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Conserved domains on  [gi|300798457|ref|NP_001178814|]
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glycerol-3-phosphate dehydrogenase 1-like protein [Rattus norvegicus]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-344 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 512.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457    7 KVCIVGSGNWGSAVAKIIGSN-VKNLQKFSSTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLGEAV 85
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENaRALPELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   86 QDADLLVFVIPHQFIHKICDEITGRVPKKAVGITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCE 165
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  166 TTIGSKVLQN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFA 241
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  242 KIFCKGQVSTATFlESCGVADLITTCYGGRNRKVAEAFARTGKTIEELEKELLNGQKLQGPQTSAEVYRILKQKGLLDKF 321
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 300798457  322 PLFTAVYQICYEGRPVTQMLSCL 344
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-344 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 512.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457    7 KVCIVGSGNWGSAVAKIIGSN-VKNLQKFSSTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLGEAV 85
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENaRALPELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   86 QDADLLVFVIPHQFIHKICDEITGRVPKKAVGITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCE 165
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  166 TTIGSKVLQN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFA 241
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  242 KIFCKGQVSTATFlESCGVADLITTCYGGRNRKVAEAFARTGKTIEELEKELLNGQKLQGPQTSAEVYRILKQKGLLDKF 321
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 300798457  322 PLFTAVYQICYEGRPVTQMLSCL 344
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 3-336 3.99e-162

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 457.56  E-value: 3.99e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   3 AAPLKVCIVGSGNWGSAVAKIIGSNVKNLQKFSSTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLG 82
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  83 EAVQDADLLVFVIPHQFIHKICDEI--TGRVPKKAVGITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAA 160
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIkeNNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 161 EKFCETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAF 240
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 241 AKIFCKgQVSTATFLESCGVADLITTCYGGRNRKVAEAFARTG--KTIEELEKELLNGQKLQGPQTSAEVYRILKQKGLL 318
Cdd:PTZ00345 249 GKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330
                 ....*....|....*...
gi 300798457 319 DKFPLFTAVYQICYEGRP 336
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGAD 345
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 7-348 4.50e-89

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 270.37  E-value: 4.50e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   7 KVCIVGSGNWGSAVAKIIGSNVKNlqkfsstVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENVVAVPNLGEAVQ 86
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARNGHE-------VTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEALA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  87 DADLLVFVIPHQFIHKICDEITGRVPKKAVGITLIKGIDegPDGLKLISDIIREKMGID--ISVLMGANIASEVAAEKFC 164
Cdd:COG0240   70 GADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPGAlrIAVLSGPSFAEEVARGLPT 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 165 ETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFAKIF 244
Cdd:COG0240  148 AVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVAL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 245 ckgQVSTATFLESCGVADLITTCYG--GRNRKVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVYRILKQKGLldKFP 322
Cdd:COG0240  228 ---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGV--EMP 299

                        330       340
                 ....*....|....*....|....*.
gi 300798457 323 LFTAVYQICYEGRPVTQMLSCLQSHP 348
Cdd:COG0240  300 ITEAVYAVLYEGKSPREAVEALMARP 325
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 195-341 2.95e-62

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 195.30  E-value: 2.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  195 DADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFAKIFCKgqvSTATFLESCGVADLITTCYGG--RN 272
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300798457  273 RKVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVYRILKQKGLldKFPLFTAVYQICYEGRPVTQML 341
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-344 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 512.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457    7 KVCIVGSGNWGSAVAKIIGSN-VKNLQKFSSTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLGEAV 85
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENaRALPELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   86 QDADLLVFVIPHQFIHKICDEITGRVPKKAVGITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCE 165
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  166 TTIGSKVLQN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFA 241
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  242 KIFCKGQVSTATFlESCGVADLITTCYGGRNRKVAEAFARTGKTIEELEKELLNGQKLQGPQTSAEVYRILKQKGLLDKF 321
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 300798457  322 PLFTAVYQICYEGRPVTQMLSCL 344
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 3-336 3.99e-162

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 457.56  E-value: 3.99e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   3 AAPLKVCIVGSGNWGSAVAKIIGSNVKNLQKFSSTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLG 82
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  83 EAVQDADLLVFVIPHQFIHKICDEI--TGRVPKKAVGITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAA 160
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIkeNNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 161 EKFCETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAF 240
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 241 AKIFCKgQVSTATFLESCGVADLITTCYGGRNRKVAEAFARTG--KTIEELEKELLNGQKLQGPQTSAEVYRILKQKGLL 318
Cdd:PTZ00345 249 GKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330
                 ....*....|....*...
gi 300798457 319 DKFPLFTAVYQICYEGRP 336
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGAD 345
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 7-348 4.50e-89

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 270.37  E-value: 4.50e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   7 KVCIVGSGNWGSAVAKIIGSNVKNlqkfsstVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENVVAVPNLGEAVQ 86
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARNGHE-------VTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEALA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  87 DADLLVFVIPHQFIHKICDEITGRVPKKAVGITLIKGIDegPDGLKLISDIIREKMGID--ISVLMGANIASEVAAEKFC 164
Cdd:COG0240   70 GADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPGAlrIAVLSGPSFAEEVARGLPT 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 165 ETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFAKIF 244
Cdd:COG0240  148 AVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVAL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 245 ckgQVSTATFLESCGVADLITTCYG--GRNRKVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVYRILKQKGLldKFP 322
Cdd:COG0240  228 ---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGV--EMP 299

                        330       340
                 ....*....|....*....|....*.
gi 300798457 323 LFTAVYQICYEGRPVTQMLSCLQSHP 348
Cdd:COG0240  300 ITEAVYAVLYEGKSPREAVEALMARP 325
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
7-344 7.01e-79

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 244.21  E-value: 7.01e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   7 KVCIVGSGNWGSAVAKIIGSNVKNlqkfsstVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENVVAVPNLGEAVQ 86
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGHD-------VTLWARDPEQ-----AAEINADRENPRYLPGIKLPDNLRATTDLAEALA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  87 DADLLVFVIPHQFIHKICDEITGRVPKKAVGITLIKGIDEGPdgLKLISDIIREKMG--IDISVLMGANIASEVAAEKFC 164
Cdd:PRK00094  71 DADLILVAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGT--GKLLSEVLEEELPdlAPIAVLSGPSFAKEVARGLPT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 165 ETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFAKIF 244
Cdd:PRK00094 149 AVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVAL 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 245 -CKgqvsTATFLESCGVADLITTCYG--GRNRKVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVYRILKQKGLldKF 321
Cdd:PRK00094 229 gAN----PETFLGLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEALAEI--GMVAEGVRTAKAVYELAKKLGV--EM 299

                        330       340
                 ....*....|....*....|...
gi 300798457 322 PLFTAVYQICYEGRPVTQMLSCL 344
Cdd:PRK00094 300 PITEAVYAVLYEGKDPREAVEDL 322
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 195-341 2.95e-62

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 195.30  E-value: 2.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  195 DADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFAKIFCKgqvSTATFLESCGVADLITTCYGG--RN 272
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300798457  273 RKVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVYRILKQKGLldKFPLFTAVYQICYEGRPVTQML 341
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 7-171 5.91e-59

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 187.40  E-value: 5.91e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457    7 KVCIVGSGNWGSAVAKIIGSNvknlqkfSSTVKMWVFEEtvngrKLTDIINNDHENVKYLPGHKLPENVVAVPNLGEAVQ 86
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADN-------GHEVRLWGRDE-----ELIEEINTTHENVRYLPGIKLPENLKATTDLAEALK 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   87 DADLLVFVIPHQFIHKICDEITGRVPKKAVGITLIKGIDEGpdGLKLISDIIREKMGI--DISVLMGANIASEVAAEKFC 164
Cdd:pfam01210  69 GADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146


                  ....*..
gi 300798457  165 ETTIGSK 171
Cdd:pfam01210 147 ATVIASK 153
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-317 4.61e-44

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 154.56  E-value: 4.61e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   1 MAAA--PLKVCIVGSGNWGSAVAKIIGSNVKNLQkfsstvkmWV-FEETVNGrkltdiINNDHENVKYLP-GHKLPENVV 76
Cdd:PRK12439   1 MAAAkrEPKVVVLGGGSWGTTVASICARRGPTLQ--------WVrSAETADD------INDNHRNSRYLGnDVVLSDTLR 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  77 AVPNLGEAVQDADLLVFVIP-HQF---IHKICDEITGRVPKkavgITLIKGIDEGPDglKLISDIIREKM-GIDISVLMG 151
Cdd:PRK12439  67 ATTDFAEAANCADVVVMGVPsHGFrgvLTELAKELRPWVPV----VSLVKGLEQGTN--MRMSQIIEEVLpGHPAGILAG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 152 ANIASEVAAEKFCETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIR 231
Cdd:PRK12439 141 PNIAREVAEGYAAAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIA 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 232 LGLMEMiafAKIFCKGQVSTATFLESCGVADLITTCYG--GRNRKVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVY 309
Cdd:PRK12439 221 RALREM---TKLGVAMGGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGA-GKPIDEIIASM--NQVAEGVKAASVVM 294


                 ....*...
gi 300798457 310 RILKQKGL 317
Cdd:PRK12439 295 EFADEYGL 302
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 8-334 1.08e-36

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 135.00  E-value: 1.08e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   8 VCIVGSGNWGSAVAKIIGSNvknlqkfSSTVKMWVFEETVNGRkltdiINNDHENVKYLPGHKLPENVVAVPNLGEAVQD 87
Cdd:PRK14618   7 VAVLGAGAWGTALAVLAASK-------GVPVRLWARRPEFAAA-----LAAERENREYLPGVALPAELYPTADPEEALAG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  88 ADLLVFVIPHqfihKICDEITGRVPKKAVGITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCETT 167
Cdd:PRK14618  75 ADFAVVAVPS----KALRETLAGLPRALGYVSCAKGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARFLPAATV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 168 IGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFAKIFCKG 247
Cdd:PRK14618 151 VASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGAE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 248 QvstATFLESCGVADLITTCYG--GRNRKVAEAFARtgktieelekellnGQKLQGPQTSAEVYRILKQKGLLDKF---- 321
Cdd:PRK14618 231 E---ATFYGLSGLGDLIATATSphSRNRAAGEAIVR--------------GVDREHLEAGGKVVEGLYTVKALDAWakah 293

                        330
                 ....*....|....*..
gi 300798457 322 ----PLFTAVYQICYEG 334
Cdd:PRK14618 294 ghdlPIVEAVARVARGG 310
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 6-346 4.36e-31

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 119.94  E-value: 4.36e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   6 LKVCIVGSGNWGSAVAKIIGSNvknlqkfSSTVKMWvfeetvnGRKLTDI--INNDHENVKYLPGHKLPENVVAVPNLGE 83
Cdd:PRK14620   1 MKISILGAGSFGTAIAIALSSK-------KISVNLW-------GRNHTTFesINTKRKNLKYLPTCHLPDNISVKSAIDE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  84 AVQD-ADLLVFVIPHQFIHKICDEITGRVPKKAVGITLI-KGIDEgpDGLKLISDIIREKMGID-ISVLMGANIASEVAA 160
Cdd:PRK14620  67 VLSDnATCIILAVPTQQLRTICQQLQDCHLKKNTPILICsKGIEK--SSLKFPSEIVNEILPNNpIAILSGPSFAKEIAE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 161 EKFCETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAF 240
Cdd:PRK14620 145 KLPCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 241 --AKifcKGQVSTATFLESCGVADLITTCYGGRNRKVAEAFArTGKTiEELEKELLNGQKL-QGPQTSAEVYRILKQkgL 317
Cdd:PRK14620 225 ysAK---NGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGFK-IGNG-FNINQILSEGKSViEGFSTVKPLISLAKK--L 297

                        330       340
                 ....*....|....*....|....*....
gi 300798457 318 LDKFPLFTAVYQICYEGRPVTQMLSCLQS 346
Cdd:PRK14620 298 NIELPICESIYNLLYENISLEKTISVILS 326
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-313 8.54e-27

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 107.77  E-value: 8.54e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457   5 PLKVCIVGSGNWGSAVAKIIGSNvknlqkfSSTVKMWvfeetvnGRKLTdiinndhenvkylpghklpenvvavPNLGEA 84
Cdd:PRK14619   4 PKTIAILGAGAWGSTLAGLASAN-------GHRVRVW-------SRRSG-------------------------LSLAAV 44

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457  85 VQDADLLVFVIPHQFIHKICDEITG-RVPKKAVGITLIKGIDegPDGLKLISDIIREKMGI-DISVLMGANIASEVAAEK 162
Cdd:PRK14619  45 LADADVIVSAVSMKGVRPVAEQVQAlNLPPETIIVTATKGLD--PETTRTPSQIWQAAFPNhPVVVLSGPNLSKEIQQGL 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 163 FCETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLCCGDNTKAAVIRLGLMEMIAFAK 242
Cdd:PRK14619 123 PAATVVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRVGT 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300798457 243 IFcKGQvsTATFLESCGVADLITTCYG--GRNRKVAEAFARtGKTIEE-LEK---------------ELLNGQKLQGPQT 304
Cdd:PRK14619 203 HL-GAQ--TETFYGLSGLGDLLATCTSplSRNYQVGYGLAQ-GKSLEQiLAElegtaegvntanvlvQLAQQQNIAVPIT 278


                 ....*....
gi 300798457 305 sAEVYRILK 313
Cdd:PRK14619 279 -EQVYRLLQ 286
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 258-327 2.74e-06

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 44.41  E-value: 2.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300798457  258 CGVADLITTCYGG--RNRKVAEAFARtGKTIEELEkellNGQKLQGPQTSAEVYRILKQKGLLDkFPLFTAV 327
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMTLAEAG----NGQVAEGVRTAKAVAAILARAHNVE-MPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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