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Conserved domains on  [gi|296010882|ref|NP_001171557|]
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zinc finger X-chromosomal protein isoform 2 [Homo sapiens]

Protein Classification

Zfx_Zfy_act and COG5048 domain-containing protein( domain architecture ID 12057222)

protein containing domains Zfx_Zfy_act, COG5048, zf-C2H2, and zf-H2C2_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 1-181 2.09e-112

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 338.37  E-value: 2.09e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882    1 MTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPE 80
Cdd:pfam04704 153 LTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQE 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882   81 DEDLNVAEIADEVYMEVIVGEEDaaaaaaAAAVHEQQMDDNEI-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESA 159
Cdd:pfam04704 233 DEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESA 306

                         170       180
                  ....*....|....*....|..
gi 296010882  160 GLGRLAKQKPKKRRRPDSRQYQ 181
Cdd:pfam04704 307 SLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
314-438 8.23e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 8.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882 314 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 391
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 296010882 392 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC 438
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154
ROS_MUCR super family cl19880
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 148-228 4.84e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


The actual alignment was detected with superfamily member pfam05443:

Pssm-ID: 473244  Cd Length: 122  Bit Score: 40.14  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882  148 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 223
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 296010882  224 KKKYR 228
Cdd:pfam05443  88 PEEYR 92
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-528 4.66e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.66e-03
                          10        20
                  ....*....|....*....|....*
gi 296010882  504 ELKKHMKTHSGRKVYQCEYCEYSTT 528
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 490-512 7.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.58e-03
                          10        20
                  ....*....|....*....|...
gi 296010882  490 FRCKRCRKGFRQQSELKKHMKTH 512
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 1-181 2.09e-112

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 338.37  E-value: 2.09e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882    1 MTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPE 80
Cdd:pfam04704 153 LTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQE 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882   81 DEDLNVAEIADEVYMEVIVGEEDaaaaaaAAAVHEQQMDDNEI-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESA 159
Cdd:pfam04704 233 DEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESA 306

                         170       180
                  ....*....|....*....|..
gi 296010882  160 GLGRLAKQKPKKRRRPDSRQYQ 181
Cdd:pfam04704 307 SLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
314-438 8.23e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 8.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882 314 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 391
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 296010882 392 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC 438
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-357 3.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.29e-04
                          10        20
                  ....*....|....*....|....*
gi 296010882  333 ELKKHMRIHTGEKPYQCQYCEYRSA 357
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 148-228 4.84e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 40.14  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882  148 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 223
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 296010882  224 KKKYR 228
Cdd:pfam05443  88 PEEYR 92
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-528 4.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.66e-03
                          10        20
                  ....*....|....*....|....*
gi 296010882  504 ELKKHMKTHSGRKVYQCEYCEYSTT 528
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 490-512 7.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.58e-03
                          10        20
                  ....*....|....*....|...
gi 296010882  490 FRCKRCRKGFRQQSELKKHMKTH 512
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 1-181 2.09e-112

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 338.37  E-value: 2.09e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882    1 MTMDTESEIDPCKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQPE 80
Cdd:pfam04704 153 LTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQE 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882   81 DEDLNVAEIADEVYMEVIVGEEDaaaaaaAAAVHEQQMDDNEI-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESA 159
Cdd:pfam04704 233 DEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESA 306

                         170       180
                  ....*....|....*....|..
gi 296010882  160 GLGRLAKQKPKKRRRPDSRQYQ 181
Cdd:pfam04704 307 SLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
314-438 8.23e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 8.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882 314 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 391
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 296010882 392 QQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC 438
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-357 3.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.29e-04
                          10        20
                  ....*....|....*....|....*
gi 296010882  333 ELKKHMRIHTGEKPYQCQYCEYRSA 357
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 148-228 4.84e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 40.14  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882  148 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 223
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 296010882  224 KKKYR 228
Cdd:pfam05443  88 PEEYR 92
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
282-425 2.33e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882 282 KEKGANKMHKCKFCEYETAEQGLLNRHLLAVH---SKNFPHICVE--CGKGFRHPSELKKHMRIHTGEKPYQCQYC---- 352
Cdd:COG5048  282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNhsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsss 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296010882 353 ------------------------EYRSADSSNLKTHVKTKHSKEMP----------FKCDICLLTFSDTKEVQQHALIH 398
Cdd:COG5048  362 kfspllnneppqslqqykdlkndkKSETLSNSCIRNFKRDSNLSLHIithlsfrpynCKNPPCSKSFNRHYNLIPHKKIH 441

                        170       180
                 ....*....|....*....|....*..
gi 296010882 399 QESKTHQCLHCDhKSSNSSDLKRHIIS 425
Cdd:COG5048  442 TNHAPLLCSILK-SFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-528 4.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.66e-03
                          10        20
                  ....*....|....*....|....*
gi 296010882  504 ELKKHMKTHSGRKVYQCEYCEYSTT 528
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 490-512 7.58e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.58e-03
                          10        20
                  ....*....|....*....|...
gi 296010882  490 FRCKRCRKGFRQQSELKKHMKTH 512
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 319-341 7.66e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.66e-03
                          10        20
                  ....*....|....*....|...
gi 296010882  319 HICVECGKGFRHPSELKKHMRIH 341
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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