NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|597709791|ref|NP_001177370|]
View 

galectin-16 [Homo sapiens]

Protein Classification

galectin family protein( domain architecture ID 10658251)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 11-135 3.35e-40

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


:

Pssm-ID: 214904  Cd Length: 122  Bit Score: 130.79  E-value: 3.35e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597709791    11 PVSLSVGSCVIIKGTLIDssiNEPQLQVDFYTEMNEDseIAFHLRVHLGRR-VVMNSREFGIWMLEENLHYVPFEDGKPF 89
Cdd:smart00908   1 PGGLSPGSSITIRGIVLP---DAKRFSINLQCGPNAD--IALHFNPRFDEGtIVRNSKQNGKWGKEERSGGFPFQPGQPF 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 597709791    90 DLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSV 135
Cdd:smart00908  76 ELEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSV 121
 
Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 11-135 3.35e-40

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 130.79  E-value: 3.35e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597709791    11 PVSLSVGSCVIIKGTLIDssiNEPQLQVDFYTEMNEDseIAFHLRVHLGRR-VVMNSREFGIWMLEENLHYVPFEDGKPF 89
Cdd:smart00908   1 PGGLSPGSSITIRGIVLP---DAKRFSINLQCGPNAD--IALHFNPRFDEGtIVRNSKQNGKWGKEERSGGFPFQPGQPF 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 597709791    90 DLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSV 135
Cdd:smart00908  76 ELEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSV 121
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 11-136 7.33e-38

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 125.06  E-value: 7.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597709791   11 PVSLSVGSCVIIKGTLIDssiNEPQLQVDFYTEMNEDSEIAFHLRVHLGRR-VVMNSREFGIWMLEENLHYVPFEDGKPF 89
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLP---DAQRFSINLQTGVGPSDDIALHFNPRFDENvIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 597709791   90 DLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSVL 136
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 6-135 7.59e-34

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 114.65  E-value: 7.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597709791   6 VPYKLPVSLSVGSCVIIKGTLIDssiNEPQLQVDFYTEMnedSEIAFHLRVHLGRR-VVMNSREFGIWMLEENLHYVPFE 84
Cdd:cd00070    2 YKLPLPGGLKPGSTLTVKGRVLP---NAKRFSINLGTGS---SDIALHFNPRFDENvIVRNSFLNGNWGPEERSGGFPFQ 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 597709791  85 DGKPFDLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSV 135
Cdd:cd00070   76 PGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSV 126
 
Name Accession Description Interval E-value
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 11-135 3.35e-40

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 130.79  E-value: 3.35e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597709791    11 PVSLSVGSCVIIKGTLIDssiNEPQLQVDFYTEMNEDseIAFHLRVHLGRR-VVMNSREFGIWMLEENLHYVPFEDGKPF 89
Cdd:smart00908   1 PGGLSPGSSITIRGIVLP---DAKRFSINLQCGPNAD--IALHFNPRFDEGtIVRNSKQNGKWGKEERSGGFPFQPGQPF 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 597709791    90 DLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSV 135
Cdd:smart00908  76 ELEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSV 121
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 11-136 7.33e-38

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 125.06  E-value: 7.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597709791   11 PVSLSVGSCVIIKGTLIDssiNEPQLQVDFYTEMNEDSEIAFHLRVHLGRR-VVMNSREFGIWMLEENLHYVPFEDGKPF 89
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLP---DAQRFSINLQTGVGPSDDIALHFNPRFDENvIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 597709791   90 DLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSVL 136
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 6-135 7.59e-34

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 114.65  E-value: 7.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597709791   6 VPYKLPVSLSVGSCVIIKGTLIDssiNEPQLQVDFYTEMnedSEIAFHLRVHLGRR-VVMNSREFGIWMLEENLHYVPFE 84
Cdd:cd00070    2 YKLPLPGGLKPGSTLTVKGRVLP---NAKRFSINLGTGS---SDIALHFNPRFDENvIVRNSFLNGNWGPEERSGGFPFQ 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 597709791  85 DGKPFDLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSV 135
Cdd:cd00070   76 PGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSV 126
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 8-135 4.41e-27

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 97.68  E-value: 4.41e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597709791     8 YKLPVSLSVGSCVIIKGTLidsSINEPQLQVDFYTEMNEdseIAFHLRVHLGRR-VVMNSREFGIWMLEENLHYVPFEDG 86
Cdd:smart00276   3 LPIPGGLKPGQTLTVRGIV---LPDAKRFSINLLTGGDD---IALHFNPRFNENkIVCNSKLNGSWGSEEREGGFPFQPG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 597709791    87 KPFDLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSV 135
Cdd:smart00276  77 QPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSV 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH