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Conserved domains on  [gi|307775422|ref|NP_001182732|]
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low-density lipoprotein receptor isoform 6 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
402-442 1.15e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 425445  Cd Length: 41  Bit Score: 65.27  E-value: 1.15e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775422  402 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 442
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLLTEDLQHPNGIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 1.08e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.57  E-value: 1.08e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 307775422   25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
108-143 1.43e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.18  E-value: 1.43e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 307775422  108 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 143
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 8.33e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 8.33e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 307775422   66 VTCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
426-468 1.36e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.36e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 307775422   426 YSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNR 468
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
360-398 2.30e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 425445  Cd Length: 41  Bit Score: 56.02  E-value: 2.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 307775422  360 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVD 398
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLLTEDLQHPNGIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
489-528 3.53e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 425445  Cd Length: 41  Bit Score: 52.56  E-value: 3.53e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775422  489 DKVFWTDIINEAIFSANRLTGSDV-NLLAENLLSPEDMVLF 528
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLLTEDLQHPNGIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
312-355 4.42e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 425445  Cd Length: 41  Bit Score: 52.17  E-value: 4.42e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 307775422  312 NRIYWSDLSQRMicSTQLDRAHGvSSYDTVISRDIQAPDGLAVD 355
Cdd:pfam00058   1 GRLYWTDSSLRA--SISSADLNG-SDRKTLLTEDLQHPNGIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-181 5.35e-08

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 5.35e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 307775422  151 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 181
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
227-261 5.75e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 5.75e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 307775422   227 DIDECQDPDTCSQ--LCVNLEGGYKCQCEEGFQLDPH 261
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
191-219 6.69e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 46.08  E-value: 6.69e-07
                          10        20
                  ....*....|....*....|....*....
gi 307775422  191 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 219
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYKL 29
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
292-330 5.54e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.27  E-value: 5.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 307775422   292 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 330
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
402-442 1.15e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 65.27  E-value: 1.15e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775422  402 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 442
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLLTEDLQHPNGIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 1.08e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.57  E-value: 1.08e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 307775422   25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
108-143 1.43e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.18  E-value: 1.43e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 307775422  108 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 143
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 8.33e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 8.33e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 307775422   66 VTCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
426-468 1.36e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.36e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 307775422   426 YSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNR 468
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
360-398 2.30e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 56.02  E-value: 2.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 307775422  360 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVD 398
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLLTEDLQHPNGIAVD 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
109-143 2.54e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 2.54e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775422 109 CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 143
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
108-140 1.54e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.54e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775422   108 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 140
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
27-58 1.68e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.68e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 307775422  27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
26-58 2.97e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 2.97e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775422    26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
68-104 3.01e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 3.01e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 307775422  68 CKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
489-528 3.53e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 52.56  E-value: 3.53e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775422  489 DKVFWTDIINEAIFSANRLTGSDV-NLLAENLLSPEDMVLF 528
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLLTEDLQHPNGIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
340-381 3.64e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 3.64e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 307775422   340 TVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKR 381
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
446-487 3.89e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 52.56  E-value: 3.89e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 307775422  446 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEkrLAHPFSLAVF 487
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLLTED--LQHPNGIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
312-355 4.42e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 52.17  E-value: 4.42e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 307775422  312 NRIYWSDLSQRMicSTQLDRAHGvSSYDTVISRDIQAPDGLAVD 355
Cdd:pfam00058   1 GRLYWTDSSLRA--SISSADLNG-SDRKTLLTEDLQHPNGIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
67-101 9.32e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 9.32e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 307775422    67 TCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDE 101
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-181 5.35e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 5.35e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 307775422  151 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 181
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
227-261 5.75e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 5.75e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 307775422   227 DIDECQDPDTCSQ--LCVNLEGGYKCQCEEGFQLDPH 261
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
191-219 6.69e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 46.08  E-value: 6.69e-07
                          10        20
                  ....*....|....*....|....*....
gi 307775422  191 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 219
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYKL 29
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
382-422 9.40e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 9.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 307775422   382 KTLFRENGSKPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 422
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
151-181 1.22e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.22e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 307775422 151 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 181
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
227-259 2.70e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 2.70e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775422 227 DIDECQDPDTCS--QLCVNLEGGYKCQCEEGFQLD 259
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
151-181 9.96e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 9.96e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 307775422   151 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 181
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
339-501 2.37e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 2.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775422 339 DTVISRDIQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 412
Cdd:cd14963   94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775422 413 akikkgglNGVDIYSLVTENIQWPNGITLDLLS------------GRLYWVDSKLHSISSIDVNGGNRKTIL---EDEKR 477
Cdd:cd14963  169 --------GRIQVFDKNGKFIKELNGSPDGKSGfvnprgiavdpdGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDGQ 240
                        170       180
                 ....*....|....*....|....*
gi 307775422 478 LAHPFSLAVFEDKVFW-TDIINEAI 501
Cdd:cd14963  241 FNLPNGLFIDDDGRLYvTDRENNRV 265
EGF_CA pfam07645
Calcium-binding EGF domain;
227-255 3.18e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 3.18e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 307775422  227 DIDECQDP-DTCSQ--LCVNLEGGYKCQCEEG 255
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
292-330 5.54e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.27  E-value: 5.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 307775422   292 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 330
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
402-442 1.15e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 65.27  E-value: 1.15e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775422  402 GFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 442
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLLTEDLQHPNGIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
25-58 1.08e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.57  E-value: 1.08e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 307775422   25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
108-143 1.43e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 59.18  E-value: 1.43e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 307775422  108 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 143
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
66-104 8.33e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 8.33e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 307775422   66 VTCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:pfam00057   1 STCSPNEFQCGSG--ECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
426-468 1.36e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.36e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 307775422   426 YSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNR 468
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
360-398 2.30e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 56.02  E-value: 2.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 307775422  360 NIYWTDSVLG-TVSVADTKGVKRKTLFRENGSKPRAIVVD 398
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLLTEDLQHPNGIAVD 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
109-143 2.54e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 2.54e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775422 109 CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 143
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
108-140 1.54e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.54e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775422   108 TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 140
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
27-58 1.68e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.68e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 307775422  27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
26-58 2.97e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 2.97e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775422    26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
68-104 3.01e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 3.01e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 307775422  68 CKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDEQGC 104
Cdd:cd00112    1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
489-528 3.53e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 52.56  E-value: 3.53e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 307775422  489 DKVFWTDIINEAIFSANRLTGSDV-NLLAENLLSPEDMVLF 528
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLLTEDLQHPNGIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
340-381 3.64e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 3.64e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 307775422   340 TVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKR 381
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
446-487 3.89e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 52.56  E-value: 3.89e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 307775422  446 GRLYWVDSKLH-SISSIDVNGGNRKTILEDEkrLAHPFSLAVF 487
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLLTED--LQHPNGIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
312-355 4.42e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 425445  Cd Length: 41  Bit Score: 52.17  E-value: 4.42e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 307775422  312 NRIYWSDLSQRMicSTQLDRAHGvSSYDTVISRDIQAPDGLAVD 355
Cdd:pfam00058   1 GRLYWTDSSLRA--SISSADLNG-SDRKTLLTEDLQHPNGIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
67-101 9.32e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 9.32e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 307775422    67 TCKSGDFSCGGRvnRCIPQFWRCDGQVDCDNGSDE 101
Cdd:smart00192   1 TCPPGEFQCDNG--RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
151-181 5.35e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 5.35e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 307775422  151 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 181
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
227-261 5.75e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 5.75e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 307775422   227 DIDECQDPDTCSQ--LCVNLEGGYKCQCEEGFQLDPH 261
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
191-219 6.69e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 46.08  E-value: 6.69e-07
                          10        20
                  ....*....|....*....|....*....
gi 307775422  191 CLDNNGGCSHVCNDLKIGYECLCPDGFQL 219
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYKL 29
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
382-422 9.40e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 9.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 307775422   382 KTLFRENGSKPRAIVVDPVHGFMYWTDWGTPaKIKKGGLNG 422
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDG 40
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
151-181 1.22e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.22e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 307775422 151 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 181
Cdd:cd00112    2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
227-259 2.70e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 2.70e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 307775422 227 DIDECQDPDTCS--QLCVNLEGGYKCQCEEGFQLD 259
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
151-181 9.96e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 9.96e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 307775422   151 GPNKFKCHSGECITLDKVCNMARDCRDWSDE 181
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
339-501 2.37e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 2.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775422 339 DTVISRDIQAPDGLAVDwiHSNIYWTDSVLGTVSVADTKGVKRKTlFRENGSK------PRAIVVDPvHGFMYWTDWGTp 412
Cdd:cd14963   94 EKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE-FGKPGSEpgelsyPNGIAVDE-DGNIYVADSGN- 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775422 413 akikkgglNGVDIYSLVTENIQWPNGITLDLLS------------GRLYWVDSKLHSISSIDVNGGNRKTIL---EDEKR 477
Cdd:cd14963  169 --------GRIQVFDKNGKFIKELNGSPDGKSGfvnprgiavdpdGNLYVVDNLSHRVYVFDEQGKELFTFGgrgKDDGQ 240
                        170       180
                 ....*....|....*....|....*
gi 307775422 478 LAHPFSLAVFEDKVFW-TDIINEAI 501
Cdd:cd14963  241 FNLPNGLFIDDDGRLYvTDRENNRV 265
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
346-486 3.22e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 46.04  E-value: 3.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775422 346 IQAPDGLAVDWiHSNIYWTDSVLGTVSVADTKGVKRKTLFRENG---SKPRAIVVDPvHGFMYWTDwGTPAKIKKGGLNG 422
Cdd:cd14962   11 LTRPYGVAADG-RGRIYVADTGRGAVFVFDLPNGKVFVIGNAGPnrfVSPIGVAIDA-NGNLYVSD-AELGKVFVFDRDG 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 307775422 423 VDIYSLVTENIQW-PNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILED---EKRLAHPFSLAV 486
Cdd:cd14962   88 KFLRAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgPGEFNLPTDLAV 155
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
349-498 7.21e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.00  E-value: 7.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775422 349 PDGLAVDwIHSNIYWTDSVLGTVSVADTKGvKRKTLFRENGSK------PRAIVVDPvHGFMYWTDWGTpAKIKK----- 417
Cdd:cd05819   10 PQGIAVD-SSGNIYVADTGNNRIQVFDPDG-NFITSFGSFGSGdgqfnePAGVAVDS-DGNLYVADTGN-HRIQKfdpdg 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775422 418 GGLNGVDIYSLVTENIQWPNGITLDLlSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDEKRLAHPFSLAVF-EDKVFW 493
Cdd:cd05819   86 NFLASFGGSGDGDGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDsDGNIYV 164

                 ....*
gi 307775422 494 TDIIN 498
Cdd:cd05819  165 ADTGN 169
EGF_CA pfam07645
Calcium-binding EGF domain;
227-255 3.18e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 3.18e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 307775422  227 DIDECQDP-DTCSQ--LCVNLEGGYKCQCEEG 255
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
237-265 5.05e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 434114 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 5.05e-04
                          10        20
                  ....*....|....*....|....*....
gi 307775422  237 CSQLCVNLEGGYKCQCEEGFQLDPHTKAC 265
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYKLQDDGRTC 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
230-261 5.21e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 5.21e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 307775422 230 ECQDPDTCS--QLCVNLEGGYKCQCEEGFQLDPH 261
Cdd:cd00053    1 ECAASNPCSngGTCVNTPGSYRCVCPPGYTGDRS 34
EGF smart00181
Epidermal growth factor-like domain;
230-261 1.04e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.11  E-value: 1.04e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 307775422   230 ECQDPDTCSQ-LCVNLEGGYKCQCEEGFQLDPH 261
Cdd:smart00181   1 ECASGGPCSNgTCINTPGSYTCSCPPGYTGDKR 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
208-230 1.08e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteristic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 432704  Cd Length: 24  Bit Score: 36.65  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|....
gi 307775422  208 GYECLCPDGFQLVA-QRRCEDIDE 230
Cdd:pfam12662   1 SYTCSCPPGYTLAGdGRTCVDIDE 24
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
347-490 1.33e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307775422 347 QAPDGLAVDWiHSNIYWTDSVLGTVSVADTKGVKRKTL----FRENGSKPRAIVVDpvHGFMYWTDWGtPAKIKKGGLNG 422
Cdd:cd14963   56 KYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKYFpekkDRVKLISPAGLAID--DGKLYVSDVK-KHKVIVFDLEG 131
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 307775422 423 VDIYSLVTE-----NIQWPNGITLDlLSGRLYWVDSKLHSISSIDVNGGNRKTI---LEDEKRLAHPFSLAVFEDK 490
Cdd:cd14963  132 KLLLEFGKPgsepgELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELngsPDGKSGFVNPRGIAVDPDG 206
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
225-264 3.33e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 39.68  E-value: 3.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 307775422 225 CEDIDECQD-PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA 264
Cdd:cd01475  184 CVVPDLCATlSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
292-330 5.54e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.27  E-value: 5.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 307775422   292 YTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLD 330
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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