NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|312433991|ref|NP_001186075|]
View 

G-protein-signaling modulator 1 isoform 2 [Mus musculus]

Protein Classification

TPR and TPR_12 domain-containing protein; tetratricopeptide repeat protein( domain architecture ID 11421212)

protein containing domains TPR, TPR_12, and GoLoco; tetratricopeptide repeat (TPR) protein such as kinesin light chain, which mediates the selective binding of kinesin to its cargo

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
69-322 2.18e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 79.28  E-value: 2.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  69 YSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARA 148
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALELDP------DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD------AEA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 149 LYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTF 228
Cdd:COG0457   79 LNNLGLALQALGR--------------------YEEALEDYDKALEL------DPDDAEALYNLGLALLELGRYDEAIEA 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 229 HKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEY 308
Cdd:COG0457  133 YERALELDPDDAD------ALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206

                        250
                 ....*....|....
gi 312433991 309 HLRHLVIAQELADR 322
Cdd:COG0457  207 LRKKLAILTLAALA 220
GoLoco pfam02188
GoLoco motif;
434-455 2.03e-07

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 47.03  E-value: 2.03e-07
                          10        20
                  ....*....|....*....|..
gi 312433991  434 ECFFDLLSKFQSSRMDDQRCPL 455
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
487-507 1.39e-05

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.39e-05
                          10        20
                  ....*....|....*....|.
gi 312433991  487 EEFFDLIASSQSRRLDDQRAS 507
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco pfam02188
GoLoco motif;
569-590 1.43e-05

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.43e-05
                          10        20
                  ....*....|....*....|..
gi 312433991  569 EDFFSLIQRVQAKRMDEQRVDL 590
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 534-556 1.52e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


:

Pssm-ID: 214645  Cd Length: 23  Bit Score: 41.72  E-value: 1.52e-05
                           10        20
                   ....*....|....*....|...
gi 312433991   534 GDEFFNMLIKYQSSRIDDQRCPP 556
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
TPR_12 pfam13424
Tetratricopeptide repeat;
290-358 3.23e-04

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 3.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312433991  290 YSLGNTYTLLQDYERAAEYHLRHLVIAQEL--ADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQE 358
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
69-322 2.18e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 79.28  E-value: 2.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  69 YSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARA 148
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALELDP------DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD------AEA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 149 LYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTF 228
Cdd:COG0457   79 LNNLGLALQALGR--------------------YEEALEDYDKALEL------DPDDAEALYNLGLALLELGRYDEAIEA 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 229 HKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEY 308
Cdd:COG0457  133 YERALELDPDDAD------ALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206

                        250
                 ....*....|....
gi 312433991 309 HLRHLVIAQELADR 322
Cdd:COG0457  207 LRKKLAILTLAALA 220
TPR_12 pfam13424
Tetratricopeptide repeat;
207-278 3.52e-09

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 53.55  E-value: 3.52e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312433991  207 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEF--GDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 278
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
GoLoco pfam02188
GoLoco motif;
434-455 2.03e-07

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 47.03  E-value: 2.03e-07
                          10        20
                  ....*....|....*....|..
gi 312433991  434 ECFFDLLSKFQSSRMDDQRCPL 455
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
487-507 1.39e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.39e-05
                          10        20
                  ....*....|....*....|.
gi 312433991  487 EEFFDLIASSQSRRLDDQRAS 507
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco pfam02188
GoLoco motif;
569-590 1.43e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.43e-05
                          10        20
                  ....*....|....*....|..
gi 312433991  569 EDFFSLIQRVQAKRMDEQRVDL 590
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 433-455 1.47e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 41.72  E-value: 1.47e-05
                           10        20
                   ....*....|....*....|...
gi 312433991   433 EECFFDLLSKFQSSRMDDQRCPL 455
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 534-556 1.52e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 41.72  E-value: 1.52e-05
                           10        20
                   ....*....|....*....|...
gi 312433991   534 GDEFFNMLIKYQSSRIDDQRCPP 556
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco pfam02188
GoLoco motif;
535-555 1.56e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.64  E-value: 1.56e-05
                          10        20
                  ....*....|....*....|.
gi 312433991  535 DEFFNMLIKYQSSRIDDQRCP 555
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 486-508 3.04e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.95  E-value: 3.04e-05
                           10        20
                   ....*....|....*....|...
gi 312433991   486 TEEFFDLIASSQSRRLDDQRASV 508
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 40-398 9.13e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 45.68  E-value: 9.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  40 KAGDFKAGVAFFEAAVQV-----GTEDLKTLSAiYSQLGNAYFYLKEYARALQfhkhdllLARTIGDRMGEAK------- 107
Cdd:NF040586 404 LRGDYESARDLAERALERwrerlGPDDRQTLRL-RFHLANALRSLGRYEEARE-------LDEDTLERQRRVLglgedhp 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 108 ----ASGNLGNTLKVLGRFDEAivccqrhLDIAQEqgdkvgearalynignvyhakgkqlSWNAAQDPghLPPDVRETLh 183
Cdd:NF040586 476 htlmTAGGLGADLRALGRFREA-------LELDEE-------------------------TLERHRRV--FGEDHPRTL- 520

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 184 rasefyernlslvkelgdraaqgRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFG--DKAAERRAYSNLGNAHIFLGR 261
Cdd:NF040586 521 -----------------------RAANNLAVSLRLLGDYREALELDREVLRRRRRVLgpDHPRTLLSANNLARDLRELGR 577

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 262 FDVAAEHYKKTLQLSRQLR---DQAVEAQACYSLGNTYTLLQDYERAAEYHLRhlvIAQELADRVGEG----RAC-WSLG 333
Cdd:NF040586 578 YAEALDLLEEALERYREVLggpDHPDTLRAAKSLAVALRRAGRLEEALELAED---TYERYRRRFGPDhpdtLAAaLSLA 654

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 334 NAYVSMGSPAQALTFAKKHLQISQEigdRNGE-----LTARMNIAHLQLALGRltsPAAAEKPDLAGYEA 398
Cdd:NF040586 655 NDLRALGDADEARELAREVLDRYRR---VLGEdhpftLACRNNLAVLLRALGD---PEEARELAEAALEG 718
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 568-590 9.48e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 39.41  E-value: 9.48e-05
                           10        20
                   ....*....|....*....|...
gi 312433991   568 DEDFFSLIQRVQAKRMDEQRVDL 590
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
TPR_12 pfam13424
Tetratricopeptide repeat;
290-358 3.23e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 3.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312433991  290 YSLGNTYTLLQDYERAAEYHLRHLVIAQEL--ADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQE 358
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 106-138 7.11e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.43  E-value: 7.11e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 312433991   106 AKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQE 138
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
69-322 2.18e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 79.28  E-value: 2.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  69 YSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARA 148
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALELDP------DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD------AEA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 149 LYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTF 228
Cdd:COG0457   79 LNNLGLALQALGR--------------------YEEALEDYDKALEL------DPDDAEALYNLGLALLELGRYDEAIEA 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 229 HKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEY 308
Cdd:COG0457  133 YERALELDPDDAD------ALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206

                        250
                 ....*....|....
gi 312433991 309 HLRHLVIAQELADR 322
Cdd:COG0457  207 LRKKLAILTLAALA 220
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-389 2.61e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 78.90  E-value: 2.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 105 EAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEqgdkvgEARALYNIGNVYHAKGKqlswnaaqdpghlppdvretLHR 184
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPD------DAEALYNLGLAYLRLGR--------------------YEE 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 185 ASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDV 264
Cdd:COG0457   61 ALADYEQALEL------DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAE------ALYNLGLALLELGRYDE 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 265 AAEHYKKTLQLSRQLrdqaveAQACYSLGNTYTLLQDYERAAEYHLRHLviAQELADRVGEGRACWSLGNAYVSMGSPAQ 344
Cdd:COG0457  129 AIEAYERALELDPDD------ADALYNLGIALEKLGRYEEALELLEKLE--AAALAALLAAALGEAALALAAAEVLLALL 200

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 312433991 345 ALTFAKKHLQISQEIGDRNGELTARMNIAHLQLALGRLTSPAAAE 389
Cdd:COG0457  201 LALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
145-428 4.29e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 75.43  E-value: 4.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 145 EARALYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLVKELGDraaqgrAYGNLGNTHYLLGNFTE 224
Cdd:COG0457    7 DAEAYNNLGLAYRRLGR--------------------YEEAIEDYEKALELDPDDAE------ALYNLGLAYLRLGRYEE 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 225 ATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLrdqaveAQACYSLGNTYTLLQDYER 304
Cdd:COG0457   61 ALADYEQALELDPDDAE------ALNNLGLALQALGRYEEALEDYDKALELDPDD------AEALYNLGLALLELGRYDE 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 305 AAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQisQEIGDRNGELTARMNIAHLQLALGRLTS 384
Cdd:COG0457  129 AIEAYERALELDPDDAD------ALYNLGIALEKLGRYEEALELLEKLEA--AALAALLAAALGEAALALAAAEVLLALL 200

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 312433991 385 PAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDRGIPRA 428
Cdd:COG0457  201 LALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 33-354 9.23e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 72.07  E-value: 9.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  33 LEGERLCKAGDFKAGVAFFEAAVQVGTEDLKTlsaiYSQLGNAYFYLKEYARALQFHKHdlLLARTiGDRmgeAKASGNL 112
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEA----HLALGNLYRRRGEYDRAIRIHQK--LLERD-PDR---AEALLEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 113 GNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARALYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERn 192
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKLLELDPDD------AEALRLLAEIYEQEGD--------------------WEKAIEVLER- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 193 lsLVKELGDRAaqgRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFgdkaaeRRAYSNLGNAHIFLGRFDVAAEHYKKT 272
Cdd:COG2956  136 --LLKLGPENA---HAYCELAELYLEQGDYDEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERA 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 273 LQLSRQLrdqaveAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVgegracwSLGNAYVSMGSPAQALTFAKKH 352
Cdd:COG2956  205 LEQDPDY------LPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL-------ALADLLERKEGLEAALALLERQ 271


                 ..
gi 312433991 353 LQ 354
Cdd:COG2956  272 LR 273
TPR_12 pfam13424
Tetratricopeptide repeat;
207-278 3.52e-09

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 53.55  E-value: 3.52e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312433991  207 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEF--GDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 278
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 184-382 7.77e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.47  E-value: 7.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 184 RASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFD 263
Cdd:COG3914   16 ALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 264 VAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPA 343
Cdd:COG3914   96 EALALYRRALALNPD------NAEALFNLGNLLLALGRLEEALAALRRALALNPDFAE------AYLNLGEALRRLGRLE 163

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 312433991 344 QALTFAKKHLQIsqeigdRNGELTARMNIAHLQLALGRL 382
Cdd:COG3914  164 EAIAALRRALEL------DPDNAEALNNLGNALQDLGRL 196
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-285 8.47e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.47  E-value: 8.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991   2 ASPAPPVAEELPGPASRRLYSRMEASCLELALEGERLCKAGDFKAGVAFFEAAvqvgtEDLKTLSAIYSQLGNAYFYLKE 81
Cdd:COG3914   19 AAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAA-----AALLLLAALLELAALLLQALGR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  82 YARALQFHKHDLLLARTigdrmgEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARALYNIGNVYHAKGK 161
Cdd:COG3914   94 YEEALALYRRALALNPD------NAEALFNLGNLLLALGRLEEALAALRRALALNPDF------AEAYLNLGEALRRLGR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 162 qlswnaaqdpghlppdvretLHRASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFgd 241
Cdd:COG3914  162 --------------------LEEAIAALRRALEL------DPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDN-- 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 312433991 242 kaaeRRAYSNLgnahIFLGRFDVAAEHYKKTLQLSRQLRDQAVE 285
Cdd:COG3914  214 ----ADAHSNL----LFALRQACDWEVYDRFEELLAALARGPSE 249
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 111-382 1.59e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.28  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 111 NLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARALYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYE 190
Cdd:COG2956   47 ALGNLYRRRGEYDRAIRIHQKLLERDPDR------AEALLELAQDYLKAGL--------------------LDRAEELLE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 191 RnlsLVKELGDRAaqgRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEfgdkaaERRAYSNLGNAHIFLGRFDVAAEHYK 270
Cdd:COG2956  101 K---LLELDPDDA---EALRLLAEIYEQEGDWEKAIEVLERLLKLGPE------NAHAYCELAELYLEQGDYDEAIEALE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 271 KTLQLSRQlrdqAVEAQacYSLGNTYTLLQDYERAAEYHLRhlVIAQELADRVGEGRacwsLGNAYVSMGSPAQALTFAK 350
Cdd:COG2956  169 KALKLDPD----CARAL--LLLAELYLEQGDYEEAIAALER--ALEQDPDYLPALPR----LAELYEKLGDPEEALELLR 236

                        250       260       270
                 ....*....|....*....|....*....|..
gi 312433991 351 KHLQisqeigdRNGELTARMNIAHLQLALGRL 382
Cdd:COG2956  237 KALE-------LDPSDDLLLALADLLERKEGL 261
COG3899 COG3899
Predicted ATPase [General function prediction only];
122-431 2.73e-08

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 57.18  E-value: 2.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  122 FDEAIVCCQRHLDIAQEQGDKVGEARALYNIGNVYHAKGKqlswnaaqdpghlPPDVRETLHRASEFYERNLSLVKELGD 201
Cdd:COG3899   721 YAEALRYLERALELLPPDPEEEYRLALLLELAEALYLAGR-------------FEEAEALLERALAARALAALAALRHGN 787

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  202 RAAQGRAYGNLGntHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRD 281
Cdd:COG3899   788 PPASARAYANLG--LLLLGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGD 865

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  282 QAVEAQACYSLGNTyTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGD 361
Cdd:COG3899   866 AALALLALAAAAAA-AAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAA 944

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  362 RNGELTARMNIAHLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDRGIPRAPSS 431
Cdd:COG3899   945 LAAAAAAAALAAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAA 1014
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 203-358 1.83e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.58  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 203 AAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQlrdq 282
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPE------AFALLGEILLQLGDLDEAIVLLHEALELDPD---- 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312433991 283 avEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQISQE 358
Cdd:COG4783   71 --EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE------AYLRLARAYRALGRPDEAIAALEKALELDPD 138
GoLoco pfam02188
GoLoco motif;
434-455 2.03e-07

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 47.03  E-value: 2.03e-07
                          10        20
                  ....*....|....*....|..
gi 312433991  434 ECFFDLLSKFQSSRMDDQRCPL 455
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
TPR_12 pfam13424
Tetratricopeptide repeat;
247-318 4.24e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 45.07  E-value: 4.24e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312433991  247 RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLR--DQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQE 318
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
35-161 4.69e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  35 GERLCKAGDFKAGVAFFEAAVQVGTEDlktlSAIYSQLGNAYFYLKEYARALQFHKHDLLLartigdRMGEAKASGNLGN 114
Cdd:COG0457   49 GLAYLRLGRYEEALADYEQALELDPDD----AEALNNLGLALQALGRYEEALEDYDKALEL------DPDDAEALYNLGL 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 312433991 115 TLKVLGRFDEAIVCCQRHLDIaqeqgdKVGEARALYNIGNVYHAKGK 161
Cdd:COG0457  119 ALLELGRYDEAIEAYERALEL------DPDDADALYNLGIALEKLGR 159
COG3899 COG3899
Predicted ATPase [General function prediction only];
174-428 7.74e-06

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 49.09  E-value: 7.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  174 LPPDVRETLH-RASEFYERNLSLVKEL------------GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFG 240
Cdd:COG3899   660 LPPEERRALHrRIARALEARGPEPLEErlfelahhlnraGERDRAARLLLRAARRALARGAYAEALRYLERALELLPPDP 739

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  241 DKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYT-----LLQDYERAAEYHLRHLVI 315
Cdd:COG3899   740 EEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYAnlgllLLGDYEEAYEFGELALAL 819

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  316 AQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDRNGELTARMNIAHLQLALGRLTSPAAAEKPDLAG 395
Cdd:COG3899   820 AERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAAALAAAAAAAARLLAA 899

                         250       260       270
                  ....*....|....*....|....*....|...
gi 312433991  396 YEAQGARPKRTQRLSAETWDLLRLPLDRGIPRA 428
Cdd:COG3899   900 AAAALAAAAAAAALAAAELARLAAAAAAAAALA 932
TPR_12 pfam13424
Tetratricopeptide repeat;
106-162 1.19e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.53  E-value: 1.19e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 312433991  106 AKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQ--GDKVGEARALYNIGNVYHAKGKQ 162
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRY 61
GoLoco pfam02188
GoLoco motif;
487-507 1.39e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.39e-05
                          10        20
                  ....*....|....*....|.
gi 312433991  487 EEFFDLIASSQSRRLDDQRAS 507
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco pfam02188
GoLoco motif;
569-590 1.43e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.43e-05
                          10        20
                  ....*....|....*....|..
gi 312433991  569 EDFFSLIQRVQAKRMDEQRVDL 590
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 433-455 1.47e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 41.72  E-value: 1.47e-05
                           10        20
                   ....*....|....*....|...
gi 312433991   433 EECFFDLLSKFQSSRMDDQRCPL 455
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 534-556 1.52e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 41.72  E-value: 1.52e-05
                           10        20
                   ....*....|....*....|...
gi 312433991   534 GDEFFNMLIKYQSSRIDDQRCPP 556
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco pfam02188
GoLoco motif;
535-555 1.56e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.64  E-value: 1.56e-05
                          10        20
                  ....*....|....*....|.
gi 312433991  535 DEFFNMLIKYQSSRIDDQRCP 555
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 486-508 3.04e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.95  E-value: 3.04e-05
                           10        20
                   ....*....|....*....|...
gi 312433991   486 TEEFFDLIASSQSRRLDDQRASV 508
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
TPR_12 pfam13424
Tetratricopeptide repeat;
146-238 5.05e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 5.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  146 ARALYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLVKEL--GDRAAQGRAYGNLGNTHYLLGNFT 223
Cdd:pfam13424   3 ATALNNLAAVLRRLGR--------------------YDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYE 62

                          90
                  ....*....|....*
gi 312433991  224 EATTFHKERLAIAKE 238
Cdd:pfam13424  63 EALELLERALALAEK 77
COG3899 COG3899
Predicted ATPase [General function prediction only];
29-428 7.30e-05

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 46.00  E-value: 7.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991   29 LELALE-GERLCKAGDFKAGVAFFEAAVQVGT-------EDLKTLSAIYSQLGNAYFYLKEYARALQFHKHDLLLARTIG 100
Cdd:COG3899   745 LALLLElAEALYLAGRFEEAEALLERALAARAlaalaalRHGNPPASARAYANLGLLLLGDYEEAYEFGELALALAERLG 824

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  101 DRMGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQGDKVGEARALYniGNVYHAKGKQLSWNAAQDPGHLPPDVRE 180
Cdd:COG3899   825 DRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALA--AAAAAAAAAAALAAAAAAAARLLAAAAA 902

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  181 TLHRASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLG 260
Cdd:COG3899   903 ALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALALAAAAAAAAAAALAAAAAAAAAA 982

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  261 RFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMG 340
Cdd:COG3899   983 AAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALLAALAAAAAAAAAAAAL 1062

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  341 SPAQALTFAKKHLQISQEIGDRNGELTARMNIAHLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLP 420
Cdd:COG3899  1063 AAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALAAALAALALAAAARAAAALLLLAAAL 1142


                  ....*...
gi 312433991  421 LDRGIPRA 428
Cdd:COG3899  1143 ALALAALL 1150
TPR_12 pfam13424
Tetratricopeptide repeat;
65-138 7.78e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.22  E-value: 7.78e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312433991   65 LSAIYSQLGNAYFYLKEYARALQFHKHDLLLARTI--GDRMGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQE 138
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 40-398 9.13e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 45.68  E-value: 9.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  40 KAGDFKAGVAFFEAAVQV-----GTEDLKTLSAiYSQLGNAYFYLKEYARALQfhkhdllLARTIGDRMGEAK------- 107
Cdd:NF040586 404 LRGDYESARDLAERALERwrerlGPDDRQTLRL-RFHLANALRSLGRYEEARE-------LDEDTLERQRRVLglgedhp 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 108 ----ASGNLGNTLKVLGRFDEAivccqrhLDIAQEqgdkvgearalynignvyhakgkqlSWNAAQDPghLPPDVRETLh 183
Cdd:NF040586 476 htlmTAGGLGADLRALGRFREA-------LELDEE-------------------------TLERHRRV--FGEDHPRTL- 520

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 184 rasefyernlslvkelgdraaqgRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFG--DKAAERRAYSNLGNAHIFLGR 261
Cdd:NF040586 521 -----------------------RAANNLAVSLRLLGDYREALELDREVLRRRRRVLgpDHPRTLLSANNLARDLRELGR 577

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 262 FDVAAEHYKKTLQLSRQLR---DQAVEAQACYSLGNTYTLLQDYERAAEYHLRhlvIAQELADRVGEG----RAC-WSLG 333
Cdd:NF040586 578 YAEALDLLEEALERYREVLggpDHPDTLRAAKSLAVALRRAGRLEEALELAED---TYERYRRRFGPDhpdtLAAaLSLA 654

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 334 NAYVSMGSPAQALTFAKKHLQISQEigdRNGE-----LTARMNIAHLQLALGRltsPAAAEKPDLAGYEA 398
Cdd:NF040586 655 NDLRALGDADEARELAREVLDRYRR---VLGEdhpftLACRNNLAVLLRALGD---PEEARELAEAALEG 718
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 568-590 9.48e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 39.41  E-value: 9.48e-05
                           10        20
                   ....*....|....*....|...
gi 312433991   568 DEDFFSLIQRVQAKRMDEQRVDL 590
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 243-382 1.47e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 243 AAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYhlrhlvIAQELADR 322
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPD------NPEAFALLGEILLQLGDLDEAIVL------LHEALELD 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 323 VGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDrngeltARMNIAHLQLALGRL 382
Cdd:COG4783   69 PDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE------AYLRLARAYRALGRP 122
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 30-161 2.35e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.72  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  30 ELALEGERLCKAGDFKAGVAFFEAAVQVGTEDLktlsAIYSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKAS 109
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALELDPDNP----EAFALLGEILLQLGDLDEAIVLLHEALELDP------DEPEAR 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 312433991 110 GNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARALYNIGNVYHAKGK 161
Cdd:COG4783   76 LNLGLALLKAGDYDEALALLEKALKLDPEH------PEAYLRLARAYRALGR 121
TPR_7 pfam13176
Tetratricopeptide repeat;
288-322 2.42e-04

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 38.68  E-value: 2.42e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 312433991  288 ACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADR 322
Cdd:pfam13176   1 ALLNLGRIYRKLGDYDEAISLYEQALALAKDPYDR 35
TPR_12 pfam13424
Tetratricopeptide repeat;
290-358 3.23e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 3.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312433991  290 YSLGNTYTLLQDYERAAEYHLRHLVIAQEL--ADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQE 358
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 199-316 3.25e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 199 LGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 278
Cdd:COG5010   47 RDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPE------LYYNLALLYSRSGDKDEAKEYYEKALALSPD 120

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 312433991 279 lrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIA 316
Cdd:COG5010  121 ------NPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
TPR_1 pfam00515
Tetratricopeptide repeat;
106-138 5.61e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.40  E-value: 5.61e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 312433991  106 AKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQE 138
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 106-138 7.11e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.43  E-value: 7.11e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 312433991   106 AKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQE 138
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
145-328 8.79e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.05  E-value: 8.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 145 EARALYNIGNVYHAKGKqlsWNAAqdpghlppdvRETLHRAsefyernLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTE 224
Cdd:COG4785   72 LAQLYYERGVAYDSLGD---YDLA----------IADFDQA-------LEL------DPDLAEAYNNRGLAYLLLGDYDA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 225 ATtfhkERLAIAKEFGDKAAErrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYslgntytLLQDYER 304
Cdd:COG4785  126 AL----EDFDRALELDPDYAY--AYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAE-------RKLDPEK 192

                        170       180
                 ....*....|....*....|....
gi 312433991 305 AAEYHLRHLVIAQELADRVGEGRA 328
Cdd:COG4785  193 ALALLLEDWATAYLLQGDTEEARE 216
TPR_1 pfam00515
Tetratricopeptide repeat;
247-275 1.40e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.63  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|....*....
gi 312433991  247 RAYSNLGNAHIFLGRFDVAAEHYKKTLQL 275
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALEL 30
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
184-281 1.52e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 184 RASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTFHKerlAIAKEFGDKaaerRAYSNLGNAHIFLGRFD 263
Cdd:COG3063   10 EAEEYYEKALEL------DPDNADALNNLGLLLLEQGRYDEAIALEK---ALKLDPNNA----EALLNLAELLLELGDYD 76

                         90
                 ....*....|....*...
gi 312433991 264 VAAEHYKKTLQLSRQLRD 281
Cdd:COG3063   77 EALAYLERALELDPSALR 94
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 247-356 1.90e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.83  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 247 RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQEladrvgEG 326
Cdd:COG4235   18 EGWLLLGRAYLRLGRYDEALAAYEKALRLDPD------NADALLDLAEALLAAGDTEEAEELLERALALDPD------NP 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 312433991 327 RACWSLGNAYVSMGSPAQALTFAKKHLQIS 356
Cdd:COG4235   86 EALYLLGLAAFQQGDYAEAIAAWQKLLALL 115
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
35-205 2.24e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  35 GERLCKAGDFKAGVAFFEAAVQVGTEDlktlSAIYSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKASGNLGN 114
Cdd:COG0457   83 GLALQALGRYEEALEDYDKALELDPDD----AEALYNLGLALLELGRYDEAIEAYERALELDP------DDADALYNLGI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 115 TLKVLGRFDEAIVCCQRHLDIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAAQDPGHLPPDVRETLHRASEFYERNLS 194
Cdd:COG0457  153 ALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLA 232

                        170
                 ....*....|.
gi 312433991 195 LVKELGDRAAQ 205
Cdd:COG0457  233 LRLAALALYQY 243
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
255-358 3.12e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 255 AHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHlRHLVIAQELADrvgegrACWSLGN 334
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPD------NADALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAE------ALLNLAE 67

                         90       100
                 ....*....|....*....|....
gi 312433991 335 AYVSMGSPAQALTFAKKHLQISQE 358
Cdd:COG3063   68 LLLELGDYDEALAYLERALELDPS 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 195-308 3.22e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 3.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 195 LVKELGDRAAQ----GRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYK 270
Cdd:COG4235    2 AIARLRQALAAnpndAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNAD------ALLDLAEALLAAGDTEEAEELLE 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 312433991 271 KTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEY 308
Cdd:COG4235   76 RALALDPD------NPEALYLLGLAAFQQGDYAEAIAA 107
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 220-382 3.57e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 39.99  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  220 GNFTEATTFHKERLAIAKEfgDKAAER-RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTl 298
Cdd:pfam17874  15 GDAERALELAEQALALLPE--DDLLARgLATFVLGEAYLCLGDLDAALQAMREAEALARRADSPHVTLWALLQQGEILR- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  299 LQDYERAAEYHLRHlviAQELADRVGE------GRACWSLGNAYVSMGSPAQALTFAKKHLQISQEiGDRNGELTARMNI 372
Cdd:pfam17874  92 AQGRLHQALETYQQ---ALQLARDHGLqhlplhGFLLVGLADLLYEWNDLEEAEQHAQQGIQLGRQ-WEPDAAVDAYVLL 167

                         170
                  ....*....|
gi 312433991  373 AHLQLALGRL 382
Cdd:pfam17874 168 ARIALAQGEL 177
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
216-308 4.94e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 216 HYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDvAAEHYKKTLQLSRQlrdqavEAQACYSLGNT 295
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNAD------ALNNLGLLLLEQGRYD-EAIALEKALKLDPN------NAEALLNLAEL 68

                         90
                 ....*....|...
gi 312433991 296 YTLLQDYERAAEY 308
Cdd:COG3063   69 LLELGDYDEALAY 81
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 255-351 6.16e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.89  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 255 AHIFLGRFDVAAEHYKktlQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRhlvIAQELADRVGEGRACWSLGN 334
Cdd:COG1729    2 ALLKAGDYDEAIAAFK---AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEK---LLKRYPDSPKAPDALLKLGL 75

                         90
                 ....*....|....*..
gi 312433991 335 AYVSMGSPAQALTFAKK 351
Cdd:COG1729   76 SYLELGDYDKARATLEE 92
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 194-274 8.00e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.51  E-value: 8.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991 194 SLVKELGDRAAQGRAYGNLGNTHYLLGNFTEA-TTFhkerLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKT 272
Cdd:COG1729   18 AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAaEAF----EKLLKRYPDSPKAPDALLKLGLSYLELGDYDKARATLEEL 93


                 ..
gi 312433991 273 LQ 274
Cdd:COG1729   94 IK 95
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
40-138 8.21e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.92  E-value: 8.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312433991  40 KAGDFKAGVAFFEAAVQVGTEDlktlSAIYSQLGNAYFYLKEYARALQFHKhdlllARTIGDRMGEAKAsgNLGNTLKVL 119
Cdd:COG3063    4 KLGDLEEAEEYYEKALELDPDN----ADALNNLGLLLLEQGRYDEAIALEK-----ALKLDPNNAEALL--NLAELLLEL 72

                         90
                 ....*....|....*....
gi 312433991 120 GRFDEAIVCCQRHLDIAQE 138
Cdd:COG3063   73 GDYDEALAYLERALELDPS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH