|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
94-516 |
2.10e-66 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 219.64 E-value: 2.10e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 94 LSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSlFGQKEVRKdps 173
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAA-LGSEKRSK--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 174 qeseentakttlgrqrfhwicrltPGRRMNIVGtsGRASSSPSPTQPVlGAQPHsraqPLTSSCLASSRG-------WLW 246
Cdd:COG0471 77 ------------------------FGSALLLPI--AFAASIGGMGTLI-GTPPN----LIAAGLLEEATGipisffeWML 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 247 ISFLYGGLS-----FRGWRKNKSEIRTNAEdrARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPgwaslf 321
Cdd:COG0471 126 VGLPVALVGllllwLVLYRLLPPEIKEVPG--SKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP------ 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 322 npgflsDAVTGVAIVTILFFFPsqrpslkwwfdfkapntetepLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVW 401
Cdd:COG0471 198 ------IAVVALLGAVLLLLTG---------------------VLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAW 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 402 IGGQL-HPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPN 480
Cdd:COG0471 251 LADALlPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPN 330
|
410 420 430
....*....|....*....|....*....|....*.
gi 301069346 481 SIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTW 516
Cdd:COG0471 331 AIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
42-508 |
5.24e-59 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 200.50 E-value: 5.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 42 LFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVG 121
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 122 VQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAIlkslfgqkevrkdpsqeseentakttlgrqrfhwicrltpgrr 201
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGL------------------------------------------- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 202 mnivgtsgrASSSPSPTQPVLGAQPHSRAQPLTSSCLASSRGWLWISFLygglsfrgwrknkseirtnaedraravireE 281
Cdd:cd01115 118 ---------AAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYL------------------------------E 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 282 YQNLGPIKFAEQAVFILFCMFAILLF----TRDPKFIPGW----ASLFNPGFLSDAVTGVAIVTILFFFPsqrpslkwwf 353
Cdd:cd01115 159 SLGGQGFSFFEFTPIGLPLLIIGLLYlwfiFRLAVLIITIvllaALAAITGLLPVSVAIAIGAIVLVFGG---------- 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 354 dfkapntetepLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHP-LENVPPALAVLLITVVIAFFTEFA 432
Cdd:cd01115 229 -----------VLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNFI 297
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 301069346 433 SNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLL 508
Cdd:cd01115 298 SNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVV 373
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
9-516 |
4.35e-52 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 184.50 E-value: 4.35e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 9 KKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQ---- 84
Cdd:pfam00939 1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKALSWalsg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 85 YFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQParLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLfg 164
Cdd:pfam00939 81 FSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSL-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 165 qkevrkDPSQESE-ENTAKTTLGRQRFHWICRLTP-GRRMNIVGTSGRASSSpSPTQPVLG-----AQPHSRAQPLTSSC 237
Cdd:pfam00939 157 ------PPAFGSDpEKGSERRIGAYLMWTVYQSTSiTSAMFLTAMAPNLLLL-GLMNSILGvtitwASWFLAAIPPGVIL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 238 LASSrgWLWISFLYGGLSFRGwrknkseirtnaeDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIpgw 317
Cdd:pfam00939 230 LLLA--PLLLYVLYPPEIKSV-------------PDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLNI--- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 318 aslfnpgflSDAVTGVAIVTILFFFPsqrpslkwwfdfkapntetepLLTWKKA-QETVPWNIILLLGGGFAMAKGCEES 396
Cdd:pfam00939 292 ---------DATTVAIIGLALMLLLR---------------------ILDWKDIvKNKGAWNTLIWLGGLIMLANGLERS 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 397 GLSVWIGGQLHPL--ENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHP-LYLMIPGTVGCSFA-FM 472
Cdd:pfam00939 342 GFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPGAPpLLAALLLGFAISLGgFL 421
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 301069346 473 LPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTW 516
Cdd:pfam00939 422 TPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWW 465
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
29-517 |
1.71e-40 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 152.11 E-value: 1.71e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 29 PVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPI-VLFPFMGIL--PSNKVCPQYFLD-TNFLFLSGLIMASAIE 104
Cdd:TIGR00785 1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLAIpIIAVLLGVLsaFKFKNALSGFADpTIWLFFGAFILATALV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 105 EWNLHRRIALKILMLVGVQPARL-ILGMMVTTSFLSMWLSNTA-STAMMLPIANAILKSLfgqkevrkdpsQESEENTAK 182
Cdd:TIGR00785 81 KTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL-----------GSKPEKSPR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 183 TTlgrqrFHWIcrltpgrrMNIVGTSGRASSSPSPTqpvlGAQPHSRAQPLTSSCLASSRGWL-WisFLYG--------- 252
Cdd:TIGR00785 150 KI-----GKYL--------MLGIAYSASIGSSGFLT----GSAPNALAAGILSKILGIQISWGdW--FLAGlplgiilll 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 253 ---GLSFRGWrknKSEIRTNaeDRARAVIREEYQNLGPIKFAEQAVFILFcMFAILLFtrdpkfipgwasLFNPGFLSDA 329
Cdd:TIGR00785 211 lvpLLLYVLF---PPELKLK--DEVDLWAKEELEEMGPMSFREKALLGIF-LLALLLW------------IFGGSLGINA 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 330 VTGVAIVTILFFFPSqrpslkwwfdfkapntetepLLTWKKAQE-TVPWNIILLLGGGFAMAKGCEESGLSVWIGGQL-H 407
Cdd:TIGR00785 273 SVVALLAVVLMLFLG--------------------IVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLvG 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 408 PLENVPPALAVLLITVVIAFF-TEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFA-FMLPVSTPPNSIAFA 485
Cdd:TIGR00785 333 ILDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYG 412
|
490 500 510
....*....|....*....|....*....|..
gi 301069346 486 SGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWA 517
Cdd:TIGR00785 413 SGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
11-162 |
3.12e-05 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 46.15 E-value: 3.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 11 VWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTN 90
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTL 257
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 301069346 91 FLFLSGLIMASAIEEWNLHRRIALkiLMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSL 162
Cdd:pfam03600 258 LFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAA 327
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
17-162 |
5.43e-05 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 45.65 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 17 LLVLLFTPLALLPVVFalppkegrclfvILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSG 96
Cdd:cd01115 183 LYLWFIFRLAVLIITI------------VLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGG 250
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 301069346 97 LIMASAIEEWNLHRRIALKILMLVGVQPARLILGMM-VTTSFLSMWLSNTASTAMMLPIANAILKSL 162
Cdd:cd01115 251 IPLGKALESSGAAALIAEALISLLGGLPPFAILLLLcLLTLVLTNFISNTATAVLLAPIALSIALSL 317
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
94-516 |
2.10e-66 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 219.64 E-value: 2.10e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 94 LSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSlFGQKEVRKdps 173
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAA-LGSEKRSK--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 174 qeseentakttlgrqrfhwicrltPGRRMNIVGtsGRASSSPSPTQPVlGAQPHsraqPLTSSCLASSRG-------WLW 246
Cdd:COG0471 77 ------------------------FGSALLLPI--AFAASIGGMGTLI-GTPPN----LIAAGLLEEATGipisffeWML 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 247 ISFLYGGLS-----FRGWRKNKSEIRTNAEdrARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPgwaslf 321
Cdd:COG0471 126 VGLPVALVGllllwLVLYRLLPPEIKEVPG--SKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP------ 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 322 npgflsDAVTGVAIVTILFFFPsqrpslkwwfdfkapntetepLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVW 401
Cdd:COG0471 198 ------IAVVALLGAVLLLLTG---------------------VLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAW 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 402 IGGQL-HPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPN 480
Cdd:COG0471 251 LADALlPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPN 330
|
410 420 430
....*....|....*....|....*....|....*.
gi 301069346 481 SIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTW 516
Cdd:COG0471 331 AIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
42-508 |
5.24e-59 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 200.50 E-value: 5.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 42 LFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVG 121
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 122 VQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAIlkslfgqkevrkdpsqeseentakttlgrqrfhwicrltpgrr 201
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGL------------------------------------------- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 202 mnivgtsgrASSSPSPTQPVLGAQPHSRAQPLTSSCLASSRGWLWISFLygglsfrgwrknkseirtnaedraravireE 281
Cdd:cd01115 118 ---------AAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYL------------------------------E 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 282 YQNLGPIKFAEQAVFILFCMFAILLF----TRDPKFIPGW----ASLFNPGFLSDAVTGVAIVTILFFFPsqrpslkwwf 353
Cdd:cd01115 159 SLGGQGFSFFEFTPIGLPLLIIGLLYlwfiFRLAVLIITIvllaALAAITGLLPVSVAIAIGAIVLVFGG---------- 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 354 dfkapntetepLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHP-LENVPPALAVLLITVVIAFFTEFA 432
Cdd:cd01115 229 -----------VLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNFI 297
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 301069346 433 SNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLL 508
Cdd:cd01115 298 SNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVV 373
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
9-516 |
4.35e-52 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 184.50 E-value: 4.35e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 9 KKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQ---- 84
Cdd:pfam00939 1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLAKALSWalsg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 85 YFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQParLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLfg 164
Cdd:pfam00939 81 FSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSL-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 165 qkevrkDPSQESE-ENTAKTTLGRQRFHWICRLTP-GRRMNIVGTSGRASSSpSPTQPVLG-----AQPHSRAQPLTSSC 237
Cdd:pfam00939 157 ------PPAFGSDpEKGSERRIGAYLMWTVYQSTSiTSAMFLTAMAPNLLLL-GLMNSILGvtitwASWFLAAIPPGVIL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 238 LASSrgWLWISFLYGGLSFRGwrknkseirtnaeDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIpgw 317
Cdd:pfam00939 230 LLLA--PLLLYVLYPPEIKSV-------------PDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLNI--- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 318 aslfnpgflSDAVTGVAIVTILFFFPsqrpslkwwfdfkapntetepLLTWKKA-QETVPWNIILLLGGGFAMAKGCEES 396
Cdd:pfam00939 292 ---------DATTVAIIGLALMLLLR---------------------ILDWKDIvKNKGAWNTLIWLGGLIMLANGLERS 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 397 GLSVWIGGQLHPL--ENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHP-LYLMIPGTVGCSFA-FM 472
Cdd:pfam00939 342 GFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPGAPpLLAALLLGFAISLGgFL 421
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 301069346 473 LPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTW 516
Cdd:pfam00939 422 TPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWW 465
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
29-517 |
1.71e-40 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 152.11 E-value: 1.71e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 29 PVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPI-VLFPFMGIL--PSNKVCPQYFLD-TNFLFLSGLIMASAIE 104
Cdd:TIGR00785 1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLAIpIIAVLLGVLsaFKFKNALSGFADpTIWLFFGAFILATALV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 105 EWNLHRRIALKILMLVGVQPARL-ILGMMVTTSFLSMWLSNTA-STAMMLPIANAILKSLfgqkevrkdpsQESEENTAK 182
Cdd:TIGR00785 81 KTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL-----------GSKPEKSPR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 183 TTlgrqrFHWIcrltpgrrMNIVGTSGRASSSPSPTqpvlGAQPHSRAQPLTSSCLASSRGWL-WisFLYG--------- 252
Cdd:TIGR00785 150 KI-----GKYL--------MLGIAYSASIGSSGFLT----GSAPNALAAGILSKILGIQISWGdW--FLAGlplgiilll 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 253 ---GLSFRGWrknKSEIRTNaeDRARAVIREEYQNLGPIKFAEQAVFILFcMFAILLFtrdpkfipgwasLFNPGFLSDA 329
Cdd:TIGR00785 211 lvpLLLYVLF---PPELKLK--DEVDLWAKEELEEMGPMSFREKALLGIF-LLALLLW------------IFGGSLGINA 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 330 VTGVAIVTILFFFPSqrpslkwwfdfkapntetepLLTWKKAQE-TVPWNIILLLGGGFAMAKGCEESGLSVWIGGQL-H 407
Cdd:TIGR00785 273 SVVALLAVVLMLFLG--------------------IVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLvG 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 408 PLENVPPALAVLLITVVIAFF-TEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFA-FMLPVSTPPNSIAFA 485
Cdd:TIGR00785 333 ILDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYG 412
|
490 500 510
....*....|....*....|....*....|..
gi 301069346 486 SGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWA 517
Cdd:TIGR00785 413 SGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
49-513 |
5.20e-31 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 124.67 E-value: 5.20e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 49 AVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKIlMLVGVQPARLI 128
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKL-ARASKGSRRLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 129 LGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLfgqkevrkdpsqeseentakttlgrqrfhwicRLTPGRRMNI-VGT 207
Cdd:cd00625 80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKL--------------------------------GLSPPVPLLLaLAF 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 208 SGRASSSPS----PTQPVLGAQPHSRAQPLTSSCLASSRGWLWISFLYGGLSFRGWRKnkseirTNAEDRARAVIREEYQ 283
Cdd:cd00625 128 AANIGGAATpignPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLL------LPDEDKLTVLAEPLPA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 284 NLGPIKFAEQAVFILFCMFAILLFTRDPKFIpgwaslfnpgflsdAVTGVAIVTILFFFpsqrpslkwwfdfkapntete 363
Cdd:cd00625 202 RPLLKKFLLLALLLLLLFVLLFFFLIPLGLI--------------ALLGALLLLLLLVR--------------------- 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 364 pLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLP 443
Cdd:cd00625 247 -GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLP 325
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 301069346 444 VLAEL-----AIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAfasgHLLVKDMVRTGLLMNLMgVLLLSLAM 513
Cdd:cd00625 326 IAASLappepAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPLTLL-SLVVSLLY 395
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
49-449 |
2.16e-22 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 98.54 E-value: 2.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 49 AVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLI 128
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 129 LGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLfgqkevrkdpsqeseentakttlgrqrfhwicRLTPGRRMNIVGTS 208
Cdd:pfam03600 81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRL--------------------------------GLPPSPLLIALAFA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 209 GRASSSPSPT-QPVLGAqphsraqpltsscLASSRGWLWISFLYGGLSFRGwrknkseirtnaedraravireeyqnlgp 287
Cdd:pfam03600 129 ANIGGTATPIgDPPNII-------------IASALGLSFGDFGFFMFPPVG----------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 288 IKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIV---TILFFFPSQRPSLKWwfdfkAPNTETEP 364
Cdd:pfam03600 167 VALLLVGLLPLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVlalVILGFLLLSVLALAG-----ALLLLLTG 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 365 LLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLenVPPALAVLLITVVIAFFTEFASNTATIIIFLPV 444
Cdd:pfam03600 242 VLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL--SGLLVALALILWLSALLSAFISNVPTAALMAPI 319
|
....*
gi 301069346 445 LAELA 449
Cdd:pfam03600 320 IVGMA 324
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
364-513 |
2.50e-10 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 61.94 E-value: 2.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 364 PLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLP 443
Cdd:pfam03600 26 GVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIP 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 301069346 444 VLAELAIRLRVHPLYLMIPGTVGCSFAFML-PVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAM 513
Cdd:pfam03600 106 IVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
28-162 |
3.23e-08 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 55.55 E-value: 3.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 28 LPVVFALPPKEGRCLFVILLMAVYWCTEA---LPLSVTALLPIVLFPFMGILPSNKVcpQYFLDTNFLFL--SGLIMASA 102
Cdd:COG0471 164 LAELGPLSRREKIALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDA--YKSIPWGVLLLfgGGLALGAA 241
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 301069346 103 IEEWNLHRRIALKIL-MLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSL 162
Cdd:COG0471 242 LEKTGLAAWLADALLpLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
365-489 |
3.56e-08 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 55.90 E-value: 3.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 365 LLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPV 444
Cdd:COG1055 41 VVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPV 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 301069346 445 LAELAIRLRVHPLYLMIpgtvGCSFA-----FMLPVSTPPNSIAFASGHL 489
Cdd:COG1055 121 VLAIARRLGLNPVPFLI----AIVFAaniggAATPIGNPTNIMIASAGGL 166
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
11-162 |
3.12e-05 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 46.15 E-value: 3.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 11 VWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTN 90
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTL 257
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 301069346 91 FLFLSGLIMASAIEEWNLHRRIALkiLMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSL 162
Cdd:pfam03600 258 LFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAA 327
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
42-162 |
4.44e-05 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 45.89 E-value: 4.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 42 LFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVG 121
Cdd:COG1055 8 IFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAK 87
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 301069346 122 VQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSL 162
Cdd:COG1055 88 GSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRL 128
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
17-162 |
5.43e-05 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 45.65 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 17 LLVLLFTPLALLPVVFalppkegrclfvILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSG 96
Cdd:cd01115 183 LYLWFIFRLAVLIITI------------VLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGG 250
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 301069346 97 LIMASAIEEWNLHRRIALKILMLVGVQPARLILGMM-VTTSFLSMWLSNTASTAMMLPIANAILKSL 162
Cdd:cd01115 251 IPLGKALESSGAAALIAEALISLLGGLPPFAILLLLcLLTLVLTNFISNTATAVLLAPIALSIALSL 317
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
375-461 |
5.10e-04 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 42.42 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 375 VPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRV 454
Cdd:COG1055 268 VDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNP 347
|
....*..
gi 301069346 455 HPLYLMI 461
Cdd:COG1055 348 EPLWLAL 354
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
375-470 |
6.27e-04 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 42.24 E-value: 6.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 375 VPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRV 454
Cdd:cd01116 268 VEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGI 347
|
90
....*....|....*.
gi 301069346 455 HPLYLMIPGTVGCSFA 470
Cdd:cd01116 348 PLLPLWWALALGACLG 363
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
377-489 |
2.38e-03 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 40.33 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 377 WNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHP 456
Cdd:cd01118 52 WDVTLTLIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKK 131
|
90 100 110
....*....|....*....|....*....|....*..
gi 301069346 457 L----YLMIPGTVGCSFAFMLPVSTPPNSIAFASGHL 489
Cdd:cd01118 132 NrtlpFLYACAFIADAASLPLPISNLVNIVTAGYFGI 168
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
24-155 |
4.39e-03 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 39.54 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069346 24 PLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYF-LDTNFLFLSGLIMASA 102
Cdd:cd00625 195 LAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVdWGTLLFFAGLFVLVGA 274
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 301069346 103 IEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIA 155
Cdd:cd00625 275 LESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIA 327
|
|
| |
