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Conserved domains on  [gi|295389963|ref|NP_001171315|]
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FERM domain-containing protein 4A isoform 3 [Mus musculus]

Protein Classification

innate immunity activator family protein( domain architecture ID 10570578)

innate immunity activator family protein similar to Homo sapiens innate immunity activator protein that is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF3338 pfam11819
Domain of unknown function (DUF3338); This family of proteins are functionally uncharacterized. ...
47-182 6.76e-52

Domain of unknown function (DUF3338); This family of proteins are functionally uncharacterized. This family is found in eukaryotes. This presumed domain is about 130 amino acids in length.


:

Pssm-ID: 432099  Cd Length: 136  Bit Score: 176.35  E-value: 6.76e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389963   47 GSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKRLCLREAELTGKLPVEYPLDPGEEP 126
Cdd:pfam11819   1 ESKGEIISSSSGSLLSSGSDSSTSSEKQKKEKTAALKKKQQALQERLELKLEELKKLCLREAELTGKLPKEYPLEPGEKP 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 295389963  127 PIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKK 182
Cdd:pfam11819  81 PQVRRRVGTAFKLDEQHVLQYAEDPELESLEREFALQQQIVEAARRLALEPNLSKT 136
PH-like super family cl17171
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
1-18 1.90e-05

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


The actual alignment was detected with superfamily member cd13191:

Pssm-ID: 450165  Cd Length: 113  Bit Score: 44.26  E-value: 1.90e-05
                         10
                 ....*....|....*...
gi 295389963   1 MAISQHQFYLDRKQSKSK 18
Cdd:cd13191   96 MAIAQHQFYLDRKQSKKK 113
 
Name Accession Description Interval E-value
DUF3338 pfam11819
Domain of unknown function (DUF3338); This family of proteins are functionally uncharacterized. ...
47-182 6.76e-52

Domain of unknown function (DUF3338); This family of proteins are functionally uncharacterized. This family is found in eukaryotes. This presumed domain is about 130 amino acids in length.


Pssm-ID: 432099  Cd Length: 136  Bit Score: 176.35  E-value: 6.76e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389963   47 GSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKRLCLREAELTGKLPVEYPLDPGEEP 126
Cdd:pfam11819   1 ESKGEIISSSSGSLLSSGSDSSTSSEKQKKEKTAALKKKQQALQERLELKLEELKKLCLREAELTGKLPKEYPLEPGEKP 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 295389963  127 PIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKK 182
Cdd:pfam11819  81 PQVRRRVGTAFKLDEQHVLQYAEDPELESLEREFALQQQIVEAARRLALEPNLSKT 136
FERM_C_FRMD4A_FRMD4B cd13191
FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B); FRMD4A is part ...
1-18 1.90e-05

FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B); FRMD4A is part of the Par-3/FRMD4A/cytohesin-1 complex that activates Arf6, a central player in actin cytoskeleton dynamics and membrane trafficking, during junctional remodeling and epithelial polarization. The Par-3/Par-6/aPKC/Cdc42 complex regulates the conversion of primordial adherens junctions (AJs) into belt-like AJs and the formation of linear actin cables. When primordial AJs are formed, Par-3 recruits scaffolding protein FRMD4A which connects Par-3 and the Arf6 guanine-nucleotide exchange factor (GEF), cytohesin-1. FRMD4B (also called GRP1-binding protein, GRSP1) is a novel member of GRP1 signaling complexes that are recruited to plasma membrane ruffles in response to insulin receptor signaling. The GRSP1/FRMD4B protein contains a FERM protein domain as well as two coiled coil domains and may function as a scaffolding protein. GRP1 and GRSP1 interact through the coiled coil domains in the two proteins. The FERM domain has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3). The C-lobe/F3 within the FERM domain is part of the PH domain family. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites.


Pssm-ID: 270012  Cd Length: 113  Bit Score: 44.26  E-value: 1.90e-05
                         10
                 ....*....|....*...
gi 295389963   1 MAISQHQFYLDRKQSKSK 18
Cdd:cd13191   96 MAIAQHQFYLDRKQSKKK 113
 
Name Accession Description Interval E-value
DUF3338 pfam11819
Domain of unknown function (DUF3338); This family of proteins are functionally uncharacterized. ...
47-182 6.76e-52

Domain of unknown function (DUF3338); This family of proteins are functionally uncharacterized. This family is found in eukaryotes. This presumed domain is about 130 amino acids in length.


Pssm-ID: 432099  Cd Length: 136  Bit Score: 176.35  E-value: 6.76e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389963   47 GSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKRLCLREAELTGKLPVEYPLDPGEEP 126
Cdd:pfam11819   1 ESKGEIISSSSGSLLSSGSDSSTSSEKQKKEKTAALKKKQQALQERLELKLEELKKLCLREAELTGKLPKEYPLEPGEKP 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 295389963  127 PIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKK 182
Cdd:pfam11819  81 PQVRRRVGTAFKLDEQHVLQYAEDPELESLEREFALQQQIVEAARRLALEPNLSKT 136
FERM_C_FRMD4A_FRMD4B cd13191
FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B); FRMD4A is part ...
1-18 1.90e-05

FERM domain C-lobe of FERM domain-containing protein 4A and 4B (FRMD4A and 4B); FRMD4A is part of the Par-3/FRMD4A/cytohesin-1 complex that activates Arf6, a central player in actin cytoskeleton dynamics and membrane trafficking, during junctional remodeling and epithelial polarization. The Par-3/Par-6/aPKC/Cdc42 complex regulates the conversion of primordial adherens junctions (AJs) into belt-like AJs and the formation of linear actin cables. When primordial AJs are formed, Par-3 recruits scaffolding protein FRMD4A which connects Par-3 and the Arf6 guanine-nucleotide exchange factor (GEF), cytohesin-1. FRMD4B (also called GRP1-binding protein, GRSP1) is a novel member of GRP1 signaling complexes that are recruited to plasma membrane ruffles in response to insulin receptor signaling. The GRSP1/FRMD4B protein contains a FERM protein domain as well as two coiled coil domains and may function as a scaffolding protein. GRP1 and GRSP1 interact through the coiled coil domains in the two proteins. The FERM domain has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3). The C-lobe/F3 within the FERM domain is part of the PH domain family. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites.


Pssm-ID: 270012  Cd Length: 113  Bit Score: 44.26  E-value: 1.90e-05
                         10
                 ....*....|....*...
gi 295389963   1 MAISQHQFYLDRKQSKSK 18
Cdd:cd13191   96 MAIAQHQFYLDRKQSKKK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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