|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
12-1142 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1974.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 12 PSYTPpARTAAPQILAG---SLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVE 88
Cdd:TIGR00918 13 PSYCD-AAFALEQIDKGkatGRRAPLWLRAKFQRLLFTLGCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 89 VGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLI 168
Cdd:TIGR00918 92 VGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPST 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 169 ENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFAS-LEGFRELLDKAQVGQAY 247
Cdd:TIGR00918 172 EGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSqVESWEEMLKKAAVGQGY 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 248 VGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQ 327
Cdd:TIGR00918 252 MERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPKQ 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 328 LYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLA 407
Cdd:TIGR00918 332 MYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLA 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 408 YACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPL 487
Cdd:TIGR00918 412 YACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNIPF 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 488 QERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
Cdd:TIGR00918 492 EERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCC 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 568 FSSPCSAQVIQILPQELGDG-TVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLL 646
Cdd:TIGR00918 572 FFSPCSARVIQIEPQAYADGsAPPVYSSHMQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQPSDPLSCQSPDIAGSTRDLL 651
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 647 GQEEETrqKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAF 726
Cdd:TIGR00918 652 SQFEDS--KAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDF 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 727 LSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRIT 806
Cdd:TIGR00918 730 LDAQFRYFSFYNMYAVTQGNFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFRDWLQGLQKAFDEDWRDGRIT 809
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 807 RHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWL 886
Cdd:TIGR00918 810 KENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSNDPVAYAASQANIYPHPPEWL 889
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 887 HDKYDTTGENLRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLL 966
Cdd:TIGR00918 890 HDKNDYDPENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSYPSGYPFLFWEQYMGLRHWLLL 969
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 967 AVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGS 1046
Cdd:TIGR00918 970 SISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGD 1049
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 1047 RNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKE 1126
Cdd:TIGR00918 1050 RNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEPEVSPAEGR 1129
|
1130
....*....|....*.
gi 261823993 1127 SPEILSPPAPQGGGLR 1142
Cdd:TIGR00918 1130 SRLPTPSPEPPPGGVR 1145
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
38-1089 |
2.02e-50 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 195.13 E-value: 2.02e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 38 AYFQGLLFSL----GCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGeeAAYTSQ 113
Cdd:TIGR00917 303 STVQGHLARFfgkyGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFG--PFYRIE 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 114 MLIQTARQEGEN-----ILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLieNGMIERMIEKLFPcviltp 188
Cdd:TIGR00917 381 QLIIATVQTSSHekapeILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPY--NCFIYSTCKKLQN------ 452
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 189 ldcfwegaklqggsaylpgrpdiQWTNLDPEQLlEELGPFASLEGFRELLdkaqvgqayvgrpcLHPDDLHCPPSAPnhh 268
Cdd:TIGR00917 453 -----------------------MYSKLKPENY-DDYGGVDYVKYCFEHF--------------TSPESCLSAFGGP--- 491
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 269 srqapnvahelsggchgfshkfmhWQEELLLGGMARDPQGEllrAEALQSTFLLmsprqlyehfrgdyqthDIGWSEEQA 348
Cdd:TIGR00917 492 ------------------------VDPTTVLGGFSGNNFSE---ASAFVVTFPV-----------------NNFVNKTNK 527
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 349 STVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTM-----LRWDCAQSQG 423
Cdd:TIGR00917 528 TEKAVAWEKAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLgdsprLKSLYVTSKV 607
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 424 SVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAF-----------TEALPGTPLQERMG 492
Cdd:TIGR00917 608 LLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgVDNEQELTLERRLS 687
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 493 ECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSspc 572
Cdd:TIGR00917 688 RALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIK--- 764
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 573 saqviqilpqeLGDGtvpvGIAHLTATVQAFTHCeassqhvvtilppqahlvpppsdplgselfspggstrdllgqeeet 652
Cdd:TIGR00917 765 -----------TSKS----SISAEKGSGQRKAGL---------------------------------------------- 783
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 653 rqkaackslpcarwnLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTK-EHAFLSAQL 731
Cdd:TIGR00917 784 ---------------LTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYlQIYFASLTP 848
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 732 RYFSLYEVALVTQGGFDYAHSQ---RALFDLHQRFSSLKAVLP--PPATQAPRTWLHYYRNWLQGIQAAFDQDWASGrit 806
Cdd:TIGR00917 849 LLEVGPPFYIVIKGDYNYTDFEsqnKLCTMGGCDKDSIVNVFNnlSYIAKPASSWLDDYLVWLSPQASCCCRKFTNG--- 925
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 807 rhSYRNGSEDGALAYKLLIQTGDAQ-EPLDFSQLTTRKLVDregLIPPELFYMGLTVWVSSDPLGLAAS--QANFYpppp 883
Cdd:TIGR00917 926 --TFCNGPDPQCFRCADLSSDAQGRpSTTQFKEKLPWFLNA---LPSADCAKGGHAAYSSAVDLQGYATiiQASSF---- 996
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 884 ewlhDKYDTTgenlrippaqplefaqfpfllrgLQKTADFVEAIEGARAACAEAGQ-AGVHAYPSGSPFLFWEQYLGLRR 962
Cdd:TIGR00917 997 ----RTYHTP-----------------------LNTQVDFINAMRAAQEFAAKVSRsSKMEVYPYSVFYVFFEQYLTIWK 1049
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 963 CFLLAVCILLVCTFLVCALLL-LNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFL 1041
Cdd:TIGR00917 1050 TAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFS 1129
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|
gi 261823993 1042 TT-QGSRNLRAAHALEHTFAPVTDG-AISTLLGLLMLAGSHFDFIVRYFF 1089
Cdd:TIGR00917 1130 TGkHFSRNHRAKEALGGMGSSVFSGiTLTKLVGVVVLGFSRSEIFVVYYF 1179
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
418-570 |
1.06e-49 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 172.77 E-value: 1.06e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 418 CAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQR 497
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261823993 498 TGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSS 570
Cdd:pfam12349 81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
374-1077 |
5.06e-43 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 169.46 E-value: 5.06e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 374 QIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVT-----MLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLG 448
Cdd:pfam02460 195 QFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlsSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMG 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 449 ITFNAATTqVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFS 528
Cdd:pfam02460 275 FPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFC 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 529 LQAAIVVGCTFVAVMLVFPAILSLDLRRrhcqrldvlccfsspcsaqviqilpqelgdgtvpvgiahltatvqafthcEA 608
Cdd:pfam02460 354 AYTAVAIFFDFIYQITFFAAIMAICAKP--------------------------------------------------EA 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 609 SSQHVVtilppqahLVPPPSDPlgSELFSpggstrdllgqeEETRQKAACKSLPCARwnlaHFARYQFAPLLLQSHAKAI 688
Cdd:pfam02460 384 EGRHCL--------FVWATSSP--QRIDS------------EGSEPDKSHNIEQLKS----RFFLDIYCPFLLNPSVRVC 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 689 VLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQ----LRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFS 764
Cdd:pfam02460 438 MLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLRekhfWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFE 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 765 SLKAVLPPPATQaprTWLHYYRNWLQGIQAAFDQDwasgritrhsyrngsedgalayklliqtgdaqepldfsqlttrkl 844
Cdd:pfam02460 518 NTPYSLGPNSTL---FWLREYENFLSTLNMEEEED--------------------------------------------- 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 845 vdreglIPPELFYMGLTVWvssdplgLAASqanFYPPppeWLHDKY--DTTGEnlrippaqpLEFAQFPFLLRGLQKTAD 922
Cdd:pfam02460 550 ------EEKEWSYGNLPSF-------LKAP---GNSH---WAGDLVwdDNTTM---------VTKFRFTLAGKGLSTWND 601
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 923 FVEAIEGARAACAEAGQAGVHAYPSGSPFLfwEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVE 1002
Cdd:pfam02460 602 RTRALQEWRSIADQYPEFNVTVFDEDAPFA--DQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIG 679
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261823993 1003 LFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSR-NLRAAHALEHTFAPVTDGAISTLLGLLMLA 1077
Cdd:pfam02460 680 VFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTpAERVVDALEALGWPVFQGGLSTILGVLVLL 755
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
384-1085 |
3.47e-23 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 106.48 E-value: 3.47e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 384 DDILHAFSEVSAARVVGGYLLMLAYACVTMLRWdcaqsqgSVGLAGVLLVALAVASGLGLCALLGITFNAATTqVLPFLA 463
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 464 LGIGVDD-VFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAV 542
Cdd:COG1033 282 LAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 543 MLVFPAILSLdlrrrhcqrldvlccfsspcsaqviqilpqelgdgtvpvgiahltatvqafthceassqhvvtiLPPQAH 622
Cdd:COG1033 362 LTLLPALLSL----------------------------------------------------------------LPRPKP 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 623 LVPPPSDPLGSELFSPGgstrdllgqeeetrqkaackslpcarwnLAHFARyqfaplllqsHAKAIVLVLFGALLGLSLY 702
Cdd:COG1033 378 KTRRLKKPPELGRLLAK----------------------------LARFVL----------RRPKVILVVALVLAVVSLY 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 703 GATLVQDGLALTDVVPRGT---KEHAFLSAQLRYFSLYEVAL--VTQGGFDYAHSQRALFDLHQRFSSLKAVLpppATQA 777
Cdd:COG1033 420 GISRLKVEYDFEDYLPEDSpirQDLDFIEENFGGSDPLEVVVdtGEPDGLKDPEVLKEIDRLQDYLESLPEVG---KVLS 496
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 778 PRTWLHYYRnwlqgiQAAFDQDWASGRITRhsyrngSEDGALAYKLLIQTGDAQEpldfsqltTRKLVDREGLippelfY 857
Cdd:COG1033 497 LADLVKELN------QALNEGDPKYYALPE------SRELLAQLLLLLSSPPGDD--------LSRFVDEDYS------A 550
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 858 MGLTVWVSsdplglaasqanfyppppewlhdkyDTTGENLRippaqplefaqfpfllrglqktaDFVEAIEgaRAACAEA 937
Cdd:COG1033 551 ARVTVRLK-------------------------DLDSEEIK-----------------------ALVEEVR--AFLAENF 580
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 938 GQAGVHAYPSGSPFLF--WEQYL--GLRRCFLLAvcILLVctFLVCALLLLNpWTAGLIVLVLAMMTVEL-FGIMGFLGI 1012
Cdd:COG1033 581 PPDGVEVTLTGSAVLFaaINESVieSQIRSLLLA--LLLI--FLLLLLAFRS-LRLGLISLIPNLLPILLtFGLMGLLGI 655
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261823993 1013 KLSAIPVVILVASVGIGVEFTVHVALGFLT-TQGSRNLRAA--HALEHTFAPVTDGAISTLLGLLMLAGSHFDFIV 1085
Cdd:COG1033 656 PLNIATAVVASIALGIGVDYTIHFLSRYREeRRKGGDLEEAirRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLA 731
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
424-561 |
4.00e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 83.76 E-value: 4.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 424 SVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPfLALGIGVDDVFLLAHAFTEAL-PGTPLQERMGECLQRTGTSV 502
Cdd:COG1033 630 RLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYTIHFLSRYREERrKGGDLEEAIRRALRTTGKAI 708
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 261823993 503 VLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLdLRRRHCQR 561
Cdd:COG1033 709 LFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLL-LDPRIAKK 766
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
909-1088 |
4.19e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 77.21 E-value: 4.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 909 QFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWT 988
Cdd:COG1033 165 VVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRG 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 989 AGLIVLVLAMMTVELFGIMGFLGIKLS----AIPVVILvasvGIGVEFTVHVALGF---LTTQGSRNLRAAHALEHTFAP 1061
Cdd:COG1033 245 VLLPLLVVLLAVIWTLGLMGLLGIPLSpltiLVPPLLL----AIGIDYGIHLLNRYreeRRKGLDKREALREALRKLGPP 320
|
170 180
....*....|....*....|....*..
gi 261823993 1062 VTDGAISTLLGLLMLAGSHFDfIVRYF 1088
Cdd:COG1033 321 VLLTSLTTAIGFLSLLFSDIP-PIRDF 346
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
423-557 |
1.47e-08 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 59.01 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 423 GSVGLAGV--LLVALAVASGLGLCALLG--ITFNAATTQVLPFLALGIGVD-DVFLLAhAFTEALP-GTPLQERMGECLQ 496
Cdd:COG2409 191 RSLVAALLplLTAGLAVGVALGLLALLAafTDVSSFAPNLLTMLGLGVGIDyALFLVS-RYREELRaGEDREEAVARAVA 269
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261823993 497 RTGTSVV---LTSInnmAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLdLRRR 557
Cdd:COG2409 270 TAGRAVLfsgLTVA---IALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALLAL-LGRR 329
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
425-552 |
1.50e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 59.08 E-value: 1.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 425 VGLAGVLLVALAVasgLGLCALLGITFNAaTTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVL 504
Cdd:TIGR00921 596 FPLIAIGSGILWA---IGLMGLRGIPSFL-AMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILF 671
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 261823993 505 TSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSL 552
Cdd:TIGR00921 672 SGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
357-550 |
1.90e-08 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 58.86 E-value: 1.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 357 RRFVQLAQEALPENASQQIHAFSSTtlDDILHAFSEVSAARVVGGYLLMLayacVTMLRW-DCAqsqgsVGLAGVLLVAL 435
Cdd:TIGR03480 683 RRFVRAVRKVAPDATGAPVSILESG--DTVVGAFLQAFIYALVAITVLLL----LTLRRVrDVL-----LVLAPLLLAGL 751
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 436 AVasgLGLCALLGITFNAATTQVLPFLaLGIGVDDVFLLAHAFTEA-LPGTPLQermgeclQRTGTSVVLTSINNMAAFL 514
Cdd:TIGR03480 752 LT---VAAMVLLGIPFNFANIIALPLL-LGLGVDFGIYMVHRWRNGvDSGNLLQ-------SSTARAVFFSALTTATAFG 820
|
170 180 190
....*....|....*....|....*....|....*.
gi 261823993 515 MAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAIL 550
Cdd:TIGR03480 821 SLAVSSHPGTASMGILLSLGLGLTLLCTLIFLPALL 856
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
426-566 |
4.18e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 57.54 E-value: 4.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 426 GLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLaLGIGVD-DVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVL 504
Cdd:TIGR00921 220 PLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPML-IGVGIDyGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLI 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261823993 505 TSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAIL-SLDLRRRHCQRLDVLC 566
Cdd:TIGR00921 299 ALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLqSIDIGREKVKKEIIAI 361
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
941-1084 |
2.37e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 51.76 E-value: 2.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 941 GVHAYPSGSPFLFWEQY----LGLRRcfllavcILLVCTFLVCALLLL---NPWTAglIVLVLAMMTVELF--GIMGFLG 1011
Cdd:TIGR00921 546 GVKVGVTGLPVAFAEMHelvnEGMRR-------MTIAGAILVLMILLAvfrNPIKA--VFPLIAIGSGILWaiGLMGLRG 616
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 261823993 1012 IKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAA--HALEHTFAPVTDGAISTLLGLLMLAGSHFDFI 1084
Cdd:TIGR00921 617 IPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAitHTMERTGPGILFSGLTTAGGFLSLLLSHFPIM 691
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
941-1087 |
4.01e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 47.91 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 941 GVHAYPSGSPFLFWEQYLGLRRCF--LLAVCILLVCTFLvcaLLLLNPWTAGLIVLVLAMMTVEL-FGIMGFLGIKLSAI 1017
Cdd:TIGR00921 172 GKFLDVTGSPAINYDIEREFGKDMgtTMAISGILVVLVL---LLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYAT 248
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261823993 1018 PVVILVASVGIGVEFTVHVALGFLTTQG-SRNLRAA--HALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRY 1087
Cdd:TIGR00921 249 TLLAVPMLIGVGIDYGIQTLNRYEEERDiGRAKGEAivTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEF 321
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
965-1080 |
3.02e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.84 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 965 LLAVCILLVctFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVhvalgFLTtq 1044
Cdd:COG4258 644 LLLLALLLI--LLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYAL-----FFT-- 714
|
90 100 110
....*....|....*....|....*....|....*.
gi 261823993 1045 gsRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSH 1080
Cdd:COG4258 715 --EGLLDKGELARTLLSILLAALTTLLGFGLLAFSS 748
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
376-548 |
5.34e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.07 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 376 HAFSSTTLDDILHAFSEVSAArvvgGYLLMLAYACVTMLRWdcaqsqgSVGLAGVLLVALAVASGLGLCALLGITFNAAT 455
Cdd:COG4258 627 KAESSSLFGRYRNDALWLLLL----ALLLILLLLLLRLRSL-------RRALRVLLPPLLAVLLTLAILGLLGIPLNLFH 695
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 456 TQVLpFLALGIGVD-DVFllahaFTEALPGtplqermGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIV 534
Cdd:COG4258 696 LIAL-LLVLGIGIDyALF-----FTEGLLD-------KGELARTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLG 762
|
170
....*....|....
gi 261823993 535 VGCTFVAVMLVFPA 548
Cdd:COG4258 763 ILLALLLAPLLAPR 776
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
427-552 |
3.75e-03 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 41.29 E-value: 3.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261823993 427 LAGVLLVALAVASGLGLCA--------LLGITFNAATTQVLPFL---ALGIGVD-DVFLLAHAFTEALPGTPLQERMGEC 494
Cdd:COG2409 545 LKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVPLLLfviLFGLGMDyEVFLVSRIREEYDRGGGTREAVIRG 624
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261823993 495 LQRTGtSVVlTSinnmAAFLMAA------LVPIPALR--AFSLQAAIVVGCTFVAVMLVfPAILSL 552
Cdd:COG2409 625 LARTG-RVI-TS----AALIMAAvfaafaTSPLVFLKqiGFGLAVGVLLDAFVVRMLLV-PALMAL 683
|
|
| |
