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Conserved domains on  [gi|312222779|ref|NP_001185922|]
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NAD kinase isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pnk super family cl28462
bifunctional NADP phosphatase/NAD kinase;
96-433 3.55e-93

bifunctional NADP phosphatase/NAD kinase;


The actual alignment was detected with superfamily member PLN02727:

Pssm-ID: 333282 [Multi-domain]  Cd Length: 986  Bit Score: 302.19  E-value: 3.55e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779  96 QRLTWNKSPKSVLVIKKMRDAsLLQPFKELCTHLM-EENMIVYVEKKVLEdpAIASDESFGAVKkkfcTF-REDYDDISN 173
Cdd:PLN02727 670 QMLMWKSTPKTVLLLKKLGQE-LMEEAKEVASFLYhQEKMNVLVEPDVHD--IFARIPGFGFVQ----TFySQDTSDLHE 742

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 174 QIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAA-----VVLRSRLKVRVVKel 248
Cdd:PLN02727 743 RVDFVACLGGDGVILHASNLFRGAVPPVVSFNLGSLGFLTSHYFEDFRQDLRQVIHGNNTldgvyITLRMRLRCEIFR-- 820

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 249 rgkktavhnglgeNGSQAAGLDMDVgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PLN02727 821 -------------NGKAMPGKVFDV---------LNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYS 878

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 329 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVP--AGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLP 406
Cdd:PLN02727 879 TAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPdsARLELKI--PDDARSNAWVSFDGKRRQQLSRGDSVRISMSQHPLP 956

                        330       340
                 ....*....|....*....|....*..
gi 312222779 407 SICVRDPVSDWFESLAQCLHWNVRKKQ 433
Cdd:PLN02727 957 TVNKSDQTGDWFRSLIRCLNWNERLDQ 983
 
Name Accession Description Interval E-value
PLN02727 PLN02727
NAD kinase
 96-433 3.55e-93

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 302.19  E-value: 3.55e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779  96 QRLTWNKSPKSVLVIKKMRDAsLLQPFKELCTHLM-EENMIVYVEKKVLEdpAIASDESFGAVKkkfcTF-REDYDDISN 173
Cdd:PLN02727 670 QMLMWKSTPKTVLLLKKLGQE-LMEEAKEVASFLYhQEKMNVLVEPDVHD--IFARIPGFGFVQ----TFySQDTSDLHE 742

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 174 QIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAA-----VVLRSRLKVRVVKel 248
Cdd:PLN02727 743 RVDFVACLGGDGVILHASNLFRGAVPPVVSFNLGSLGFLTSHYFEDFRQDLRQVIHGNNTldgvyITLRMRLRCEIFR-- 820

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 249 rgkktavhnglgeNGSQAAGLDMDVgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PLN02727 821 -------------NGKAMPGKVFDV---------LNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYS 878

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 329 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVP--AGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLP 406
Cdd:PLN02727 879 TAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPdsARLELKI--PDDARSNAWVSFDGKRRQQLSRGDSVRISMSQHPLP 956

                        330       340
                 ....*....|....*....|....*..
gi 312222779 407 SICVRDPVSDWFESLAQCLHWNVRKKQ 433
Cdd:PLN02727 957 TVNKSDQTGDWFRSLIRCLNWNERLDQ 983
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
105-430 6.08e-60

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 196.90  E-value: 6.08e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 105 KSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAiasdesfgavkkkfctfreDYDDISNQIDFIICLGGD 184
Cdd:COG0061    2 KRIAIVAKPGKPEALEAAEELAELLEERGIEVVLDEDTAVPGV-------------------PLEELGEEADLVIVLGGD 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 185 GTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktavhnglgengs 264
Cdd:COG0061   63 GTLLRAARLLAPLGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATVDRD----------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 265 qaagldmdvGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTgstayaaaagasMIHPNVPAIM 344
Cdd:COG0061  126 ---------GEVVHEALALNEVVVLRGSIARMIELEVYIDGEFLEEFRGDGLIVSTPTgstaynlsaggpIVHPGLDALV 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 345 ITPICPHSLSFRPIVVPAGVELKIMLSPEARNtAWVSFDGRKRQEIRHGDSISITTSCYPLpSIcVRDPVSDWFESLAQC 424
Cdd:COG0061  197 LTPIAPHTLSSRPLVLPDDSEIEIEVLEDSRP-AVLVADGQEVRDLEPGDRVEIRRSPKPV-RL-LRLKDHSFFERLREK 273


                 ....*.
gi 312222779 425 LHWNVR 430
Cdd:COG0061  274 LGWGGD 279
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 283-408 1.63e-31

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 117.02  E-value: 1.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779  283 LNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPA 362
Cdd:pfam20143   1 LNEVVYVRGPGATMIEFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLSSRPIVVSS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 312222779  363 GVELKIMlsPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSI 408
Cdd:pfam20143  81 SSKLRIR--VLSRAEALLVDDGDPELDISPGDRVRVRKSYYKAKFI 124
 
Name Accession Description Interval E-value
PLN02727 PLN02727
NAD kinase
 96-433 3.55e-93

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 302.19  E-value: 3.55e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779  96 QRLTWNKSPKSVLVIKKMRDAsLLQPFKELCTHLM-EENMIVYVEKKVLEdpAIASDESFGAVKkkfcTF-REDYDDISN 173
Cdd:PLN02727 670 QMLMWKSTPKTVLLLKKLGQE-LMEEAKEVASFLYhQEKMNVLVEPDVHD--IFARIPGFGFVQ----TFySQDTSDLHE 742

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 174 QIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAA-----VVLRSRLKVRVVKel 248
Cdd:PLN02727 743 RVDFVACLGGDGVILHASNLFRGAVPPVVSFNLGSLGFLTSHYFEDFRQDLRQVIHGNNTldgvyITLRMRLRCEIFR-- 820

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 249 rgkktavhnglgeNGSQAAGLDMDVgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PLN02727 821 -------------NGKAMPGKVFDV---------LNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYS 878

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 329 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVP--AGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLP 406
Cdd:PLN02727 879 TAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPdsARLELKI--PDDARSNAWVSFDGKRRQQLSRGDSVRISMSQHPLP 956

                        330       340
                 ....*....|....*....|....*..
gi 312222779 407 SICVRDPVSDWFESLAQCLHWNVRKKQ 433
Cdd:PLN02727 957 TVNKSDQTGDWFRSLIRCLNWNERLDQ 983
PLN02935 PLN02935
Bifunctional NADH kinase/NAD(+) kinase
 98-433 1.87e-88

Bifunctional NADH kinase/NAD(+) kinase


Pssm-ID: 215505 [Multi-domain]  Cd Length: 508  Bit Score: 278.25  E-value: 1.87e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779  98 LTWNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMI-VYVEKKVLEDpAIASDESFGAVKKkfCTFREDYDDISNQID 176
Cdd:PLN02935 188 LKWESDPQTVLIITKPNSTSVRVLCAEMVRWLREQKGLnIYVEPRVKKE-LLSESSYFNFVQT--WEDEKEILLLHTKVD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 177 FIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktAVH 256
Cdd:PLN02935 265 LVITLGGDGTVLWAASMFKGPVPPVVPFSMGSLGFMTPFHSEQYRDCLDAILKGPISITLRHRLQCHIIRD------AAK 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 257 NGLGENGSqaagldmdvgkqamqYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMI 336
Cdd:PLN02935 339 NEYETEEP---------------ILVLNEVTIDRGISSFLTNLECYCDNSFVTCVQGDGLILSTTSGSTAYSLAAGGSMV 403

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 337 HPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPVSD 416
Cdd:PLN02935 404 HPQVPGILFTPICPHSLSFRPLILPEYVTIRVQVPFNSRGQAWASFDGKDRKQLSAGDALVCSMAPWPVPTACQVESTND 483

                        330
                 ....*....|....*..
gi 312222779 417 WFESLAQCLHWNVRKKQ 433
Cdd:PLN02935 484 FLRSIHDGLHWNLRKTQ 500
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
105-430 6.08e-60

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 196.90  E-value: 6.08e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 105 KSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAiasdesfgavkkkfctfreDYDDISNQIDFIICLGGD 184
Cdd:COG0061    2 KRIAIVAKPGKPEALEAAEELAELLEERGIEVVLDEDTAVPGV-------------------PLEELGEEADLVIVLGGD 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 185 GTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktavhnglgengs 264
Cdd:COG0061   63 GTLLRAARLLAPLGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATVDRD----------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 265 qaagldmdvGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTgstayaaaagasMIHPNVPAIM 344
Cdd:COG0061  126 ---------GEVVHEALALNEVVVLRGSIARMIELEVYIDGEFLEEFRGDGLIVSTPTgstaynlsaggpIVHPGLDALV 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 345 ITPICPHSLSFRPIVVPAGVELKIMLSPEARNtAWVSFDGRKRQEIRHGDSISITTSCYPLpSIcVRDPVSDWFESLAQC 424
Cdd:COG0061  197 LTPIAPHTLSSRPLVLPDDSEIEIEVLEDSRP-AVLVADGQEVRDLEPGDRVEIRRSPKPV-RL-LRLKDHSFFERLREK 273


                 ....*.
gi 312222779 425 LHWNVR 430
Cdd:COG0061  274 LGWGGD 279
ppnK PRK01231
NAD(+) kinase;
101-430 5.45e-38

NAD(+) kinase;


Pssm-ID: 179257 [Multi-domain]  Cd Length: 295  Bit Score: 139.71  E-value: 5.45e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 101 NKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLE-----DPAIASDESFGAVkkkfCtfredyddisnqi 175
Cdd:PRK01231   1 MPSFRNIGLIGRLGSSSVVETLRRLKDFLLDRGLEVILDEETAEvlpghGLQTVSRKLLGEV----C------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 176 DFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVrvvkELRGKKTAV 255
Cdd:PRK01231  64 DLVIVVGGDGSLLGAARALARHNVPVLGINRGRLGFLTDIRPDELEFKLAEVLDGHYQEEERFLLEA----EVRRGGEVI 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 256 HNGLGengsqaagldmdvgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASM 335
Cdd:PRK01231 140 GQGDA----------------------LNDVVLHPGKSTRMIEFELYIDGQFVCSQRSDGLIVSTPTGSTAYALSGGGPI 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 336 IHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDpvS 415
Cdd:PRK01231 198 MHPKLDAIVLVPMFPHTLSSRPIVVDGNSEIKIVISKDNRTYPRVSCDGQNSVTLAPGDTVTIRKKPQKLRLIHPLD--Y 275

                        330
                 ....*....|....*
gi 312222779 416 DWFESLAQCLHWNVR 430
Cdd:PRK01231 276 NYYETCRTKLGWGSR 290
pnk PRK14076
bifunctional NADP phosphatase/NAD kinase;
100-401 3.19e-37

bifunctional NADP phosphatase/NAD kinase;


Pssm-ID: 237601 [Multi-domain]  Cd Length: 569  Bit Score: 142.94  E-value: 3.19e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 100 WNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEdpaiasdesfgAVKKKFCTFREDYDDISNqIDFII 179
Cdd:PRK14076 286 WRIKPTKFGIVSRIDNEEAINLALKIIKYLDSKGIPYELESFLYN-----------KLKNRLNEECNLIDDIEE-ISHII 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 180 CLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKelrgkktavhngl 259
Cdd:PRK14076 354 SIGGDGTVLRASKLVNGEEIPIICINMGTVGFLTEFSKEEIFKAIDSIISGEYEIEKRTKLSGFILK------------- 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 260 gengsqaagldmdVGKQAMQYQVLNEVVI-DRGPSSYLsNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHP 338
Cdd:PRK14076 421 -------------DGHQNILPSALNEVVItTKNPAKML-HFEVYVNGELVEEVRADGIIISTPTGSTAYSLSAGGPIVEP 486

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312222779 339 NVPAIMITPICPHSLSFRPIVVPAGVELKIMLSpeaRNTAWVSFDGRKRQEIRHGDSISITTS 401
Cdd:PRK14076 487 TVDGFIIVPICPFKLSSRPLVVSANSEIKIKLL---KKSALVVIDGSIEFEAKKGDEIIFRKS 546
ppnK PRK02155
NAD kinase;
167-428 2.26e-32

NAD kinase;


Pssm-ID: 179379 [Multi-domain]  Cd Length: 291  Bit Score: 124.28  E-value: 2.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 167 DYDDISNQIDFIICLGGDGTLL-YASSLFQGSVPPVMAFHlGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVV 245
Cdd:PRK02155  56 TPEEIGARADLAVVLGGDGTMLgIGRQLAPYGVPLIGINH-GRLGFITDIPLDDMQETLPPMLAGNYEEEERMLLEARVV 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 246 kelRGKKTaVHNGLgengsqaagldmdvgkqAMqyqvlNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGST 325
Cdd:PRK02155 135 ---RDGEP-IFHAL-----------------AF-----NDVVVNRSGFSGMVELRVSVDGRFMYNQRSDGLIVATPTGST 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 326 AYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSpEARNTAwVSFDGRKRQEIRHGDSISITTSCYpl 405
Cdd:PRK02155 189 AYALSAGGPILHPQLPGWVLVPIAPHTLSNRPIVLPDDSEVAIQIV-GGRDVS-VNFDMQSLTSLELGDRIEVRRSPH-- 264

                        250       260
                 ....*....|....*....|....
gi 312222779 406 pSICVRDPVS-DWFESLAQCLHWN 428
Cdd:PRK02155 265 -TVRFLHPVGySYYATLRKKLHWN 287
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 283-408 1.63e-31

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 117.02  E-value: 1.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779  283 LNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPA 362
Cdd:pfam20143   1 LNEVVYVRGPGATMIEFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLSSRPIVVSS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 312222779  363 GVELKIMlsPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSI 408
Cdd:pfam20143  81 SSKLRIR--VLSRAEALLVDDGDPELDISPGDRVRVRKSYYKAKFI 124
ppnK PRK04539
inorganic polyphosphate/ATP-NAD kinase; Provisional
 125-430 6.79e-31

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179862 [Multi-domain]  Cd Length: 296  Bit Score: 120.35  E-value: 6.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 125 LCTHLMEENMIVYVEKKVLEDPAIASDESFGavkkkfCTFReDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAF 204
Cdd:PRK04539  26 LITFLKQHGFTVYLDEVGIKEGCIYTQDTVG------CHIV-NKTELGQYCDLVAVLGGDGTFLSVAREIAPRAVPIIGI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 205 HLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktavhnglgengsqaagldmdvGKQAMQYQVLN 284
Cdd:PRK04539  99 NQGHLGFLTQIPREYMTDKLLPVLEGKYLAEERILIEAALIRE--------------------------GKTAERALALN 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 285 EVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGV 364
Cdd:PRK04539 153 DAVLSRGGAGQMIEFEVFVNREFVYTQRSDGLIVSTPTGSTAYSLAAGGPIMQAGLHAFTLVPICPQSMTNRPIAIPDTS 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312222779 365 ELKIMLSP--EARntawVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDpvSDWFESLAQCLHWNVR 430
Cdd:PRK04539 233 EIEILVTQggDAR----VHFDGQTHIDVQNLDRITIRRYRNPLRILHPTD--YQYFKTLRQKLHWGEQ 294
ppnK PRK01911
inorganic polyphosphate/ATP-NAD kinase; Provisional
 123-385 5.34e-29

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179352 [Multi-domain]  Cd Length: 292  Bit Score: 115.02  E-value: 5.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 123 KELCTHLMEENMIVYVEKKVLEdpAIASDESFgavKKKFCTFrEDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVM 202
Cdd:PRK01911  19 QELFDELEERGAEVLIEEKFLD--FLKQDLKF---HPSYDTF-SDNEELDGSADMVISIGGDGTFLRTATYVGNSNIPIL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 203 AFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKELRGkktavhnglgenGSQAAgldmdvgkqamqyqv 282
Cdd:PRK01911  93 GINTGRLGFLATVSKEEIEETIDELLNGDYTIEERSLLQLESNPKLFG------------ELNFA--------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 283 LNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPA 362
Cdd:PRK01911 146 LNEIAILKRDTSSMITVHTYLNGEYLNSYWADGLIVATPTGSTGYSLSCGGPIIVPDAKSFVITPIAPHNLNVRPLVIPD 225

                        250       260
                 ....*....|....*....|....
gi 312222779 363 GVElkIMLSPEARNTAW-VSFDGR 385
Cdd:PRK01911 226 DTE--ITLEVESRSDNFlVSLDSR 247
ppnK PRK01185
NAD(+) kinase;
176-401 5.22e-28

NAD(+) kinase;


Pssm-ID: 179241 [Multi-domain]  Cd Length: 271  Bit Score: 111.83  E-value: 5.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 176 DFIICLGGDGTLLYASSLFQGsvpPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVvkelrgkktav 255
Cdd:PRK01185  54 DVIITIGGDGTILRTLQRAKG---PILGINMGGLGFLTEIEIDEVGSAIKKLIRGEYFIDERMKLKVYI----------- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 256 hnglgeNGSQAagldmdvgkqamqYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASM 335
Cdd:PRK01185 120 ------NGERL-------------EDCTNEAVIHTDRIAKIRQFKIYYDGHFLDTFKADGVIVATPTGSTSYSSSAGGPI 180

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312222779 336 IHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTawVSFDGRKRQEIRHGDSISITTS 401
Cdd:PRK01185 181 LLPNLEGMVISYIAPYSSRPKSVVVPSESTVEIKIAGDQSSL--LILDGQYEYKISKGDTVEISKS 244
ppnK PRK03708
NAD(+) kinase;
159-401 6.53e-27

NAD(+) kinase;


Pssm-ID: 179635 [Multi-domain]  Cd Length: 277  Bit Score: 109.03  E-value: 6.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 159 KKFCTFRE-DYDDISN-QIDFIICLGGDGTLLYASSLFQGSVpPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVvl 236
Cdd:PRK03708  40 EHLPEFSEeDVLPLEEmDVDFIIAIGGDGTILRIEHKTKKDI-PILGINMGTLGFLTEVEPEETFFALSRLLEGDYFI-- 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 237 RSRLKVRVvkelrgkktaVHNglGENGSQAagldmdvgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGV 316
Cdd:PRK03708 117 DERIKLRV----------YIN--GENVPDA----------------LNEVVILTGIPGKIIHLKYYVDGELADEVRADGL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 317 IVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNtAWVSFDGRKRQEIRHGDSI 396
Cdd:PRK03708 169 IISTPTGSTAYAMSAGGPFVDPRLDAILIAPLCPFKLSSRPMVVPSSSRIDVKLLRTGRE-IILVIDGQYYEELPPDTEI 247


                 ....*
gi 312222779 397 SITTS 401
Cdd:PRK03708 248 TIKKS 252
ppnK PRK02645
NAD(+) kinase;
172-427 2.02e-24

NAD(+) kinase;


Pssm-ID: 179455 [Multi-domain]  Cd Length: 305  Bit Score: 102.68  E-value: 2.02e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 172 SNQIDFIICLGGDGTLLYAS-SLFQGSVPpVMAFHLG-SLGFLT-PFSFENFQSQVTQVIEGNAAVVLRSRLKVRVvkeL 248
Cdd:PRK02645  55 SELIDLAIVLGGDGTVLAAArHLAPHDIP-ILSVNVGgHLGFLThPRDLLQDESVWDRLQEDRYAIERRMMLQARV---F 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 249 RGKKTavhnglgengsqaagldmDVGKQAMQYQVLNE-----VVIDRGPSSYLsnvDVYLDGHLITTVQGDGVIVSTPTG 323
Cdd:PRK02645 131 EGDRS------------------NEEPVSESYYALNDfylkpASEDRSPTCIL---ELEIDGEVVDQYQGDGLIVSTPTG 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 324 STAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAG--VELKIMLSPEARNTAWVsfDGRKRQEIRHGDSISITTS 401
Cdd:PRK02645 190 STAYTMAAGGPILHPGIDAIIVTPICPMSLSSRPIVIPPGsrVVIWPLGDYDLNIKLWK--DGVLATSIWPGQRCVIQKA 267

                        250       260
                 ....*....|....*....|....*.
gi 312222779 402 CYPLPSICVRDPVSdWFESLAQCLHW 427
Cdd:PRK02645 268 RHPAKFIILEESYS-YYRTLREKLHW 292
pnk PRK14077
NAD(+) kinase;
169-427 2.91e-24

NAD(+) kinase;


Pssm-ID: 172567 [Multi-domain]  Cd Length: 287  Bit Score: 101.78  E-value: 2.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 169 DDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKEl 248
Cdd:PRK14077  59 DELFKISDFLISLGGDGTLISLCRKAAEYDKFVLGIHAGHLGFLTDITVDEAEKFFQAFFQGEFEIEKPYMLSVFLEKK- 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 249 RGKktavhnglgengsqaagldmdvgkqAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PRK14077 138 QGK-------------------------ILEKLAFNDVVISKNNQASMAHIEAFLNEKYFNEYFGDGVIVATPAGSTAYN 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 329 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMlspeARNTAWVSFDGRKRQEIRHGDSISITTScyPLPSI 408
Cdd:PRK14077 193 MSANGPIIYPLSQVFILTPVCSHSLTQRPIVLPKGFEVEFK----TKSDCILCIDGQDRYKMNDFKSIKVGLS--DKNVA 266

                        250
                 ....*....|....*....
gi 312222779 409 CVRDPVSDWFESLAQCLHW 427
Cdd:PRK14077 267 LIRHKNRDYFQILKEKLHW 285
ppnK PRK03378
inorganic polyphosphate/ATP-NAD kinase; Provisional
 109-405 1.44e-23

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235122 [Multi-domain]  Cd Length: 292  Bit Score: 100.02  E-value: 1.44e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 109 VIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAIaSDESFGavkkkfctfreDYDDISNQIDFIICLGGDGTLL 188
Cdd:PRK03378  10 IVGHPRHPTALTTHEMLYHWLTSKGYEVIVEQQIAHELQL-KNVKTG-----------TLAEIGQQADLAIVVGGDGNML 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 189 YAS---SLFQGSVPPVmafHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKelrgkktavHNGLGENGSq 265
Cdd:PRK03378  78 GAArvlARYDIKVIGI---NRGNLGFLTDLDPDNALQQLSDVLEGHYISEKRFLLEAQVCR---------HGQQKRIST- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 266 aagldmdvgkqamqyqVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMI 345
Cdd:PRK03378 145 ----------------AINEVVLHPGKVAHMIEFEVYIDDNFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITL 208

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 346 TPICPHSLSFRPIVVPAGVELKIMLSPEaRNTAWVSFDGRKRQEIRHGDSISITTSCYPL 405
Cdd:PRK03378 209 VPMFPHTLSARPLVIDSSSTIRLKFSPN-RSDLEISCDSQIALPIQPGEEVLIRRSDYHL 267
ppnK PRK02649
NAD(+) kinase;
175-427 4.08e-19

NAD(+) kinase;


Pssm-ID: 179456 [Multi-domain]  Cd Length: 305  Bit Score: 87.34  E-value: 4.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 175 IDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVvkeLRGKKTa 254
Cdd:PRK02649  69 MKFAIVLGGDGTVLSAARQLAPCGIPLLTINTGHLGFLTEAYLNQLDEAIDQVLAGQYTIEERTMLTVSV---MRGDQL- 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 255 vhngLGENGSqaagldmdvgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGAS 334
Cdd:PRK02649 145 ----RWEALS------------------LNEMVLHREPLTSMCHFEIAIGRHAPVDIAADGVILSTPTGSTAYSLSAGGP 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 335 MIHPNVPAIMITPICPHSLSFRPIVVPAGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPv 414
Cdd:PRK02649 203 VITPDVPVLQLTPICPHSLASRALVFSDSEPVTV--FPATPERLVMVVDGNAGCYVWPEDRVLIRRSPYPVRFIRLQDP- 279

                        250
                 ....*....|...
gi 312222779 415 sDWFESLAQCLHW 427
Cdd:PRK02649 280 -EFFRVLREKLGW 291
ppnK PRK02231
NAD(+) kinase;
129-427 3.42e-16

NAD(+) kinase;


Pssm-ID: 167337 [Multi-domain]  Cd Length: 272  Bit Score: 78.31  E-value: 3.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 129 LMEENMIVYVEKKVledpAIASDESFGAVKkkfctfreDYDDISNQIDFIICLGGDGTLL-YASSLFQGSVPpVMAFHLG 207
Cdd:PRK02231   9 LKERGYQVLVEKEI----AEQLNLPENHLA--------SLEEIGQRAQLAIVIGGDGNMLgRARVLAKYDIP-LIGINRG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 208 SLGFLTPFSFENFQSQVTQVIE-GNAAVVLRSRLKVRVvkELRGKKTAVHNGLgengsqaagldmdvgkqamqyqvlNEV 286
Cdd:PRK02231  76 NLGFLTDIDPKNAYEQLEACLErGEFFVEERFLLEAKI--ERNGKIIATSNAL------------------------NEV 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 287 VIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVEL 366
Cdd:PRK02231 130 VIHPAKIAHMIDFHVYIDDKFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPNLNAIALVPMFPHTLSSRPLVIDGDSKI 209

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312222779 367 KIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDpvSDWFESLAQCLHW 427
Cdd:PRK02231 210 SLRFAEYNTPQLEVSCDSQIALPFTPDDRVHVQKSPDKLRLLHLKN--YNYYNVLSSKLGW 268
pnk PRK14075
NAD(+) kinase;
175-361 1.24e-15

NAD(+) kinase;


Pssm-ID: 184489 [Multi-domain]  Cd Length: 256  Bit Score: 76.31  E-value: 1.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 175 IDFIICLGGDGTLLYASSLFQGsvpPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKelrgkkta 254
Cdd:PRK14075  42 ADLIIVVGGDGTVLKAAKKVGT---PLVGFKAGRLGFLSSYTLEEIDRFLEDLKNWNFREEKRWFLKIESEL-------- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 255 vhnglgengsqaagldmdvgkqaMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGAS 334
Cdd:PRK14075 111 -----------------------GNHLALNDVTLERDPSQKMVEIEVSFEDHSSMWFFADGVVISTPTGSTAYSLSLGGP 167

                        170       180
                 ....*....|....*....|....*..
gi 312222779 335 MIHPNVPAIMITPICPHSLSFRPIVVP 361
Cdd:PRK14075 168 IILPNCEVFEITPIAPQFLATRSIVIP 194
NAD_kinase pfam01513
ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 107-229 1.67e-15

ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.


Pssm-ID: 426300 [Multi-domain]  Cd Length: 128  Bit Score: 72.78  E-value: 1.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779  107 VLVIKKMRDASLLQPFKELCTHLMEENMI-VYVEKKVLEDPAIASDESFGAVKKKFCTFREDYDDISNQI----DFIICL 181
Cdd:pfam01513   1 VGIVVNPDKKEALERAREVARWLLDRLGItVTVEEKMGESLAFAAGDRPEVIGCLKKVVDDTRRATRAFAdagvDLIIVL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 312222779  182 GGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIE 229
Cdd:pfam01513  81 GGDGTALRAARLLQKAVIPILGVNTGVLGFLTEFEPEAAFELLERLLE 128
ppnK PRK03372
inorganic polyphosphate/ATP-NAD kinase; Provisional
 142-405 1.46e-13

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235121 [Multi-domain]  Cd Length: 306  Bit Score: 71.10  E-value: 1.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 142 VLEDPAIASDESFGAV---KKKFCTFREDyDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFE 218
Cdd:PRK03372  38 RVLDAEAVDLGATHPApddFRAMEVVDAD-PDAADGCELVLVLGGDGTILRAAELARAADVPVLGVNLGHVGFLAEAEAE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 219 NFQSQVTQVIEGNAAVVLRSRLKVRVvkelRGKKTAVHNGLGengsqaagldmdvgkqamqyqvLNEVVIDRGPSSYLSN 298
Cdd:PRK03372 117 DLDEAVERVVDRDYRVEERMTLDVTV----RVGGEIVWRGWA----------------------LNEASLEKADREGMLE 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 299 VDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEArNTA 378
Cdd:PRK03372 171 VVLEVDGRPVSSFGCDGVLVSTPTGSTAYAFSAGGPVVWPDLEALLVVPLNAHALFARPLVVSPTSTVAVEILADT-SDA 249

                        250       260
                 ....*....|....*....|....*..
gi 312222779 379 WVSFDGRKRQEIRHGDSISITTSCYPL 405
Cdd:PRK03372 250 VLWCDGRRSVDLPPGARVEVRRGATPV 276
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 158-398 8.55e-11

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 62.14  E-value: 8.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 158 KKKFCTFREDYDDisNQIDFIICLGGDGTLLYASSLFQGSVPPVmAF---HLGSLGFLT---PFSFENFqsqVTQVIEGN 231
Cdd:PRK04885  21 KKYLKDFGFILDE--KNPDIVISVGGDGTLLSAFHRYENQLDKV-RFvgvHTGHLGFYTdwrPFEVDKL---VIALAKDP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 232 AAVVLRSRLKVRVVKElrgkktavhnglgeNGSQAAgldmdvgkqamqYQVLNEVVIDRgPSSYLSnVDVYLDGHLITTV 311
Cdd:PRK04885  95 GQVVSYPLLEVKITYE--------------DGEKEK------------YLALNEATIKR-IEGTLV-ADVYINGVLFERF 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 312 QGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICphSLS---FR----PIVVPAGVelKIMLSPEARNTAWVSFDg 384
Cdd:PRK04885 147 RGDGLCVSTPTGSTAYNKSLGGAVLHPSIEALQLTEIA--SINnrvFRtlgsPLILPKHH--TITLKPVNDDDYQITVD- 221

                        250
                 ....*....|....
gi 312222779 385 rkRQEIRHGDSISI 398
Cdd:PRK04885 222 --HLTIKHKNVKSI 233
ppnK PRK04761
inorganic polyphosphate/ATP-NAD kinase; Reviewed
 168-321 3.04e-04

inorganic polyphosphate/ATP-NAD kinase; Reviewed


Pssm-ID: 179876 [Multi-domain]  Cd Length: 246  Bit Score: 42.11  E-value: 3.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 168 YDDIS-NQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFL-TPFSFENFQSQVtqviegNAAVVLRSRLKVRVV 245
Cdd:PRK04761  18 YGDVPiEEADVIVALGGDGFMLQTLHRYMNSGKPVYGMNRGSVGFLmNEYSEDDLLERI------AAAEPTVLHPLRMTA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 246 KELRGKktaVHNGLGEN-------GSQAAGLDMDV-GKQAMQyqvlnEVVidrgpssylsnvdvyldghlittvqGDGVI 317
Cdd:PRK04761  92 TDVSGE---VHEALAINevslfrqTRQAAKLRISIdGKVRME-----ELV-------------------------CDGVL 138


                 ....
gi 312222779 318 VSTP 321
Cdd:PRK04761 139 VATP 142
ppnK PRK03501
NAD kinase;
276-322 3.17e-03

NAD kinase;


Pssm-ID: 179584  Cd Length: 264  Bit Score: 39.19  E-value: 3.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 312222779 276 QAMQYQVLNEVVIDrgpSSYLSN--VDVYLDGHLITTVQGDGVIVSTPT 322
Cdd:PRK03501 113 GSTSFYCLNEFSIR---SSIIKTfvIDVYIDDLHFETFRGDGMVVSTPT 158
PLN02929 PLN02929
NADH kinase
 162-244 3.19e-03

NADH kinase


Pssm-ID: 215502 [Multi-domain]  Cd Length: 301  Bit Score: 39.25  E-value: 3.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 162 CTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPvmafhLG----------------------SLGFLTPFSFEN 219
Cdd:PLN02929  52 CVLRNELSQPIRDVDLVVAVGGDGTLLQASHFLDDSIPV-----LGvnsdptqkdeveeysdefdarrSTGHLCAATAED 126

                         90       100
                 ....*....|....*....|....*
gi 312222779 220 FQSQVTQVIEGNAAVVLRSRLKVRV 244
Cdd:PLN02929 127 FEQVLDDVLFGRLKPTELSRISTVV 151
ppnK PRK00561
NAD(+) kinase;
173-398 8.56e-03

NAD(+) kinase;


Pssm-ID: 100598 [Multi-domain]  Cd Length: 259  Bit Score: 37.93  E-value: 8.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 173 NQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSF----ENFQSQVTQviegnaavvlrsrLKVRVVKEL 248
Cdd:PRK00561  32 DGADYLFVLGGDGFFVSTAANYNCAGCKVVGINTGHLGFYTSFNEtdldQNFANKLDQ-------------LKFTQIDLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222779 249 RgkktavhnglgengsqaagldmdVGKQAMQYQVLNEVVIDrgpSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PRK00561  99 E-----------------------VQIDDQIHLVLNELAVY---TNTAYPINIFIDNEFWEKYRGSGLLIGPRTGSTALA 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312222779 329 AAAGASMIHPNVPAIMITPICP--HSlSF----RPIVVPAGVELKIMLSPEARNTAWVSF--DGRKRQEIRHGDSISI 398
Cdd:PRK00561 153 KSAKGAVIFPRIDVIQIIELNPllHP-NQttiqSPIILPIDTKVEFEIKKAFDHDQFPRFyaDGAKLRLGNSDTTIEI 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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