQCSQTCGlTGKMIRKRTVTQPFQGDGRPCPSLmEQSKPCPVKPC 1329
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-GGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 350-404 1.25e-12

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 63.84  E-value: 1.25e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 259013354   350 CQVSEWLEWSPCSKTCHdvtspTGTRVRTRTITQFPIGSEKECPALEEKEPCVSQ 404
Cdd:pfam19028    1 CVVSEWSEWSECSVTCG-----GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLP 50
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1025-1065 2.68e-11

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 59.99  E-value: 2.68e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 259013354  1025 CKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKL 1065
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL 41
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 761-817 9.43e-10

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 55.75  E-value: 9.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 259013354   761 CVVTPYSDWTPCPSSCREGdsgarKQSRQRVIIQLPANGGKECSdPLYEEKACEAPP 817
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGG-----VQTRTRTVIVEPQNGGRPCP-ELLERRPCNLPP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 186-236 5.07e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.74  E-value: 5.07e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 259013354    186 VSEFSPWSECSRTCGSGLQHRTRHVV-APPQYGGSGCP-NLTEFQVCQSNPCE 236
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCsPPPQNGGGPCTgEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1404-1463 2.10e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 51.90  E-value: 2.10e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013354  1404 CYLNDWSSWSLCQLTCvngedlgFGGIQVRSRAVIIQELENQHLCPEQmLETKSCDDGQC 1463
Cdd:pfam19028    1 CVVSEWSEWSECSVTC-------GGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1155-1206 2.58e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 51.51  E-value: 2.58e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 259013354  1155 CVISEWGPWTQCALPCNPsGSRQRSADPIRQPADEGRACPDAVEKEPCSLNK 1206
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGG-GVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1279-1329 4.38e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.35  E-value: 4.38e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 259013354   1279 SDWSSWSQCSQTCGlTGKMIRKRTVT-QPFQGDGRPCPSLMEQSKPCPVKPC 1329
Cdd:smart00209    2 SEWSEWSPCSVTCG-GGVQTRTRSCCsPPPQNGGGPCTGEDVETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
187-235 1.35e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.64  E-value: 1.35e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 259013354   187 SEFSPWSECSRTCGSGLQHRTRHVVAPPQYGGSGCPNLTEFQVCQSNPC 235
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
1279-1329 2.05e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.26  E-value: 2.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 259013354  1279 SDWSSWSQCSQTCGLtGKMIRKRTVTQPFQGdGRPCPSLMEQSKPCPVKPC 1329
Cdd:pfam00090    1 SPWSPWSPCSVTCGK-GIQVRQRTCKSPFPG-GEPCTGDDIETQACKMDKC 49
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1088-1150 8.20e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.75  E-value: 8.20e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 259013354  1088 WVTEPWSVCKVTfvdmrdnCGEGVQTRKVRCMQntADGPSEhVEDYLCDPEDMPLGSRECKLP 1150
Cdd:pfam19030    1 WVAGPWGECSVT-------CGGGVQTRLVQCVQ--KGGGSI-VPDSECSAQKKPPETQSCNLK 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 502-562 9.54e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.19  E-value: 9.54e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 259013354   502 CEVSPWSAWGPCTYEnCNdqqgkKGFKLRKRRITNEPTGGSGAtgnCPHLLEAIPCEEPSC 562
Cdd:pfam19028    1 CVVSEWSEWSECSVT-CG-----GGVQTRTRTVIVEPQNGGRP---CPELLERRPCNLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 688-756 2.39e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 2.39e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013354   688 WQTGPWGQCiedtsvssfnttttwngEASCSVGMQTRKVICVRVNVGQ-VGPKKCPESLRPETVRPCLLP 756
Cdd:pfam19030    1 WVAGPWGEC-----------------SVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLK 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1028-1066 1.07e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 1.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 259013354   1028 SEWSNWSRCSKSCGSGVKVRSKW-LREKPYNGGRPCPKLD 1066
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRScCSPPPQNGGGPCTGED 41
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 191-235 1.58e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.90  E-value: 1.58e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 259013354   191 PWSECSRTCGSGLQHRT---RHVVAPPQYGGSGCPNL---TEFQVCQSNPC 235
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLvqcVQKGGGSIVPDSECSAQkkpPETQSCNLKPC 55
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 189-235 2.52e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 37.31  E-value: 2.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 259013354   189 FSPWSECSRTCGSGLQHRTRhvvappqYGGSGCPNLTEFQVCQSNPC 235
Cdd:pfam19035    5 STEWSPCSKTCGMGVSTRVS-------NDNAECKLVTETRLCQLRPC 44
TSP_1 pfam00090
Thrombospondin type 1 domain;
1028-1079 2.66e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.40  E-value: 2.66e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 259013354  1028 SEWSNWSRCSKSCGSGVKVRSKwLREKPYNGGRPCPklDHVNQAQVYEVVPC 1079
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQR-TCKSPFPGGEPCT--GDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
353-404 4.27e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.63  E-value: 4.27e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 259013354   353 SEWLEWSPCSKTCHDvtsptGTRVRTRTITQFPIGSEkECPA-LEEKEPCVSQ 404
Cdd:pfam00090    1 SPWSPWSPCSVTCGK-----GIQVRQRTCKSPFPGGE-PCTGdDIETQACKMD 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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