NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|312836769|ref|NP_001186111|]
View 

calcium-transporting ATPase type 2C member 1 isoform 2c [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
73-891 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1537.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  73 QFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVP 152
Cdd:cd02085   25 QFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNKLVPPECHCLRDGKLEHFLARELVP 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 153 GDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGE 232
Cdd:cd02085  105 GDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASNGDLTTRSNIAFMGTLVRCGHGKGIVIGTGE 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 233 NSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVT 312
Cdd:cd02085  185 NSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLLEMFTIGVSLAVAAIPEGLPIVVTVT 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 313 LALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfy 392
Cdd:cd02085  265 LALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT------------------------------ 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 393 npavsriveaGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEIC 472
Cdd:cd02085  315 ----------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEIPFSSEQKWMAVKCIPKYNSDNEEIY 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 473 FMKGAYEQVIKYCTTYQSKGQT-LTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAV 551
Cdd:cd02085  385 FMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGPELGDLTFLGLVGINDPPRPGVREAI 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 552 TTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNG 631
Cdd:cd02085  465 QILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVVRKVTVFYRASPRHKLKIVKALQKSG 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 632 SVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTL 711
Cdd:cd02085  545 AVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAALSL 624
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 712 ISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWR 791
Cdd:cd02085  625 IALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSAAIIVSGTLWVFWK 704
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 792 ELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSIL 871
Cdd:cd02085  705 EMSDDNVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSLIGQLLVIYFPPLQRVFQTEALGLL 784
                        810       820
                 ....*....|....*....|
gi 312836769 872 DLLFLLGLTSSVCIVAEIIK 891
Cdd:cd02085  785 DLLFLLGLTSSVFIVSELRK 804
Cation_ATPase_N super family cl02930
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
13-89 6.37e-04

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


The actual alignment was detected with superfamily member pfam00690:

Pssm-ID: 445964 [Multi-domain]  Cd Length: 69  Bit Score: 39.07  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   13 FKKYPLHAIRRYLST-----LRNQRAEEQVARFqkipnGENEtmipvltskkaseLPVSEVASIL-----QFKNPLIMLL 82
Cdd:pfam00690   1 WHALSVEEVLKKLGTdlekgLTEAEAEKRLKKY-----GPNE-------------LPEKKPKSLWklflrQFKDPLIIIL 62

                  ....*..
gi 312836769   83 LASAVIS 89
Cdd:pfam00690  63 LIAAIVS 69
 
Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
73-891 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1537.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  73 QFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVP 152
Cdd:cd02085   25 QFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNKLVPPECHCLRDGKLEHFLARELVP 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 153 GDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGE 232
Cdd:cd02085  105 GDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASNGDLTTRSNIAFMGTLVRCGHGKGIVIGTGE 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 233 NSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVT 312
Cdd:cd02085  185 NSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLLEMFTIGVSLAVAAIPEGLPIVVTVT 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 313 LALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfy 392
Cdd:cd02085  265 LALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT------------------------------ 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 393 npavsriveaGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEIC 472
Cdd:cd02085  315 ----------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEIPFSSEQKWMAVKCIPKYNSDNEEIY 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 473 FMKGAYEQVIKYCTTYQSKGQT-LTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAV 551
Cdd:cd02085  385 FMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGPELGDLTFLGLVGINDPPRPGVREAI 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 552 TTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNG 631
Cdd:cd02085  465 QILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVVRKVTVFYRASPRHKLKIVKALQKSG 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 632 SVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTL 711
Cdd:cd02085  545 AVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAALSL 624
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 712 ISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWR 791
Cdd:cd02085  625 IALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSAAIIVSGTLWVFWK 704
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 792 ELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSIL 871
Cdd:cd02085  705 EMSDDNVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSLIGQLLVIYFPPLQRVFQTEALGLL 784
                        810       820
                 ....*....|....*....|
gi 312836769 872 DLLFLLGLTSSVCIVAEIIK 891
Cdd:cd02085  785 DLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
57-898 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 1498.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   57 SKKASELPVSEVASILQ-----------------------------------------FKNPLIMLLLASAVISVLMHQF 95
Cdd:TIGR01522   1 SKQYCELSVEETCSKLQtdlqnglnssqeashrrafhgwnefdveedeslwkkflsqfVKNPLILLLIASAVISVFMGNI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   96 DDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVD 175
Cdd:TIGR01522  81 DDAVSITLAILIVVTVGFVQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADLRIVEAVD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  176 LSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQK 255
Cdd:TIGR01522 161 LSIDESNLTGETTPVSKVTAPIPAATNGDLAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTPLQK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  256 SMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 335
Cdd:TIGR01522 241 SMDLLGKQLSLVSFGVIGVICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPSVET 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  336 LGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNN- 414
Cdd:TIGR01522 321 LGSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLNAVSLNQFGEVIVDGDVLHGFYTVAVSRILEAGNLCNNAKFRNEa 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  415 -TLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRtqQDRPEICFMKGAYEQVIKYCTTYQSK-G 492
Cdd:TIGR01522 401 dTLLGNPTDVALIELLMKFGLDDLRETYIRVAEVPFSSERKWMAVKCVHR--QDRSEMCFMKGAYEQVLKYCTYYQKKdG 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  493 QTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETA 572
Cdd:TIGR01522 479 KTLTLTQQQRDVIQEEAAEMASAGLRVIAFASGPEKGQLTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETA 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  573 VAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADI 652
Cdd:TIGR01522 559 VSIARRLGMPSKTSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADI 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  653 GVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWI 732
Cdd:TIGR01522 639 GVAMGQTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWI 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  733 NIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVF 812
Cdd:TIGR01522 719 NILMDGPPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTLFVFVREMQDGVITARDTTMTFTCFVF 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  813 FDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKK 892
Cdd:TIGR01522 799 FDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEALSIKDLLFLLLITSSVCIVDEIRKK 878

                  ....*.
gi 312836769  893 VERSRE 898
Cdd:TIGR01522 879 VERSRE 884
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
23-865 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 223550 [Multi-domain]  Cd Length: 917  Bit Score: 776.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  23 RYLSTLRNQRAEEQVARFQKIpNGENEtmipvLTSKKASELpvsEVASILQFKNPLIMLLLASAVISVLMHQF----DDA 98
Cdd:COG0474   36 ELFTSPTTGLSEEEVKRRLKK-YGPNE-----LPEEKKRSL---LKKFLRQFKDPFIILLLVAALLSAFVGDWvdagVDA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  99 VSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSI 178
Cdd:COG0474  107 IVILLVVVINALLGFVQEYRAEKALEALKKMSSPKAKVLRDGKFVEIPASELVPGDIVLLEAGDVVPADLRLLESSDLEV 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 179 DESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMD 258
Cdd:COG0474  187 DESALTGESLPVEKQALPLTKSDAPLGLDRDNMLFSGTTVVSGRAKGIVVATGFETEFGKIARLLPTKKEVKTPLQRKLN 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 259 LLGKQLSFYSFGIIGIIMLVGWLLGK-DILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLG 337
Cdd:COG0474  267 KLGKFLLVLALVLGALVFVVGLFRGGnGLLESFLTALALAVAAVPEGLPAVVTIALALGAQRMAKDNAIVRSLNAIETLG 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 338 CCNVICSDKTGTLTKNEMTVTHIFTSDGLHaevtgvgynqfgevivDGDVVHGFYNPAVSRIVEAGCVCNDAVI--RNNT 415
Cdd:COG0474  347 SVDVICSDKTGTLTQNKMTVKKIYINGGGK----------------DIDDKDLKDSPALLRFLLAAALCNSVTPekNGWY 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 416 LMGKPTEGALIALAMKMG----LDGLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPeICFMKGAYEQVIKYCTTYqsk 491
Cdd:COG0474  411 QAGDPTEGALVEFAEKLGfsldLSGLEVEYPILAEIPFDSERKRMSV--IVKTDEGKY-ILFVKGAPEVILERCKSI--- 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 492 GQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGP-----------ELGQ-LTFLGLVGIIDPPRTGVKEAVTTLIASGV 559
Cdd:COG0474  485 GELEPLTEEGLRTLEEAVKELASEGLRVLAVAYKKldraekddevdEIESdLVFLGLTGIEDPPREDVKEAIEELREAGI 564
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 560 SIKMITGDSQETAVAIASRLGLYSKTSQS--VSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMT 637
Cdd:COG0474  565 KVWMITGDHVETAIAIAKECGIEAEAESAlvIDGAELDALSDEELAELVEELSVFARVSPEQKARIVEALQKSGHVVAMT 644
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 638 GDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATL 717
Cdd:COG0474  645 GDGVNDAPALKAADVGIAMGGEGTDAAKEAADIVLLDDNFATIVLAVVEGRRVYVNIKKFILYLLSKNVGEVLTLLIYSL 724
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 718 MNFPN-PLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILK-ILVSSIIIVCGTLFVF------ 789
Cdd:COG0474  725 FNLFFlPLTPLQLLWINLLTDSLPALALGVEDPESDVMKRPPRGPEEGLFNRKIFWRfILIIGLLSAILFILTFllyllg 804
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312836769 790 --WRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQ-KVFQT 865
Cdd:COG0474  805 fiANTLGLDLFQALLQTTAFTVLVLIQLLLTLAVRSRGRPFLSSLLFSNKYLWLALLVIIILQLLIIFLPPLNlKIFQP 883
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
74-789 4.86e-98

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 328.57  E-value: 4.86e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  74 FKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR--EGKLEHTLA---- 147
Cdd:PRK10517 101 YRNPFNILLTILGAISYATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRviNDKGENGWLeipi 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 148 RDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLaSRSNIAFMGTLVRCGKAKGVV 227
Cdd:PRK10517 181 DQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFATTRQPEHSNPL-ECDTLCFMGTNVVSGTAQAVV 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 228 IGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV-GWLLGkDILEMFTISVSLAVAAIPEGLP 306
Cdd:PRK10517 260 IATGANTWFGQLAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLInGYTKG-DWWEAALFALSVAVGLTPEMLP 338
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 307 IVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEmtvthIFTSDglHAEVtgvgynqFGEviVDGD 386
Cdd:PRK10517 339 MIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDK-----IVLEN--HTDI-------SGK--TSER 402
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 387 VVH-----GFYNPAVSRIVEAgcvcndAVIrnntlmgkptEGALIALAMKMGldglqQDYIRKAEYPFSSEQKWMAVkcV 461
Cdd:PRK10517 403 VLHsawlnSHYQTGLKNLLDT------AVL----------EGVDEESARSLA-----SRWQKIDEIPFDFERRRMSV--V 459
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 462 HRTQQDRPE-ICfmKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGP-----------ELG 529
Cdd:PRK10517 460 VAENTEHHQlIC--KGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYlparegdyqraDES 537
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 530 QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKV 609
Cdd:PRK10517 538 DLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--DAGEVLIGSDIETLSDDELANLAERT 615
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 610 AVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKG 689
Cdd:PRK10517 616 TLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISV-DGAVDIAREAADIILLEKSLMVLEEGVIEGRR 694
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 690 IYNNIKNFVRFQLSTSIAAL--TLISLATLmnfPN-PLNAMQILWINIIMDgpPAQ-SLGVEPVDKDVIRKPPRnWKDSI 765
Cdd:PRK10517 695 TFANMLKYIKMTASSNFGNVfsVLVASAFL---PFlPMLPLHLLIQNLLYD--VSQvAIPFDNVDDEQIQKPQR-WNPAD 768
                        730       740
                 ....*....|....*....|....*..
gi 312836769 766 LTKNLILKILVSSII-IVCGTL--FVF 789
Cdd:PRK10517 769 LGRFMVFFGPISSIFdILTFCLmwWVF 795
E1-E2_ATPase pfam00122
E1-E2 ATPase;
128-323 2.15e-49

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 172.76  E-value: 2.15e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  128 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaatngdlaS 207
Cdd:pfam00122   1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSA-SVDESLLTGESLPVEK--------------K 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  208 RSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIL 287
Cdd:pfam00122  66 KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPL 145
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 312836769  288 EMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 323
Cdd:pfam00122 146 RALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
13-89 6.37e-04

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 425824 [Multi-domain]  Cd Length: 69  Bit Score: 39.07  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   13 FKKYPLHAIRRYLST-----LRNQRAEEQVARFqkipnGENEtmipvltskkaseLPVSEVASIL-----QFKNPLIMLL 82
Cdd:pfam00690   1 WHALSVEEVLKKLGTdlekgLTEAEAEKRLKKY-----GPNE-------------LPEKKPKSLWklflrQFKDPLIIIL 62

                  ....*..
gi 312836769   83 LASAVIS 89
Cdd:pfam00690  63 LIAAIVS 69
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
17-92 2.82e-03

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 37.18  E-value: 2.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769    17 PLHAIRRYLST-----LRNQRAEEQVARFqkipnGENEtmipvLTSKKaSELPVSEVasILQFKNPLIMLLLASAVISVL 91
Cdd:smart00831   8 SLEEVLERLQTdlekgLSSEEAARRLERY-----GPNE-----LPPPK-KTSPLLRF--LRQFHNPLIYILLAAAVLSAL 74

                   .
gi 312836769    92 M 92
Cdd:smart00831  75 L 75
 
Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
73-891 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1537.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  73 QFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVP 152
Cdd:cd02085   25 QFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNKLVPPECHCLRDGKLEHFLARELVP 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 153 GDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGE 232
Cdd:cd02085  105 GDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASNGDLTTRSNIAFMGTLVRCGHGKGIVIGTGE 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 233 NSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVT 312
Cdd:cd02085  185 NSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLLEMFTIGVSLAVAAIPEGLPIVVTVT 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 313 LALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfy 392
Cdd:cd02085  265 LALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT------------------------------ 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 393 npavsriveaGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEIC 472
Cdd:cd02085  315 ----------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEIPFSSEQKWMAVKCIPKYNSDNEEIY 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 473 FMKGAYEQVIKYCTTYQSKGQT-LTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAV 551
Cdd:cd02085  385 FMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGPELGDLTFLGLVGINDPPRPGVREAI 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 552 TTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNG 631
Cdd:cd02085  465 QILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVVRKVTVFYRASPRHKLKIVKALQKSG 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 632 SVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTL 711
Cdd:cd02085  545 AVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAALSL 624
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 712 ISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWR 791
Cdd:cd02085  625 IALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSAAIIVSGTLWVFWK 704
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 792 ELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSIL 871
Cdd:cd02085  705 EMSDDNVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSLIGQLLVIYFPPLQRVFQTEALGLL 784
                        810       820
                 ....*....|....*....|
gi 312836769 872 DLLFLLGLTSSVCIVAEIIK 891
Cdd:cd02085  785 DLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
57-898 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 1498.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   57 SKKASELPVSEVASILQ-----------------------------------------FKNPLIMLLLASAVISVLMHQF 95
Cdd:TIGR01522   1 SKQYCELSVEETCSKLQtdlqnglnssqeashrrafhgwnefdveedeslwkkflsqfVKNPLILLLIASAVISVFMGNI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   96 DDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVD 175
Cdd:TIGR01522  81 DDAVSITLAILIVVTVGFVQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADLRIVEAVD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  176 LSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQK 255
Cdd:TIGR01522 161 LSIDESNLTGETTPVSKVTAPIPAATNGDLAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTPLQK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  256 SMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 335
Cdd:TIGR01522 241 SMDLLGKQLSLVSFGVIGVICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPSVET 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  336 LGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNN- 414
Cdd:TIGR01522 321 LGSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLNAVSLNQFGEVIVDGDVLHGFYTVAVSRILEAGNLCNNAKFRNEa 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  415 -TLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRtqQDRPEICFMKGAYEQVIKYCTTYQSK-G 492
Cdd:TIGR01522 401 dTLLGNPTDVALIELLMKFGLDDLRETYIRVAEVPFSSERKWMAVKCVHR--QDRSEMCFMKGAYEQVLKYCTYYQKKdG 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  493 QTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETA 572
Cdd:TIGR01522 479 KTLTLTQQQRDVIQEEAAEMASAGLRVIAFASGPEKGQLTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETA 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  573 VAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADI 652
Cdd:TIGR01522 559 VSIARRLGMPSKTSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADI 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  653 GVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWI 732
Cdd:TIGR01522 639 GVAMGQTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWI 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  733 NIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVF 812
Cdd:TIGR01522 719 NILMDGPPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTLFVFVREMQDGVITARDTTMTFTCFVF 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  813 FDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKK 892
Cdd:TIGR01522 799 FDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEALSIKDLLFLLLITSSVCIVDEIRKK 878

                  ....*.
gi 312836769  893 VERSRE 898
Cdd:TIGR01522 879 VERSRE 884
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
23-865 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 223550 [Multi-domain]  Cd Length: 917  Bit Score: 776.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  23 RYLSTLRNQRAEEQVARFQKIpNGENEtmipvLTSKKASELpvsEVASILQFKNPLIMLLLASAVISVLMHQF----DDA 98
Cdd:COG0474   36 ELFTSPTTGLSEEEVKRRLKK-YGPNE-----LPEEKKRSL---LKKFLRQFKDPFIILLLVAALLSAFVGDWvdagVDA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  99 VSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSI 178
Cdd:COG0474  107 IVILLVVVINALLGFVQEYRAEKALEALKKMSSPKAKVLRDGKFVEIPASELVPGDIVLLEAGDVVPADLRLLESSDLEV 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 179 DESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMD 258
Cdd:COG0474  187 DESALTGESLPVEKQALPLTKSDAPLGLDRDNMLFSGTTVVSGRAKGIVVATGFETEFGKIARLLPTKKEVKTPLQRKLN 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 259 LLGKQLSFYSFGIIGIIMLVGWLLGK-DILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLG 337
Cdd:COG0474  267 KLGKFLLVLALVLGALVFVVGLFRGGnGLLESFLTALALAVAAVPEGLPAVVTIALALGAQRMAKDNAIVRSLNAIETLG 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 338 CCNVICSDKTGTLTKNEMTVTHIFTSDGLHaevtgvgynqfgevivDGDVVHGFYNPAVSRIVEAGCVCNDAVI--RNNT 415
Cdd:COG0474  347 SVDVICSDKTGTLTQNKMTVKKIYINGGGK----------------DIDDKDLKDSPALLRFLLAAALCNSVTPekNGWY 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 416 LMGKPTEGALIALAMKMG----LDGLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPeICFMKGAYEQVIKYCTTYqsk 491
Cdd:COG0474  411 QAGDPTEGALVEFAEKLGfsldLSGLEVEYPILAEIPFDSERKRMSV--IVKTDEGKY-ILFVKGAPEVILERCKSI--- 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 492 GQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGP-----------ELGQ-LTFLGLVGIIDPPRTGVKEAVTTLIASGV 559
Cdd:COG0474  485 GELEPLTEEGLRTLEEAVKELASEGLRVLAVAYKKldraekddevdEIESdLVFLGLTGIEDPPREDVKEAIEELREAGI 564
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 560 SIKMITGDSQETAVAIASRLGLYSKTSQS--VSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMT 637
Cdd:COG0474  565 KVWMITGDHVETAIAIAKECGIEAEAESAlvIDGAELDALSDEELAELVEELSVFARVSPEQKARIVEALQKSGHVVAMT 644
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 638 GDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATL 717
Cdd:COG0474  645 GDGVNDAPALKAADVGIAMGGEGTDAAKEAADIVLLDDNFATIVLAVVEGRRVYVNIKKFILYLLSKNVGEVLTLLIYSL 724
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 718 MNFPN-PLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILK-ILVSSIIIVCGTLFVF------ 789
Cdd:COG0474  725 FNLFFlPLTPLQLLWINLLTDSLPALALGVEDPESDVMKRPPRGPEEGLFNRKIFWRfILIIGLLSAILFILTFllyllg 804
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312836769 790 --WRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQ-KVFQT 865
Cdd:COG0474  805 fiANTLGLDLFQALLQTTAFTVLVLIQLLLTLAVRSRGRPFLSSLLFSNKYLWLALLVIIILQLLIIFLPPLNlKIFQP 883
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
71-891 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 747.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  71 ILQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKlEHTL-ARD 149
Cdd:cd02080   32 LRQFNNPLIYILLAAAVVTAFLGHWVDAIVIFGVVLINAIIGYIQEGKAEKALAAIKNMLSPEATVLRDGK-KLTIdAEE 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 150 LVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNgdLASRSNIAFMGTLVRCGKAKGVVIG 229
Cdd:cd02080  111 LVPGDIVLLEAGDKVPADLRLIEARNLQIDESALTGESVPVEKQEGPLEEDTP--LGDRKNMAYSGTLVTAGSATGVVVA 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 230 TGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGK-DILEMFTISVSLAVAAIPEGLPIV 308
Cdd:cd02080  189 TGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLIVILVLAALTFVFGLLRGDySLVELFMAVVALAVAAIPEGLPAV 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 309 VTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvv 388
Cdd:cd02080  269 ITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVICSDKTGTLTRNEMTVQAIVT-------------------------- 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 389 hgfynpavsriveagcVCNDAVIRNN----TLMGKPTEGALIALAMKMGLD--GLQQDYIRKAEYPFSSEQKWMAVkcvh 462
Cdd:cd02080  323 ----------------LCNDAQLHQEdghwKITGDPTEGALLVLAAKAGLDpdRLASSYPRVDKIPFDSAYRYMAT---- 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 463 RTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLtqqQRDVYQQEKARMGSAGLRVLALASGPE------------LGQ 530
Cdd:cd02080  383 LHRDDGQRVIYVKGAPERLLDMCDQELLDGGVSPL---DRAYWEAEAEDLAKQGLRVLAFAYREVdseveeidhadlEGG 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 531 LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLySKTSQSVSGEEIDAMDVQQLSQIVPKVA 610
Cdd:cd02080  460 LTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGL-GDGKKVLTGAELDALDDEELAEAVDEVD 538
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 611 VFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGI 690
Cdd:cd02080  539 VFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRV 618
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 691 YNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNL 770
Cdd:cd02080  619 YDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPSEPLLSREL 698
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 771 ILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQ 850
Cdd:cd02080  699 IWRILLVSLLMLGGAFGLFLWALDRGYSLETARTMAVNTIVVAQIFYLFNCRSLHRSILKLGVFSNKILFLGIGALILLQ 778
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|.
gi 312836769 851 LLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIK 891
Cdd:cd02080  779 LAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFIVVELEK 819
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
34-759 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 734.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  34 EEQVARFQKIpNGENEtmipvLTSKKaselPVSEVASIL-QFKNPLIMLLLASAVISVLMHQFDDAVSItVAILIVVTV- 111
Cdd:cd02089    4 EEEAERRLAK-YGPNE-----LVEKK----KRSPWKKFLeQFKDFMVIVLLAAAVISGVLGEYVDAIVI-IAIVILNAVl 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 112 AFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCS 191
Cdd:cd02089   73 GFVQEYKAEKALAALKKMSAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLRVEESSLTGESEPVE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 192 KVTAPQPAATNGdLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGI 271
Cdd:cd02089  153 KDADTLLEEDVP-LGDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGKRLAIAALII 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 272 IGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 351
Cdd:cd02089  232 CALVFALGLLRGEDLLDMLLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKTGTLT 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 352 KNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndavirnntlMGKPTEGALIALAMK 431
Cdd:cd02089  312 QNKMTVEKIYT------------------------------------------------------IGDPTETALIRAARK 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 432 MGLD--GLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRpeICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEK 509
Cdd:cd02089  338 AGLDkeELEKKYPRIAEIPFDSERKLMTT--VHKDAGKY--IVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKILAVN 413
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 510 ARMGSAGLRVLALA----------SGPEL-GQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASR 578
Cdd:cd02089  414 EEFSEEALRVLAVAykpldedpteSSEDLeNDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKE 493
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 579 LGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQ 658
Cdd:cd02089  494 LGILEDGDKALTGEELDKMSDEELEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGI 573
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 659 TGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDG 738
Cdd:cd02089  574 TGTDVAKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDG 653
                        730       740
                 ....*....|....*....|.
gi 312836769 739 PPAQSLGVEPVDKDVIRKPPR 759
Cdd:cd02089  654 LPALALGVEPAEPDIMDRKPR 674
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
62-865 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 645.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  62 ELPVSEVASIL-----QFKNPLIMLLLASAVISVLMHQFDDAVSIT-------VAILIVV---TVAFVQEYRSEKSLEEL 126
Cdd:cd02083   36 ELPAEEGKSLWelvleQFDDLLVRILLLAAIISFVLALFEEGEEGVtafvepfVILLILIanaVVGVWQERNAEKAIEAL 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 127 SKLVPPECHCVREGK-LEHTLARDLVPGDTVCLSVGDRVPADLRL--FEAVDLSIDESSLTGETTPCSKVTA--PQPAAT 201
Cdd:cd02083  116 KEYEPEMAKVLRNGKgVQRIRARELVPGDIVEVAVGDKVPADIRIieIKSTTLRVDQSILTGESVSVIKHTDvvPDPRAV 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 202 NGDlasRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV--- 278
Cdd:cd02083  196 NQD---KKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEEEKTPLQQKLDEFGEQLSKVISVICVAVWAInig 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 279 ---------GWLLGKdiLEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGT 349
Cdd:cd02083  273 hfndpahggSWIKGA--IYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGT 350
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 350 LTKNEMTVTHIFTSDGLHA-------EVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNN------TL 416
Cdd:cd02083  351 LTTNQMSVSRMFILDKVEDdsslnefEVTGSTYAPEGEVFKNGKKVKAGQYDGLVELATICALCNDSSLDYNeskgvyEK 430
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 417 MGKPTEGALIALAMKMGLDG------------------LQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEIcFMKGAY 478
Cdd:cd02083  431 VGEATETALTVLVEKMNVFNtdksglskreranacndvIEQLWKKEFTLEFSRDRKSMSVYCSPTKASGGNKL-FVKGAP 509
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 479 EQVIKYCTTYQSKGQTLT-LTQQQRDVYQQEKARMGSAGLRVLALASGPELGQ------------------LTFLGLVGI 539
Cdd:cd02083  510 EGVLERCTHVRVGGGKVVpLTAAIKILILKKVWGYGTDTLRCLALATKDTPPKpedmdledstkfykyetdLTFVGVVGM 589
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 540 IDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQ----SVSGEEIDAMDVQQLSQIVPKVAVFYRA 615
Cdd:cd02083  590 LDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGEDEDttgkSYTGREFDDLSPEEQREACRRARLFSRV 669
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 616 SPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK 695
Cdd:cd02083  670 EPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMK 748
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 696 NFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKIL 775
Cdd:cd02083  749 QFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYL 828
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 776 VSSIIIVCGTLFVF--------------WRELR-----------------DNVITPRDTTMTFTCFVFFDMFNALSSRSQ 824
Cdd:cd02083  829 AIGTYVGLATVGAFawwfmyyeegpqvsFYQLThfmqcsswepnfegvdcEIFEDPHPMTMALSVLVVIEMFNALNSLSE 908
                        890       900       910       920
                 ....*....|....*....|....*....|....*....|.
gi 312836769 825 TKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQT 865
Cdd:cd02083  909 NQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQI 949
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
73-895 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 600.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   73 QFKNPLIMLLLASAVISVLMHQFDDAVSIT-------VAILIVV---TVAFVQEYRSEKSLEELSKLVPPECHCVREGKL 142
Cdd:TIGR01116   4 QFEDLLVRILLLAACVSFVLAWFEEGEETVtafvepfVILLILVanaIVGVWQERNAEKAIEALKEYESEHAKVLRDGRW 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  143 EHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAaTNGDLASRSNIAFMGTLVRCGK 222
Cdd:TIGR01116  84 SVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTESVPD-ERAVNQDKKNMLFSGTLVVAGK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  223 AKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSfysfGIIGIIMLVGWLLG--------------KDILE 288
Cdd:TIGR01116 163 ARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLS----KVIGLICILVWVINighfndpalgggwiQGAIY 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  289 MFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHA 368
Cdd:TIGR01116 239 YFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVALDPSSS 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  369 E-----VTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTL------MGKPTEGALIALAMKMGLDG- 436
Cdd:TIGR01116 319 SlnefcVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERkgvyekVGEATEAALKVLVEKMGLPAt 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  437 -----------------LQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDrpeiCFMKGAYEQVIKYCTTYQSK-GQTLTLT 498
Cdd:TIGR01116 399 kngvsskrrpalgcnsvWNDKFKKLATLEFSRDRKSMSVLCKPSTGNK----LFVKGAPEGVLERCTHILNGdGRAVPLT 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  499 QQQRDVYQQEKARMGSA-GLRVLALASGPELGQ------------------LTFLGLVGIIDPPRTGVKEAVTTLIASGV 559
Cdd:TIGR01116 475 DKMKNTILSVIKEMGTTkALRCLALAFKDIPDPreedllsdpanfeaiesdLTFIGVVGMLDPPRPEVADAIEKCRTAGI 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  560 SIKMITGDSQETAVAIASRLGLYSK----TSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVA 635
Cdd:TIGR01116 555 RVIMITGDNKETAEAICRRIGIFSPdedvTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELLQEQGEIVA 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  636 MTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLA 715
Cdd:TIGR01116 635 MTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIFLT 713
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  716 TLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSI--IIVCGTLFVFWREL 793
Cdd:TIGR01116 714 AALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVyvGLATVGGFVWWYLL 793
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  794 -------RDNVITPRD---------------TTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQL 851
Cdd:TIGR01116 794 thftgcdEDSFTTCPDfedpdcyvfegkqpaRTISLSVLVVIEMFNALNALSEDQSLLRMPPWVNKWLIGAICLSMALHF 873
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....
gi 312836769  852 LVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVER 895
Cdd:TIGR01116 874 LILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
62-768 7.41e-157

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 478.62  E-value: 7.41e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  62 ELPVSEVASILQ-----FKNPLIMLLLASAVISV---LMHQFDDA---------VSITVAILIVVTVAFVQEYRSEKSLE 124
Cdd:cd02081   12 EIPPKPPKSFLQlvweaLQDPTLIILLIAAIVSLglgFYTPFGEGegktgwiegVAILVAVILVVLVTAGNDYQKEKQFR 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 125 EL-SKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTapqpaatng 203
Cdd:cd02081   92 KLnSKKEDQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTGESDPIKKTP--------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 204 DLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFG---IIGIIMLVGW 280
Cdd:cd02081  163 DNQIPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVGLIvaaLTFIVLIIRF 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 281 LL--------------GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDK 346
Cdd:cd02081  243 IIdgfvndgksfsaedLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 347 TGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndavirnntlmGKPTEGALI 426
Cdd:cd02081  323 TGTLTQNRMTVVQGYI-------------------------------------------------------GNKTECALL 347
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 427 ALAMKMGLDglqQDYIRKAE-------YPFSSEQKWMAVkcVHRTQQDRPEIcFMKGAYEQVIKYCTTYQSK-GQTLTLT 498
Cdd:cd02081  348 GFVLELGGD---YRYREKRPeekvlkvYPFNSARKRMST--VVRLKDGGYRL-YVKGASEIVLKKCSYILNSdGEVVFLT 421
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 499 QQQRDVYQQEKARMGSAGLRVLALASG------------------PELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVS 560
Cdd:cd02081  422 SEKKEEIKRVIEPMASDSLRTIGLAYRdfspdeeptaerdwddeeDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGIT 501
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 561 IKMITGDSQETAVAIASRLGLYSKTSQSV----------SGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKN 630
Cdd:cd02081  502 VRMVTGDNINTARAIARECGILTEGEDGLvlegkefrelIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS 581
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 631 GSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALT 710
Cdd:cd02081  582 GEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVI 661
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 312836769 711 LISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTK 768
Cdd:cd02081  662 LAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISR 719
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
71-863 6.33e-156

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 482.73  E-value: 6.33e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  71 ILQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDL 150
Cdd:cd02086   32 LRQVANAMTLVLIIAMALSFAVKDWIEGGVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAHVIRSGKTETISSKDV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 151 VPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKvTAPQPAATNGDL--ASRSNIAFMGTLVRCGKAKGVVI 228
Cdd:cd02086  112 VPGDIVLLKVGDTVPADLRLIETKNFETDEALLTGESLPVIK-DAELVFGKEEDVsvGDRLNLAYSSSTVTKGRAKGIVV 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 229 GTGENSEFGEVFKMMQ----AEEAPK-------------------------TPLQKSMDLLGKQLSFYSFGIIGIIMLVG 279
Cdd:cd02086  191 ATGMNTEIGKIAKALRgkggLISRDRvkswlygtlivtwdavgrflgtnvgTPLQRKLSKLAYLLFFIAVILAIIVFAVN 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 280 WLLGKDilEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTH 359
Cdd:cd02086  271 KFDVDN--EVIIYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQ 348
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 360 IFTSDGLhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvCNDAVIRNN------TLMGKPTEGALIALAMKMG 433
Cdd:cd02086  349 VWIPAAL---------------------------------------CNIATVFKDeetdcwKAHGDPTEIALQVFATKFD 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 434 L------DGLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRD--VY 505
Cdd:cd02086  390 MgknaltKGGSAQFQHVAEFPFDSTVKRMSV--VYYNNQAGDYYAYMKGAVERVLECCSSMYGKDGIIPLDDEFRKtiIK 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 506 QQEKarMGSAGLRVLALAS--------------GPELGQ------LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMIT 565
Cdd:cd02086  468 NVES--LASQGLRVLAFASrsftkaqfnddqlkNITLSRadaesdLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLT 545
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 566 GDSQETAVAIASRLGL-------YSKT---------SQ--SVSGEEIDAMDVQQLsqivpkvaVFYRASPRHKMKIIKSL 627
Cdd:cd02086  546 GDHPGTAKAIAREVGIlppnsyhYSQEimdsmvmtaSQfdGLSDEEVDALPVLPL--------VIARCSPQTKVRMIEAL 617
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 628 QKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIA 707
Cdd:cd02086  618 HRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVA 697
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 708 --ALTLISLA-----TLMNFpnPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSII 780
Cdd:cd02086  698 qvILLLIGLAfkdedGLSVF--PLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDTFVYGTF 775
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 781 --IVCGTLFVF-----------------WRELRDNVITPRDTtmTFTCFVFFDMFNALSSRSQTKSVFEIG--------- 832
Cdd:cd02086  776 mgVLCLASFTLviygigngdlgsdcnesYNSSCEDVFRARAA--VFATLTWCALILAWEVVDMRRSFFNMHpdtdspvks 853
                        890       900       910
                 ....*....|....*....|....*....|....*.
gi 312836769 833 ----LCSNRMFCYAVLGSIMGQLLVIYFPPL-QKVF 863
Cdd:cd02086  854 ffktLWKNKFLFWSVVLGFVSVFPTLYIPVInDDVF 889
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
73-747 1.11e-141

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 436.08  E-value: 1.11e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  73 QFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVRE--GKLEHTLARDL 150
Cdd:cd07539   35 QLELPPVALLGLAAGASASTGGGVDAVLIVGVLTVNAVIGGVQRLRAERALAALLAQQQQPARVVRApaGRTQTVPAESL 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 151 VPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAAtngDLASRSNIAFMGTLVRCGKAKGVVIGT 230
Cdd:cd07539  115 VPGDVIELRAGEVVPADARLLEADDLEVDESALTGESLPVDKQVAPTPGA---PLADRACMLYEGTTVVSGQGRAVVVAT 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 231 GENSEFGEVFKMMQAEEApKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVT 310
Cdd:cd07539  192 GPHTEAGRAQSLVAPVET-ATGVQAQLRELTSQLLPLSLGGGAAVTGLGLLRGAPLRQAVADGVSLAVAAVPEGLPLVAT 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 311 VTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhg 390
Cdd:cd07539  271 LAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRLRVVQVRP---------------------------- 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 391 fynpavsriveagcvcndavirnntlmgkPTegalialamkmgldglqqdyirkAEYPFSSEQKWMAVkcVHRTQQDRPE 470
Cdd:cd07539  323 -----------------------------PL-----------------------AELPFESSRGYAAA--IGRTGGGIPL 348
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 471 ICfMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALA-----SGPEL------GQLTFLGLVGI 539
Cdd:cd07539  349 LA-VKGAPEVVLPRCDRRMTGGQVVPLTEADRQAIEEVNELLAGQGLRVLAVAyrtldAGTTHaveavvDDLELLGLLGL 427
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 540 IDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLySKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRH 619
Cdd:cd07539  428 ADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL-PRDAEVVTGAELDALDEEALTGLVADIDVFARVSPEQ 506
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 620 KMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVR 699
Cdd:cd07539  507 KLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVH 586
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*...
gi 312836769 700 FQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVE 747
Cdd:cd07539  587 VLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
10-867 2.05e-136

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 432.28  E-value: 2.05e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   10 FSYFKKYPLHAIRRYLST-------LRNQRAEEQVARFqkipnGENEtmipvltskkaseLPVSEVASILQ-----FKNP 77
Cdd:TIGR01517  37 PLYEKLGGAEGIATKLKTdlnegvrLSSSTLERREKVY-----GKNE-------------LPEKPPKSFLQivwaaLSDQ 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   78 LIMLLLASAVISVLMHQFD---------------DAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPP-ECHCVREGK 141
Cdd:TIGR01517  99 TLILLSVAAVVSLVLGLYVpsvgedkadtetgwiEGVAILVSVILVVLVTAVNDYKKELQFRQLNREKSAqKIAVIRGGQ 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  142 LEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPcSKVTAPQPaatngdlasrsNIAFMGTLVRCG 221
Cdd:TIGR01517 179 EQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP-IKKGPVQD-----------PFLLSGTVVNEG 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  222 KAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLL------------------G 283
Cdd:TIGR01517 247 SGRMLVTAVGVNSFGGKLMMELRQAGEEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRyvfriirgdgrfedteedA 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  284 KDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTS 363
Cdd:TIGR01517 327 QTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIG 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  364 dGLHAEVTGVGYNQFGEVIVDGDVVHGFY-NPAVSRIVEAGcvcndaviRNNTLMGKPTEGALIALAMKMGLDGLQQDYI 442
Cdd:TIGR01517 407 -EQRFNVRDEIVLRNLPAAVRNILVEGISlNSSSEEVVDRG--------GKRAFIGSKTECALLDFGLLLLLQSRDVQEV 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  443 RKAE-----YPFSSEQKWMAVKCVHRTQQDRpeiCFMKGAYEQVIKYCTTYQSKGQTLT-LTQQQRDVYQQEKARMGSAG 516
Cdd:TIGR01517 478 RAEEkvvkiYPFNSERKFMSVVVKHSGGKYR---EFRKGASEIVLKPCRKRLDSNGEATpISEDDKDRCADVIEPLASDA 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  517 LRVLALA-----------SGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKT 585
Cdd:TIGR01517 555 LRTICLAyrdfapeefprKDYPNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFG 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  586 SQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCK 665
Cdd:TIGR01517 635 GLAMEGKEFRSLVYEEMDPILPKLRVLARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAK 714
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  666 EAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLM--NFPNPLNAMQILWINIIMDGPPAQS 743
Cdd:TIGR01517 715 EASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCIssSHTSPLTAVQLLWVNLIMDTLAALA 794
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  744 LGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSI--IIVCGTLFVFWRELRD----NVITPRDT----TMTFTCFVFF 813
Cdd:TIGR01517 795 LATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGyqLVVTFILLFAGGSIFDvsgpDEITSHQQgelnTIVFNTFVLL 874
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 312836769  814 DMFNALSSRS--QTKSVFEiGLCSNRMFCYAVLGSIMGQLLVIYFppLQKVFQTES 867
Cdd:TIGR01517 875 QLFNEINARKlyEGMNVFE-GLFKNRIFVTIMGFTFGFQVIIVEF--GGSFFSTVS 927
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
55-773 2.92e-133

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 414.92  E-value: 2.92e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  55 LTSKKASELPVSEVASILQ-----FKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKL 129
Cdd:cd07538   11 LESGGKNELPQPKKRTLLAsildvLREPMFLLLLAAALIYFVLGDPREGLILLIFVVVIIAIEVVQEWRTERALEALKNL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 130 VPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGdlASRS 209
Cdd:cd07538   91 SSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLGVDESTLTGESVPVWKRIDGKAMSAPG--GWDK 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 210 NIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEM 289
Cdd:cd07538  169 NFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTGRLVKLCALAALVFCALIVAVYGVTRGDWIQA 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 290 FTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglhae 369
Cdd:cd07538  249 ILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGTLTKNQMEVVELTS------- 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 370 vtgvgynqfgevivdgdvvhgfynpavsriveagcvcndaVIRnntlmgkptegalialamkmgldglqqdyirkaEYPF 449
Cdd:cd07538  322 ----------------------------------------LVR---------------------------------EYPL 328
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 450 SSEQKWMAvkcvHRTQQDRPEICFMKGAYEQVIKYCTtyqskgqtltLTQQQRDVYQQEKARMGSAGLRVLALASG---- 525
Cdd:cd07538  329 RPELRMMG----QVWKRPEGAFAAAKGSPEAIIRLCR----------LNPDEKAAIEDAVSEMAGEGLRVLAVAACride 394
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 526 ----PELGQLTF--LGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLySKTSQSVSGEEIDAMDV 599
Cdd:cd07538  395 sflpDDLEDAVFifVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGL-DNTDNVITGQELDAMSD 473
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 600 QQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQT 679
Cdd:cd07538  474 EELAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSS 553
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 680 IMSAIEEGKGIYNNIKN---FVrFQLSTSIAALTLisLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRK 756
Cdd:cd07538  554 IVSTIRLGRRIYDNLKKaitYV-FAIHVPIAGLAL--LPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRR 630
                        730
                 ....*....|....*..
gi 312836769 757 PPRNWKDSILTKNLILK 773
Cdd:cd07538  631 PPRPPDEPLFGPRLVIK 647
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
80-771 1.33e-125

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 402.50  E-value: 1.33e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  80 MLLLASAVISVLMH----QFDDAVS-------ITVAILIVVT--VAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTL 146
Cdd:cd02608   41 MLLWIGAILCFLAYgiqaATEEEPSndnlylgIVLAAVVIVTgcFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQIN 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 147 ARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKvtapQPAATNGDLASRSNIAFMGTLVRCGKAKGV 226
Cdd:cd02608  121 AEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGESEPQTR----SPEFTHENPLETKNIAFFSTNCVEGTARGI 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 227 VIGTGENSEFGEVFKMMQAEEAPKTPLQKSMD-----------LLGkqlsfYSFGIIGIIMLVGWLlgkdilEMFTISVS 295
Cdd:cd02608  197 VINTGDRTVMGRIATLASGLEVGKTPIAREIEhfihiitgvavFLG-----VSFFILSLILGYTWL------EAVIFLIG 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 296 LAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFtsdglhaevtgvgy 375
Cdd:cd02608  266 IIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW-------------- 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 376 nqFGEVIVDGDVVHGFYN----------PAVSRIVeagCVCNDAVIRNN---------TLMGKPTEGALIALA-MKMG-L 434
Cdd:cd02608  332 --FDNQIHEADTTEDQSGasfdkssatwLALSRIA---GLCNRAEFKAGqenvpilkrDVNGDASESALLKCIeLSCGsV 406
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 435 DGLQQDYIRKAEYPFSSEQKWMAvkCVHRTQQDRPE--ICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARM 512
Cdd:cd02608  407 MEMRERNPKVAEIPFNSTNKYQL--SIHENEDPGDPryLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNAYLEL 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 513 GSAGLRVLALA-------SGPE------------LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAV 573
Cdd:cd02608  485 GGLGERVLGFChlylpddKFPEgfkfdtdevnfpTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAK 564
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 574 AIASRLGlysktsqsvsgeeidamdvqqlsqivpkVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIG 653
Cdd:cd02608  565 AIAKGVG----------------------------IIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIG 616
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 654 VAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWIN 733
Cdd:cd02608  617 VAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCID 696
                        730       740       750
                 ....*....|....*....|....*....|....*....
gi 312836769 734 IIMDGPPAQSLGVEPVDKDVIRKPPRN-WKDSILTKNLI 771
Cdd:cd02608  697 LGTDMVPAISLAYEKAESDIMKRQPRNpKTDKLVNERLI 735
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
28-789 4.70e-125

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 397.00  E-value: 4.70e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  28 LRNQRAEEQVARFqkipnGENEtmipVLTSKKASELpvseVASILQFKNPLIMLLLASAVIS----VLMHQ----FDDAV 99
Cdd:cd02077    2 LTNEEAEERLEKY-----GPNE----ISHEKFPSWF----KLLLKAFINPFNIVLLVLALVSfftdVLLAPgefdLVGAL 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 100 SITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARD-LVPGDTVCLSVGDRVPADLRLFEAVDLSI 178
Cdd:cd02077   69 IILLMVLISGLLDFIQEIRSLKAAEKLKKMVKNTATVIRDGSKYMEIPIDeLVPGDIVYLSAGDMIPADVRIIQSKDLFV 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 179 DESSLTGETTPCSKVTAPQpAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQaEEAPKTPLQKSMD 258
Cdd:cd02077  149 SQSSLTGESEPVEKHATAK-KTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSIT-EKRPETSFDKGIN 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 259 LLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGC 338
Cdd:cd02077  227 KVSKLLIRFMLVMVPVVFLINGLTKGDWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGA 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 339 CNVICSDKTGTLTKNEMTVTHIFTSDGlhaevtgvgynQFGEVIVDgdvvHGFYNPavsrIVEAGcvcndavIRNntLMG 418
Cdd:cd02077  307 MDILCTDKTGTLTQDKIVLERHLDVNG-----------KESERVLR----LAYLNS----YFQTG-------LKN--LLD 358
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 419 KptegALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVkCVHRTQQDRPEICfmKGAYEQVIKYCTTYQSKGQTLTLT 498
Cdd:cd02077  359 K----AIIDHAEEANANGLIQDYTKIDEIPFDFERRRMSV-VVKDNDGKHLLIT--KGAVEEILNVCTHVEVNGEVVPLT 431
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 499 QQQRDVYQQEKARMGSAGLRVLALA----SGPELG-------QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGD 567
Cdd:cd02077  432 DTLREKILAQVEELNREGLRVLAIAykklPAPEGEysvkdekELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGD 511
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 568 SQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVAL 647
Cdd:cd02077  512 NEIVTKAICKQVGL--DINRVLTGSEIEALSDEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPAL 589
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 648 KAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLAT-LMNFpNPLNA 726
Cdd:cd02077  590 RQADVGISV-DSAVDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASSNFGNVFSVLVASaFLPF-LPMLP 667
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 312836769 727 MQILWINIIMDgpPAQ-SLGVEPVDKDVIRKpPRNWKDSILTKNLILKILVSSI---IIVCGTLFVF 789
Cdd:cd02077  668 IQLLLQNLLYD--FSQlAIPFDNVDEEFLKK-PQKWDIKNIGRFMIWIGPISSIfdiLTFLVMWFVF 731
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
73-789 7.45e-125

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 404.39  E-value: 7.45e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769    73 QFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVP 152
Cdd:TIGR01523   59 QVCNAMCMVLIIAAAISFAMHDWIEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKSDAIDSHDLVP 138
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   153 GDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSK----VTAPQPAATNGDlasRSNIAFMGTLVRCGKAKGVVI 228
Cdd:TIGR01523  139 GDICLLKTGDTIPADLRLIETKNFDTDEALLTGESLPVIKdahaTFGKEEDTPIGD---RINLAFSSSAVTKGRAKGICI 215
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   229 GTGENSEFGEVFKMMQAE---------EAPK--------------------------TPLQKSMDLLGKQLsFYSFGIIG 273
Cdd:TIGR01523  216 ATALNSEIGAIAAGLQGDgglfqrpekDDPNkrrklnkwilkvtkkvtgaflglnvgTPLHRKLSKLAVIL-FCIAIIFA 294
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   274 IIMLVGWLLGKDiLEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKN 353
Cdd:TIGR01523  295 IIVMAAHKFDVD-KEVAIYAICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQG 373
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   354 EMTVTHIF----------TSD--------------------GLHAEVTGVGYNQ-FGEVIVDGDVVHGFYNPAVSRIVEA 402
Cdd:TIGR01523  374 KMIARQIWiprfgtisidNSDdafnpnegnvsgiprfspyeYSHNEAADQDILKeFKDELKEIDLPEDIDMDLFIKLLET 453
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   403 GCVCNDAVIRNNT------LMGKPTEGALIALAMKMGL-----------------------------DGLQQDYIRkaEY 447
Cdd:TIGR01523  454 AALANIATVFKDDatdcwkAHGDPTEIAIHVFAKKFDLphnaltgeedllksnendqsslsqhnekpGSAQFEFIA--EF 531
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   448 PFSSEQKWMAVkcVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKG--QTLTLTQQQRDVYQQEKARMGSAGLRVLALAS- 524
Cdd:TIGR01523  532 PFDSEIKRMAS--IYEDNHGETYNIYAKGAFERIIECCSSSNGKDgvKISPLEDCDRELIIANMESLAAEGLRVLAFASk 609
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   525 --------GPELGQLT-----------FLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLG----- 580
Cdd:TIGR01523  610 sfdkadnnDDQLKNETlnrataesdleFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGiippn 689
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   581 LYSKTSQSVS-----GEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVA 655
Cdd:TIGR01523  690 FIHDRDEIMDsmvmtGSQFDALSDEEVDDLKALCLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIA 769
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   656 MGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPN-----PLNAMQIL 730
Cdd:TIGR01523  770 MGINGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVEIL 849
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 312836769   731 WINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVF 789
Cdd:TIGR01523  850 WCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYGFFLGGSCLASF 908
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
96-771 1.30e-122

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 396.85  E-value: 1.30e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   96 DDAVSITVAILIVVTV----AFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLF 171
Cdd:TIGR01106 101 NDNLYLGVVLSAVVIItgcfSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRII 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  172 EAVDLSIDESSLTGETTPCSKvtapQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKT 251
Cdd:TIGR01106 181 SAQGCKVDNSSLTGESEPQTR----SPEFTHENPLETRNIAFFSTNCVEGTARGIVVNTGDRTVMGRIASLASGLENGKT 256
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  252 PLQKSMD-----LLGKQLSF-YSFGIIGIIMLVGWLlgkdilEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRA 325
Cdd:TIGR01106 257 PIAIEIEhfihiITGVAVFLgVSFFILSLILGYTWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNC 330
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  326 IVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLH-AEVT----GVGYNQFGEVIVdgdvvhgfynpAVSRIV 400
Cdd:TIGR01106 331 LVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHeADTTedqsGVSFDKSSATWL-----------ALSRIA 399
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  401 EagcVCNDAVIRNN---------TLMGKPTEGALIA-LAMKMG-LDGLQQDYIRKAEYPFSSEQKWMAvkCVHRTQ--QD 467
Cdd:TIGR01106 400 G---LCNRAVFKAGqenvpilkrAVAGDASESALLKcIELCLGsVMEMRERNPKVVEIPFNSTNKYQL--SIHENEdpRD 474
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  468 RPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVL-----ALASG--PE------------L 528
Cdd:TIGR01106 475 PRHLLVMKGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLgfchlYLPDEqfPEgfqfdtddvnfpT 554
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  529 GQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVS------------------ 590
Cdd:TIGR01106 555 DNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEdiaarlnipvsqvnprda 634
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  591 ------GEEIDAMDVQQLSQIV---PKVaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGT 661
Cdd:TIGR01106 635 kacvvhGSDLKDMTSEQLDEILkyhTEI-VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGS 713
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  662 DVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPA 741
Cdd:TIGR01106 714 DVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPA 793
                         730       740       750
                  ....*....|....*....|....*....|.
gi 312836769  742 QSLGVEPVDKDVIRKPPRN-WKDSILTKNLI 771
Cdd:TIGR01106 794 ISLAYEKAESDIMKRQPRNpKTDKLVNERLI 824
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
100-730 2.91e-120

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 377.04  E-value: 2.91e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  100 SITVAILIVVTVAFVQEYRSEKSLEELSKLV--PPECHCVREGKLEHTlARDLVPGDTVCLSVGDRVPADLRLFEAvDLS 177
Cdd:TIGR01494   1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSLvnTATVLVLRNGWKEIS-SKDLVPGDVVLVKSGDTVPADGVLLSG-SAF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  178 IDESSLTGETTPCSKVTAPQPAATNGdlasrsniafmGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSM 257
Cdd:TIGR01494  79 VDESSLTGESLPVLKTALPDGDAVFA-----------GTINFGGTLIVKVTATGILTTVGKIAVVVYTGFSTKTPLQSKA 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  258 DLLGKQLSFYSFGIIGIIMLVGWLL----GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIV 333
Cdd:TIGR01494 148 DKFENFIFILFLLLLALAVFLLLPIggwdGNSIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNAL 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  334 ETLGCCNVICSDKTGTLTKNEMTVTHIFTsDGLHAEVTGVGYNQFGEvivdgdvvhgfynpavsriveagcvcndavirN 413
Cdd:TIGR01494 228 EELGKVDVICFDKTGTLTTNKMTLQKVII-IGGVEEASLALALLAAS--------------------------------L 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  414 NTLMGKPTEGALIALAMKMG-LDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPeicFMKGAYEQVIKYCTtyqskg 492
Cdd:TIGR01494 275 EYLSGHPLERAIVKSAEGVIkSDEINVEYKILDVFPFSSVLKRMGVIVEGANGSDLL---FVKGAPEFVLERCN------ 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  493 qtltltqqQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETA 572
Cdd:TIGR01494 346 --------NENDYDEKVDEYARQGLRVLAFASKKLPDDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTA 417
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  573 VAIASRLGLysktsqsvsgeeidamdvqqlsqivpkvAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADI 652
Cdd:TIGR01494 418 KAIAKELGI----------------------------DVFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADV 469
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312836769  653 GVAMGQtgTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 730
Cdd:TIGR01494 470 GIAMGS--GDVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVIILLPPLLAALAL 545
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
62-855 2.20e-111

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 361.16  E-value: 2.20e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  62 ELPVSEVASIL----QFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCV 137
Cdd:cd02076   18 ELPEKKENPILkflsFFWGPIPWMLEAAAILAAALGDWVDFAIILLLLLINAGIGFIEERQAGNAVAALKKSLAPKARVL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 138 REGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKvtapqpaaTNGDlasrsnIAFMGTL 217
Cdd:cd02076   98 RDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALQVDQSALTGESLPVTK--------HPGD------EAYSGSI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 218 VRCGKAKGVVIGTGENSEFGEVFKMMQAEEaPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLA 297
Cdd:cd02076  164 VKQGEMLAVVTATGSNTFFGKTAALVASAE-EQGHLQKVLNKIGNFLILLALILVLIIVIVALYRHDPFLEILQFVLVLL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 298 VAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynq 377
Cdd:cd02076  243 IASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTGTLTLNKLSLDEPYSLEGDGKD-------- 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 378 fgEVIVdgdvvhgfynpavsriveAGCVCNDAviRNNTLMGKPTEGALIALamKMGLDGLQQ-DYirkaeYPFSSEqkwm 456
Cdd:cd02076  315 --ELLL------------------LAALASDT--ENPDAIDTAILNALDDY--KPDLAGYKQlKF-----TPFDPV---- 361
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 457 aVKCVHRTQQDRPEICF--MKGAYEQVIKYCttyqskgqtlTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFL 534
Cdd:cd02076  362 -DKRTEATVEDPDGERFkvTKGAPQVILELV----------GNDEAIRQAVEEKIDELASRGYRSLGVARKEDGGRWELL 430
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 535 GLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSK---TSQSVSGEEIDAMDVQQLSQIVPKVAV 611
Cdd:cd02076  431 GLLPLFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGMGTNilsAERLKLGGGGGGMPGSELIEFIEDADG 510
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 612 FYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIY 691
Cdd:cd02076  511 FAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAV-SGATDAARAAADIVLTAPGLSVIIDAIKTSRQIF 589
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 692 NNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGpPAQSLGvepVDKDVIRKPPRNWKdsiLTKNLI 771
Cdd:cd02076  590 QRMKSYVIYRIAETLRILVFFTLGILILNFYPLPLIMIVLIAILNDG-ATLTIA---YDNVPPSPRPVRWN---MPELLG 662
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 772 LKIL------VSSIIIVC---GTLFVFWRELRDNVItprdTTMTFTCFVFFDMFNALSSRsqTKSVFEIGLCSNRMFCYA 842
Cdd:cd02076  663 IATVlgvvltISSFLLLWlldDQGWFEDIVLSAGEL----QTILYLQLSISGHLTIFVTR--TRGPFWRPRPSPLLFIAV 736
                        810
                 ....*....|...
gi 312836769 843 VLGSIMGQLLVIY 855
Cdd:cd02076  737 VLTQILATLLAVY 749
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
341-744 8.37e-108

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 336.35  E-value: 8.37e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 341 VICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndavirnntlmgkp 420
Cdd:cd01431    1 VICSDKTGTLTKNGMTVTKLFI---------------------------------------------------------- 22
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 421 tegalialamkmgldglqqdyirkAEYPFSSEQKWMAVKCVHrtqqDRPEICFMKGAYEQVIKYCTTyqskgqtlTLTQQ 500
Cdd:cd01431   23 ------------------------EEIPFNSTRKRMSVVVRL----PGRYRAIVKGAPETILSRCSH--------ALTEE 66
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 501 QRDVYQQEKARMGSAGLRVLALASGP---------ELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQET 571
Cdd:cd01431   67 DRNKIEKAQEESAREGLRVLALAYREfdpetskeaVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLT 146
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 572 AVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAAD 651
Cdd:cd01431  147 AIAIAREIGIDTKASGVILGEEADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQAD 226
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 652 IGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILW 731
Cdd:cd01431  227 VGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILW 306
                        410
                 ....*....|...
gi 312836769 732 INIIMDGPPAQSL 744
Cdd:cd01431  307 INLVTDLIPALAL 319
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
62-739 1.34e-107

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 350.47  E-value: 1.34e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   62 ELPVSEVASILQFK----NPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCV 137
Cdd:TIGR01647  18 ELPEKKVSPLLKFLgffwNPLSWVMEAAAIIAIALENWVDFVIILGLLLLNATIGFIEENKAGNAVEALKQSLAPKARVL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  138 REGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTapqpaatnGDlasrsnIAFMGTL 217
Cdd:TIGR01647  98 RDGKWQEIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQVDQAALTGESLPVTKKT--------GD------IAYSGST 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  218 VRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLL-GKDILEMFTISVSL 296
Cdd:TIGR01647 164 VKQGEAEAVVTATGMNTFFGKAAALVQSTETGSGHLQKILSKIGLFLIVLIGVLVLIELVVLFFGrGESFREGLQFALVL 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  297 AVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgyn 376
Cdd:TIGR01647 244 LVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELAGMDILCSDKTGTLTLNKLSIDEILP-------------- 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  377 QFGEVIVDGDVVHGFYnpaVSRivEAGcvcNDAVirNNTLMGKptegaLIALAMKMgldglqqDYIRKAEY-PFSSEQKw 455
Cdd:TIGR01647 310 FFNGFDKDDVLLYAAL---ASR--EED---QDAI--DTAVLGS-----AKDLKEAR-------DGYKVLEFvPFDPVDK- 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  456 mAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYqskgqtltltQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLG 535
Cdd:TIGR01647 367 -RTEATVEDPETGKRFKVTKGAPQVILDLCDNK----------KEIEEKVEEKVDELASRGYRALGVARTDEEGRWHFLG 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  536 LVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSK--TSQSVSGEEIDAMDVQQLSQIVPKVAVFY 613
Cdd:TIGR01647 436 LLPLFDPPRHDTKETIERARHLGVEVKMVTGDHLAIAKETARRLGLGTNiyTADVLLKGDNRDDLPSGLGEMVEDADGFA 515
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  614 RASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNN 693
Cdd:TIGR01647 516 EVFPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIAV-AGATDAARSAADIVLTEPGLSVIVDAILESRKIFQR 594
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*..
gi 312836769  694 IKNFVRFQLSTSIAALTLISLATL-MNFpnPLNAMQILWINIIMDGP 739
Cdd:TIGR01647 595 MKSYVIYRIAETIRIVFFFGLLILiLNF--YFPPIMVVIIAILNDGT 639
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
74-789 4.86e-98

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 328.57  E-value: 4.86e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  74 FKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR--EGKLEHTLA---- 147
Cdd:PRK10517 101 YRNPFNILLTILGAISYATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRviNDKGENGWLeipi 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 148 RDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLaSRSNIAFMGTLVRCGKAKGVV 227
Cdd:PRK10517 181 DQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFATTRQPEHSNPL-ECDTLCFMGTNVVSGTAQAVV 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 228 IGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV-GWLLGkDILEMFTISVSLAVAAIPEGLP 306
Cdd:PRK10517 260 IATGANTWFGQLAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLInGYTKG-DWWEAALFALSVAVGLTPEMLP 338
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 307 IVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEmtvthIFTSDglHAEVtgvgynqFGEviVDGD 386
Cdd:PRK10517 339 MIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDK-----IVLEN--HTDI-------SGK--TSER 402
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 387 VVH-----GFYNPAVSRIVEAgcvcndAVIrnntlmgkptEGALIALAMKMGldglqQDYIRKAEYPFSSEQKWMAVkcV 461
Cdd:PRK10517 403 VLHsawlnSHYQTGLKNLLDT------AVL----------EGVDEESARSLA-----SRWQKIDEIPFDFERRRMSV--V 459
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 462 HRTQQDRPE-ICfmKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGP-----------ELG 529
Cdd:PRK10517 460 VAENTEHHQlIC--KGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYlparegdyqraDES 537
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 530 QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKV 609
Cdd:PRK10517 538 DLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--DAGEVLIGSDIETLSDDELANLAERT 615
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 610 AVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKG 689
Cdd:PRK10517 616 TLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISV-DGAVDIAREAADIILLEKSLMVLEEGVIEGRR 694
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 690 IYNNIKNFVRFQLSTSIAAL--TLISLATLmnfPN-PLNAMQILWINIIMDgpPAQ-SLGVEPVDKDVIRKPPRnWKDSI 765
Cdd:PRK10517 695 TFANMLKYIKMTASSNFGNVfsVLVASAFL---PFlPMLPLHLLIQNLLYD--VSQvAIPFDNVDDEQIQKPQR-WNPAD 768
                        730       740
                 ....*....|....*....|....*..
gi 312836769 766 LTKNLILKILVSSII-IVCGTL--FVF 789
Cdd:PRK10517 769 LGRFMVFFGPISSIFdILTFCLmwWVF 795
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
28-790 3.58e-96

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 322.59  E-value: 3.58e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   28 LRNQRAEEQVARFqkipnGENETmipvltskkASELPVSEVASILQ-FKNPLIMLLLASAVISVLMHQFDDAVSITVAIL 106
Cdd:TIGR01524  34 LTNVEVTERLAEF-----GPNQT---------VEEKKVPNLRLLIRaFNNPFIYILAMLMGVSYLTDDLEATVIIALMVL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  107 IVVTVAFVQEYRSEKSLEELSKLVPPECHCVR------EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDE 180
Cdd:TIGR01524 100 ASGLLGFIQESRAERAAYALKNMVKNTATVLRvinengNGSMDEVPIDALVPGDLIELAAGDIIPADARVISARDLFINQ 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  181 SSLTGETTPCSKVTAPQPAATNgDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMqAEEAPKTPLQKSMDLL 260
Cdd:TIGR01524 180 SALTGESLPVEKFVEDKRARDP-EILERENLCFMGTNVLSGHAQAVVLATGSSTWFGSLAIAA-TERRGQTAFDKGVKSV 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  261 GKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCN 340
Cdd:TIGR01524 258 SKLLIRFMLVMVPVVLMINGLMKGDWLEAFLFALAVAVGLTPEMLPMIVSSNLAKGAINMSKKKVIVKELSAIQNFGAMD 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  341 VICSDKTGTLTKNEMTVTHiftsdglHAEVTGVGYNQfgevivdgdVVHGFYNPAVSRiVEAGCVCNDAVIRnntlmgKP 420
Cdd:TIGR01524 338 ILCTDKTGTLTQDKIELEK-------HIDSSGETSER---------VLKMAWLNSYFQ-TGWKNVLDHAVLA------KL 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  421 TEGALIALAMKmgldglqqdYIRKAEYPFSSEQKWMAVkCVHRTQQDRPEICfmKGAYEQVIKYCTTYQSKGQTLTLTQQ 500
Cdd:TIGR01524 395 DESAARQTASR---------WKKVDEIPFDFDRRRLSV-VVENRAEVTRLIC--KGAVEEMLTVCTHKRFGGAVVTLSES 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  501 QRDVYQQEKARMGSAGLRVLALAS--GPELG---------QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQ 569
Cdd:TIGR01524 463 EKSELQDMTAEMNRQGIRVIAVATktLKVGEadftktdeeQLIIEGFLGFLDPPKESTKEAIAALFKNGINVKVLTGDNE 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  570 ETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKA 649
Cdd:TIGR01524 543 IVTARICQEVGI--DANDFLLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGINDAPALRK 620
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  650 ADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQI 729
Cdd:TIGR01524 621 ADVGISV-DTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVASAFIPFLPMLSLHL 699
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312836769  730 LWINIIMDGPPAqSLGVEPVDKDVIRKpPRNWKDSILTKNLILKILVSSIIIVCGTLFVFW 790
Cdd:TIGR01524 700 LIQNLLYDFSQL-TLPWDKMDREFLKK-PHQWEQKGMGRFMLCIGPVSSIFDIATFLLMWF 758
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
25-761 2.07e-88

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 301.94  E-value: 2.07e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  25 LSTLRNQR----AEEQVARFQKipNGENETmipvltskkASELPVSEVASILQ-FKNPLIMLLLASAVISVLM------H 93
Cdd:PRK15122  36 LANLNTHRqgltEEDAAERLQR--YGPNEV---------AHEKPPHALVQLLQaFNNPFIYVLMVLAAISFFTdywlplR 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  94 QFDDAVSITVAILIV-VTVA----FVQEYRSEKSLEELSKLVPPECHCVR------EGKLEHTLARDLVPGDTVCLSVGD 162
Cdd:PRK15122 105 RGEETDLTGVIIILTmVLLSgllrFWQEFRSNKAAEALKAMVRTTATVLRrghagaEPVRREIPMRELVPGDIVHLSAGD 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 163 RVPADLRLFEAVDLSIDESSLTGETTPCSKV---------TAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGEN 233
Cdd:PRK15122 185 MIPADVRLIESRDLFISQAVLTGEALPVEKYdtlgavagkSADALADDEGSLLDLPNICFMGTNVVSGTATAVVVATGSR 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 234 SEFGEVFKMMQAEEaPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTL 313
Cdd:PRK15122 265 TYFGSLAKSIVGTR-AQTAFDRGVNSVSWLLIRFMLVMVPVVLLINGFTKGDWLEALLFALAVAVGLTPEMLPMIVSSNL 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 314 ALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHiftsdglHaevtgvgynqfgeviVDgdvVHGFYN 393
Cdd:PRK15122 344 AKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEH-------H---------------LD---VSGRKD 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 394 PAVSRIV------EAGcvcndavIRNntLMGKptegALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVkCVHRTQQD 467
Cdd:PRK15122 399 ERVLQLAwlnsfhQSG-------MKN--LMDQ----AVVAFAEGNPEIVKPAGYRKVDELPFDFVRRRLSV-VVEDAQGQ 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 468 RPEICfmKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASgPELGQ--------------LTF 533
Cdd:PRK15122 465 HLLIC--KGAVEEMLAVATHVRDGDTVRPLDEARRERLLALAEAYNADGFRVLLVAT-REIPGgesraqystaderdLVI 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 534 LGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFY 613
Cdd:PRK15122 542 RGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVTAKICREVGL--EPGEPLLGTEIEAMDDAALAREVEERTVFA 619
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 614 RASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNN 693
Cdd:PRK15122 620 KLTPLQKSRVLKALQANGHTVGFLGDGINDAPALRDADVGISV-DSGADIAKESADIILLEKSLMVLEEGVIKGRETFGN 698
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 694 IKNFVRFQLSTsiaaltlislatlmNFPN--------------PLNAMQILWINIIMDgpPAQ-SLGVEPVDKDVIRKpP 758
Cdd:PRK15122 699 IIKYLNMTASS--------------NFGNvfsvlvasafipflPMLAIHLLLQNLMYD--ISQlSLPWDKMDKEFLRK-P 761

                 ...
gi 312836769 759 RNW 761
Cdd:PRK15122 762 RKW 764
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
81-761 3.37e-82

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 279.17  E-value: 3.37e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  81 LLLASAVISVLMHQFDDAVSITVAILIVVtVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSV 160
Cdd:cd02609   42 INFVIAVLLILVGSYSNLAFLGVIIVNTV-IGIVQEIRAKRQLDKLSILNAPKVTVIRDGQEVKIPPEELVLDDILILKP 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 161 GDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTapqpaatnGDLAsrsniaFMGTLVRCGKAKGVVIGTGENSefgevF 240
Cdd:cd02609  121 GEQIPADGEVVEGGGLEVDESLLTGESDLIPKKA--------GDKL------LSGSFVVSGAAYARVTAVGAES-----Y 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 241 KMMQAEEAPK-----TPLQKSMDLLGKqlsFYSFGII--GIIMLVG--WLLGKDILEMFTISVSLAVAAIPEGLPIVVTV 311
Cdd:cd02609  182 AAKLTLEAKKhklinSELLNSINKILK---FTSFIIIplGLLLFVEalFRRGGGWRQAVVSTVAALLGMIPEGLVLLTSV 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 312 TLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLhaevtgvgynqfgevivdgdvvhgf 391
Cdd:cd02609  259 ALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEA------------------------- 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 392 YNPAVSRIVEAGCvcnDAVIRNNtlmgkPTEGALialamkmgLDGLQQD--YIRKAEYPFSSEQKWMAVkcvhrTQQDR- 468
Cdd:cd02609  314 NEAEAAAALAAFV---AASEDNN-----ATMQAI--------RAAFFGNnrFEVTSIIPFSSARKWSAV-----EFRDGg 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 469 ------PEIcFMKGAYEQVikycttyqskgqtltltQQQRDVYQQEkarmgsaGLRVLALASGPE-------LGQLTFLG 535
Cdd:cd02609  373 twvlgaPEV-LLGDLPSEV-----------------LSRVNELAAQ-------GYRVLLLARSAGaltheqlPVGLEPLA 427
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 536 LVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysktsqsvSGEEIDA-----MDVQQLSQIVPKVA 610
Cdd:cd02609  428 LILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGL--------EGAESYIdastlTTDEELAEAVENYT 499
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 611 VFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGI 690
Cdd:cd02609  500 VFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRV 578
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 691 YNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRK----------PPRN 760
Cdd:cd02609  579 VNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKRRIEGGflrrvltkalPPLN 658

                 .
gi 312836769 761 W 761
Cdd:cd02609  659 R 659
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
79-726 4.41e-58

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 209.41  E-value: 4.41e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   79 IMLLLASAVI-SVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR-EGKLEHTLARDLVPGDTV 156
Cdd:TIGR01525   1 MDTLMALAAIaAYAMGLVLEGALLLFLFLLGETLEERAKSRASDALSALLALAPSTARVLQgDGSEEEVPVEELQVGDIV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  157 CLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaatngdlaSRSNIAFMGTLVRCGKAKGVVIGTGENSEF 236
Cdd:TIGR01525  81 IVRPGERIPVDGVVISGES-EVDESALTGESMPVEK--------------KEGDEVFAGTINGDGSLTIRVTKLGEDSTL 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  237 GEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALG 316
Cdd:TIGR01525 146 AQIVELVEEAQSSKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGALWREALYRALTVLVVACPCALGLATPVAILVA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  317 VMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHI-FTSDGLHAEVTGVgynqfgevivdgdvvhgfynpa 395
Cdd:TIGR01525 226 IGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIePLDDASEEELLAL---------------------- 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  396 vsriveAGCvcndavirnntlMGKPTEGAlIALAMkmgldglqQDYIRKAEYPFSSEQkwmavkcvhrtQQDRPEiCFMK 475
Cdd:TIGR01525 284 ------AAA------------LEQSSSHP-LARAI--------VRYAKERGLELPPED-----------VEEVPG-KGVE 324
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  476 GAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELgqltfLGLVGIIDPPRTGVKEAVTTLI 555
Cdd:TIGR01525 325 ATVDGGREVRIGNPRFLGNRELAIEPISASPDLLNEGESQGKTVVFVAVDGEL-----LGVIALRDQLRPEAKEAIAALK 399
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  556 ASGV-SIKMITGDSQETAVAIASRLGLYSKtsqsvsgeeidamdvqqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVV 634
Cdd:TIGR01525 400 RAGGiKLVMLTGDNRSAAEAVAAELGIDDE--------------------------VHAELLPEDKLAIVKKLQEEGGPV 453
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  635 AMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK-NFVrfqlstsiAALTLIS 713
Cdd:TIGR01525 454 AMVGDGINDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKqNLA--------WALGYNL 524
                         650
                  ....*....|....*.
gi 312836769  714 LA---TLMNFPNPLNA 726
Cdd:TIGR01525 525 VAiplAAGGLLPLWLA 540
ZntA COG2217
Cation transport ATPase [Inorganic ion transport and metabolism];
70-727 3.44e-56

Cation transport ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 225127 [Multi-domain]  Cd Length: 713  Bit Score: 207.06  E-value: 3.44e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  70 SILQFKNPLIMLL-----LASAVISVLMH----QFDDAVSITVAILIVvtvAFVQEY---RSEKSLEELSKLVPPECHCV 137
Cdd:COG2217  140 RALRRGRLNMDTLvalatIGAYAYSLYATlfpvYFEEAAMLIFLFLLG---RYLEARakgRARRAIRALLDLAPKTATVV 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 138 REGKLEHTL-ARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaaTNGDlasrsnIAFMGT 216
Cdd:COG2217  217 RGDGEEEEVpVEEVQVGDIVLVRPGERIPVDGVVVSGSS-SVDESMLTGESLPVEK--------KPGD------EVFAGT 281
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 217 LVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGK-DILEMFTISVS 295
Cdd:COG2217  282 VNLDGSLTIRVTRVGADTTLARIIRLVEEAQSSKAPIQRLADRVASYFVPVVLVIAALTFALWPLFGGgDWETALYRALA 361
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 296 LAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGY 375
Cdd:COG2217  362 VLVIACPCALGLATPTAILVGIGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVTDVVALDGDEDELLALAA 441
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 376 N-------QFGEVIVDGDVVHGfyNPAVSRIVE-AGC-----VCNDAVirnntLMGKPtegalialamkmgldglqqdyi 442
Cdd:COG2217  442 AleqhsehPLAKAIVKAAAERG--LPDVEDFEEiPGRgveaeVDGERV-----LVGNA---------------------- 492
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 443 rkaeypfsseqKWMavkcvhrtQQDRPEICFMKGAYEQvikycttYQSKGQTltltqqqrdvyqqekarmgsaglrVLAL 522
Cdd:COG2217  493 -----------RLL--------GEEGIDLPLLSERIEA-------LESEGKT------------------------VVFV 522
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 523 ASGPELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDAmdvqql 602
Cdd:COG2217  523 AVDGKL-----VGVIALADELRPDAKEAIAALKALGIKVVMLTGDNRRTAEAIAKELG-------------IDE------ 578
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 603 sqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMS 682
Cdd:COG2217  579 --------VRAELLPEDKAEIVRELQAEGRKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAADVVLMRDDLSAVPE 649
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*.
gi 312836769 683 AIEEGKGIYNNIK-NFVrFQLSTSIAALTLislaTLMNFPNPLNAM 727
Cdd:COG2217  650 AIDLSRATRRIIKqNLF-WAFGYNAIAIPL----AAGGLLTPWIAA 690
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
72-727 8.42e-54

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 198.21  E-value: 8.42e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  72 LQFKNPLIMLLLASAVI-----SVLMHQ------FDDAVSITVAILIVvtvAFVQEY---RSEKSLEELSKLVPPECHCV 137
Cdd:cd02079   54 LRRGRLNMDVLVSLAAIgafvaSLLTPLlggigyFEEAAMLLFLFLLG---RYLEERarsRARSALKALLSLAPETATVL 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 138 REGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKVTapqpaatnGDLAsrsniaFMGTL 217
Cdd:cd02079  131 EDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGES-SVDESSLTGESLPVEKGA--------GDTV------FAGTI 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 218 VRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLA 297
Cdd:cd02079  196 NLNGPLTIEVTKTGEDTTLAKIIRLVEEAQSSKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSLALYRALAVL 275
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 298 VAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynq 377
Cdd:cd02079  276 VVACPCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEIEPLEGFSED-------- 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 378 fgEVIvdgdvvhgfynpAVSRIVEAGCvcndavirnntlmGKPtegalIALAMkmgldglqQDYIRKAEypfsseqkwmA 457
Cdd:cd02079  348 --ELL------------ALAAALEQHS-------------EHP-----LARAI--------VEAAEEKG----------L 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 458 VKCVHRTQQDRPEicfmKGAYEQVIkycttyqskGQTLTLTQQ---QRDVYQQEKARMGSAG-LRVLALASGPELgqltf 533
Cdd:cd02079  378 PPLEVEDVEEIPG----KGISGEVD---------GREVLIGSLsfaEEEGLVEAADALSDAGkTSAVYVGRDGKL----- 439
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 534 LGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSktsqsvsgeeidamdvqqlsqivpkvaVFY 613
Cdd:cd02079  440 VGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGIDE---------------------------VHA 492
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 614 RASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQtGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNN 693
Cdd:cd02079  493 GLLPEDKLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGS-GTDVAIETADIVLLSNDLSKLPDAIRLARRTRRI 571
                        650       660       670
                 ....*....|....*....|....*....|....*
gi 312836769 694 IK-NFVrFQLSTSIAALTLislaTLMNFPNPLNAM 727
Cdd:cd02079  572 IKqNLA-WALGYNAIALPL----AALGLLTPWIAA 601
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
81-726 2.51e-50

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 186.76  E-value: 2.51e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   81 LLLASAVISVLMHQFDDAVSItvaILIVVTVAFVQEY---RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVC 157
Cdd:TIGR01512   4 LMALAALGAVAIGEYLEGALL---LLLFSIGETLEEYasgRARRALKALMELAPDTARRLQGDSLEEVAVEELKVGDVVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  158 LSVGDRVPADLRLfEAVDLSIDESSLTGETTPCSKvtapqpaatngdlaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFG 237
Cdd:TIGR01512  81 VKPGERVPVDGEV-LSGTSSVDESALTGESVPVEK--------------APGDEVFAGAINLDGVLTIEVTKLPADSTIA 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  238 EVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKD-ILEMFTISVSLAVAAIPEGLPIVVTVTLALG 316
Cdd:TIGR01512 146 KIVNLVEEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVPPLLGAGpFLEWIYRALVLLVVASPCALVISAPAAYLSA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  317 VMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgevivdgdvvhGFYNPAV 396
Cdd:TIGR01512 226 ISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTDVHPADGHSES--------------------EVLRLAA 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  397 SriVEAGCVcndavirnntlmgKPtegalIALAMkmgldglqQDYIRKAEYPFSSEQkwmavkcvhrtQQDRPEicfmKG 476
Cdd:TIGR01512 286 A--AEQGST-------------HP-----LARAI--------VDYARARELAPPVED-----------VEEVPG----EG 322
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  477 AYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQekarmgSAGLRVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIA 556
Cdd:TIGR01512 323 VRAVVDGGEVRIGNPRSLSEAVGASIAVPES------AGKTIVLVARDG------TLLGYIALSDELRPDAAEAIAELKA 390
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  557 SGVS-IKMITGDSQETAVAIASRLGlysktsqsvsgeeIDamdvqqlsqivpkvAVFYRASPRHKMKIIKSLQKNGSVVA 635
Cdd:TIGR01512 391 LGIKrLVMLTGDRRAVAEAVARELG-------------ID--------------EVHAELLPEDKLEIVKELREKAGPVA 443
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  636 MTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFqlstSIAALTLISLA 715
Cdd:TIGR01512 444 MVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVI----ALGIILVLILL 519
                         650
                  ....*....|.
gi 312836769  716 TLMNFPNPLNA 726
Cdd:TIGR01512 520 ALFGVLPLWLA 530
E1-E2_ATPase pfam00122
E1-E2 ATPase;
128-323 2.15e-49

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 172.76  E-value: 2.15e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  128 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaatngdlaS 207
Cdd:pfam00122   1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSA-SVDESLLTGESLPVEK--------------K 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  208 RSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIL 287
Cdd:pfam00122  66 KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPL 145
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 312836769  288 EMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 323
Cdd:pfam00122 146 RALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
72-728 3.98e-49

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 184.82  E-value: 3.98e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  72 LQFKNPLIMLLLASA--------VISVLMHQFDDAV---SITVAILIVVTV-------AFVQEYRSekSLEELSKLVPPE 133
Cdd:cd07552   55 LKSKKPGMMTLIALGitvayvysVYAFLGNYFGEHGmdfFWELATLIVIMLlghwiemKAVMGAGD--ALKKLAELLPKT 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 134 CHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQ--PAATNGDlasrsni 211
Cdd:cd07552  133 AHLVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEG-ESSVNESMVTGESKPVEKKPGDEviGGSVNGN------- 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 212 afmGTL-VRcgkakgvVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLsFYSFGIIGIIMLVGWLLGKDILEMF 290
Cdd:cd07552  205 ---GTLeVK-------VTKTGEDSYLSQVMELVAQAQASKSRAENLADKVAGWL-FYIALGVGIIAFIIWLILGDLAFAL 273
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 291 TISVSLAVAAIPEGL----PIVVTVTLALGVMR--MVKKRaivKKLPIVETLgccNVICSDKTGTLTKNEMTVTHIFTSD 364
Cdd:cd07552  274 ERAVTVLVIACPHALglaiPLVVARSTSIAAKNglLIRNR---EALERARDI---DVVLFDKTGTLTEGKFGVTDVITFD 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 365 GLHAEvtgvgynqfgEVI-----VDGDVVHgfynPAVSRIVEAgcvcndavirnntlmgkptegalialamkmgldgLQQ 439
Cdd:cd07552  348 EYDED----------EILslaaaLEAGSEH----PLAQAIVSA----------------------------------AKE 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 440 dyiRKAEYPFSSEQKWMAVKCVHRTQQDRpeicfmkgayeqvikyctTYQSKGQTLtLTQQQRDVYQQEKARMGSAGLRV 519
Cdd:cd07552  380 ---KGIRPVEVENFENIPGVGVEGTVNGK------------------RYQVVSPKY-LKELGLKYDEELVKRLAQQGNTV 437
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 520 LALASGPELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSktsqsvsgeeidamdv 599
Cdd:cd07552  438 SFLIQDGEV-----IGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGIDE---------------- 496
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 600 qqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQT 679
Cdd:cd07552  497 -----------YFAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESADVVLVKSDPRD 564
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312836769 680 IMSAIEEGKGIYNNIK---------NFVRFQLSTSIAALTLISL-----ATLMNFPN---PLNAMQ 728
Cdd:cd07552  565 IVDFLELAKATYRKMKqnlwwgagyNVIAIPLAAGVLAPIGIILspavgAVLMSLSTvivAINAMT 630
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
95-698 8.20e-48

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 179.78  E-value: 8.20e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   95 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLA-RDLVPGDTVCLSVGDRVPADLRLFEA 173
Cdd:TIGR01511  54 FDASAMLITFILLGRWLEMLAKGRASDALSKLAKLQPSTATLLTKDGSIEEVPvALLQPGDIVKVLPGEKIPVDGTVIEG 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  174 vDLSIDESSLTGETTPCSKVTapqpaatnGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPL 253
Cdd:TIGR01511 134 -ESEVDESLVTGESLPVPKKV--------GD------PVIAGTVNGTGSLVVRATATGEDTTLAQIVRLVRQAQQSKAPI 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  254 QKSMDLLGKQLsFYSFGIIGIIMLVGWLLGkdilemFTISVSLAVAAIPEGL----PIVVTVTLALGVMRMVkkraIVKK 329
Cdd:TIGR01511 199 QRLADKVAGYF-VPVVIAIALITFVIWLFA------LEFAVTVLIIACPCALglatPTVIAVATGLAAKNGV----LIKD 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  330 LPIVETLGCCNVICSDKTGTLTKNEMTVTHI-FTSDGLHAEVTgvgynqfgevivdgdvvhgfynpavsriveagcvcnd 408
Cdd:TIGR01511 268 GDALERAANIDTVVFDKTGTLTQGKPTVTDVhVFGDRDRTELL------------------------------------- 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  409 avirnnTLMGKPTEGALIALAMKMgldglqQDYIRKAEYPFSSEQKWMAVK-CVHRTQQDRPEICFMKGAYEQVIKYCTT 487
Cdd:TIGR01511 311 ------ALAAALEAGSEHPLAKAI------VSYAKEKGITLVTVSDFKAIPgIGVEGTVEGTKIQLGNEKLLGENAIKID 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  488 YQSKGQTltltqqqrdvyqqekarmgsagLRVLALASGpELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGD 567
Cdd:TIGR01511 379 GKAGQGS----------------------TVVLVAVNG-EL-----AGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGD 430
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  568 SQETAVAIASRLGlysktsqsvsgeeIDamdvqqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVAL 647
Cdd:TIGR01511 431 NRKTAKAVAKELG-------------ID---------------VRAEVLPDDKAALIKKLQEKGPVVAMVGDGINDAPAL 482
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 312836769  648 KAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK-NFV 698
Cdd:TIGR01511 483 AQADVGIAIG-AGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKqNLL 533
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
78-698 2.46e-46

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 176.90  E-value: 2.46e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  78 LIMLLLASAVISVLMHQFDDAVsitvailiVVTVAFVQ-----EYRS-EKSLEELSKLV---PPECHCVREGKLEHTLAR 148
Cdd:cd02094   84 LVALLFPALFPGGAPHVYFEAA--------AVIITFILlgkylEARAkGKTSEAIKKLLglqPKTARVIRDGKEVEVPIE 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 149 DLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSK-----VTApqpAATNGDlasrsniafmGTLVrcGKA 223
Cdd:cd02094  156 EVQVGDIVRVRPGEKIPVDGVVVEG-ESSVDESMLTGESLPVEKkpgdkVIG---GTINGN----------GSLL--VRA 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 224 KGVvigtGENSEFGEVFKMMQAEEAPKTPLQKSMDllgkQLSFYsF--GIIGI--IMLVGWLL---GKDILEMFTISVSL 296
Cdd:cd02094  220 TRV----GADTTLAQIIRLVEEAQGSKAPIQRLAD----RVSGV-FvpVVIAIaiLTFLVWLLlgpEPALTFALVAAVAV 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 297 AVAAIPEGL----PIVVTVtlalGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtg 372
Cdd:cd02094  291 LVIACPCALglatPTAIMV----GTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVTDVVPLPGDDED--- 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 373 vgynqfgEVIvdgdvvhgfynpAVSRIVEAGCvcndavirnntlmGKPTEGALIALAMKMGLDGLQQDYIR-------KA 445
Cdd:cd02094  364 -------ELL------------RLAASLEQGS-------------EHPLAKAIVAAAKEKGLELPEVEDFEaipgkgvRG 411
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 446 EYP----FSSEQKWMAVKCVHRTQQDrpeicfmkgayeqvikycttyqskgqtltltqqqrdvyqQEKARMGSAGLRVLA 521
Cdd:cd02094  412 TVDgrrvLVGNRRLMEENGIDLSALE---------------------------------------AEALALEEEGKTVVL 452
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 522 LASGPELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDamdvqq 601
Cdd:cd02094  453 VAVDGEL-----AGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELG-------------ID------ 508
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 602 lsqivpkvAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIM 681
Cdd:cd02094  509 --------EVIAEVLPEDKAEKVKKLQAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLRGVV 579
                        650
                 ....*....|....*...
gi 312836769 682 SAIEEGKGIYNNIK-NFV 698
Cdd:cd02094  580 TAIDLSRATMRNIKqNLF 597
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
721-893 1.74e-45

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 161.25  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  721 PNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITP 800
Cdd:pfam00689   1 PLPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  801 RDT--TMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLG 878
Cdd:pfam00689  81 SQNaqTMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKLLLLAILLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLL 160
                         170
                  ....*....|....*
gi 312836769  879 LTSSVCIVAEIIKKV 893
Cdd:pfam00689 161 LALVVLLVVELRKLL 175
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
80-721 1.43e-44

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 170.89  E-value: 1.43e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  80 MLLLASAVISVLMHQFDDAvsitvAILIVV--TVAFVQEY---RSEKSLEELSKLVPPECHCV-REGKLEHTLARDLVPG 153
Cdd:cd07551   60 LLMILAAIGAAAIGYWAEG-----ALLIFIfsLSHALEDYamgRSKRAITALMQLAPETARRIqRDGEIEEVPVEELQIG 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 154 DTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaaTNGDLAsrsniaFMGTLVRCGKAKGVVIGTGEN 233
Cdd:cd07551  135 DRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEK--------TPGDEV------FAGTINGSGALTVRVTKLSSD 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 234 SEFGEVFKMMQAEEAPKTPLQKSMDllgKQLSFYSFGIIGII---MLVG-WLLGKDILEMFTISVSLAVAAIPEGLPIVV 309
Cdd:cd07551  200 TVFAKIVQLVEEAQSEKSPTQSFIE---RFERIYVKGVLLAVlllLLLPpFLLGWTWADSFYRAMVFLVVASPCALVAST 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 310 TVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVIvdgdvvh 389
Cdd:cd07551  277 PPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVTDVIPAEGVDEE----------ELL------- 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 390 gfynpavsRIVEAgcvcndavirnntlMGKPTEGALiALAMkmgldglqqdyIRKAEypfsseqkwmavkcvHRTQQDRP 469
Cdd:cd07551  340 --------QVAAA--------------AESQSEHPL-AQAI-----------VRYAE---------------ERGIPRLP 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 470 EICFmkgayEQVIKYCTTYQSKGQTLTLTQQQRdvYQQEKARMGSAGLRVLALASGPEL-----GQlTFLGLVGIIDPPR 544
Cdd:cd07551  371 AIEV-----EAVTGKGVTATVDGQTYRIGKPGF--FGEVGIPSEAAALAAELESEGKTVvyvarDD-QVVGLIALMDTPR 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 545 TGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDAmdvqqlsqivpkvavfYRAS--PRHKMK 622
Cdd:cd07551  443 PEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELG-------------IDE----------------VVANllPEDKVA 493
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 623 IIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQL 702
Cdd:cd07551  494 IIRELQQEYGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRKMRRIIKQNLIFAL 572
                        650
                 ....*....|....*....
gi 312836769 703 sTSIAALTLISLATLMNFP 721
Cdd:cd07551  573 -AVIALLIVANLFGLLNLP 590
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
46-864 8.05e-44

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 172.55  E-value: 8.05e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769    46 GENETMIPVltsKKASELPVSEVasilqfKNPLIMLLLASaVISVLMHQFDDAVSITVAILIVVTVAFVQEYRseKSLEE 125
Cdd:TIGR01657  153 GKNEIEIPV---PSFLELLKEEV------LHPFYVFQVFS-VILWLLDEYYYYSLCIVFMSSTSISLSVYQIR--KQMQR 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   126 LSKLV-PPECHCV-REGKLEHTLARDLVPGDtvCLSVGDR----VPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQPA 199
Cdd:TIGR01657  221 LRDMVhKPQSVIViRNGKWVTIASDELVPGD--IVSIPRPeektMPCDSVLLSG-SCIVNESMLTGESVPVLKFPIPDNG 297
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   200 ATNGDLA----SRSNIAFMGTLV-------RCGKAKGVVIGTGENSEFGE-VFKMMQAEEAPKTPLQKSMDLLGKQLSFY 267
Cdd:TIGR01657  298 DDDEDLFlyetSKKHVLFGGTKIlqirpypGDTGCLAIVVRTGFSTSKGQlVRSILYPKPRVFKFYKDSFKFILFLAVLA 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   268 SFGIIGIImLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMvKKRAIVKKLPI-VETLGCCNVICSDK 346
Cdd:TIGR01657  378 LIGFIYTI-IELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARL-KKKGIFCTSPFrINFAGKIDVCCFDK 455
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   347 TGTLTknemtvthiftSDGLHAE-VTGVGYNQFGEVIVDGDVvhgfyNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGAL 425
Cdd:TIGR01657  456 TGTLT-----------EDGLDLRgVQGLSGNQEFLKIVTEDS-----SLKPSITHKALATCHSLTKLEGKLVGDPLDKKM 519
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   426 -------------------IALAMKMGLDGLQQDYIRKaeYPFSSEQKWMAVKCvhRTQQDRPEICFMKGAYEQVIKYCt 486
Cdd:TIGR01657  520 featgwtleeddesaeptsILAVVRTDDPPQELSIIRR--FQFSSALQRMSVIV--STNDERSPDAFVKGAPETIQSLC- 594
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   487 tyqsKGQTLtltqqQRDvYQQEKARMGSAGLRVLALASGPeLGQ-----------------LTFLGLVGIIDPPRTGVKE 549
Cdd:TIGR01657  595 ----SPETV-----PSD-YQEVLKSYTREGYRVLALAYKE-LPKltlqkaqdlsrdavesnLTFLGFIVFENPLKPDTKE 663
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   550 AVTTLIASGVSIKMITGDSQETAVAIASRLGLYSK---------------------------TSQSVSGEEID------- 595
Cdd:TIGR01657  664 VIKELKRASIRTVMITGDNPLTAVHVARECGIVNPsntlilaeaeppesgkpnqikfevidsIPFASTQVEIPyplgqds 743
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   596 ----------------------AMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIG 653
Cdd:TIGR01657  744 vedllasryhlamsgkafavlqAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVG 823
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   654 VAMGQTGTDVckeAADMILVDDDFQTIMSAIEEGKGiyNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWIN 733
Cdd:TIGR01657  824 ISLSEAEASV---AAPFTSKLASISCVPNVIREGRC--ALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTID 898
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   734 IIMDGPPAQSLGVEPVDKDVIRKPPrnwKDSILTKNLILKILvSSIIIVCGTLFVFWREL-------RDNVITPRDT--- 803
Cdd:TIGR01657  899 LLLIFPVALLMSRNKPLKKLSKERP---PSNLFSVYILTSVL-IQFVLHILSQVYLVFELhaqpwykPENPVDLEKEnfp 974
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312836769   804 TMTFTCFVFFDMFNALSsrsqTKSVFEIG------LCSNRMFCYAVLGSIMG-QLLVIYFPPLQ-KVFQ 864
Cdd:TIGR01657  975 NLLNTVLFFVSSFQYLI----TAIVNSKGppfrepIYKNKPFVYLLITGLGLlLVLLLDPHPLLgKILQ 1039
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
83-698 2.84e-43

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 166.68  E-value: 2.84e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  83 LASAVISVLMHQFDDAVSITVAIlivvtvafvqeyRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGD 162
Cdd:cd07550   63 YLAANTIAFLLELGELLEDYTAR------------KSEKALLDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGD 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 163 RVPADLRLFEAVDLsIDESSLTGETTPCSKvtapqpaaTNGDLAsrsniaFMGTLVRCGKAKGVVIGTGENSEFGEVFKM 242
Cdd:cd07550  131 VIPVDGTVLSGEAL-IDQASLTGESLPVEK--------REGDLV------FASTVVEEGQLVIRAERVGRETRAARIAEL 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 243 MQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIImlvgWLLGKDI---LEMFTISVSLAVaaipeGLPIVVTVtlaLGVMR 319
Cdd:cd07550  196 IEQSPSLKARIQNYAERLADRLVPPTLGLAGLV----YALTGDIsraAAVLLVDFSCGI-----RLSTPVAV---LSALN 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 320 MVKKRAI-VKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNqfgevivdGDVVHGFYNPAVSR 398
Cdd:cd07550  264 HAARHGIlVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAIITFDGRLSEEDLLYLA--------ASAEEHFPHPVARA 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 399 IVEAgcvcndAVIRNNTLMGKPTEGALIALAMKMGLDGLQqdyIRKAEYPFsseqkwMAvkcvhrtQQDRPEICFMKGAY 478
Cdd:cd07550  336 IVRE------AEERGIEHPEHEEVEYIVGHGIASTVDGKR---IRVGSRHF------ME-------EEEIILIPEVDELI 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 479 EqvikyctTYQSKGQTLtltqqqrdvyqqekarmgsaglrvLALASGPELgqltfLGLVGIIDPPRTGVKEAVTTLIASG 558
Cdd:cd07550  394 E-------DLHAEGKSL------------------------LYVAIDGRL-----IGVIGLSDPLRPEAAEVIARLRALG 437
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 559 V-SIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDAmdvqqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMT 637
Cdd:cd07550  438 GkRIIMLTGDHEQRARALAEQLG-------------IDR--------------YHAEALPEDKAEIVEKLQAEGRTVAFV 490
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 312836769 638 GDGVNDAVALKAADIGVAMGQtGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK-NFV 698
Cdd:cd07550  491 GDGINDSPALSYADVGISMRG-GTDIARETADVVLLEDDLRGLAEAIELARETMALIKrNIA 551
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
87-788 1.94e-42

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 166.65  E-value: 1.94e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  87 VISVLMHQFDDAVSITVAILIV----VTVAFVQEYRSEKSLEELSKLVPPECHCvREGKLEHTLARDLVPGDTVCLSV-G 161
Cdd:cd07542   39 LFSVILWSSDDYYYYAACIVIIsvisIFLSLYETRKQSKRLREMVHFTCPVRVI-RDGEWQTISSSELVPGDILVIPDnG 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 162 DRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQPAATNGDLAS-----RSNIAFMGTLV------RCGKAKGVVIGT 230
Cdd:cd07542  118 TLLPCDAILLSG-SCIVNESMLTGESVPVTKTPLPDESNDSLWSIYsiedhSKHTLFCGTKViqtrayEGKPVLAVVVRT 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 231 GENSEFGE-VFKMMQAEEAPKTPLQKSMDLLGKQ--LSFYSFGIIGIIMLvgwLLGKDILEMFTISVSLAVAAIPEGLPI 307
Cdd:cd07542  197 GFNTTKGQlVRSILYPKPVDFKFYRDSMKFILFLaiIALIGFIYTLIILI---LNGESLGEIIIRALDIITIVVPPALPA 273
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 308 VVTVTLALGVMRMvKKRAIVKKLPI-VETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGlhaevtgvgyNQFGEVIVDGD 386
Cdd:cd07542  274 ALTVGIIYAQSRL-KKKGIFCISPQrINICGKINLVCFDKTGTLTEDGLDLWGVRPVSG----------NNFGDLEVFSL 342
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 387 VVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPtegaliaLAMKM------GLDGLQQdyirkaeYPFSSEQKWMAVKC 460
Cdd:cd07542  343 DLDLDSSLPNGPLLRAMATCHSLTLIDGELVGDP-------LDLKMfeftgwSLEILRQ-------FPFSSALQRMSVIV 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 461 VHrTQQDRPEIcFMKGAYEQVIKYCttyqsKGQTLTltqqqrDVYQQEKARMGSAGLRVLALAS-----GPELGQ----- 530
Cdd:cd07542  409 KT-PGDDSMMA-FTKGAPEMIASLC-----KPETVP------SNFQEVLNEYTKQGFRVIALAYkalesKTWLLQklsre 475
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 531 -----LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGE--EIDAMDVQQLS 603
Cdd:cd07542  476 evesdLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVARECGMISPSKKVILIEavKPEDDDSASLT 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 604 -QIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVckeAADMILVDDDFQTIMS 682
Cdd:cd07542  556 wTLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLSEAEASV---AAPFTSKVPDISCVPT 632
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 683 AIEEGkgiynniknfvRFQLSTSIAALTLISLATLMNF---------PNPLNAMQILWINIIMDGPPAQSLG-VEPVDKD 752
Cdd:cd07542  633 VIKEG-----------RAALVTSFSCFKYMALYSLIQFisvlilysiNSNLGDFQFLFIDLVIITPIAVFMSrTGAYPKL 701
                        730       740       750
                 ....*....|....*....|....*....|....*.
gi 312836769 753 VIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFV 788
Cdd:cd07542  702 SSKRPPASLVSPPVLVSLLGQIVLILLFQVIGFLIV 737
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
118-717 2.48e-42

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 164.11  E-value: 2.48e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 118 RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKVT-AP 196
Cdd:cd07546   85 RARSGVKALMALVPETALREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAAgDK 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 197 QPA-ATNGDLASRsniafmgtlVRCGKAKgvvigtGENSeFGEVFKMMQAEEAPKTPLQKSMDLLGKqlsFYSFGIIGII 275
Cdd:cd07546  164 VFAgSINVDGVLR---------IRVTSAP------GDNA-IDRILHLIEEAEERRAPIERFIDRFSR---WYTPAIMAVA 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 276 MLVG----WLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 351
Cdd:cd07546  225 LLVIvvppLLFGADWQTWIYRGLALLLIGCPCALVISTPAAITSGLAAAARRGALIKGGAALEQLGRVTTVAFDKTGTLT 304
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 352 KNEMTVTHIFTSDGLHAevtgvgynqfGEVIvdgdvvhgfynpAVSRIVEAGCvcndavirnntlmGKPTEGALIALAMK 431
Cdd:cd07546  305 RGKPVVTDVVPLTGISE----------AELL------------ALAAAVEMGS-------------SHPLAQAIVARAQA 349
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 432 MGLdglqqdyirkaEYPFSSEQKWMAVKCVHRTQQDRP-EICFMKGAYEQVikyctTYQSKGQTLTLTQQQRDVyqqeka 510
Cdd:cd07546  350 AGL-----------TIPPAEEARALVGRGIEGQVDGERvLIGAPKFAADRG-----TLEVQGRIAALEQAGKTV------ 407
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 511 rmgsaglrVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYsktsqsvs 590
Cdd:cd07546  408 --------VVVLANG------RVLGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGLD-------- 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 591 geeidamdvqqlsqivpkvavfYRAS--PRHKMKIIKSLQKNGSvVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAA 668
Cdd:cd07546  466 ----------------------FRAGllPEDKVKAVRELAQHGP-VAMVGDGINDAPAMKAASIGIAMG-SGTDVALETA 521
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 312836769 669 DMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLS-------TSIAALTLISLATL 717
Cdd:cd07546  522 DAALTHNRLGGVAAMIELSRATLANIRQNITIALGlkavflvTTLLGITGLWLAVL 577
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
138-656 1.14e-36

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 149.07  E-value: 1.14e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 138 REGKLEHTLARDLVPGDTVCLSVGDR---VPADLRLFEAVDLsIDESSLTGETTPCSK---VTAPQPAATNGDLASRSNI 211
Cdd:cd07543   92 RDGKWVPISSDELLPGDLVSIGRSAEdnlVPCDLLLLRGSCI-VNEAMLTGESVPLMKepiEDRDPEDVLDDDGDDKLHV 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 212 AFMGTLV-------RCG-KAK-----GVVIGTGENSEFGEVFKMM--QAEEAPKTPLQKSMDLL-----GKQLSFYSFgI 271
Cdd:cd07543  171 LFGGTKVvqhtppgKGGlKPPdggclAYVLRTGFETSQGKLLRTIlfSTERVTANNLETFIFILfllvfAIAAAAYVW-I 249
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 272 IGIIMlvGWLLGKDILEMFTISVSLavaaIPEGLPIvvtvTLALGV---MRMVKKRAIVKKLPI-VETLGCCNVICSDKT 347
Cdd:cd07543  250 EGTKD--GRSRYKLFLECTLILTSV----VPPELPM----ELSLAVntsLIALAKLYIFCTEPFrIPFAGKVDICCFDKT 319
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 348 GTLTKNEMtvthiftsdglhaEVTGV-GYNQFGEVIVDGDVVHGfynpavsRIVEAGCVCNDAVIR-NNTLMGKPTEGA- 424
Cdd:cd07543  320 GTLTSDDL-------------VVEGVaGLNDGKEVIPVSSIEPV-------ETILVLASCHSLVKLdDGKLVGDPLEKAt 379
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 425 LIALAMKMGLD--------GLQQDYIRKAeYPFSSEQKWMAVKCVHR--TQQDRPEICFMKGAYEqvikycttyqskgqt 494
Cdd:cd07543  380 LEAVDWTLTKDekvfprskKTKGLKIIQR-FHFSSALKRMSVVASYKdpGSTDLKYIVAVKGAPE--------------- 443
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 495 lTLTQQQRDV---YQQEKARMGSAGLRVLALASG--PELGQ--------------LTFLGLVGIIDPPRTGVKEAVTTLI 555
Cdd:cd07543  444 -TLKSMLSDVpadYDEVYKEYTRQGSRVLALGYKelGHLTKqqardykredvesdLTFAGFIVFSCPLKPDSKETIKELN 522
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 556 ASGVSIKMITGDSQETAVAIASRLGLyskTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVA 635
Cdd:cd07543  523 NSSHRVVMITGDNPLTACHVAKELGI---VDKPVLILILSEEGKSNEWKLIPHVKVFARVAPKQKEFIITTLKELGYVTL 599
                        570       580
                 ....*....|....*....|.
gi 312836769 636 MTGDGVNDAVALKAADIGVAM 656
Cdd:cd07543  600 MCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
73-656 2.82e-35

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 144.27  E-value: 2.82e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  73 QFKNPLIMLLLASAVISVLMHQFDDAVSItVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARD-LV 151
Cdd:cd02082   28 EFKKPFNFFQYFGVILWGIDEYVYYAITV-VFMTTINSLSCIYIRGVMQKELKDACLNNTSVIVQRHGYQEITIASNmIV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 152 PGDTVCLSV-GDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQPAATNG---DLASRSNIAFMGTLVRCGKA---- 223
Cdd:cd02082  107 PGDIVLIKRrEVTLPCDCVLLEG-SCIVTEAMLTGESVPIGKCQIPTDSHDDVlfkYESSKSHTLFQGTQVMQIIPpedd 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 224 --KGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLgkQLSFYSFGIIGIIMLvgWLLGKDI----LEMFTISVSLA 297
Cdd:cd02082  186 ilKAIVVRTGFGTSKGQLIRAILYPKPFNKKFQQQAVKF--TLLLATLALIGFLYT--LIRLLDIelppLFIAFEFLDIL 261
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 298 VAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIftsdglhaevTGVGYNQ 377
Cdd:cd02082  262 TYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLIGY----------QLKGQNQ 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 378 FGevivdgDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALI-ALAMKMGLDGLQQDYIRKA---------EY 447
Cdd:cd02082  332 TF------DPIQCQDPNNISIEHKLFAICHSLTKINGKLLGDPLDVKMAeASTWDLDYDHEAKQHYSKSgtkrfyiiqVF 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 448 PFSSEQKWMAVKC--VHRTQQDRPEICFMKGAYEQVIKYCTTYQS--KGQTLTLTQQqrdvyqqekarmgsaGLRVLALA 523
Cdd:cd02082  406 QFHSALQRMSVVAkeVDMITKDFKHYAFIKGAPEKIQSLFSHVPSdeKAQLSTLINE---------------GYRVLALG 470
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 524 SgPELGQLT-----------------FLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTS 586
Cdd:cd02082  471 Y-KELPQSEidafldlsreaqeanvqFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEIINRKN 549
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312836769 587 QSVSGEEI---DAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAM 656
Cdd:cd02082  550 PTIIIHLLipeIQKDNSTQWILIIHTNVFARTAPEQKQTIIRLLKESDYIVCMCGDGANDCGALKEADVGISL 622
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
118-737 4.59e-34

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 139.09  E-value: 4.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 118 RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapq 197
Cdd:cd07545   82 RARRSIRSLMDIAPKTALVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGES-SVNQAAITGESLPVEK----- 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 198 paaTNGDLAsrsniaFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKqlsFYSFGIIGIIML 277
Cdd:cd07545  156 ---GVGDEV------FAGTLNGEGALEVRVTKPAEDSTIARIIHLVEEAQAERAPTQAFVDRFAR---YYTPVVMAIAAL 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 278 VG----WLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKN 353
Cdd:cd07545  224 VAivppLFFGGAWFTWIYRGLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKG 303
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 354 EmtvthiftsdglhaevtgvgynqfgevivdgdvvhgfynPAVSRIVEAGCvcndavirnntlmgkPTEGALIALAMKMG 433
Cdd:cd07545  304 K---------------------------------------PVVTDVVVLGG---------------QTEKELLAIAAALE 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 434 ldglqqdyiRKAEYPFSS------EQKWMAVKCVHrtqqdrpEICFMKGAYEQVIKYCTTYQSKGQTL--TLTQQQRDVY 505
Cdd:cd07545  330 ---------YRSEHPLASaivkkaEQRGLTLSAVE-------EFTALTGRGVRGVVNGTTYYIGSPRLfeELNLSESPAL 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 506 QQEKARMGSAGLRVLALASGPelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVS-IKMITGDSQETAVAIASRLGLysk 584
Cdd:cd07545  394 EAKLDALQNQGKTVMILGDGE-----RILGVIAVADQVRPSSRNAIAALHQLGIKqTVMLTGDNPQTAQAIAAQVGV--- 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 585 tsQSVSGEEIdamdvqqlsqivpkvavfyrasPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVC 664
Cdd:cd07545  466 --SDIRAELL----------------------PQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTA 521
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312836769 665 KEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLIslatlmnFPnplnAMQILWINIIMD 737
Cdd:cd07545  522 LETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALLLV-------IP----GWLTLWMAVFAD 583
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
68-685 8.06e-34

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 138.22  E-value: 8.06e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  68 VASILQF-------KNPLIMLLLASAVISVLMHQFDDA------VSITVAILIVVTVAfVQEY----------------- 117
Cdd:cd07544   12 IALILCFglhqpllAAWIVLIGGVVIALSLLWEMIKTLrrgrygVDLLAILAIVATLL-VGEYwasliillmltggeale 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 118 -----RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLfEAVDLSIDESSLTGETTPCSK 192
Cdd:cd07544   91 dyaqrRASRELTALLDRAPRIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEV-VSGTATLDESSLTGESKPVSK 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 193 VTAPQ--PAATNGDLAsrsniafmgtlvrcgkAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGkqlsfYSFG 270
Cdd:cd07544  170 RPGDRvmSGAVNGDSA----------------LTMVATKLAADSQYAGIVRLVKEAQANPAPFVRLADRYA-----VPFT 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 271 IIGI-IMLVGWLLGKDIlemfTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGT 349
Cdd:cd07544  229 LLALaIAGVAWAVSGDP----VRFAAVLVVATPCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGT 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 350 LTKNEMTVTHIFTSDGLHA-EVTGVGYNqfgeviVDGDVVHgfynPAVSRIVEAGcvcndaviRNNTL-MGKPTEgalIA 427
Cdd:cd07544  305 LTYGQPKVVDVVPAPGVDAdEVLRLAAS------VEQYSSH----VLARAIVAAA--------RERELqLSAVTE---LT 363
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 428 LAMKMGLDG-LQQDYIRKAEYPFSSEQKWMAvkcvhrtqqdrpeicfmkgayeqvikycttyqskgqtltltqqqrdvyq 506
Cdd:cd07544  364 EVPGAGVTGtVDGHEVKVGKLKFVLARGAWA------------------------------------------------- 394
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 507 QEKARMGSAGLRVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVS-IKMITGDSQETAVAIASRLGLyskt 585
Cdd:cd07544  395 PDIRNRPLGGTAVYVSVDG------KYAGAITLRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGI---- 464
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 586 sQSVSGEeidamdvqqlsqivpkvavfyrASPRHKMKIIKSLQKNGsVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCK 665
Cdd:cd07544  465 -DEVRAE----------------------LLPEDKLAAVKEAPKAG-PTIMVGDGVNDAPALAAADVGIAMGARGSTAAS 520
                        650       660
                 ....*....|....*....|
gi 312836769 666 EAADMILVDDDFQTIMSAIE 685
Cdd:cd07544  521 EAADVVILVDDLDRVVDAVA 540
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
73-730 1.40e-32

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 135.08  E-value: 1.40e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  73 QFKNPLIMLLLASAVISVLMHQFDDAVS--------ITVAILIVVTVAF------VQEYRSE---KSL-----EELSKLV 130
Cdd:cd02078   21 LAKNPVMFVVEIGSIITTVLTFFPLLFSgggpagfnLAVSLWLWFTVLFanfaeaIAEGRGKaqaDSLrktktETQAKRL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 131 ppechcVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVdLSIDESSLTGETTPCSKVTAPQPAATNGdlasrsn 210
Cdd:cd02078  101 ------RNDGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGV-ASVDESAITGESAPVIRESGGDRSSVTG------- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 211 iafmGTLVRCGKAKGVVigtgeNSEFGEVF--KMMQAEEAP---KTPLQKSMDllgkqlsfysfgiigiIMLVGwllgkd 285
Cdd:cd02078  167 ----GTKVLSDRIKVRI-----TANPGETFldRMIALVEGAsrqKTPNEIALT----------------ILLVG------ 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 286 ilemFTISVSLAVAAIP-----EGLPIVVTVTLAL-------------------GVMRMVKKRAIVKKLPIVETLGCCNV 341
Cdd:cd02078  216 ----LTLIFLIVVATLPpfaeySGAPVSVTVLVALlvclipttiggllsaigiaGMDRLLRFNVIAKSGRAVEAAGDVDT 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 342 ICSDKTGTLT-KNEMTVTHIftsdglhaEVTGVGYNQFGEVivdgdvvhgfynpavsriveagcvCNDAVIRNNTLMGKp 420
Cdd:cd02078  292 LLLDKTGTITlGNRQATEFI--------PVGGVDEKELADA------------------------AQLASLADETPEGR- 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 421 tegALIALAMKMGLDGLQQDYiRKAEY-PFSSEQKWMAVKCVHRTQqdrpeicFMKGAYEQVIKYCTTYQSKgqtltLTQ 499
Cdd:cd02078  339 ---SIVILAKQLGGTERDLDL-SGAEFiPFSAETRMSGVDLPDGTE-------IRKGAVDAIRKYVRSLGGS-----IPE 402
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 500 QQRDVYQqEKARMGSAGLRVLALAsgpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRL 579
Cdd:cd02078  403 ELEAIVE-EISKQGGTPLVVAEDD--------RVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEA 473
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 580 GLYSKTSQsvsgeeidamdvqqlsqivpkvavfyrASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQT 659
Cdd:cd02078  474 GVDDFLAE---------------------------AKPEDKLELIRKEQAKGKLVAMTGDGTNDAPALAQADVGVAM-NS 525
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312836769 660 GTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 730
Cdd:cd02078  526 GTQAAKEAGNMVDLDSDPTKLIEVVEIGKQLLMTRGALTTFSIANDVAKYFAIIPAMFAAAYPQLGALNIM 596
KdpB COG2216
High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism];
73-730 9.25e-32

High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism];


Pssm-ID: 225126 [Multi-domain]  Cd Length: 681  Bit Score: 132.78  E-value: 9.25e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  73 QFKNPLIMLLLASAVISVLMHQFDDAV---------SITVAILIVVTVAF------VQEYRSEK---SLEELSKLVppEC 134
Cdd:COG2216   29 LVKNPVMFVVEVGSILTTFLTIFPDLFggtggsrlfNLAITIILWFTVLFanfaeaVAEGRGKAqadSLRKTKTET--IA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 135 HCVRE-GKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKVTAPQPAATNGdlasrsniaf 213
Cdd:COG2216  107 RLLRAdGSIEMVPATELKKGDIVLVEAGEIIPSDGEVIEGVA-SVDESAITGESAPVIRESGGDFSSVTG---------- 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 214 mGTLVRCGKAKgVVIGtgenSEFGEVF--KMMQAEEAP---KTPLQKSMDLLGKQLSfysfgiigIIMLVGwllgkdILE 288
Cdd:COG2216  176 -GTRVLSDWLK-IRIT----ANPGETFldRMIALVEGAerqKTPNEIALTILLSGLT--------LIFLLA------VAT 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 289 MFTISVSLAVAAIPEGLPIVVTVTL----------ALGV--M-RMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT-KNE 354
Cdd:COG2216  236 LYPFAIYSGGGAASVTVLVALLVCLipttiggllsAIGIagMdRVTQFNVIATSGRAVEAAGDVDTLLLDKTGTITlGNR 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 355 MTVTHIftsdglhaEVTGVGYNQFGEVivdgdvvhgfynpavsriveagcvCNDAVIRNNTLMGKptegALIALAMKMGL 434
Cdd:COG2216  316 QASEFI--------PVPGVSEEELADA------------------------AQLASLADETPEGR----SIVELAKKLGI 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 435 DGLQQDYIRKAEY-PFSSEQKWMAVKCvhrtqQDRPEIcfMKGAYEQVIKYCTTYQSKgqtltlTQQQRDVYQQEKARMG 513
Cdd:COG2216  360 ELREDDLQSHAEFvPFTAQTRMSGVDL-----PGGREI--RKGAVDAIRRYVRERGGH------IPEDLDAAVDEVSRLG 426
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 514 SAGLRVLalasgpELGQltFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysktsqsvsgEE 593
Cdd:COG2216  427 GTPLVVV------ENGR--ILGVIYLKDIVKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----------DD 488
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 594 IDAmdvqqlsqivpkvavfyRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILV 673
Cdd:COG2216  489 FIA-----------------EATPEDKLALIRQEQAEGRLVAMTGDGTNDAPALAQADVGVAM-NSGTQAAKEAANMVDL 550
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 312836769 674 DDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 730
Cdd:COG2216  551 DSNPTKLIEVVEIGKQLLITRGALTTFSIANDVAKYFAIIPAMFAAAYPQLGALNIM 607
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
73-730 7.60e-28

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 120.37  E-value: 7.60e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   73 QFKNPLIMLL----LASAVISVLMHQFDDA------VSITVAILIVVTVAF------VQEYRSEKSL--------EELSK 128
Cdd:TIGR01497  29 QWRNPVMFIVwvgsLLTTCITIAPASFGMPgnnlalFNAIITGILFITVLFanfaeaVAEGRGKAQAdslkgtkkTTFAK 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  129 LVPPEchcvreGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVdLSIDESSLTGETTPCSKvtapqpaATNGDLASR 208
Cdd:TIGR01497 109 LLRDD------GAIDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGV-ASVDESAITGESAPVIK-------ESGGDFASV 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  209 SNiafmGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIle 288
Cdd:TIGR01497 175 TG----GTRILSDWLVVECTANPGETFLDRMIALVEGAQRRKTPNEIALTILLIALTLVFLLVTATLWPFAAYGGNAI-- 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  289 MFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTknemtvthiftsdglha 368
Cdd:TIGR01497 249 SVTVLVALLVCLIPTTIGGLLSAIGIAGMDRVLGFNVIATSGRAVEACGDVDTLLLDKTGTIT----------------- 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  369 evtgVGYNQFGEVIVDGDVvhgfynpAVSRIVEAGCVCNdavIRNNTLMGKptegALIALAMKMGLDGLQQDYIRKAEYP 448
Cdd:TIGR01497 312 ----LGNRLASEFIPAQGV-------DEKTLADAAQLAS---LADDTPEGK----SIVILAKQLGIREDDVQSLHATFVE 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  449 FSSEQKWMAVKCVHRTQqdrpeicFMKGAYEQVIKYCttyQSKGQTLTltqQQRDVYQQEKARMGSAGLrvlALASGPEL 528
Cdd:TIGR01497 374 FTAQTRMSGINLDNGRM-------IRKGAVDAIKRHV---EANGGHIP---TDLDQAVDQVARQGGTPL---VVCEDNRI 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  529 gqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQsvsgeeidamdvqqlsqivpk 608
Cdd:TIGR01497 438 -----YGVIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGVDDFIAE--------------------- 491
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  609 vavfyrASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGK 688
Cdd:TIGR01497 492 ------ATPEDKIALIRQEQAEGKLVAMTGDGTNDAPALAQADVGVAM-NSGTQAAKEAANMVDLDSDPTKLIEVVHIGK 564
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 312836769  689 GIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 730
Cdd:TIGR01497 565 QLLITRGALTTFSIANDVAKYFAIIPAIFAAAYPQLQALNIM 606
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
118-695 3.51e-25

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 112.01  E-value: 3.51e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 118 RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQ 197
Cdd:PRK11033 229 RARRGVSALMALVPETATRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSP-FASFDESALTGESIPVERATGEK 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 198 PAAtnGDLASRSniafmgtLVRCGkakgVVIGTGENSeFGEVFKMMQAEEAPKTPLQKSMDLLGKqlsFYSfgiiGIIML 277
Cdd:PRK11033 308 VPA--GATSVDR-------LVTLE----VLSEPGASA-IDRILHLIEEAEERRAPIERFIDRFSR---IYT----PAIML 366
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 278 VgwllgkdilemftisvSLAVAAIP-------------EGL---------------PIVVTVTLALGVMRmvkkRAIVKK 329
Cdd:PRK11033 367 V----------------ALLVILVPpllfaapwqewiyRGLtllligcpcalvistPAAITSGLAAAARR----GALIKG 426
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 330 LPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVIvdgdvvhgfynpAVSRIVEAGCvcnda 409
Cdd:PRK11033 427 GAALEQLGRVTTVAFDKTGTLTEGKPQVTDIHPATGISES----------ELL------------ALAAAVEQGS----- 479
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 410 virnntlmGKPTEGALIALAMKMGLDglqqdyirkaeYPFSSEQKWMAVKCVH-RTQQDRPEICfmkgayeqvikyctty 488
Cdd:PRK11033 480 --------THPLAQAIVREAQVRGLA-----------IPEAESQRALAGSGIEgQVNGERVLIC---------------- 524
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 489 qSKGQTLTLTQQQrdvyQQEKARMGSAG-LRVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGD 567
Cdd:PRK11033 525 -APGKLPPLADAF----AGQINELESAGkTVVLVLRND------DVLGLIALQDTLRADARQAISELKALGIKGVMLTGD 593
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 568 SQETAVAIASRLGlysktsqsvsgeeidaMDvqqlsqivpkvavfYRAS--PRHKMKIIKSLQKNgSVVAMTGDGVNDAV 645
Cdd:PRK11033 594 NPRAAAAIAGELG----------------ID--------------FRAGllPEDKVKAVTELNQH-APLAMVGDGINDAP 642
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 312836769 646 ALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK 695
Cdd:PRK11033 643 AMKAASIGIAMG-SGTDVALETADAALTHNRLRGLAQMIELSRATHANIR 691
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
95-738 1.15e-24

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 109.91  E-value: 1.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  95 FDdavSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVRE---GKLEHTLARDLVPGDTVCLSVGDRVPADLRLF 171
Cdd:cd07553   91 FD---SLSVLVFLMLVGRWLQVVTQERNRNRLADSRLEAPITEIEtgsGSRIKTRADQIKSGDVYLVASGQRVPVDGKLL 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 172 EAvDLSIDESSLTGETTPCSKvtapqpaatngdlaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKT 251
Cdd:cd07553  168 SE-QASIDMSWLTGESLPRIV--------------ERGDKVPAGTSLENQAFEIRVEHSLAESWSGSILQKVEAQEARKT 232
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 252 PLqksmDLLGKQLSFYSFGIIGIIMLVGWL--LGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKK 329
Cdd:cd07553  233 PR----DLLADKIIHYFTVIALLIAVAGFGvwLAIDLSIALKVFTSVLIVACPCALALATPFTDEIALARLKKKGVLIKN 308
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 330 LPIVETLGCCNVICSDKTGTLTKNEMTVthiftsdglhaevtgvgynqfgeVIVDGDVVHGFYNPAVSRIVEAgcvCNDA 409
Cdd:cd07553  309 ASSLERLSRVRTIVFDKTGTLTRGKSSF-----------------------VMVNPEGIDRLALRAISAIEAH---SRHP 362
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 410 VIRnntlmgkptegALIALAMKMGLdglqqdyirkaeypfsseqkwmavkcvhrtqqDRPEICFMKgayEQVIKYCTTYQ 489
Cdd:cd07553  363 ISR-----------AIREHLMAKGL--------------------------------IKAGASELV---EIVGKGVSGNS 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 490 SKGQTltltqqqrdvyqqekaRMGSAGLRVLALASGPELGQLTFLGLVGII-DPPRTGVKEAVTTLIASGVSIKMITGDS 568
Cdd:cd07553  397 SGSLW----------------KLGSAPDACGIQESGVVIARDGRQLLDLSFnDLLRPDSNREIEELKKGGLSIAILSGDN 460
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 569 QETAVAIASRLGLysktsqsvsgeeidamDVQQLsqivpkvavFYRASPRHKMKIIKSLQKNGSVvaMTGDGVNDAVALK 648
Cdd:cd07553  461 EEKVRLVGDSLGL----------------DPRQL---------FGNLSPEEKLAWIESHSPENTL--MVGDGANDALALA 513
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 649 AADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTL-----IS---LATLMnf 720
Cdd:cd07553  514 SAFVGIAV-AGEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNLVAIGLalsgwISplvAAILM-- 590
                        650
                 ....*....|....*...
gi 312836769 721 pnPLNAMQILWINIIMDG 738
Cdd:cd07553  591 --PLSSITILGIVWAALG 606
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
105-660 1.06e-23

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 107.64  E-value: 1.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 105 ILIVVTVAFVQE----YRSEKSLEELSKLvppECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLS--- 177
Cdd:cd02073   55 LLFVLGVTAIKEgyedIRRHKSDNEVNNR---PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDglc 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 178 -IDESSLTGET------------TPCS---------KVTAPQPaatNGDLASrsniaFMGTLVRCGKAK----------- 224
Cdd:cd02073  132 yVETANLDGETnlkirqalpetaLLLSeedlarfsgEIECEQP---NNDLYT-----FNGTLELNGGRElplspdnlllr 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 225 -----------GVVIGTGENSefgevfKMMQaeEAPKTPLQKS-MDLLGKQLSFYSFGIIGIIMLVG-----WLLGKDIL 287
Cdd:cd02073  204 gctlrntewvyGVVVYTGHET------KLML--NSGGTPLKRSsIEKKMNRFIIAIFCILIVMCLISaigkgIWLSKHGR 275
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 288 EMFTISVSLAVAAIPEGLPIVVT--------VTLALGV-MRMVK-------------------KRAIVKKLPIVETLGCC 339
Cdd:cd02073  276 DLWYLLPKEERSPALEFFFDFLTfiilynnlIPISLYVtIEVVKflqsffinwdldmydeetdTPAEARTSNLNEELGQV 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 340 NVICSDKTGTLTKNEMTvthiftsdglhaevtgvgynqFGEVIVDGdVVHGFYnpavsrivEAGCVCNDAVIRNNTLMGK 419
Cdd:cd02073  356 EYIFSDKTGTLTENIME---------------------FKKCSING-VDYGFF--------LALALCHTVVPEKDDHPGQ 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 420 -------PTEGALIALAMKMG--LDGLQQDYI------RKAEY------PFSSEQKWMAVkcVHRTQQDRpeIC-FMKGA 477
Cdd:cd02073  406 lvyqassPDEAALVEAARDLGfvFLSRTPDTVtinalgEEEEYeilhilEFNSDRKRMSV--IVRDPDGR--ILlYCKGA 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 478 ----YEQVIKycttyqSKGQTLTLTQQQRDVYQQEkarmgsaGLRVLALA------------------------------ 523
Cdd:cd02073  482 dsviFERLSP------SSLELVEKTQEHLEDFASE-------GLRTLCLAyreiseeeyeewnekydeastalqnreell 548
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 524 --SGPELGQ-LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVsGEEID----- 595
Cdd:cd02073  549 deVAEEIEKdLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDMENL-ALVIDgktlt 627
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312836769 596 -AMDVQQLSQIVP-----KVAVFYRASPRHKMKIIKSLQKNGSVVAMT-GDGVNDAVALKAADIGVA-MGQTG 660
Cdd:cd02073  628 yALDPELERLFLElalkcKAVICCRVSPLQKALVVKLVKKSKKAVTLAiGDGANDVSMIQEAHVGVGiSGQEG 700
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
139-730 1.81e-23

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 106.32  E-value: 1.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 139 EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVdLSIDESSLTGETTPCSKvtapqpaATNGDLasrsNIAFMGTLV 218
Cdd:PRK14010 112 DGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGL-ATVDESAITGESAPVIK-------ESGGDF----DNVIGGTSV 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 219 RCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIleMFTISVSLAV 298
Cdd:PRK14010 180 ASDWLEVEITSEPGHSFLDKMIGLVEGATRKKTPNEIALFTLLMTLTIIFLVVILTMYPLAKFLNFNL--SIAMLIALAV 257
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 299 AAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTknemtvthifTSDGLHAEVTGVGYNQF 378
Cdd:PRK14010 258 CLIPTTIGGLLSAIGIAGMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTIT----------YGNRMADAFIPVKSSSF 327
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 379 gevivdgdvvhgfynpavSRIVEAGCVCNdavIRNNTlmgkPTEGALIALAMKMGLDgLQQDyiRKAEYPFSSEQKWMAV 458
Cdd:PRK14010 328 ------------------ERLVKAAYESS---IADDT----PEGRSIVKLAYKQHID-LPQE--VGEYIPFTAETRMSGV 379
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 459 KCVHRTqqdrpeicFMKGAYEQVIKycTTYQSKGQtltlTQQQRDVYQQEKARMGSAGLRVLAlasgpelgQLTFLGLVG 538
Cdd:PRK14010 380 KFTTRE--------VYKGAPNSMVK--RVKEAGGH----IPVDLDALVKGVSKKGGTPLVVLE--------DNEILGVIY 437
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 539 IIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQsvsgeeidamdvqqlsqivpkvavfyrASPR 618
Cdd:PRK14010 438 LKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVDRFVAE---------------------------CKPE 490
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 619 HKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFV 698
Cdd:PRK14010 491 DKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAM-NSGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLT 569
                        570       580       590
                 ....*....|....*....|....*....|..
gi 312836769 699 RFQLSTSIAALTLISLATLMNFPNPLNAMQIL 730
Cdd:PRK14010 570 TFSIANDIAKYFAILPAMFMAAMPAMNHLNIM 601
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
95-685 2.80e-23

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 105.52  E-value: 2.80e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  95 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR-EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEA 173
Cdd:cd02092   89 FDAAVMLLFFLLIGRYLDHRMRGRARSAAEELAALEARGAQRLQaDGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSG 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 174 VDLsIDESSLTGETtpcskvtAPQPAATNGDL-ASRSNIAfmGTL-VRcgkakgvVIGTGENSEFGEVFKMMQAEEAPKT 251
Cdd:cd02092  169 TSE-LDRSLLTGES-------APVTVAPGDLVqAGAMNLS--GPLrLR-------ATAAGDDTLLAEIARLMEAAEQGRS 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 252 plqKSMDLLGKQLSFYS--FGIIGIIMLVGW-LLGKDILEMFTISVSLAVAAIPEGL----PIVVTVtlALGvmRMVKKR 324
Cdd:cd02092  232 ---RYVRLADRAARLYApvVHLLALLTFVGWvAAGGDWRHALLIAVAVLIITCPCALglavPAVQVV--ASG--RLFRRG 304
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 325 AIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGvgynqfgevivdGDVVHGFYNPAVSRIVEAGC 404
Cdd:cd02092  305 VLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGAHAISADLLALAA------------ALAQASRHPLSRALAAAAGA 372
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 405 VcnDAVIRNNT-LMGKPTEGALIALAMKMGldglqqdyirkaeypfsseqkwmavkcvhrtqqdRPEICfmkGAYEQVIK 483
Cdd:cd02092  373 R--PVELDDAReVPGRGVEGRIDGARVRLG----------------------------------RPAWL---GASAGVST 413
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 484 YCTTYQSKGqtltltqqqrdvyQQEKARMGSAglrvlalasgpelgqltflglvgiiDPPRTGVKEAVTTLIASGVSIKM 563
Cdd:cd02092  414 ASELALSKG-------------GEEAARFPFE-------------------------DRPRPDAREAISALRALGLSVEI 455
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 564 ITGDSQETAVAIASRLGLysktsQSVSGEeidamdvqqlsqivpkvavfyrASPRHKMKIIKSLQKNGSVVAMTGDGVND 643
Cdd:cd02092  456 LSGDREPAVRALARALGI-----EDWRAG----------------------LTPAEKVARIEELKAQGRRVLMVGDGLND 508
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|..
gi 312836769 644 AVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIE 685
Cdd:cd02092  509 APALAAAHVSMAPA-SAVDASRSAADIVFLGDSLAPVPEAIE 549
copA PRK10671
copper-exporting P-type ATPase CopA;
118-719 4.97e-22

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 102.13  E-value: 4.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 118 RSEKSLEELSKLVPPECHCV-REGKLEHTLArDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTap 196
Cdd:PRK10671 309 RSSKALEKLLDLTPPTARVVtDEGEKSVPLA-DVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGE-- 384
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 197 qpaatnGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDllgKQLSFYSFGIIGIIM 276
Cdd:PRK10671 385 ------GD------SVHAGTVVQDGSVLFRASAVGSHTTLSRIIRMVRQAQSSKPEIGQLAD---KISAVFVPVVVVIAL 449
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 277 LVG--WLL---GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 351
Cdd:PRK10671 450 VSAaiWYFfgpAPQIVYTLVIATTVLIIACPCALGLATPMSIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLT 529
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 352 KNEMTVTHIFTsdglhaevtgvgYNQFGEVIV---DGDVVHGFYNPAVSRIVE-AGCVCNDAVIRNNTLMGKPTEGALIA 427
Cdd:PRK10671 530 EGKPQVVAVKT------------FNGVDEAQAlrlAAALEQGSSHPLARAILDkAGDMTLPQVNGFRTLRGLGVSGEAEG 597
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 428 LAMKMGldglqqdyirkaeypfssEQKWMAvkcvhrtqqdrpeicfmkgayeqvikycttyqskgqtltltQQQRDV--Y 505
Cdd:PRK10671 598 HALLLG------------------NQALLN-----------------------------------------EQQVDTkaL 618
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 506 QQEKARMGSAGLRVLALASGpelGQLTflGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlyskt 585
Cdd:PRK10671 619 EAEITAQASQGATPVLLAVD---GKAA--ALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAG----- 688
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 586 sqsvsgeeIDamdvqqlsQIVPKVAvfyrasPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCK 665
Cdd:PRK10671 689 --------ID--------EVIAGVL------PDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAI 745
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 666 EAADMILVDDDFQTIMSAIEEGKGIYNNIKN-----FVRFQLSTSIAALTLISL-ATLMN 719
Cdd:PRK10671 746 ETAAITLMRHSLMGVADALAISRATLRNMKQnllgaFIYNSLGIPIAAGILWPFtGTLLN 805
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
404-488 2.72e-20

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 433060 [Multi-domain]  Cd Length: 91  Bit Score: 86.11  E-value: 2.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  404 CVCNDAVIRNN------TLMGKPTEGALIALAMKMGLD--GLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPEICFMK 475
Cdd:pfam13246   1 ALCNSAAFDENeekgkwEIVGDPTESALLVFAEKMGIDveELRKDYPKVAEIPFNSDRKRMST--VHKLPDDGKYRLFVK 78
                          90
                  ....*....|...
gi 312836769  476 GAYEQVIKYCTTY 488
Cdd:pfam13246  79 GAPEIILDRCTHI 91
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
73-660 6.52e-17

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 85.90  E-value: 6.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769    73 QFKNPLIMLLLasaVISVLmhQFDDAVSIT------VAILIVVTVAFVQE----YRSEKS-LEELSKLVppecHCVRE-G 140
Cdd:TIGR01652   24 QFKRFANLYFL---VVALL--QQVPILSPTyrgtsiVPLAFVLIVTAIKEaiedIRRRRRdKEVNNRLT----EVLEGhG 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   141 KLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLS----IDESSLTGET----------TPC-----------SKVTA 195
Cdd:TIGR01652   95 QFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvcyVETANLDGETnlklrqaleeTQKmldeddiknfsGEIEC 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   196 PQPAAT----NGDLA---------SRSNIAFMGTLVRCGK-AKGVVIGTGensefGEVFKMMQAEEAP--KTPLQKSMDL 259
Cdd:TIGR01652  175 EQPNASlysfQGNMTingdrqyplSPDNILLRGCTLRNTDwVIGVVVYTG-----HDTKLMRNATQAPskRSRLEKELNF 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   260 LGKQLSFYSFGIIgIIMLVG------------WLLGKDILEM---------FTISVSLAVAAIPEGLPI---VVTVTLAL 315
Cdd:TIGR01652  250 LIIILFCLLFVLC-LISSVGagiwndahgkdlWYIRLDVSERnaaangffsFLTFLILFSSLIPISLYVsleLVKSVQAY 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   316 ---GVMRMVKKR----AIVKKLPIVETLGCCNVICSDKTGTLTKNEM----------TVTHIFT--SDGLH--------- 367
Cdd:TIGR01652  329 finSDLQMYHEKtdtpASVRTSNLNEELGQVEYIFSDKTGTLTQNIMefkkcsiagvSYGDGFTeiKDGIRerlgsyven 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   368 ---AEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAV-IRNNTLMGK-------PTEGALIALAMKMGLD- 435
Cdd:TIGR01652  409 ensMLVESKGFTFVDPRLVDLLKTNKPNAKRINEFFLALALCHTVVpEFNDDGPEEityqaasPDEAALVKAARDVGFVf 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   436 ---------------GLQQDYIRKAEYPFSSEQKWMAVKCvhRTQQDRPEIcFMKGAYEQVIKYCTTYQSkgqtltltqQ 500
Cdd:TIGR01652  489 fertpksislliemhGETKEYEILNVLEFNSDRKRMSVIV--RNPDGRIKL-LCKGADTVIFKRLSSGGN---------Q 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   501 QRDVYQQEKARMGSAGLRVLALASgPELGQ----------------------------------LTFLGLVGIIDPPRTG 546
Cdd:TIGR01652  557 VNEETKEHLENYASEGLRTLCIAY-RELSEeeyeewneeyneastaltdreekldvvaesiekdLILLGATAIEDKLQEG 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   547 VKEAVTTLIASGVSIKMITGDSQETA--VAIASRL----------GLYSKTSQSVSGEEI-----DAMDVQQLSQIVPKV 609
Cdd:TIGR01652  636 VPETIELLRQAGIKIWVLTGDKVETAinIGYSCRLlsrnmeqiviTSDSLDATRSVEAAIkfgleGTSEEFNNLGDSGNV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   610 A------------------VFY------------RASPRHKMKIIKSLQKNGSVVAMT-GDGVNDAVALKAADIGVAM-G 657
Cdd:TIGR01652  716 AlvidgkslgyaldeelekEFLqlalkckaviccRVSPSQKADVVRLVKKSTGKTTLAiGDGANDVSMIQEADVGVGIsG 795

                   ...
gi 312836769   658 QTG 660
Cdd:TIGR01652  796 KEG 798
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
103-717 1.94e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 83.82  E-value: 1.94e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 103 VAILIVVTVA-FVQEY---RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSI 178
Cdd:cd07548   76 VAVMLFYEVGeLFQDLaveRSRKSIKALLDIRPDYANLKRNNELKDVKPEEVQIGDIIVVKPGEKIPLDGVVLKGES-FL 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 179 DESSLTGETTPcskvtapqpaatnGDLASRSNIaFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMD 258
Cdd:cd07548  155 DTSALTGESVP-------------VEVKEGSSV-LAGFINLNGVLEIKVTKPFKDSAVAKILELVENASARKAPTEKFIT 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 259 LLGKqlsFYSFGIIGI---IMLVGWLLGKDilEMFTISVSLA----VAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLP 331
Cdd:cd07548  221 KFAR---YYTPIVVFLallLAVIPPLFSPD--GSFSDWIYRAlvflVISCPCALVISIPLGYFGGIGAASRKGILIKGSN 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 332 IVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgevivdgDVVHgfynpaVSRIVEAGCvcndavi 411
Cdd:cd07548  296 YLEALSQVKTVVFDKTGTLTKGVFKVTEIVPAPGFSKE----------------ELLK------LAALAESNS------- 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 412 rnntlmGKPtegalIALAmkmgldglqqdyIRKAeypfsseqkwmavkCVHRTQQDRPEicfmkgAYEQVikycttyqsK 491
Cdd:cd07548  347 ------NHP-----IARS------------IQKA--------------YGKMIDPSEIE------DYEEI---------A 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 492 GQTLTLTQQQRDVYQQEKARMGSAGLR---------VLALASGpelgqLTFLGLVGIIDPPRTGVKEAVTTLIASGVS-I 561
Cdd:cd07548  375 GHGIRAVVDGKEILVGNEKLMEKFNIEhdedeiegtIVHVALD-----GKYVGYIVISDEIKEDAKEAIKGLKELGIKnL 449
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 562 KMITGDSQETAVAIASRLGLysktsQSVSGEeidamdvqqlsqIVP--KVAVFYRASPRHKMKiikslqkngsvVAMTGD 639
Cdd:cd07548  450 VMLTGDRKSVAEKVAKKLGI-----DEVYAE------------LLPedKVEKVEELKAESKGK-----------VAFVGD 501
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 640 GVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKG----IYNNIKnfvrFQLSTSIAALTL--IS 713
Cdd:cd07548  502 GINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAEAIKIARKtrriVWQNII----LALGVKAIVLILgaLG 577

                 ....
gi 312836769 714 LATL 717
Cdd:cd07548  578 LATM 581
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
73-656 2.38e-16

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 83.80  E-value: 2.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  73 QFKNPLIMLLLasaVISVLmhQFDDAVSIT------VAILIVVTVAFVQE----YRSEKSLEELSKlvpPECHCVREGKL 142
Cdd:cd07536   22 QFKRFLNLYFL---VIACL--QFVPALKPGylyttwAPLIFILAVTMTKEaiddFRRFQRDKEVNK---KQLYSKLTGRK 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 143 EHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLS----IDESSLTGETTPCSKV--TAPQPAATNGDLASRS------- 209
Cdd:cd07536   94 VQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDLKLRVavSCTQQLPALGDLMKISayvecqk 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 210 ----------------------------NIAFMGT-LVRCGKAKGVVIGTGENSefgevfKMMQAEEAPKtPLQKSMDLL 260
Cdd:cd07536  174 pqmdihsfegnftledsdppiheslsieNTLLRAStLRNTGWVIGVVVYTGKET------KLVMNTSNAK-NKVGLLDLE 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 261 GKQLSFYSFGI---IGIIMLVGWLLGKD--------ILEMFTISVSLAVAAIPEGL------PIVVTVTLALG---VMRM 320
Cdd:cd07536  247 LNRLTKALFLAlvvLSLVMVTLQGFWGPwygeknwyIKKMDTTSDNFGRNLLRFLLlfsyiiPISLRVNLDMVkavYAWF 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 321 VKKR-----------AIVKKLPIVETLGCCNVICSDKTGTLTKNEMtvthIFTsdglHAEVTGVGYNqfGEVIVDGdvvh 389
Cdd:cd07536  327 IMWDenmyyigndtgTVARTSTIPEELGQVVYLLTDKTGTLTQNEM----IFK----RCHIGGVSYG--GQVLSFC---- 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 390 gfynpavsrIVEAgcvcndavirnntlmgkptegalialamkmgldglqqdyirkaeYPFSSEQKWMAVkcVHRTQQDRP 469
Cdd:cd07536  393 ---------ILQL--------------------------------------------LEFTSDRKRMSV--IVRDESTGE 417
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 470 EICFMKGAYEQVIKYCTTYQSKGQTL------------TLTQQQRD-----------VYQQEKARMGSAGLRVLALASGP 526
Cdd:cd07536  418 ITLYMKGADVAISPIVSKDSYMEQYNdwleeecgeglrTLCVAKKAlteneyqewesRYTEASLSLHDRSLRVAEVVESL 497
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 527 ElGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTS-----QSVSGEEIDAMDVQQ 601
Cdd:cd07536  498 E-RELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLVSRTQdihllRQDTSRGERAAITQH 576
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 602 LS-----------------------------------QIVPKVAVFYRASPRHKMKIIKSLQK-NGSVVAMTGDGVNDAV 645
Cdd:cd07536  577 AHlelnafrrkhdvalvidgdslevalkyyrhefvelACQCPAVICCRVSPTQKARIVTLLKQhTGRRTLAIGDGGNDVS 656
                        730
                 ....*....|.
gi 312836769 646 ALKAADIGVAM 656
Cdd:cd07536  657 MIQAADCGVGI 667
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
147-654 4.14e-15

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 79.76  E-value: 4.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 147 ARDLVPGDTVCLSVGDRVPADLRLFEAVDLS----IDESSLTGETTPCSKVTAP--QPAATNGDLASRS----------- 209
Cdd:cd07541   96 SSDIKVGDLIIVEKNQRIPADMVLLRTSEKSgscfIRTDQLDGETDWKLRIAVPctQKLPEEGILNSISavyaeapqkdi 175
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 210 ---------------------NIAFMGTLVRCGKAKGVVIGTGEnsefgEVFKMMQAEEaPKTP---LQKSMDLLGKQLS 265
Cdd:cd07541  176 hsfygtftinddptseslsveNTLWANTVVASGTVIGVVVYTGK-----ETRSVMNTSQ-PKNKvglLDLEINFLTKILF 249
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 266 FYSFGI-IGIIMLVGwLLGKDILEMFTIsvSLAVAAIpegLPIVVTVTLALGVM---RMVKK-----RAIVKKLPIVETL 336
Cdd:cd07541  250 CAVLALsIVMVALQG-FQGPWYIYLFRF--LILFSSI---IPISLRVNLDMAKIvysWQIEHdknipGTVVRTSTIPEEL 323
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 337 GCCNVICSDKTGTLTKNEMTVTHiftsdgLHaevtgVGYNQFGEVIVDGDVVHGFynpavsriveagcvcndavirnntl 416
Cdd:cd07541  324 GRIEYLLSDKTGTLTQNEMVFKK------LH-----LGTVSYGGQNLNYEILQIF------------------------- 367
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 417 mgkptegalialamkmgldglqqdyirkaeyPFSSEQKWMAVkcVHRTQQDRpEICF-MKGA---YEQVIKY-------C 485
Cdd:cd07541  368 -------------------------------PFTSESKRMGI--IVREEKTG-EITFyMKGAdvvMSKIVQYndwleeeC 413
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 486 TTYQSKG-QTLT-----LTQQQ----RDVYQQEKARMGSAGLRVLALASGPELGqLTFLGLVGIIDPPRTGVKEAVTTLI 555
Cdd:cd07541  414 GNMAREGlRTLVvakkkLSEEEyqafEKRYNAAKLSIHDRDLKVAEVVESLERE-LELLCLTGVEDKLQEDVKPTLELLR 492
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 556 ASGVSIKMITGDSQETAVAIASRLGLYSKTSQ----------------------------SVSGEEIDAM------DVQQ 601
Cdd:cd07541  493 NAGIKIWMLTGDKLETATCIAKSSKLVSRGQYihvfrkvttreeahlelnnlrrkhdcalVIDGESLEVClkyyehEFIE 572
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....
gi 312836769 602 LSQIVPKVaVFYRASPRHKMKIIKSLQK-NGSVVAMTGDGVNDAVALKAADIGV 654
Cdd:cd07541  573 LACQLPAV-VCCRCSPTQKAQIVRLIQKhTGKRTCAIGDGGNDVSMIQAADVGV 625
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
534-651 5.50e-11

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Pseudomonas sp. (S)-2-haloacid dehalogenase 1. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 395571 [Multi-domain]  Cd Length: 191  Bit Score: 62.60  E-value: 5.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  534 LGLVGIIDP--PRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIdamdvqqlsqivpkvaV 611
Cdd:pfam00702  88 LGVIALADElkLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDV----------------G 151
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 312836769  612 FYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAAD 651
Cdd:pfam00702 152 VGKPKPEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAAG 191
PLN03190 PLN03190
aminophospholipid translocase; Provisional
279-660 5.21e-09

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 60.30  E-value: 5.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  279 GWllGKDILEMFTISVSLAVAAIPEGLPI---VVTVTLALGVMRMVK-------KRAIVKKLPIVETLGCCNVICSDKTG 348
Cdd:PLN03190  385 GW--GWEIFFTFLMSVIVFQIMIPISLYIsmeLVRVGQAYFMIRDDQmydeasnSRFQCRALNINEDLGQIKYVFSDKTG 462
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  349 TLTKNEM-----TVTHIFTSDG----------LHAEVTGVGYNQFGEVIVDGDVVH----GFYNPAVSRIVE-----AGC 404
Cdd:PLN03190  463 TLTENKMefqcaSIWGVDYSDGrtptqndhagYSVEVDGKILRPKMKVKVDPQLLElsksGKDTEEAKHVHDfflalAAC 542
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  405 ------VCNDAVIRNNTLMG----KPTEGALIALAMKMG--------------LDGLQQDYIRKAEYPFSSEQKWMAV-- 458
Cdd:PLN03190  543 ntivpiVVDDTSDPTVKLMDyqgeSPDEQALVYAAAAYGfmliertsghividIHGERQRFNVLGLHEFDSDRKRMSVil 622
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  459 KCVHRTQQdrpeiCFMKGA-----------YEQVIKYCT-----TYQSKGQTlTLTQQQRDVYQQE------------KA 510
Cdd:PLN03190  623 GCPDKTVK-----VFVKGAdtsmfsvidrsLNMNVIRATeahlhTYSSLGLR-TLVVGMRELNDSEfeqwhfsfeaasTA 696
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  511 RMGSAGLrVLALASGPElGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAI--------------- 575
Cdd:PLN03190  697 LIGRAAL-LRKVASNVE-NNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIgyssklltnkmtqii 774
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769  576 -------------------ASRLGLYSKTSQSVSGEEIDAMDV-------------------QQLSQIVPKVAVFY--RA 615
Cdd:PLN03190  775 insnskescrksledalvmSKKLTTVSGISQNTGGSSAAASDPvaliidgtslvyvldseleEQLFQLASKCSVVLccRV 854
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 312836769  616 SPRHKMKIIKSLQKNGSVVAMT-GDGVNDAVALKAADIGVAM-GQTG 660
Cdd:PLN03190  855 APLQKAGIVALVKNRTSDMTLAiGDGANDVSMIQMADVGVGIsGQEG 901
COG4087 COG4087
Soluble P-type ATPase [General function prediction only];
551-674 1.28e-08

Soluble P-type ATPase [General function prediction only];


Pssm-ID: 226572 [Multi-domain]  Cd Length: 152  Bit Score: 54.87  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 551 VTTLIASGVSIKMITGDSQETavaIASRLGLYSKTSQSVsGEEIDAMDV-----------QQLSQI--VPKVAVFYRASP 617
Cdd:COG4087    4 VEIYFGSGLIVDSKAGKVLYT---IATGGKLFSEVSETI-QELHDMVDIyiasgdrkgslVQLAEFvgIPVERVFAGADP 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 618 RHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGtDVCK---EAADMILVD 674
Cdd:COG4087   80 EMKAKIIRELKKRYEKVVMVGNGANDILALREADLGICTIQQE-GVPErllLTADVVLKE 138
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
638-697 4.53e-05

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 45.68  E-value: 4.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 312836769 638 GDGVNDAVALKAADIGVAMGQTGTDVcKEAADMIL--VDDDfqtimsaieegkGIYNNIKNF 697
Cdd:cd07517  164 GDGLNDIEMLEAVGIGIAMGNAHEEL-KEIADYVTkdVDED------------GILKALKHF 212
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
619-676 1.13e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 44.95  E-value: 1.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312836769  619 HKMKIIKSLQKNGSV----VAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMI--LVDDD 676
Cdd:TIGR00099 188 SKGSALQSLAEALGIsledVIAFGDGMNDIEMLEAAGYGVAMG-NADEELKALADYVtdSNNED 250
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
13-89 6.37e-04

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 425824 [Multi-domain]  Cd Length: 69  Bit Score: 39.07  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769   13 FKKYPLHAIRRYLST-----LRNQRAEEQVARFqkipnGENEtmipvltskkaseLPVSEVASIL-----QFKNPLIMLL 82
Cdd:pfam00690   1 WHALSVEEVLKKLGTdlekgLTEAEAEKRLKKY-----GPNE-------------LPEKKPKSLWklflrQFKDPLIIIL 62

                  ....*..
gi 312836769   83 LASAVIS 89
Cdd:pfam00690  63 LIAAIVS 69
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
622-676 7.75e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 42.22  E-value: 7.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 312836769  622 KIIKSLQKNGS-VVAMtGDGVNDAVALKAADIGVAMGQtGTDVCKEAADMIL--VDDD 676
Cdd:pfam08282 194 ALAKHLNISLEeVIAF-GDGENDIEMLEAAGLGVAMGN-ASPEVKAAADYVTdsNNED 249
HAD_like cd01427
Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily ...
547-656 2.14e-03

Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others. This superfamily includes a variety of enzymes that catalyze the cleavage of substrate C-Cl, P-C, and P-OP bonds via nucleophilic substitution pathways. All of which use a nucleophilic aspartate in their phosphoryl transfer reaction. They catalyze nucleophilic substitution reactions at phosphorus or carbon centers, using a conserved Asp carboxylate in covalent catalysis. All members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. Members of this superfamily are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319763 [Multi-domain]  Cd Length: 106  Bit Score: 38.53  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769 547 VKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEidamdvqqlsqivpkvavFYRASPRHKMKIIKS 626
Cdd:cd01427   12 AVELLKRLRAAGIKLAIVTNRSREALRALLEKLGLGDLFDGIIGSDG------------------GGTPKPKPKPLLLLL 73
                         90       100       110
                 ....*....|....*....|....*....|...
gi 312836769 627 LQKNGS--VVAMTGDGVNDAVALKAA-DIGVAM 656
Cdd:cd01427   74 LKLGVDpeEVLFVGDSENDIEAARAAgGRTVAV 106
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
633-701 2.73e-03

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 223635 [Multi-domain]  Cd Length: 264  Bit Score: 40.47  E-value: 2.73e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312836769 633 VVAMtGDGVNDAVALKAADIGVAMGqTGTDVCKEAADmilvdddfQTIMSAIEEgkGIYNNIKNFVRFQ 701
Cdd:COG0561  208 VIAF-GDSTNDIEMLEVAGLGVAMG-NADEELKELAD--------YVTTSNDED--GVAEALEKLLLLE 264
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
17-92 2.82e-03

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 37.18  E-value: 2.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312836769    17 PLHAIRRYLST-----LRNQRAEEQVARFqkipnGENEtmipvLTSKKaSELPVSEVasILQFKNPLIMLLLASAVISVL 91
Cdd:smart00831   8 SLEEVLERLQTdlekgLSSEEAARRLERY-----GPNE-----LPPPK-KTSPLLRF--LRQFHNPLIYILLAAAVLSAL 74

                   .
gi 312836769    92 M 92
Cdd:smart00831  75 L 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH