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Conserved domains on  [gi|270309132|ref|NP_001161947|]
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tetratricopeptide repeat protein 23 isoform 2 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 100-385 6.78e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 100 LKGLSLQAKQHAEKAKEILANSIESPCHNktdifkcsLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivke 179
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPET--------VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD---------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 180 ewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEyteitKDEKSLEcvqVLRELAGVEQALGLYAAAISHFSRAHliil 259
Cdd:COG2956   75 -----RAEALLELAQDYLKAGLLDRAEELLEKLLE-----LDPDDAE---ALRLLAEIYEQEGDWEKAIEVLERLL---- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 260 skdpspEEAADSAHFIARAAAASGMHDHRDVAEKYFQESmtsIKDSEGAERAKFLSIQdefcsFLQTTGQKERAAMILRE 339
Cdd:COG2956  138 ------KLGPENAHAYCELAELYLEQGDYDEAIEALEKA---LKLDPDCARALLLLAE-----LYLEQGDYEEAIAALER 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 270309132 340 SLEAkvgafgdfSPEVAETYRALGRADLAQGNNSGAYAKLKKCVQI 385
Cdd:COG2956  204 ALEQ--------DPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 100-385 6.78e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 100 LKGLSLQAKQHAEKAKEILANSIESPCHNktdifkcsLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivke 179
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPET--------VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD---------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 180 ewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEyteitKDEKSLEcvqVLRELAGVEQALGLYAAAISHFSRAHliil 259
Cdd:COG2956   75 -----RAEALLELAQDYLKAGLLDRAEELLEKLLE-----LDPDDAE---ALRLLAEIYEQEGDWEKAIEVLERLL---- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 260 skdpspEEAADSAHFIARAAAASGMHDHRDVAEKYFQESmtsIKDSEGAERAKFLSIQdefcsFLQTTGQKERAAMILRE 339
Cdd:COG2956  138 ------KLGPENAHAYCELAELYLEQGDYDEAIEALEKA---LKLDPDCARALLLLAE-----LYLEQGDYEEAIAALER 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 270309132 340 SLEAkvgafgdfSPEVAETYRALGRADLAQGNNSGAYAKLKKCVQI 385
Cdd:COG2956  204 ALEQ--------DPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241
TPR_12 pfam13424
Tetratricopeptide repeat;
187-254 8.89e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.53  E-value: 8.89e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 270309132  187 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSRA 254
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 100-385 6.78e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 100 LKGLSLQAKQHAEKAKEILANSIESPCHNktdifkcsLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivke 179
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPET--------VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD---------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 180 ewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEyteitKDEKSLEcvqVLRELAGVEQALGLYAAAISHFSRAHliil 259
Cdd:COG2956   75 -----RAEALLELAQDYLKAGLLDRAEELLEKLLE-----LDPDDAE---ALRLLAEIYEQEGDWEKAIEVLERLL---- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 260 skdpspEEAADSAHFIARAAAASGMHDHRDVAEKYFQESmtsIKDSEGAERAKFLSIQdefcsFLQTTGQKERAAMILRE 339
Cdd:COG2956  138 ------KLGPENAHAYCELAELYLEQGDYDEAIEALEKA---LKLDPDCARALLLLAE-----LYLEQGDYEEAIAALER 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 270309132 340 SLEAkvgafgdfSPEVAETYRALGRADLAQGNNSGAYAKLKKCVQI 385
Cdd:COG2956  204 ALEQ--------DPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241
TPR_12 pfam13424
Tetratricopeptide repeat;
187-254 8.89e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.53  E-value: 8.89e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 270309132  187 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSRA 254
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
51-297 1.29e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132  51 RAKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnkt 130
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA------ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 131 difkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQ 210
Cdd:COG0457   79 ---------LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYE 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 211 KALEYteitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRAHLIILSKDPSPEEAADSAHFIARAAAASGMHDHRDV 290
Cdd:COG0457  135 RALEL--------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206


                 ....*..
gi 270309132 291 AEKYFQE 297
Cdd:COG0457  207 LRKKLAI 213
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
85-268 4.03e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 4.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132  85 KLAEAYVNLAQGYLQLkGLSLQAKQHAEKAKEILANSIESpchnktdifkcslelFYTLGRALLSLQKFKDASENLIKAE 164
Cdd:COG0457    6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDAEA---------------LYNLGLAYLRLGRYEEALADYEQAL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 165 RLSKEMLQCgnivkeeWIEIqsriklsfAQLYQGQKRSKEAFPFYQKALEYteitkdekSLECVQVLRELAGVEQALGLY 244
Cdd:COG0457   70 ELDPDDAEA-------LNNL--------GLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126

                        170       180
                 ....*....|....*....|....
gi 270309132 245 AAAISHFSRAhliiLSKDPSPEEA 268
Cdd:COG0457  127 DEAIEAYERA----LELDPDDADA 146
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 140-386 1.66e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 140 FYTLGRALLSLQKFKDASENLIKAERLSKEMLQcgnivkeewieiqsrIKLSFAQLYQGQKRSKEAFPFYQKALEyteit 219
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVE---------------AHLALGNLYRRRGEYDRAIRIHQKLLE----- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 220 KDEKSLecvQVLRELAGVEQALGLYAAAISHFSRAhliiLSKDPSPEEAadsahfiaraaaasgmhdHRDVAEKYFQEsm 299
Cdd:COG2956   71 RDPDRA---EALLELAQDYLKAGLLDRAEELLEKL----LELDPDDAEA------------------LRLLAEIYEQE-- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 300 tsiKDSEGA----ERAKFLSIQDEFCSF-----LQTTGQKERAAMILRESLEAkvgafgdfSPEVAETYRALGRADLAQG 370
Cdd:COG2956  124 ---GDWEKAievlERLLKLGPENAHAYCelaelYLEQGDYDEAIEALEKALKL--------DPDCARALLLLAELYLEQG 192

                        250
                 ....*....|....*.
gi 270309132 371 NNSGAYAKLKKCVQIE 386
Cdd:COG2956  193 DYEEAIAALERALEQD 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 52-248 4.25e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132  52 AKSYSSSREYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktd 131
Cdd:COG2956  117 AEIYEQEGDWEKAIEVLERLLKLGP--------ENAHAYCELAELYLEQGDYD-EAIEALEKALKLDPDCARA------- 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 132 ifkcslelFYTLGRALLSLQKFKDASENLIKAERLSKEMLQcgnivkeewieiqsrIKLSFAQLYQGQKRSKEAFPFYQK 211
Cdd:COG2956  181 --------LLLLAELYLEQGDYEEAIAALERALEQDPDYLP---------------ALPRLAELYEKLGDPEEALELLRK 237

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 270309132 212 ALEytEITKDEKSLECVQVLRELAGVEQALGLYAAAI 248
Cdd:COG2956  238 ALE--LDPSDDLLLALADLLERKEGLEAALALLERQL 272
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 87-214 2.64e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.98  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132  87 AEAYVNLAQGYLQLkGLSLQAKQHAEKAKEIlansieSPCHnktdifkcsLELFYTLGRALLSLQKFKDASENLIKAERL 166
Cdd:COG3914  112 AEALFNLGNLLLAL-GRLEEALAALRRALAL------NPDF---------AEAYLNLGEALRRLGRLEEAIAALRRALEL 175

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 270309132 167 SKEMlqcgnivkeewIEIQSRIklsfAQLYQGQKRSKEAFPFYQKALE 214
Cdd:COG3914  176 DPDN-----------AEALNNL----GNALQDLGRLEEAIAAYRRALE 208
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 136-269 3.61e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.68  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 136 SLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEy 215
Cdd:COG4235   16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALA- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 270309132 216 teitKDEKSlecVQVLRELAGVEQALGLYAAAISHFSRAhliiLSKDPSPEEAA 269
Cdd:COG4235   80 ----LDPDN---PEALYLLGLAAFQQGDYAEAIAAWQKL----LALLPADAPAR 122
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 97-254 7.00e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 36.71  E-value: 7.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132  97 YLQLKGLSLQAKQHAEKAKEILANSIEspchnktdIFKCSLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgni 176
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALE--------LDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD------- 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 270309132 177 vkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYTEitkdekslECVQVLRELAGVEQALGLYAAAISHFSRA 254
Cdd:COG4783   71 --------EPEARLNLGLALLKAGDYDEALALLEKALKLDP--------EHPEAYLRLARAYRALGRPDEAIAALEKA 132
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 179-385 7.72e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 38.82  E-value: 7.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 179 EEWIEIQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYTEitkdekslECVQVLRELAGVEQALGLYAAAISHFSRAhlii 258
Cdd:COG3914   71 AAALLLLAALLELAALLLQALGRYEEALALYRRALALNP--------DNAEALFNLGNLLLALGRLEEALAALRRA---- 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270309132 259 LSKDPspeeaadsahfiaraaaasgmhdhrDVAEKYFQESMTsikdsegaerakflsiqdefcsfLQTTGQKERAAMILR 338
Cdd:COG3914  139 LALNP-------------------------DFAEAYLNLGEA-----------------------LRRLGRLEEAIAALR 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 270309132 339 ESLEAKvgafgdfsPEVAETYRALGRADLAQGNNSGAYAKLKKCVQI 385
Cdd:COG3914  171 RALELD--------PDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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