divergent protein kinase domain 1A [Rattus norvegicus]
Protein Classification
divergent protein kinase domain 1( domain architecture ID 10632812)
divergent protein kinase domain 1, also called protein FAM69, is a cysteine-rich type II transmembrane protein that localizes to the endoplasmic reticulum, and may function as Ca2+-dependent kinase
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| PIP49_N | pfam14875 | N-term cysteine-rich ER, FAM69; The FAM69 family of cysteine-rich type II transmembrane ... |
19-176 | 4.24e-89 | ||||
N-term cysteine-rich ER, FAM69; The FAM69 family of cysteine-rich type II transmembrane proteins localize to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. These proteins carry at least 14 luminal cysteines which are conserved in all FAM69s. There are currently few indications of the involvement of FAM69 members in human diseases. It would appear that FAM69 proteins are predicted to be have a protein kinase structure and function. Analysis of three-dimensional structure models and conservation of the classic catalytic motifs of protein kinases in four of human FAM69 proteins suggests they might have retained catalytic phosphotransferase activity. An EF-hand Ca2+-binding domain, inserted within the structure of the kinase domain, suggests they function as Ca2+-dependent kinases (unpublished). : Pssm-ID: 464353 Cd Length: 158 Bit Score: 267.31 E-value: 4.24e-89
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| PIP49_C | pfam12260 | Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ... |
194-396 | 1.79e-86 | ||||
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain. : Pssm-ID: 463512 Cd Length: 188 Bit Score: 261.45 E-value: 1.79e-86
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| Name | Accession | Description | Interval | E-value | ||||
| PIP49_N | pfam14875 | N-term cysteine-rich ER, FAM69; The FAM69 family of cysteine-rich type II transmembrane ... |
19-176 | 4.24e-89 | ||||
N-term cysteine-rich ER, FAM69; The FAM69 family of cysteine-rich type II transmembrane proteins localize to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. These proteins carry at least 14 luminal cysteines which are conserved in all FAM69s. There are currently few indications of the involvement of FAM69 members in human diseases. It would appear that FAM69 proteins are predicted to be have a protein kinase structure and function. Analysis of three-dimensional structure models and conservation of the classic catalytic motifs of protein kinases in four of human FAM69 proteins suggests they might have retained catalytic phosphotransferase activity. An EF-hand Ca2+-binding domain, inserted within the structure of the kinase domain, suggests they function as Ca2+-dependent kinases (unpublished). Pssm-ID: 464353 Cd Length: 158 Bit Score: 267.31 E-value: 4.24e-89
|
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| PIP49_C | pfam12260 | Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ... |
194-396 | 1.79e-86 | ||||
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain. Pssm-ID: 463512 Cd Length: 188 Bit Score: 261.45 E-value: 1.79e-86
|
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| Name | Accession | Description | Interval | E-value | ||||
| PIP49_N | pfam14875 | N-term cysteine-rich ER, FAM69; The FAM69 family of cysteine-rich type II transmembrane ... |
19-176 | 4.24e-89 | ||||
N-term cysteine-rich ER, FAM69; The FAM69 family of cysteine-rich type II transmembrane proteins localize to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. These proteins carry at least 14 luminal cysteines which are conserved in all FAM69s. There are currently few indications of the involvement of FAM69 members in human diseases. It would appear that FAM69 proteins are predicted to be have a protein kinase structure and function. Analysis of three-dimensional structure models and conservation of the classic catalytic motifs of protein kinases in four of human FAM69 proteins suggests they might have retained catalytic phosphotransferase activity. An EF-hand Ca2+-binding domain, inserted within the structure of the kinase domain, suggests they function as Ca2+-dependent kinases (unpublished). Pssm-ID: 464353 Cd Length: 158 Bit Score: 267.31 E-value: 4.24e-89
|
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| PIP49_C | pfam12260 | Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins ... |
194-396 | 1.79e-86 | ||||
Protein-kinase domain of FAM69; This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain. Pssm-ID: 463512 Cd Length: 188 Bit Score: 261.45 E-value: 1.79e-86
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| Blast search parameters | ||||
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