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Conserved domains on  [gi|301601644|ref|NP_001180422|]
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neutral amino acid transporter A isoform 2 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10003465)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
2-173 7.24e-55

Na+/H+-dicarboxylate symporter [Energy production and conversion];


:

Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 180.69  E-value: 7.24e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   2 NILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMC---------------------------------- 47
Cdd:COG1301  140 NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIVGWVMKlapigvfaliaatvakygldalgslgklvltvyl 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  48 ------------------------------------------SATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAA 85
Cdd:COG1301  220 alllhlfvvlplilrlltglsplkflrairpalllafstsssEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTA 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  86 IFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVN 165
Cdd:COG1301  300 IYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVN 379


                 ....*...
gi 301601644 166 VEGDALGA 173
Cdd:COG1301  380 VTGDAVAT 387
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
2-173 7.24e-55

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 180.69  E-value: 7.24e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   2 NILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMC---------------------------------- 47
Cdd:COG1301  140 NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIVGWVMKlapigvfaliaatvakygldalgslgklvltvyl 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  48 ------------------------------------------SATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAA 85
Cdd:COG1301  220 alllhlfvvlplilrlltglsplkflrairpalllafstsssEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTA 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  86 IFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVN 165
Cdd:COG1301  300 IYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVN 379


                 ....*...
gi 301601644 166 VEGDALGA 173
Cdd:COG1301  380 VTGDAVAT 387
SDF pfam00375
Sodium:dicarboxylate symporter family;
2-179 4.62e-51

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 170.39  E-value: 4.62e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644    2 NILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIM----------------------------------- 46
Cdd:pfam00375 135 NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWVMklapigvfaliantvgtyglgilsslakfllvvyl 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   47 ---------------------------------------CS--ATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAA 85
Cdd:pfam00375 215 glaihllivypllikflgkvnpfkflkkmlpalltafstASsaATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTA 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   86 IFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVN 165
Cdd:pfam00375 295 IYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVN 374

                         250
                  ....*....|....
gi 301601644  166 VEGDALGAGILHHL 179
Cdd:pfam00375 375 VTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 6-195 3.85e-19

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 85.20  E-value: 3.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   6 LVLFAL-VLGVALKKLGSEGEDLIRFfnsLNEATMVLVSWIMCSATLPSMMKCIEENnGVDKRISRFILPIGATVNMDGA 84
Cdd:PRK11283 241 ILFFALvVLGIVARLCGLSIWILIRI---LKDELILAYSTASSETVLPRIIEKMEAY-GAPKSITSFVVPTGYSFNLDGS 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  85 AIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVV 164
Cdd:PRK11283 317 TLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTAL 396

                        170       180       190
                 ....*....|....*....|....*....|..
gi 301601644 165 NVEGDALGAGILHHL-NQKATKKGEQELAEVK 195
Cdd:PRK11283 397 NVVGNALAVLVIAKWeHKFDRKKALAYEREVL 428
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
2-173 7.24e-55

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 180.69  E-value: 7.24e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   2 NILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMC---------------------------------- 47
Cdd:COG1301  140 NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIVGWVMKlapigvfaliaatvakygldalgslgklvltvyl 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  48 ------------------------------------------SATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAA 85
Cdd:COG1301  220 alllhlfvvlplilrlltglsplkflrairpalllafstsssEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTA 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  86 IFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVN 165
Cdd:COG1301  300 IYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVN 379


                 ....*...
gi 301601644 166 VEGDALGA 173
Cdd:COG1301  380 VTGDAVAT 387
SDF pfam00375
Sodium:dicarboxylate symporter family;
2-179 4.62e-51

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 170.39  E-value: 4.62e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644    2 NILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIM----------------------------------- 46
Cdd:pfam00375 135 NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWVMklapigvfaliantvgtyglgilsslakfllvvyl 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   47 ---------------------------------------CS--ATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAA 85
Cdd:pfam00375 215 glaihllivypllikflgkvnpfkflkkmlpalltafstASsaATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTA 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   86 IFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVN 165
Cdd:pfam00375 295 IYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVN 374

                         250
                  ....*....|....
gi 301601644  166 VEGDALGAGILHHL 179
Cdd:pfam00375 375 VTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 6-195 3.85e-19

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 85.20  E-value: 3.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   6 LVLFAL-VLGVALKKLGSEGEDLIRFfnsLNEATMVLVSWIMCSATLPSMMKCIEENnGVDKRISRFILPIGATVNMDGA 84
Cdd:PRK11283 241 ILFFALvVLGIVARLCGLSIWILIRI---LKDELILAYSTASSETVLPRIIEKMEAY-GAPKSITSFVVPTGYSFNLDGS 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  85 AIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVV 164
Cdd:PRK11283 317 TLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTAL 396

                        170       180       190
                 ....*....|....*....|....*....|..
gi 301601644 165 NVEGDALGAGILHHL-NQKATKKGEQELAEVK 195
Cdd:PRK11283 397 NVVGNALAVLVIAKWeHKFDRKKALAYEREVL 428
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 6-170 7.79e-19

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 84.34  E-value: 7.79e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644   6 LVLFALVLGVALKKLGSEGEDLIRFfnsLNEATMVLVSWIMCSATLPSMMKCIEeNNGVDKRISRFILPIGATVNMDGAA 85
Cdd:PRK13027 231 FVFVVVVLGAVMRLAGFSVFKLIRY---LREELLIVLGTASSDAVLPQVMRKLE-HMGIKDSTVGLVIPTGYSFNLDGFS 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  86 IFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIG-LPTHDLPLILAVDWIVDRTTTVV 164
Cdd:PRK13027 307 IYLTLAAVFIAQATNTPLSMHDLITILLVSLVTSKGAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALT 386


                 ....*.
gi 301601644 165 NVEGDA 170
Cdd:PRK13027 387 NLIGNC 392
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 49-170 6.32e-18

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 81.87  E-value: 6.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  49 ATLPSMMKCIEeNNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAG 128
Cdd:PRK01663 271 SALPRMMEKME-KLGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPLSIGHQITLLAVLLLTSKGAAGVTGS 349

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 301601644 129 GVLTIAIILEAIG-LPTHDLPLILAVDWIVDRTTTVVNVEGDA 170
Cdd:PRK01663 350 GFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIGNG 392
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 73-171 5.58e-03

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 37.34  E-value: 5.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601644  73 LPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILA 152
Cdd:PRK14695 204 IPLGSTINMAGVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVG 283

                         90       100
                 ....*....|....*....|...
gi 301601644 153 VDWIV----DRTTTVVNVEGDAL 171
Cdd:PRK14695 284 VGFVIgviqDSCETALNSSTDVL 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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