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Conserved domains on  [gi|300360515|ref|NP_001177925|]
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actin-related protein 2/3 complex subunit 1A isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-252 1.78e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 1.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515   9 IALSPN---------NHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVIL 79
Cdd:COG2319  126 VAFSPDgktlasgsaDGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  80 RINRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCR 153
Cdd:COG2319  202 GHTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 154 VFSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFL 233
Cdd:COG2319  272 LWDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        250
                 ....*....|....*....
gi 300360515 234 PLLSVSFVSENSVVAAGHD 252
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-252 1.78e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 1.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515   9 IALSPN---------NHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVIL 79
Cdd:COG2319  126 VAFSPDgktlasgsaDGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  80 RINRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCR 153
Cdd:COG2319  202 GHTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 154 VFSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFL 233
Cdd:COG2319  272 LWDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        250
                 ....*....|....*....
gi 300360515 234 PLLSVSFVSENSVVAAGHD 252
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-274 6.01e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 6.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  32 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 111
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 112 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFSayikevdekpastpwgskMPFGQLMSEFg 185
Cdd:cd00200   78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTL- 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 186 gSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFV-SENSVVAAGHDCCPMLFNYDDRG 264
Cdd:cd00200  132 -RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGK 210

                        250
                 ....*....|.
gi 300360515 265 CL-TFVSKLDI 274
Cdd:cd00200  211 CLgTLRGHENG 221
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 32-66 8.83e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 8.83e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 300360515    32 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 66
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
28-66 5.27e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 300360515   28 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 66
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-252 1.78e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 1.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515   9 IALSPN---------NHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVIL 79
Cdd:COG2319  126 VAFSPDgktlasgsaDGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  80 RINRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCR 153
Cdd:COG2319  202 GHTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 154 VFSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFL 233
Cdd:COG2319  272 LWDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        250
                 ....*....|....*....
gi 300360515 234 PLLSVSFVSENSVVAAGHD 252
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-274 6.01e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 6.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  32 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 111
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 112 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFSayikevdekpastpwgskMPFGQLMSEFg 185
Cdd:cd00200   78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTL- 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 186 gSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFV-SENSVVAAGHDCCPMLFNYDDRG 264
Cdd:cd00200  132 -RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGK 210

                        250
                 ....*....|.
gi 300360515 265 CL-TFVSKLDI 274
Cdd:cd00200  211 CLgTLRGHENG 221
WD40 COG2319
WD40 repeat [General function prediction only];
32-250 5.50e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 5.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  32 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVcyf 111
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL--- 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 112 esendWWVS----KHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAyikevdekpaSTpwgskmpfGQLMSEFggS 187
Cdd:COG2319  273 -----WDLAtgelLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL----------AT--------GKLLRTL--T 327

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300360515 188 GTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAG 250
Cdd:COG2319  328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
31-252 3.77e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 3.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  31 AHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVcy 110
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG--KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL-- 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 111 fesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCDFKCRVFSayikevdekpASTpwgskmpfGQLMSEF 184
Cdd:COG2319  189 ------WDLAT--GKLLRTltghtgAVRSVAFSPDGKLLASGSADGTVRLWD----------LAT--------GKLLRTL 242

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300360515 185 GGSgtGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHD 252
Cdd:COG2319  243 TGH--SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308
WD40 COG2319
WD40 repeat [General function prediction only];
8-220 6.75e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 6.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515   8 LIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVilRINRAATF 87
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNS 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  88 VKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCDFKCRVFSAyike 161
Cdd:COG2319  294 VAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKTLASGSDDGTVRLWDL---- 359

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 300360515 162 vdekpastpwgskmPFGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADAS 220
Cdd:COG2319  360 --------------ATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-254 1.37e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515   8 LIALSPNNHEVHIYKKNGSQwvKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILRINRAATF 87
Cdd:cd00200   65 YLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNS 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  88 VKWSPlENKFAVGSGA-RLISVCYFESEndwwvskhikKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFSayik 160
Cdd:cd00200  141 VAFSP-DGTFVASSSQdGTIKLWDLRTG----------KCVAtltghtGEVNSVAFSPDGEKLLSSSSDGTIKLWD---- 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 161 evdekpastpwgskMPFGQLMSEFGGSgtGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSF 240
Cdd:cd00200  206 --------------LSTGKCLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAW 269

                        250
                 ....*....|....*
gi 300360515 241 VSENSVVAAG-HDCC 254
Cdd:cd00200  270 SPDGKRLASGsADGT 284
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-216 2.05e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 2.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  32 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILRINRAATFVKWSPLENKFAVGSGARLI----- 106
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG--KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIklwdl 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 107 ----SVCYFESENDWwvskhikkpirstVLSLDWHPNNVLLAAGSCDFKCRVFSAYIkevdekpastpwgskmpfGQLMS 182
Cdd:cd00200  207 stgkCLGTLRGHENG-------------VNSVAFSPDGYLLASGSEDGTIRVWDLRT------------------GECVQ 255

                        170       180       190
                 ....*....|....*....|....*....|....
gi 300360515 183 EFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSV 216
Cdd:cd00200  256 TL--SGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-156 2.32e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 2.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515   8 LIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVilRINRAATF 87
Cdd:cd00200  149 FVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR--GHENGVNS 224

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300360515  88 VKWSPLENKFAVGSGARLISVcyfesendW-WVSKHIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRVFS 156
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRV--------WdLRTGECVQTLSghtNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
45-252 5.72e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 5.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515  45 DWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRinRAATFVKWSPLENKFAVGSGARLISVcyfeSENDWWVSKHIK 124
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLA--AAVASLAASPDGARLAAGAGDLTLLL----LDAAAGALLATL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360515 125 KPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAyikeVDEKPASTPWGskmpfgqlmsefggsgTGGWVHGVSFSASGSR 204
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----ATGLLLRTLTG----------------HTGAVRSVAFSPDGKT 134

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 300360515 205 LAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHD 252
Cdd:COG2319  135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 32-66 8.83e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 8.83e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 300360515    32 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 66
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
28-66 5.27e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 300360515   28 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 66
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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