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Conserved domains on  [gi|262263301|ref|NP_001160142|]
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gem-associated protein 5 isoform 3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
307-709 8.03e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 8.03e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  307 LLLWDLTQSWRRKYTLFSTSAEGHNHSRIvfnlcSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAF 386
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  387 SPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISST 466
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  467 yHKKTVYRLAWGPpvppmslggEGDRpsltLYSCGGEGVVLQHNPwklsgeafdinklvrDTNSIRYKLPVHTE----IS 542
Cdd:COG2319   203 -HTGAVRSVAFSP---------DGKL----LASGSADGTVRLWDL---------------ATGKLLRTLTGHSGsvrsVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  543 WKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpe 622
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKL------LASGSDDGTVRLWDLAT------- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  623 spitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGA 701
Cdd:COG2319   320 -----GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                  ....*...
gi 262263301  702 DDFCVYRW 709
Cdd:COG2319   392 ADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
22-455 9.70e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 9.70e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   22 AAPGGIFGFAARTSVFLVRVGPGAGASPGAPPFRVVGELVGHTERVSGFTFSHHPGQYnlcATSSDDGTVKVWDVETKTV 101
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  102 VTEHTLHQHTISALHWSPTVKDLIVSGDEKGVVFcyWlNRNDSQHLFT---EPRTIFCLTCSPhHENLVAIGYKDGIVVI 178
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--W-DLATGKLLRTltgHSGAVTSVAFSP-DGKLLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  179 IDIsKKGEVIHRLRGHDDEIHSIAWCplsgedclsisqeensepdiPNGKliaetpitkgcYLATGSKDQTIRIWSCSRG 258
Cdd:COG2319   189 WDL-ATGKLLRTLTGHTGAVRSVAFS--------------------PDGK-----------LLASGSADGTVRLWDLATG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  259 RGVMVlklpfLKRRSGGVdptvkerlwLTLHW-PKNQptQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNH--SRI 335
Cdd:COG2319   237 KLLRT-----LTGHSGSV---------RSVAFsPDGR--LLASGSADGTVRLWDL-ATGELLRTL-----TGHSGgvNSV 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  336 VFnlcslkTEDGKqLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnny 415
Cdd:COG2319   295 AF------SPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE--- 363

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 262263301  416 dVKNFWQGVKSKVTALCWHPNkeGC-LAFGTDDGKVGLYDT 455
Cdd:COG2319   364 -LLRTLTGHTGAVTSVAFSPD--GRtLASGSADGTVRLWDL 401
COG3899 super family cl28481
Predicted ATPase [General function prediction only];
872-1232 2.74e-03

Predicted ATPase [General function prediction only];


The actual alignment was detected with superfamily member COG3899:

Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 42.54  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  872 HAKAELNEDVSADLEERFHLGLFTDRATLYRMMETEGKGHLESGHPELF--HQLMLWKGDLKGVLQAAAERGELTDSLVA 949
Cdd:COG3899   806 YEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLReaLEAGLETGDAALALLALAAAAAAAAAAAA 885

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  950 VAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHKVYEAVEllksnhLYREAIAVAKARLRPEdpvlkELYLSWGS 1029
Cdd:COG3899   886 LAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAA------LALAAAAAAAAAAALA-----AAAAAAAL 954

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301 1030 ILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGEHELAASLALRCAQELLLMKNWVGAQEALGLH 1109
Cdd:COG3899   955 AAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAA 1034

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301 1110 ESLQGQRLVFCLLELLCRHLEEKQPLEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPEQCQAALQKLQDVKYPS 1189
Cdd:COG3899  1035 ALLAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAAL 1114

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 262263301 1190 ATSNTPFRQLLLHVCHDLTLAMLSQQAAAWEEAVPALLQAVVR 1232
Cdd:COG3899  1115 ALAAALAALALAAAARAAAALLLLAAALALALAALLLLAALLL 1157
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
307-709 8.03e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 8.03e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  307 LLLWDLTQSWRRKYTLFSTSAEGHNHSRIvfnlcSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAF 386
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  387 SPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISST 466
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  467 yHKKTVYRLAWGPpvppmslggEGDRpsltLYSCGGEGVVLQHNPwklsgeafdinklvrDTNSIRYKLPVHTE----IS 542
Cdd:COG2319   203 -HTGAVRSVAFSP---------DGKL----LASGSADGTVRLWDL---------------ATGKLLRTLTGHSGsvrsVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  543 WKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpe 622
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKL------LASGSDDGTVRLWDLAT------- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  623 spitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGA 701
Cdd:COG2319   320 -----GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                  ....*...
gi 262263301  702 DDFCVYRW 709
Cdd:COG2319   392 ADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
22-455 9.70e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 9.70e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   22 AAPGGIFGFAARTSVFLVRVGPGAGASPGAPPFRVVGELVGHTERVSGFTFSHHPGQYnlcATSSDDGTVKVWDVETKTV 101
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  102 VTEHTLHQHTISALHWSPTVKDLIVSGDEKGVVFcyWlNRNDSQHLFT---EPRTIFCLTCSPhHENLVAIGYKDGIVVI 178
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--W-DLATGKLLRTltgHSGAVTSVAFSP-DGKLLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  179 IDIsKKGEVIHRLRGHDDEIHSIAWCplsgedclsisqeensepdiPNGKliaetpitkgcYLATGSKDQTIRIWSCSRG 258
Cdd:COG2319   189 WDL-ATGKLLRTLTGHTGAVRSVAFS--------------------PDGK-----------LLASGSADGTVRLWDLATG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  259 RGVMVlklpfLKRRSGGVdptvkerlwLTLHW-PKNQptQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNH--SRI 335
Cdd:COG2319   237 KLLRT-----LTGHSGSV---------RSVAFsPDGR--LLASGSADGTVRLWDL-ATGELLRTL-----TGHSGgvNSV 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  336 VFnlcslkTEDGKqLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnny 415
Cdd:COG2319   295 AF------SPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE--- 363

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 262263301  416 dVKNFWQGVKSKVTALCWHPNkeGC-LAFGTDDGKVGLYDT 455
Cdd:COG2319   364 -LLRTLTGHTGAVTSVAFSPD--GRtLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-407 1.38e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.99  E-value: 1.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   57 VGELVGHTERVSGFTFSHHPgqyNLCATSSDDGTVKVWDVETKTVVTEHTLHQHTISALHWSPTVKDLIVSGDEKgVVFC 136
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG---KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK-TIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  137 YWLNRNDSQH-LFTEPRTIFCLTCSPHHEnLVAIGYKDGIVVIIDIsKKGEVIHRLRGHDDEIHSIAWCPLSGedclsis 215
Cdd:cd00200    78 WDLETGECVRtLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGT------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  216 qeensepdipngkliaetpitkgcYLATGSKDQTIRIWSCSRGRGVMVLKLPflkrrSGGVdptvkerLWLTLHwPKNQp 295
Cdd:cd00200   149 ------------------------FVASSSQDGTIKLWDLRTGKCVATLTGH-----TGEV-------NSVAFS-PDGE- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  296 tQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNHSrivfnLCSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLP 375
Cdd:cd00200   191 -KLLSSSSDGTIKLWDL-STGKCLGTL-----RGHENG-----VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258

                         330       340       350
                  ....*....|....*....|....*....|..
gi 262263301  376 SLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 407
Cdd:cd00200   259 GHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-667 7.07e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 7.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  328 EGHNHSrivfnLCSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 407
Cdd:cd00200     6 KGHTGG-----VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  408 tlsIKNNYDVKNFwQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPpQISSTYHKKTVYRLAWGPPvppmslg 487
Cdd:cd00200    80 ---LETGECVRTL-TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPD------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  488 gegdrpSLTLYSCGGEGVVlqhnpwKLsgeaFDINklvrdTNSIRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQ 563
Cdd:cd00200   147 ------GTFVASSSQDGTI------KL----WDLR-----TGKCVATLTGHTGevnsVAFSPDGEKLLSSSSDGTIKLWD 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  564 VPNLRLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKITS 643
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGY-------LLASGSEDGTIRVWDLRT------------GECVQTLSGHTNSVTS 266

                         330       340
                  ....*....|....*....|....*
gi 262263301  644 LAWSPhhDG-RLVSACYDGTAQVWD 667
Cdd:cd00200   267 LAWSP--DGkRLASGSADGTIRIWD 289
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 117-204 1.12e-08

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 53.82  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   117 WSPTvKDLIVSGDEKGVVfcyWLNRNDSQHLFT-----EPRTIFCLTCSPHhENLVAIGYKDGIVVIIDISkKGEVIHRL 191
Cdd:pfam12894    3 WCPT-MDLIALATEDGEL---LLHRLNWQRVWTlspdkEDLEVTSLAWRPD-GKLLAVGYSDGTVRLLDAE-NGKIVHHF 76

                           90
                   ....*....|...
gi 262263301   192 RGHDDEIHSIAWC 204
Cdd:pfam12894   77 SAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 629-667 3.89e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 3.89e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 262263301    629 EPYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWD 667
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 598-709 5.31e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 5.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  598 LLASGSNNAVIYVHNLKAVLESNPEspitITEPYRTLSGHTaKITSLAWSPHHDGRLVSACYDGTAQVWDALREEPLFNF 677
Cdd:PLN00181  497 FFATAGVNKKIKIFECESIIKDGRD----IHYPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                          90       100       110
                  ....*....|....*....|....*....|..
gi 262263301  678 RGHRGRLLCVAWSPVDPECIYSGADDFCVYRW 709
Cdd:PLN00181  572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 pfam00400
WD domain, G-beta repeat;
629-667 3.15e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 3.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 262263301   629 EPYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWD 667
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-95 9.33e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 9.33e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 262263301     53 PFRVVGELVGHTERVSGFTFSHHpgqYNLCATSSDDGTVKVWD 95
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 59-118 1.91e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   59 ELVGHTERVSGFTFshHPGQYNLCATSSDDGTVKVWDVETKTVVTEHTLHQHTISALHWS 118
Cdd:PTZ00421  120 HLQGHTKKVGIVSF--HPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN 177
COG3899 COG3899
Predicted ATPase [General function prediction only];
872-1232 2.74e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 42.54  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  872 HAKAELNEDVSADLEERFHLGLFTDRATLYRMMETEGKGHLESGHPELF--HQLMLWKGDLKGVLQAAAERGELTDSLVA 949
Cdd:COG3899   806 YEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLReaLEAGLETGDAALALLALAAAAAAAAAAAA 885

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  950 VAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHKVYEAVEllksnhLYREAIAVAKARLRPEdpvlkELYLSWGS 1029
Cdd:COG3899   886 LAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAA------LALAAAAAAAAAAALA-----AAAAAAAL 954

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301 1030 ILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGEHELAASLALRCAQELLLMKNWVGAQEALGLH 1109
Cdd:COG3899   955 AAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAA 1034

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301 1110 ESLQGQRLVFCLLELLCRHLEEKQPLEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPEQCQAALQKLQDVKYPS 1189
Cdd:COG3899  1035 ALLAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAAL 1114

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 262263301 1190 ATSNTPFRQLLLHVCHDLTLAMLSQQAAAWEEAVPALLQAVVR 1232
Cdd:COG3899  1115 ALAAALAALALAAAARAAAALLLLAAALALALAALLLLAALLL 1157
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
307-709 8.03e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 8.03e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  307 LLLWDLTQSWRRKYTLFSTSAEGHNHSRIvfnlcSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAF 386
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  387 SPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISST 466
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  467 yHKKTVYRLAWGPpvppmslggEGDRpsltLYSCGGEGVVLQHNPwklsgeafdinklvrDTNSIRYKLPVHTE----IS 542
Cdd:COG2319   203 -HTGAVRSVAFSP---------DGKL----LASGSADGTVRLWDL---------------ATGKLLRTLTGHSGsvrsVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  543 WKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpe 622
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKL------LASGSDDGTVRLWDLAT------- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  623 spitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGA 701
Cdd:COG2319   320 -----GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                  ....*...
gi 262263301  702 DDFCVYRW 709
Cdd:COG2319   392 ADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
22-455 9.70e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 9.70e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   22 AAPGGIFGFAARTSVFLVRVGPGAGASPGAPPFRVVGELVGHTERVSGFTFSHHPGQYnlcATSSDDGTVKVWDVETKTV 101
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  102 VTEHTLHQHTISALHWSPTVKDLIVSGDEKGVVFcyWlNRNDSQHLFT---EPRTIFCLTCSPhHENLVAIGYKDGIVVI 178
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--W-DLATGKLLRTltgHSGAVTSVAFSP-DGKLLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  179 IDIsKKGEVIHRLRGHDDEIHSIAWCplsgedclsisqeensepdiPNGKliaetpitkgcYLATGSKDQTIRIWSCSRG 258
Cdd:COG2319   189 WDL-ATGKLLRTLTGHTGAVRSVAFS--------------------PDGK-----------LLASGSADGTVRLWDLATG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  259 RGVMVlklpfLKRRSGGVdptvkerlwLTLHW-PKNQptQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNH--SRI 335
Cdd:COG2319   237 KLLRT-----LTGHSGSV---------RSVAFsPDGR--LLASGSADGTVRLWDL-ATGELLRTL-----TGHSGgvNSV 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  336 VFnlcslkTEDGKqLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnny 415
Cdd:COG2319   295 AF------SPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE--- 363

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 262263301  416 dVKNFWQGVKSKVTALCWHPNkeGC-LAFGTDDGKVGLYDT 455
Cdd:COG2319   364 -LLRTLTGHTGAVTSVAFSPD--GRtLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
295-668 4.02e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.52  E-value: 4.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  295 PTQLVSSCFGGELLLWDLTQSWRRkytlfsTSAEGHNHS--RIVFnlcslkTEDGkQLLLSTSMDRDVKCWDMATLECCW 372
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLL------RTLTGHTGAvrSVAF------SPDG-KTLASGSADGTVRLWDLATGKLLR 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  373 TLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNkeGC-LAFGTDDGKVG 451
Cdd:COG2319   157 TLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPD--GKlLASGSADGTVR 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  452 LYDTcSNKPPQISSTYHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGVVLQhnpWKLsgeafdinklvrDTNSI 531
Cdd:COG2319   230 LWDL-ATGKLLRTLTGHSGSVRSVAFSP-------DGR------LLASGSADGTVRL---WDL------------ATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  532 RYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHeHGSRpelsclLASGSNNAV 607
Cdd:COG2319   281 LRTLTGHSGgvnsVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKT------LASGSDDGT 353

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262263301  608 IYVHNLKAvlesnpespitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDA 668
Cdd:COG2319   354 VRLWDLAT------------GELLRTLTGHTGAVTSVAFSP--DGRtLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
349-709 1.55e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 1.55e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  349 QLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKV 428
Cdd:COG2319    49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGL----LLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  429 TALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISSTyHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGVVLQ 508
Cdd:COG2319   124 RSVAFSPDGK-TLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSP-------DGK------LLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  509 hnpWKLsgeafdinklvrDTNSIRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIV 584
Cdd:COG2319   189 ---WDL------------ATGKLLRTLTGHTGavrsVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  585 WHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTA 663
Cdd:COG2319   254 FSPD-GRL------LASGSADGTVRLWDLAT------------GELLRTLTGHSGGVNSVAFSP--DGKlLASGSDDGTV 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 262263301  664 QVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFCVYRW 709
Cdd:COG2319   313 RLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-407 1.38e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.99  E-value: 1.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   57 VGELVGHTERVSGFTFSHHPgqyNLCATSSDDGTVKVWDVETKTVVTEHTLHQHTISALHWSPTVKDLIVSGDEKgVVFC 136
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG---KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK-TIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  137 YWLNRNDSQH-LFTEPRTIFCLTCSPHHEnLVAIGYKDGIVVIIDIsKKGEVIHRLRGHDDEIHSIAWCPLSGedclsis 215
Cdd:cd00200    78 WDLETGECVRtLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGT------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  216 qeensepdipngkliaetpitkgcYLATGSKDQTIRIWSCSRGRGVMVLKLPflkrrSGGVdptvkerLWLTLHwPKNQp 295
Cdd:cd00200   149 ------------------------FVASSSQDGTIKLWDLRTGKCVATLTGH-----TGEV-------NSVAFS-PDGE- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  296 tQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNHSrivfnLCSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLP 375
Cdd:cd00200   191 -KLLSSSSDGTIKLWDL-STGKCLGTL-----RGHENG-----VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258

                         330       340       350
                  ....*....|....*....|....*....|..
gi 262263301  376 SLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 407
Cdd:cd00200   259 GHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-667 7.07e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 7.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  328 EGHNHSrivfnLCSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 407
Cdd:cd00200     6 KGHTGG-----VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  408 tlsIKNNYDVKNFwQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPpQISSTYHKKTVYRLAWGPPvppmslg 487
Cdd:cd00200    80 ---LETGECVRTL-TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPD------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  488 gegdrpSLTLYSCGGEGVVlqhnpwKLsgeaFDINklvrdTNSIRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQ 563
Cdd:cd00200   147 ------GTFVASSSQDGTI------KL----WDLR-----TGKCVATLTGHTGevnsVAFSPDGEKLLSSSSDGTIKLWD 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  564 VPNLRLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKITS 643
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGY-------LLASGSEDGTIRVWDLRT------------GECVQTLSGHTNSVTS 266

                         330       340
                  ....*....|....*....|....*
gi 262263301  644 LAWSPhhDG-RLVSACYDGTAQVWD 667
Cdd:cd00200   267 LAWSP--DGkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 188-563 2.31e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.58  E-value: 2.31e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  188 IHRLRGHDDEIHSIAWCPLSGedclsisqeensepdipngkliaetpitkgcYLATGSKDQTIRIWSCSRGRGVMVLKLP 267
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGK-------------------------------LLATGSGDGTIKVWDLETGELLRTLKGH 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  268 FLKrrsggvdptvkerlWLTLHWPKNQpTQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNHSrivfnLCSLKTEDG 347
Cdd:cd00200    51 TGP--------------VRDVAASADG-TYLASGSSDKTIRLWDL-ETGECVRTL-----TGHTSY-----VSSVAFSPD 104

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  348 KQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPVDvGSLAIGVGDGMIRVWNtlsIKNNYDVKNFwQGVKSK 427
Cdd:cd00200   105 GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWD---LRTGKCVATL-TGHTGE 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  428 VTALCWHPNKEgCLAFGTDDGKVGLYDTcsNKPPQISS-TYHKKTVYRLAWGPPvppmslggegdrpSLTLYSCGGEGVV 506
Cdd:cd00200   180 VNSVAFSPDGE-KLLSSSSDGTIKLWDL--STGKCLGTlRGHENGVNSVAFSPD-------------GYLLASGSEDGTI 243

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262263301  507 LQhnpWKLsgeafdinklvrDTNSIRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQ 563
Cdd:cd00200   244 RV---WDL------------RTGECVQTLSGHTNsvtsLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 373-709 6.95e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 6.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  373 TLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTlsikNNYDVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGL 452
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDL----ETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  453 YDTcsnKPPQISSTY--HKKTVYRLAWGPpvppmslggegDRPslTLYSCGGEGVVLQhnpWKLsgeafdinklvrDTNS 530
Cdd:cd00200    78 WDL---ETGECVRTLtgHTSYVSSVAFSP-----------DGR--ILSSSSRDKTIKV---WDV------------ETGK 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  531 IRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHhehgsrPELSCLLASGSNNa 606
Cdd:cd00200   127 CLTTLRGHTDwvnsVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFS------PDGEKLLSSSSDG- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  607 VIYVHNLKAvlesnpespitiTEPYRTLSGHTAKITSLAWSPhhDGRLVSACY-DGTAQVWDALREEPLFNFRGHRGRLL 685
Cdd:cd00200   200 TIKLWDLST------------GKCLGTLRGHENGVNSVAFSP--DGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVT 265

                         330       340
                  ....*....|....*....|....
gi 262263301  686 CVAWSPvDPECIYSGADDFCVYRW 709
Cdd:cd00200   266 SLAWSP-DGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-254 3.04e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 3.04e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   52 PPFRVVGELVGHTERVSGFTFSHHPGqynLCATSSDDGTVKVWDVETKTVVTEHTLHQHTISALHWSPTVKDLIVSGDEk 131
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD- 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  132 GVVFCYWLNRNDSQHLFTEPRTIFCLTCSPHHENLVAIGYKDGIVVIIDIsKKGEVIHRLRGHDDEIHSIAWCPlsgedc 211
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSP------ 271

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 262263301  212 lsisqeensepdipngkliaetpitKGCYLATGSKDQTIRIWS 254
Cdd:cd00200   272 -------------------------DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 468-716 6.04e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 6.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  468 HKKTVYRLAWGPPVPpmslggegdrpslTLYSCGGEGVVLQhnpWKLsgeafdinklvrDTNSIRYKLPVHTE----ISW 543
Cdd:cd00200     8 HTGGVTCVAFSPDGK-------------LLATGSGDGTIKV---WDL------------ETGELLRTLKGHTGpvrdVAA 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  544 KGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNlkavlesnpes 623
Cdd:cd00200    60 SADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR-------ILSSSSRDKTIKVWD----------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  624 pITITEPYRTLSGHTAKITSLAWSPHhDGRLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADD 703
Cdd:cd00200   122 -VETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSD 198

                         250
                  ....*....|...
gi 262263301  704 FCVYRWLTSMQDH 716
Cdd:cd00200   199 GTIKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
546-709 9.15e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 9.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  546 DGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLKAvlesnpespi 625
Cdd:COG2319    47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-------LLASASADGTVRLWDLAT---------- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  626 tiTEPYRTLSGHTAKITSLAWSPhhDG-RLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADDF 704
Cdd:COG2319   110 --GLLLRTLTGHTGAVRSVAFSP--DGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDG 184


                  ....*
gi 262263301  705 CVYRW 709
Cdd:COG2319   185 TVRLW 189
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 630-709 7.29e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 7.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  630 PYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPVDpECIYSGADDFCVYRW 709
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLW 78
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 117-204 1.12e-08

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 53.82  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   117 WSPTvKDLIVSGDEKGVVfcyWLNRNDSQHLFT-----EPRTIFCLTCSPHhENLVAIGYKDGIVVIIDISkKGEVIHRL 191
Cdd:pfam12894    3 WCPT-MDLIALATEDGEL---LLHRLNWQRVWTlspdkEDLEVTSLAWRPD-GKLLAVGYSDGTVRLLDAE-NGKIVHHF 76

                           90
                   ....*....|...
gi 262263301   192 RGHDDEIHSIAWC 204
Cdd:pfam12894   77 SAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 629-667 3.89e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 3.89e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 262263301    629 EPYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWD 667
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 598-709 5.31e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 5.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  598 LLASGSNNAVIYVHNLKAVLESNPEspitITEPYRTLSGHTaKITSLAWSPHHDGRLVSACYDGTAQVWDALREEPLFNF 677
Cdd:PLN00181  497 FFATAGVNKKIKIFECESIIKDGRD----IHYPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                          90       100       110
                  ....*....|....*....|....*....|..
gi 262263301  678 RGHRGRLLCVAWSPVDPECIYSGADDFCVYRW 709
Cdd:PLN00181  572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 pfam00400
WD domain, G-beta repeat;
629-667 3.15e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 3.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 262263301   629 EPYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWD 667
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 539-585 4.82e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 46.12  E-value: 4.82e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 262263301   539 TEISWKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVW 585
Cdd:pfam12894   42 TSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-95 9.33e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 9.33e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 262263301     53 PFRVVGELVGHTERVSGFTFSHHpgqYNLCATSSDDGTVKVWD 95
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-254 3.48e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 3.48e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262263301    184 KGEVIHRLRGHDDEIHSIAWCPlsgedclsisqeensepdipngkliaetpitKGCYLATGSKDQTIRIWS 254
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-------------------------------DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
54-95 5.54e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 5.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 262263301    54 FRVVGELVGHTERVSGFTFSHHPgqyNLCATSSDDGTVKVWD 95
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG---KLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 348-472 1.22e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  348 KQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPVDVGSLAIGVGDGMIRVWntlSIKNNYDVKNfwqgVKSK 427
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW---SINQGVSIGT----IKTK 617

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 262263301  428 VTALCWH-PNKEG-CLAFGTDDGKVGLYDTCSNKPPQISSTYHKKTV 472
Cdd:PLN00181  618 ANICCVQfPSESGrSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTV 664
PTZ00421 PTZ00421
coronin; Provisional
 59-118 1.91e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   59 ELVGHTERVSGFTFshHPGQYNLCATSSDDGTVKVWDVETKTVVTEHTLHQHTISALHWS 118
Cdd:PTZ00421  120 HLQGHTKKVGIVSF--HPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN 177
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 634-690 1.93e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 1.93e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 262263301   634 LSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWS 690
Cdd:pfam12894   34 PDKEDLEVTSLAWRP--DGKlLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 COG2319
WD40 repeat [General function prediction only];
55-98 4.53e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 4.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 262263301   55 RVVGELVGHTERVSGFTFSHHpGQYnLcATSSDDGTVKVWDVET 98
Cdd:COG2319   363 ELLRTLTGHTGAVTSVAFSPD-GRT-L-ASGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 593-675 9.54e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 9.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  593 PELSCLLASGSNNAVIYVHNLKavleSNPESPITITEPYRTLSGHTAKITSLAWSPHHDGRLVSACYDGTAQVWDALREE 672
Cdd:PTZ00420   84 PCFSEILASGSEDLTIRVWEIP----HNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159


                  ...
gi 262263301  673 PLF 675
Cdd:PTZ00420  160 RAF 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 672-709 1.61e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.61e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 262263301    672 EPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFCVYRW 709
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
185-254 1.62e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   185 GEVIHRLRGHDDEIHSIAWCPlsgedclsisqeensepdipngkliaetpitKGCYLATGSKDQTIRIWS 254
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-------------------------------DGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 394-478 2.29e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301   394 LAIGVGDGMI--------RVWnTLSIKNNydvknfwqgvKSKVTALCWHPNkEGCLAFGTDDGKVGLYDTcSNKPPQISS 465
Cdd:pfam12894   10 IALATEDGELllhrlnwqRVW-TLSPDKE----------DLEVTSLAWRPD-GKLLAVGYSDGTVRLLDA-ENGKIVHHF 76

                           90
                   ....*....|...
gi 262263301   466 TYHKKTVYRLAWG 478
Cdd:pfam12894   77 SAGSDLITCLGWG 89
COG3899 COG3899
Predicted ATPase [General function prediction only];
872-1232 2.74e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 42.54  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  872 HAKAELNEDVSADLEERFHLGLFTDRATLYRMMETEGKGHLESGHPELF--HQLMLWKGDLKGVLQAAAERGELTDSLVA 949
Cdd:COG3899   806 YEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLReaLEAGLETGDAALALLALAAAAAAAAAAAA 885

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301  950 VAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHKVYEAVEllksnhLYREAIAVAKARLRPEdpvlkELYLSWGS 1029
Cdd:COG3899   886 LAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAA------LALAAAAAAAAAAALA-----AAAAAAAL 954

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301 1030 ILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGEHELAASLALRCAQELLLMKNWVGAQEALGLH 1109
Cdd:COG3899   955 AAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAA 1034

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263301 1110 ESLQGQRLVFCLLELLCRHLEEKQPLEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPEQCQAALQKLQDVKYPS 1189
Cdd:COG3899  1035 ALLAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAAL 1114

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 262263301 1190 ATSNTPFRQLLLHVCHDLTLAMLSQQAAAWEEAVPALLQAVVR 1232
Cdd:COG3899  1115 ALAAALAALALAAAARAAAALLLLAAALALALAALLLLAALLL 1157
WD40 pfam00400
WD domain, G-beta repeat;
672-709 7.74e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 7.74e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 262263301   672 EPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFCVYRW 709
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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