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Conserved domains on  [gi|300797999|ref|NP_001178792|]
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peptidyl-prolyl cis-trans isomerase FKBP4 [Rattus norvegicus]

Protein Classification

FKBP-type peptidyl-prolyl cis-trans isomerase( domain architecture ID 10446594)

FKBP-type peptidyl-prolyl cis-trans isomerase acts as a PPIase that accelerates the folding of proteins

CATH:  3.10.50.40
EC:  5.2.1.8
Gene Ontology:  GO:0003755

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-134 2.04e-43

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 147.73  E-value: 2.04e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999   43 GTETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGSAGS-PPK 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 300797999  122 IPPNATLVFEVEL 134
Cdd:pfam00254  81 IPPNATLVFEVEL 93
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
275-424 2.69e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 80.73  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 275 ERGTVYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELD 349
Cdd:COG4785   78 ERGVAYDSLGDYDLAIADFDQ--------------------ALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797999 350 SNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 424
Cdd:COG4785  138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-134 2.04e-43

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 147.73  E-value: 2.04e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999   43 GTETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGSAGS-PPK 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 300797999  122 IPPNATLVFEVEL 134
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 35-134 1.81e-41

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 143.01  E-value: 1.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  35 KVIKrEGTGtETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYG 114
Cdd:COG0545    4 KVLK-EGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYG 81

                         90       100
                 ....*....|....*....|
gi 300797999 115 SAGSPPKIPPNATLVFEVEL 134
Cdd:COG0545   82 ERGAGGVIPPNSTLVFEVEL 101
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 28-138 4.16e-18

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 84.04  E-value: 4.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  28 KQDEGVLKVIKREGTGtETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITC 107
Cdd:PRK10902 143 TTSTGLLYKVEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVI 219

                         90       100       110
                 ....*....|....*....|....*....|.
gi 300797999 108 KPEYAYGSAGSpPKIPPNATLVFEVELFEFK 138
Cdd:PRK10902 220 PPELAYGKAGV-PGIPANSTLVFDVELLDVK 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
275-424 2.69e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 80.73  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 275 ERGTVYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELD 349
Cdd:COG4785   78 ERGVAYDSLGDYDLAIADFDQ--------------------ALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797999 350 SNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 424
Cdd:COG4785  138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 277-395 6.64e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 55.09  E-value: 6.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  277 GTVYFKEGKYKQALLQYKKIVSWLEyessfsgeemQKVHALRLashlnLAMCHLKLQAFSAAIESCNKALELDSNNEKGL 356
Cdd:TIGR02917 302 GASEYQLGNLEQAYQYLNQILKYAP----------NSHQARRL-----LASIQLRLGRVDEAIATLSPALGLDPDDPAAL 366

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 300797999  357 FRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 395
Cdd:TIGR02917 367 SLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 323-390 1.55e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.93  E-value: 1.55e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300797999 323 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 390
Cdd:cd24142    4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
TPR_1 pfam00515
Tetratricopeptide repeat;
321-352 4.66e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 4.66e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 300797999  321 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 326-448 6.27e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 45.16  E-value: 6.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 326 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNkaaktqlavcqqrtrrqlA 405
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 300797999 406 REKKLYANMFERLAEEE-----HKAKTEVAAGDHPTDAEMKGEPNNVA 448
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEkdlvqPVPSDLPSSVTAPPVEEADATPVVPP 152
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 322-352 8.83e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.35  E-value: 8.83e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 300797999   322 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-134 2.04e-43

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 147.73  E-value: 2.04e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999   43 GTETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGSAGS-PPK 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 300797999  122 IPPNATLVFEVEL 134
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 35-134 1.81e-41

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 143.01  E-value: 1.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  35 KVIKrEGTGtETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYG 114
Cdd:COG0545    4 KVLK-EGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYG 81

                         90       100
                 ....*....|....*....|
gi 300797999 115 SAGSPPKIPPNATLVFEVEL 134
Cdd:COG0545   82 ERGAGGVIPPNSTLVFEVEL 101
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 28-138 4.16e-18

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 84.04  E-value: 4.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  28 KQDEGVLKVIKREGTGtETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITC 107
Cdd:PRK10902 143 TTSTGLLYKVEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVI 219

                         90       100       110
                 ....*....|....*....|....*....|.
gi 300797999 108 KPEYAYGSAGSpPKIPPNATLVFEVELFEFK 138
Cdd:PRK10902 220 PPELAYGKAGV-PGIPANSTLVFDVELLDVK 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
275-424 2.69e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 80.73  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 275 ERGTVYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELD 349
Cdd:COG4785   78 ERGVAYDSLGDYDLAIADFDQ--------------------ALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797999 350 SNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 424
Cdd:COG4785  138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 51-136 7.89e-17

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 78.69  E-value: 7.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  51 DRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVF 130
Cdd:PRK11570 121 DRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFSTLVF 198


                 ....*.
gi 300797999 131 EVELFE 136
Cdd:PRK11570 199 EVELLE 204
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
276-402 8.26e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 8.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 276 RGTVYFKEGKYKQALLQYKKIVswleyessfsgeEMQKVHAlrlASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG 355
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKAL------------ELDPDDA---EALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 300797999 356 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG0457   79 LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
276-402 8.99e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 67.72  E-value: 8.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 276 RGTVYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELDS 350
Cdd:COG0457   48 LGLAYLRLGRYEEALADYEQ--------------------ALELdpddaEALNNLGLALQALGRYEEALEDYDKALELDP 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 300797999 351 NNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG0457  108 DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGR 159
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 244-400 4.45e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.10  E-value: 4.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 244 RYEVHLKSFEKAkasWEMNSEEKLEQSNIvkerGTVYFKEGKYKQALLQYKKIvswLEYESSFsgeemqkvhalrLASHL 323
Cdd:COG3914   93 RYEEALALYRRA---LALNPDNAEALFNL----GNLLLALGRLEEALAALRRA---LALNPDF------------AEAYL 150

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797999 324 NLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRT 400
Cdd:COG3914  151 NLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQA 227
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 267-402 3.24e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.40  E-value: 3.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 267 LEQSNIVKERGTVYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKAL 346
Cdd:COG3914   75 LLLAALLELAALLLQALGRYEEALALYRRAL---------------ALNPDNAEALFNLGNLLLALGRLEEALAALRRAL 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 300797999 347 ELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG3914  140 ALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGR 195
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 50-154 5.14e-11

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 60.11  E-value: 5.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  50 GDRVFVHYTGWLLDGTKFDSSLDRkDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGsagsppkiPPNATLV 129
Cdd:COG1047    4 GDVVTLHYTLKLEDGEVFDSTFEG-EPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG--------ERDPELV 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 300797999 130 FEVELFEFKGED--------LTEDEDG----GIIRRI 154
Cdd:COG1047   75 QTVPREQFPEDEelevgmqvEFQTPDGqevpGTVTEV 111
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
321-402 1.19e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 321 SHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRT 400
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL 89


                 ..
gi 300797999 401 RR 402
Cdd:COG0457   90 GR 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 252-402 1.83e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.28  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 252 FEKAKASWEMNSEEKLEQSNIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFsgeemqkvhalrlasHLNLAMCHLK 331
Cdd:COG2956   92 LDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA---------------YCELAELYLE 156

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300797999 332 LQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG2956  157 QGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGD 227
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 322-407 2.58e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 58.09  E-value: 2.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 322 HLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVC-QQRT 400
Cdd:COG4235   20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAaFQQG 99


                 ....*..
gi 300797999 401 RRQLARE 407
Cdd:COG4235  100 DYAEAIA 106
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 280-390 3.09e-10

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 57.31  E-value: 3.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 280 YFKEGKYKQALLQYKKIVSwlEYESSfsgeemqkvhALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK---GL 356
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLK--RYPNS----------PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdAL 70

                         90       100       110
                 ....*....|....*....|....*....|....
gi 300797999 357 FRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 390
Cdd:COG1729   71 LKLGLSYLELGDYDKARATLEELIKKYPDSEAAK 104
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 275-430 3.19e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.90  E-value: 3.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 275 ERGTVYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 354
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEAL---------------ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797999 355 GLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR-QLAREkklYANMFERLAEEEHKAKTEVA 430
Cdd:COG2956   78 ALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDwEKAIE---VLERLLKLGPENAHAYCELA 151
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 277-389 4.52e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 57.32  E-value: 4.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 277 GTVYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRLAS-----HLNLAMCHLKLQAFSAAIESCNKALELDSN 351
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEK--------------------ALRLDPdnadaLLDLAEALLAAGDTEEAEELLERALALDPD 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 300797999 352 NEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAA 389
Cdd:COG4235   84 NPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
248-422 5.67e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.64  E-value: 5.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 248 HLKSFEKAKASWEMNSEEKLEQSNIVKERGTVYFKEGKYKQALLQYKKIvswLEYESSFSgeemqkvhalrlASHLNLAM 327
Cdd:COG0457   54 RLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKA---LELDPDDA------------EALYNLGL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 328 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLARE 407
Cdd:COG0457  119 ALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLA 198

                        170
                 ....*....|....*
gi 300797999 408 KKLYANMFERLAEEE 422
Cdd:COG0457  199 LLLALEQALRKKLAI 213
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 276-386 7.54e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.12  E-value: 7.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 276 RGTVYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG 355
Cdd:COG4783   44 LGEILLQLGDLDEAIVLLHEAL---------------ELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 300797999 356 LFRRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:COG4783  109 YLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 249-407 2.61e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 249 LKSFEKAKASWEMNSEEKLEQSNIVKERGTVYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMC 328
Cdd:COG2956  123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKAL---------------KLDPDCARALLLLAEL 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300797999 329 HLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLARE 407
Cdd:COG2956  188 YLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALA 266
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 275-420 4.78e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 4.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 275 ERGTVYFKEGKYKQALLQYKKIVSwleyessfsgEEMQKVHALRLashlnLAMCHLKLQAFSAAIESCNKALELDSNNEK 354
Cdd:COG2956   81 ELAQDYLKAGLLDRAEELLEKLLE----------LDPDDAEALRL-----LAEIYEQEGDWEKAIEVLERLLKLGPENAH 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797999 355 GLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTR---------RQLAREKKLYANMFERLAE 420
Cdd:COG2956  146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGdyeeaiaalERALEQDPDYLPALPRLAE 220
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
279-385 1.05e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 52.48  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 279 VYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIEsCNKALELDSNNEKGLFR 358
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKAL---------------ELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLN 64

                         90       100
                 ....*....|....*....|....*..
gi 300797999 359 RGEAHLAVNDFDLARADFQKVLQLYPS 385
Cdd:COG3063   65 LAELLLELGDYDEALAYLERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 316-410 1.25e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.81  E-value: 1.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 316 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 395
Cdd:COG5010   51 AKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAA 130

                         90
                 ....*....|....*
gi 300797999 396 CQQRTRRQLAREKKL 410
Cdd:COG5010  131 LLLSLGQDDEAKAAL 145
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 275-410 3.37e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 3.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 275 ERGTVYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 354
Cdd:COG4783    9 ALAQALLLAGDYDEAEALLEKAL---------------ELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 300797999 355 GLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKL 410
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAAL 129
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 277-395 6.64e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 55.09  E-value: 6.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  277 GTVYFKEGKYKQALLQYKKIVSWLEyessfsgeemQKVHALRLashlnLAMCHLKLQAFSAAIESCNKALELDSNNEKGL 356
Cdd:TIGR02917 302 GASEYQLGNLEQAYQYLNQILKYAP----------NSHQARRL-----LASIQLRLGRVDEAIATLSPALGLDPDDPAAL 366

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 300797999  357 FRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 395
Cdd:TIGR02917 367 SLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 277-399 9.49e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 9.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 277 GTVYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGL 356
Cdd:COG2956   49 GNLYRRRGEYDRAIRIHQKLL---------------ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEAL 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 300797999 357 FRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQR 399
Cdd:COG2956  114 RLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLE 156
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 337-394 1.02e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.77  E-value: 1.02e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 300797999 337 AAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLA 394
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLA 58
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 274-384 1.58e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.73  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 274 KERGTVYFKEGKYKQALLQYKKIVSWLEYESSFsgeemqkvhalrlasHLNLAMCHLKLQAFSAAIESCNKALELDSNNE 353
Cdd:COG5010   58 SPSDNLYNKLGDFEESLALLEQALQLDPNNPEL---------------YYNLALLYSRSGDKDEAKEYYEKALALSPDNP 122

                         90       100       110
                 ....*....|....*....|....*....|.
gi 300797999 354 KGLFRRGEAHLAVNDFDLARADFQKVLQLYP 384
Cdd:COG5010  123 NAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 307-439 3.05e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.78  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  307 SGEEMQKVHALrlaSHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:TIGR02917 456 KLEKKQPDNAS---LHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKN 532

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 300797999  387 KAAKTQLAVCQQRTRRqlarekklyanmferlaEEEHKAKTEVAAGDHPTDAE 439
Cdd:TIGR02917 533 LRAILALAGLYLRTGN-----------------EEEAVAWLEKAAELNPQEIE 568
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
322-389 3.21e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.07  E-value: 3.21e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300797999 322 HLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAA 389
Cdd:COG4785   76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 245-399 4.22e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 52.29  E-value: 4.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  245 YEVHLKSFEKAKASWEMNSEEKLEqsniVKERGTVYFKEGKYKQALLQYKKIVswlEYESSFSgeemqkvhalrlASHLN 324
Cdd:TIGR00990 310 YEEAARAFEKALDLGKLGEKEAIA----LNLRGTFKCLKGKHLEALADLSKSI---ELDPRVT------------QSYIK 370

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797999  325 LAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQR 399
Cdd:TIGR00990 371 RASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQYK 445
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 316-402 1.29e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 316 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 395
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80


                 ....*..
gi 300797999 396 CQQRTRR 402
Cdd:COG4783   81 ALLKAGD 87
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 323-390 1.55e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.93  E-value: 1.55e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300797999 323 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 390
Cdd:cd24142    4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
328-402 2.39e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.55  E-value: 2.39e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797999 328 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARAdFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGD 74
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
264-419 4.12e-06

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 47.95  E-value: 4.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 264 EEKLEQSNIVKER---GTVYFKEGKYKQALLQYkkivswleyESSFSGEEMQKVHALrlashLNLAMCHLKLQAFSAAIE 340
Cdd:COG4700   80 EKALEFADTVQNRvrlADALLELGRYDEAIELY---------EEALTGIFADDPHIL-----LGLAQALFELGRYAEALE 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 341 SCNKALELDSNnekglFRRGEAHL-------AVNDFDLARADFQKVLQLYPsNKAAKTQLAVCQQRTRRQlAREKKLYAN 413
Cdd:COG4700  146 TLEKLIAKNPD-----FKSSDAHLlyaraleALGDLEAAEAELEALARRYS-GPEARYRYAKFLARQGRT-AEAKELLEE 218


                 ....*.
gi 300797999 414 MFERLA 419
Cdd:COG4700  219 ILDEAK 224
TPR_1 pfam00515
Tetratricopeptide repeat;
321-352 4.66e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 4.66e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 300797999  321 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 326-448 6.27e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 45.16  E-value: 6.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 326 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNkaaktqlavcqqrtrrqlA 405
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 300797999 406 REKKLYANMFERLAEEE-----HKAKTEVAAGDHPTDAEMKGEPNNVA 448
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEkdlvqPVPSDLPSSVTAPPVEEADATPVVPP 152
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 322-352 8.83e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.35  E-value: 8.83e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 300797999   322 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 316-425 3.11e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 316 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAv 395
Cdd:COG2956    5 VAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELA- 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 300797999 396 cqqrtrrQLAREKKLYA---NMFERLAEEEHKA 425
Cdd:COG2956   84 -------QDYLKAGLLDraeELLEKLLELDPDD 109
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 275-411 4.46e-04

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 41.77  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  275 ERGTVYFKEGKYKQALLQYKKIvswleyESSF-SGEEMQKvhalrlaSHLNLAMCHLKLQAFSAAIESCNKALELDSNNE 353
Cdd:TIGR03302  38 EEAKEALDSGDYTEAIKYFEAL------ESRYpFSPYAEQ-------AQLDLAYAYYKSGDYAEAIAAADRFIRLHPNHP 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300797999  354 K---GLFRRGEAHLA-VNDFD-------LARADFQKVLQLYPSNK---AAKTQLAVCqqrtRRQLArEKKLY 411
Cdd:TIGR03302 105 DadyAYYLRGLSNYNqIDRVDrdqtaarEAFEAFQELIRRYPNSEyapDAKKRMDYL----RNRLA-GKELY 171
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
326-402 4.86e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.44  E-value: 4.86e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797999 326 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG4785   46 LALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGD 122
TPR_1 pfam00515
Tetratricopeptide repeat;
354-386 5.07e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.40  E-value: 5.07e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 300797999  354 KGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 251-406 8.07e-04

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 41.02  E-value: 8.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 251 SFEKAKASWemnSEEKLeqsnivKERGTVYFKEGKYKQALLQYKKIVSWLEYessfsGEEMQKVhalrlasHLNLAMCHL 330
Cdd:COG4105   22 SFKKALKSW---DAEEL------YEEAKEALEKGDYEKAIKLFEELEPRYPG-----SPYAEQA-------QLMLAYAYY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 331 KLQAFSAAIESCNKALELDSNNEK---GLFRRGEAH-LAVNDFDL-------ARADFQKVLQLYP-SNKAAKtqlavCQQ 398
Cdd:COG4105   81 KQGDYEEAIAAADRFIKLYPNSPNadyAYYLRGLSYyEQSPDSDRdqtstrkAIEAFQELINRYPdSEYAED-----AKK 155

                        170
                 ....*....|.
gi 300797999 399 R---TRRQLAR 406
Cdd:COG4105  156 RideLRDKLAR 166
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
346-402 1.64e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 1.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 300797999 346 LELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGR 57
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 354-384 1.68e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.96  E-value: 1.68e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 300797999  354 KGLFRRGEAHLAVNDFDLARADFQKVLQLYP 384
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDP 32
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 354-386 2.47e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.50  E-value: 2.47e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 300797999   354 KGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 261-376 3.87e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 39.58  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  261 MNSEEKLEQSNIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSgeemqkvhalrlashlNLAMCHLKLQAFSAAIE 340
Cdd:TIGR00990 118 LSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPDPVYYS----------------NRAACHNALGDWEKVVE 181

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 300797999  341 SCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADF 376
Cdd:TIGR00990 182 DTTAALELDPDYSKALNRRANAYDGLGKYADALLDL 217
TPR_12 pfam13424
Tetratricopeptide repeat;
317-385 4.92e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.83  E-value: 4.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797999  317 LRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG--------LFRRGEAHLAVNDFDLARADFQKVLQLYPS 385
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPdhpltattLLNLGRLYLELGRYEEALELLERALALAEK 77
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 279-386 7.56e-03

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 37.53  E-value: 7.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999 279 VYFKEGKYKQALLQYKKIVSwleyesSFSGEEMQKVHALRLAShlnlamCHLKLQAFSAAIESCNKAlelDSNNEKGLF- 357
Cdd:COG2976   99 AAVDAGDLDKAAAQLQWVLD------NAKDPALKALARLRLAR------VLLAQKKYDEALATLDAV---KPEAFAALYa 163

                         90       100       110
                 ....*....|....*....|....*....|
gi 300797999 358 -RRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:COG2976  164 eLRGDILLAQGDKAEARAAYQKALAALPED 193
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 277-395 8.71e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797999  277 GTVYFKEGKYKQALLQYKKIVSwleyessfSGEEMQKVHALrlashlnLAMCHLKLQAFSAAIESCNKALELDSNNE-KG 355
Cdd:TIGR02917  63 GKIYLALGDYAAAEKELRKALS--------LGYPKNQVLPL-------LARAYLLQGKFQQVLDELPGKTLLDDEGAaEL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 300797999  356 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 395
Cdd:TIGR02917 128 LALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQ 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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