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Conserved domains on  [gi|295293157|ref|NP_001171213|]
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gonadal somatic cell derived factor precursor [Oryzias latipes]

Protein Classification

TGF-beta family protein( domain architecture ID 14443711)

transforming growth factor-beta (TGF-beta) family protein may control proliferation, differentiation, and other functions in many cell types

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGF_beta_GSDF cd19379
transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic ...
 111-205 6.00e-39

transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic cell derived factor (GSDF) and similar proteins; GSDF is a new member of transforming growth factor beta (TGF-beta) superfamily. It is a teleost- and gonad-specific growth factor that controls sex determination in some fish and plays an important role in mediating germ cell/soma signaling.


:

Pssm-ID: 381649  Cd Length: 94  Bit Score: 129.41  E-value: 6.00e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 111 LKCCSMATEVFMKDLGWDNWVIYPLSLIIDRCALCNSSDQIAQCPAAHdGVQIRGSQDQASCCKPTSLEIVPIVFMDETS 190
Cdd:cd19379    1 LKCCQETSEIFFKDLGWENWVIYPESFTYVQCVGCNAGRNSSESQCRQ-RLQGRAGARQERCCKPTSQEAVPFVYIDEDS 79

                         90
                 ....*....|....*
gi 295293157 191 TIVISSVQLARGCGC 205
Cdd:cd19379   80 SLVISPVPLTRECGC 94
 
Name Accession Description Interval E-value
TGF_beta_GSDF cd19379
transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic ...
 111-205 6.00e-39

transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic cell derived factor (GSDF) and similar proteins; GSDF is a new member of transforming growth factor beta (TGF-beta) superfamily. It is a teleost- and gonad-specific growth factor that controls sex determination in some fish and plays an important role in mediating germ cell/soma signaling.


Pssm-ID: 381649  Cd Length: 94  Bit Score: 129.41  E-value: 6.00e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 111 LKCCSMATEVFMKDLGWDNWVIYPLSLIIDRCALCNSSDQIAQCPAAHdGVQIRGSQDQASCCKPTSLEIVPIVFMDETS 190
Cdd:cd19379    1 LKCCQETSEIFFKDLGWENWVIYPESFTYVQCVGCNAGRNSSESQCRQ-RLQGRAGARQERCCKPTSQEAVPFVYIDEDS 79

                         90
                 ....*....|....*
gi 295293157 191 TIVISSVQLARGCGC 205
Cdd:cd19379   80 SLVISPVPLTRECGC 94
TGF_beta pfam00019
Transforming growth factor beta like domain;
112-205 2.57e-11

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 58.11  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157  112 KCCSMATEVFMKDLGWDNWVIYPLSLIIDRCA-LCNSSDQIAQCPAAHDGVQ-----IRGSQDQASCCKPTSLEIVPIVF 185
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSgSCPSHLNPQLSATNHAILQsllhsLKPANVPKPCCVPTKLSPLSVLY 80

                          90       100
                  ....*....|....*....|..
gi 295293157  186 MDETSTIVISSVQ--LARGCGC 205
Cdd:pfam00019  81 YDDEGNVVLKTYPdmVVESCGC 102
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 113-206 1.53e-06

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 45.34  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157   113 CCSMATEVFMKDLGWDNWVIYPLSLIIDRCalcnssdqIAQC--PAAHDG-----------VQIRGSQDQ-ASCCKPTSL 178
Cdd:smart00204   1 CRRRQLYVDFKDLGWDDWIIAPKGYNAYYC--------EGECpfPLSTSLnatnhaivqtlVHLLGPNPVpKPCCVPTKL 72

                           90       100       110
                   ....*....|....*....|....*....|
gi 295293157   179 EIVPIVFMDETSTIVISSVQ--LARGCGCG 206
Cdd:smart00204  73 SPLSMLYYDDDGNVVLRNYPnmVVEECGCR 102
 
Name Accession Description Interval E-value
TGF_beta_GSDF cd19379
transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic ...
 111-205 6.00e-39

transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic cell derived factor (GSDF) and similar proteins; GSDF is a new member of transforming growth factor beta (TGF-beta) superfamily. It is a teleost- and gonad-specific growth factor that controls sex determination in some fish and plays an important role in mediating germ cell/soma signaling.


Pssm-ID: 381649  Cd Length: 94  Bit Score: 129.41  E-value: 6.00e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 111 LKCCSMATEVFMKDLGWDNWVIYPLSLIIDRCALCNSSDQIAQCPAAHdGVQIRGSQDQASCCKPTSLEIVPIVFMDETS 190
Cdd:cd19379    1 LKCCQETSEIFFKDLGWENWVIYPESFTYVQCVGCNAGRNSSESQCRQ-RLQGRAGARQERCCKPTSQEAVPFVYIDEDS 79

                         90
                 ....*....|....*
gi 295293157 191 TIVISSVQLARGCGC 205
Cdd:cd19379   80 SLVISPVPLTRECGC 94
TGF_beta pfam00019
Transforming growth factor beta like domain;
112-205 2.57e-11

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 58.11  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157  112 KCCSMATEVFMKDLGWDNWVIYPLSLIIDRCA-LCNSSDQIAQCPAAHDGVQ-----IRGSQDQASCCKPTSLEIVPIVF 185
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSgSCPSHLNPQLSATNHAILQsllhsLKPANVPKPCCVPTKLSPLSVLY 80

                          90       100
                  ....*....|....*....|..
gi 295293157  186 MDETSTIVISSVQ--LARGCGC 205
Cdd:pfam00019  81 YDDEGNVVLKTYPdmVVESCGC 102
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 113-205 2.67e-10

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 55.56  E-value: 2.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 113 CCSMATEVFMKDLGWDNWVIYPLSLIIDRCA-LCNS----SDQIAQCPAAHDGVQIRGSQDQASCCKPTSLEIVPIVFMD 187
Cdd:cd08698    1 CCKQPLYVNFKDLGGLNWIIAPSGFTANYCRgSCNSessaTTNHTKLLQWSRTRRHTPREELKPCCVPTSYEPLSILYYD 80

                         90       100
                 ....*....|....*....|
gi 295293157 188 ETSTIVISSVQ--LARGCGC 205
Cdd:cd08698   81 NNGTVVETLLPnlIVTECGC 100
TGF_beta_GDF5 cd19399
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 112-205 2.28e-08

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation.


Pssm-ID: 381669  Cd Length: 103  Bit Score: 50.39  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 112 KCCSMATEVFMKDLGWDNWVIYPLSLIIDRC-ALCNSSDQIAQCPAAHDGVQ-IRGSQDQAS----CCKPTSLEIVPIVF 185
Cdd:cd19399    1 RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCeGLCEFPLRSHLEPTNHAVIQtLMNSMDPEStpptCCVPTRLSPISILF 80

                         90       100
                 ....*....|....*....|..
gi 295293157 186 MDETSTIVISSVQ--LARGCGC 205
Cdd:cd19399   81 IDSANNVVYKQYEdmVVESCGC 102
TGF_beta_GDF8_like cd13751
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, ...
 112-205 4.63e-08

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, GDF8 and GDF11, and similar proteins; The family includes GDF8 and GDF11. GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381629  Cd Length: 96  Bit Score: 49.19  E-value: 4.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 112 KCCSMATEVFMKDLGWDnWVIYPLSLIIDRCA-LCNSSDQIAQcPAAHDGVQIRGSQDQASCCKPTSLEIVPIVFMDETS 190
Cdd:cd13751    2 RCCRYPLTVDFEEFGWD-WIIAPKTYDANYCSgECPFVYLQSY-PHTHLVQQANPRGSAGPCCTPTKMSPLSMLYFDEDG 79

                         90
                 ....*....|....*..
gi 295293157 191 TIVISSVQ--LARGCGC 205
Cdd:cd13751   80 NIIYGTLPdmVVERCGC 96
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 122-205 5.73e-07

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 46.54  E-value: 5.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 122 MKDLGWDNWVIYPLSLIIDRCA-LCNSSDQIAQCPAAHDGVQ------IRGSQDQASCCKPTSLEIVPIVFMDETSTIVI 194
Cdd:cd13756   10 FSDLGWDDWIIAPKGYNANYCAgSCPFPLSSHANATNHAILQallhslNPKKSVPKPCCVPTKYSPLSVLYYDEDGNVVL 89

                         90
                 ....*....|...
gi 295293157 195 SSVQ--LARGCGC 205
Cdd:cd13756   90 KTYPdmVVEECGC 102
TGF_beta_GDF5_6_7 cd13766
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 113-205 1.32e-06

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins; The family includes GDF5, GDF6 and GDF7. GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. GDF6, also termed bone morphogenetic protein 13 (BMP-13), or growth/differentiation factor 16, is a growth factor that controls proliferation and cellular differentiation in the retina and bone formation. GDF7, also termed bone morphogenetic protein 12 (BMP-12), may play an active role in the motor area of the primate neocortex.


Pssm-ID: 381644  Cd Length: 102  Bit Score: 45.50  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 113 CCSMATEVFMKDLGWDNWVIYPLSLIIDRCA-LCNSSDQIAQCPAAHDGVQ-IRGSQD----QASCCKPTSLEIVPIVFM 186
Cdd:cd13766    1 CSRKPLHVNFKDLGWDDWIIAPLDYEAYHCEgVCDFPLRSHLEPTNHAIIQtLMNSMDpestPPSCCVPTKLSPISILYI 80

                         90       100
                 ....*....|....*....|.
gi 295293157 187 DETSTIVISSVQ--LARGCGC 205
Cdd:cd13766   81 DSANNVVYKQYEdmVVESCGC 101
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 113-206 1.53e-06

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 45.34  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157   113 CCSMATEVFMKDLGWDNWVIYPLSLIIDRCalcnssdqIAQC--PAAHDG-----------VQIRGSQDQ-ASCCKPTSL 178
Cdd:smart00204   1 CRRRQLYVDFKDLGWDDWIIAPKGYNAYYC--------EGECpfPLSTSLnatnhaivqtlVHLLGPNPVpKPCCVPTKL 72

                           90       100       110
                   ....*....|....*....|....*....|
gi 295293157   179 EIVPIVFMDETSTIVISSVQ--LARGCGCG 206
Cdd:smart00204  73 SPLSMLYYDDDGNVVLRNYPnmVVEECGCR 102
TGF_beta_INHA_B_like cd19377
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), ...
 113-205 1.57e-06

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381647  Cd Length: 101  Bit Score: 45.16  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 113 CCSMATEVFMKDLGWDNWVIYPLSLI----IDRCALCNSSDQIAQCPAA----HDGVQIRGSqdQASCCKPTSLEIVPIV 184
Cdd:cd19377    1 CCRVALFVSFEELGWNRWIIAPPGFNfhfcHGGCALHIVPDLSLPVPSApptpARPYSVLPG--AQPCCAPTKVTPLSVL 78

                         90       100
                 ....*....|....*....|...
gi 295293157 185 FMDETSTIVISSVQ--LARGCGC 205
Cdd:cd19377   79 YTSDGGTIKYETIPdlIVQECGC 101
TGF_beta_INHBA cd19404
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) ...
 113-205 7.61e-06

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381674  Cd Length: 108  Bit Score: 43.37  E-value: 7.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 113 CCSMATEVFMKDLGWDNWVIYPLSLIIDRC-ALCNS--SDQIAQCPAAHDGV----QIRGSQDQA---SCCKPTSLEIVP 182
Cdd:cd19404    3 CCKKQFYVSFKDIGWSDWIIAPSGYHANYCeGECPShiAGTSGSSLSFHSTVinhyRMRGYSPFAnlkSCCVPTKLRAMS 82

                         90       100
                 ....*....|....*....|....*
gi 295293157 183 IVFMDETSTIVISSVQ--LARGCGC 205
Cdd:cd19404   83 MLYYDDGQNIIKKDIQnmIVEECGC 107
TGF_beta_GDF8 cd19388
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 106-205 1.16e-05

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth.


Pssm-ID: 381658  Cd Length: 108  Bit Score: 43.10  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 106 ENDTSLKCCSMATEVFMKDLGWDnWVIYPLSLIIDRCALCNSSDQIAQCPAAHDGVQIRGSQDQASCCKPTSLEIVPIVF 185
Cdd:cd19388    7 EHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLY 85

                         90       100
                 ....*....|....*....|...
gi 295293157 186 MDETSTIV---ISSVQLARgCGC 205
Cdd:cd19388   86 FNGKEQIIygkIPAMVVDR-CGC 107
TGF_beta_BMP2 cd19390
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 120-205 1.85e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins; BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway.


Pssm-ID: 381660  Cd Length: 103  Bit Score: 42.28  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 120 VFMKDLGWDNWVIYPLSLIIDRCAlcnssdqiAQCP---------AAHDGVQIR----GSQDQASCCKPTSLEIVPIVFM 186
Cdd:cd19390   10 VDFSDVGWNDWIVAPPGYHAFYCH--------GECPfpladhlnsTNHAIVQTLvnsvNSKIPKACCVPTELSAISMLYL 81

                         90       100
                 ....*....|....*....|.
gi 295293157 187 DETSTIVISSVQ--LARGCGC 205
Cdd:cd19390   82 DENEKVVLKNYQdmVVEGCGC 102
TGF_beta_DPP cd19392
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 120-205 2.98e-05

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.


Pssm-ID: 381662  Cd Length: 109  Bit Score: 41.74  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 120 VFMKDLGWDNWVIYPLSLiidRCALCNssdqiAQCP---------AAHDGVQ--IRGSQDQA---SCCKPTSLEIVPIVF 185
Cdd:cd19392   15 VDFSDVGWDDWIVAPLGY---DAYYCN-----GECPfpladylnaTNHAVVQtlVNSVDPQAvpkACCVPTELSSIAMLY 86

                         90       100
                 ....*....|....*....|..
gi 295293157 186 MDETSTIVISSVQ--LARGCGC 205
Cdd:cd19392   87 VDEHDKVVLKNYQdmVVEGCGC 108
TGF_beta_BMP7 cd19397
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 ...
 120-205 6.67e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.


Pssm-ID: 381667  Cd Length: 107  Bit Score: 40.80  E-value: 6.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 120 VFMKDLGWDNWVIYPLSLIIDRC-ALCNSSDQIAQCPAAHDGVQ-----IRGSQDQASCCKPTSLEIVPIVFMDETSTIV 193
Cdd:cd19397   13 VSFRDLGWQDWIIAPEGYAAYYCeGECAFPLNSYMNATNHAIVQtlvhfINPETVPKPCCAPTQLNAISVLYFDDSSNVI 92

                         90
                 ....*....|....
gi 295293157 194 ISSVQ--LARGCGC 205
Cdd:cd19397   93 LKKYRnmVVRACGC 106
TGF_beta_GDF15 cd19376
transforming growth factor beta (TGF-beta) like domain found in mammalian growth ...
 112-205 7.46e-05

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.


Pssm-ID: 381646  Cd Length: 101  Bit Score: 40.37  E-value: 7.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 112 KCCSMATEVFMKDLGWDNWVIYPLSLIIDRCalcnssdqIAQCP----AAHDGVQIRGSQDQAS-------CCKPTSLEi 180
Cdd:cd19376    2 RCCRFSLRVSFKEIGWADWVLAPESYNAYYC--------DGSCPhnykPANMHAQIKSRLHRLNpgavpapCCVPSSYE- 72

                         90       100
                 ....*....|....*....|....*....
gi 295293157 181 vPIVFM--DETSTIVISSVQ--LARGCGC 205
Cdd:cd19376   73 -PLTLLhyDSDGKLTLTEFDdmIVKDCHC 100
TGF_beta_BMP4_BMP2B cd19391
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 ...
 113-205 7.77e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins; BMP-4, also termed BMP-2B, induces cartilage and bone formation. It also acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381661  Cd Length: 107  Bit Score: 40.81  E-value: 7.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 113 CCSMATEVFMKDLGWDNWVIYPLSLIIDRCAlcnssdqiAQCP---------AAHDGVQIR----GSQDQASCCKPTSLE 179
Cdd:cd19391    7 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCH--------GDCPfpladhlnsTNHAIVQTLvnsvNSSIPKACCVPTELS 78

                         90       100
                 ....*....|....*....|....*...
gi 295293157 180 IVPIVFMDETSTIVISSVQ--LARGCGC 205
Cdd:cd19391   79 AISMLYLDEYDKVVLKNYQemVVEGCGC 106
TGF_beta_BMP6 cd19396
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 ...
 120-205 1.27e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation.


Pssm-ID: 381666  Cd Length: 103  Bit Score: 40.02  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 120 VFMKDLGWDNWVIYPLSLIIDRC-ALCNSSDQIAQCPAAHDGVQ-----IRGSQDQASCCKPTSLEIVPIVFMDETSTIV 193
Cdd:cd19396    9 VSFQDLGWQDWIIAPKGYAANYCdGECSFPLNAHMNATNHAIVQtlvhlMNPEYVPKPCCAPTKLNAISVLYFDDNSNVI 88

                         90
                 ....*....|....
gi 295293157 194 ISSVQ--LARGCGC 205
Cdd:cd19396   89 LKKYRnmVVRACGC 102
TGF_beta_INHBB cd19405
transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) ...
 113-205 2.18e-04

transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) and similar proteins; INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381675  Cd Length: 107  Bit Score: 39.53  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 113 CCSMATEVFMKDLGWDNWVIYPLSLIIDRCalcnssdqIAQCPAAHDGV---------------QIRGSQDQA--SCCKP 175
Cdd:cd19405    3 CCRQQFYIDFRLIGWNDWIIAPVGYYGNYC--------EGSCPAYMAGVpgsassfhtavvnqyRMRGMNPGTvnSCCIP 74

                         90       100       110
                 ....*....|....*....|....*....|..
gi 295293157 176 TSLEIVPIVFMDETSTIVISSV--QLARGCGC 205
Cdd:cd19405   75 TKLSTMSMLYFDDEYNIVKRDVpnMIVEECGC 106
TGF_beta_univin cd19387
transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus ...
 120-205 3.15e-04

transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo.


Pssm-ID: 381657  Cd Length: 104  Bit Score: 38.63  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 120 VFMKDLGWDNWVIYPLSLIIDRCAlcnssdqiAQCP---------AAHDGVQ-----IRGSQDQASCCKPTSLEIVPIVF 185
Cdd:cd19387   10 VDFKDVGWSDWIIAPRGYQAYRCA--------GECPfplnehlngTNHAIIQtlvnsIDPSNVPKACCAPTKLSSISMLY 81

                         90       100
                 ....*....|....*....|..
gi 295293157 186 MDETSTIVISSVQ--LARGCGC 205
Cdd:cd19387   82 FDNNDNVVLRQYEdmVVEACGC 103
TGF_beta_BMP5 cd19395
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 ...
 120-205 4.25e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation.


Pssm-ID: 381665  Cd Length: 113  Bit Score: 38.53  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 120 VFMKDLGWDNWVIYPLSLIIDRC-ALCNSSDQIAQCPAAHDGVQ-----IRGSQDQASCCKPTSLEIVPIVFMDETSTIV 193
Cdd:cd19395   19 VSFRDLGWQDWIIAPEGYAAFYCdGECSFPLNAHMNATNHAIVQtlvhlMFPDNVPKPCCAPTKLNAISVLYFDDSSNVI 98

                         90
                 ....*....|....
gi 295293157 194 ISSVQ--LARGCGC 205
Cdd:cd19395   99 LKKYRnmVVRSCGC 112
TGF_beta_INHBC_E cd19406
transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), ...
 113-205 6.19e-04

transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins; The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381676  Cd Length: 104  Bit Score: 37.83  E-value: 6.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 113 CCSMATEVFMKDLGWDNWVIYPLSLIIDRCalcnssdqIAQCP---------AA--HDGV--QIRGSQDQA---SCCKPT 176
Cdd:cd19406    1 CCRRDFYVDFKDIGWNDWIIKPEGYQMNYC--------MGQCPlhiagspgiAAsfHTAVlnLVKANNIATavhSCCVPT 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 295293157 177 SLEIVPIVFMDETSTIVISSV--QLARGCGC 205
Cdd:cd19406   73 ARRPLSLLYFDRNSNIVKTDIpdMIVEACGC 103
TGF_beta_BMP3 cd19393
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 113-205 1.77e-03

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.


Pssm-ID: 381663  Cd Length: 110  Bit Score: 36.94  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 113 CCSMATEVFMKDLGWDNWVIYPLSLIIDRCA-LCNSSDQIAQCPAAHDGVQ--IRG----SQDQASCCKPTSLEIVPIVF 185
Cdd:cd19393    8 CARRYLKVDFADIGWSEWIISPKSFDAYYCSgACQFPMPKSLKPSNHATIQsiVRAvgvvPGIPEPCCVPEKMSSLSILF 87

                         90       100
                 ....*....|....*....|..
gi 295293157 186 MDETSTIVISSV--QLARGCGC 205
Cdd:cd19393   88 FDENKNVVLKVYpnMTVESCAC 109
TGF_beta_BMP10 cd19401
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 ...
 123-192 2.46e-03

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381671  Cd Length: 105  Bit Score: 36.37  E-value: 2.46e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295293157 123 KDLGWDNWVIYPLSLIIDRC-ALCNSSDQIAQCPAAHDGVQI---RGSQDQAS--CCKPTSLEIVPIVFMDETSTI 192
Cdd:cd19401   13 KEIGWDSWIIAPTGYEAYECrGVCYYPLTEHVTPTKHAIVQTlvhLKNPQKASkaCCVPTKLDPISILYLDDAGVV 88
TGF_beta_TGFbeta1_2_3 cd13753
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 113-205 3.23e-03

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381631  Cd Length: 97  Bit Score: 35.75  E-value: 3.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 113 CCSMATEV-FMKDLGWdNWVIYPLSLIIDRCAlcnssdqiAQCP------AAHDGVQIRGSQ-----DQASCCKPTSLEI 180
Cdd:cd13753    1 CCLRPLYInFRRDLGW-KWIHEPKGFNANYCA--------GACPylwsadTQHSTVLQLYNRlnpvaSAAPCCSPRELEP 71

                         90       100
                 ....*....|....*....|....*..
gi 295293157 181 VPIVFMDETSTIV--ISSVqLARGCGC 205
Cdd:cd13753   72 LTILYYDGRNPKIetLSNM-IVTSCKC 97
TGF_beta_GDF11 cd19389
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 106-205 4.23e-03

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins; GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381659  Cd Length: 109  Bit Score: 35.78  E-value: 4.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 106 ENDTSLKCCSMATEVFMKDLGWDnWVIYPLSLIIDRCALCNSSDQIAQCPAAHDGVQIRGSQDQASCCKPTSLEIVPIVF 185
Cdd:cd19389    8 EHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLY 86

                         90       100
                 ....*....|....*....|..
gi 295293157 186 MDETSTIVISSV--QLARGCGC 205
Cdd:cd19389   87 FNDKQQIIYGKIpgMVVDRCGC 108
TGF_beta_BMP9_like cd13767
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, ...
 120-189 5.14e-03

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, BMP-9, BMP-10 and similar proteins; The family includes BMP9 (also known as GDF2) and BMP10. BMP-9 is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs). BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381645  Cd Length: 105  Bit Score: 35.42  E-value: 5.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293157 120 VFMKDLGWDNWVIYPLSLIIDRCalcnssdqIAQC---------PAAHDGVQIR---GSQDQAS--CCKPTSLEIVPIVF 185
Cdd:cd13767   10 VNFADIGWDSWIIAPKGYEAYEC--------SGKCffpladhlsPTKHAIIQTLvhsKSPEKVSraCCVPTKLEPISLLY 81


                 ....
gi 295293157 186 MDET 189
Cdd:cd13767   82 IDEN 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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