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Conserved domains on  [gi|312839888|ref|NP_001186175|]
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melanoma-associated antigen D2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MAGE pfam01454
MAGE family; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety ...
286-454 3.82e-27

MAGE family; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


:

Pssm-ID: 396164  Cd Length: 202  Bit Score: 108.88  E-value: 3.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  286 LVKYLLAKDQTKIPIRRSDMLKDIIKEYTDV-YPEIIERAGYSLEKVFGIQLKEIDKNDHL------------------- 345
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGERGRRlFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaqksqkps 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  346 -----YILLSTLEPT--DAGILGTTK---------DSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGIHhslF 409
Cdd:pfam01454  81 sssksYILVSTLPPEyrVPAILWPSKapsfvldqdEATYTGLLTVILSLILLSGGSISEQKLLRYLRRLGIDTDTP---G 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 312839888  410 GDVKKLItDEFVKQKYLDYARVPNSN-PPEYEFFWGLRSYYETSKM 454
Cdd:pfam01454 158 INTDDLL-KRLVKQGYLVRTKEASDDgEEIIEYRVGPRAKVEFGPE 202
PRK13335 super family cl31400
superantigen-like protein SSL3; Reviewed;
32-125 6.90e-05

superantigen-like protein SSL3; Reviewed;


The actual alignment was detected with superfamily member PRK13335:

Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 45.50  E-value: 6.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  32 TVTQ--NLEVSETPKAEKAPEVSE----AAKAPKASgNPKATEVSKAPEASEAAATQASPTTQLSETQVLATENKSPAAD 105
Cdd:PRK13335  61 ATTQaaNTRQERTPKLEKAPNTNEektsASKIEKIS-QPKQEEQKSLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTN 139
                         90       100
                 ....*....|....*....|
gi 312839888 106 TKTQKSDLQAMTmPTTPTKK 125
Cdd:PRK13335 140 TPQPMQSTKSDT-PQSPTIK 158
PRK13914 super family cl36314
invasion associated endopeptidase;
33-224 4.63e-04

invasion associated endopeptidase;


The actual alignment was detected with superfamily member PRK13914:

Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 42.87  E-value: 4.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  33 VTQNLEVSET-PKAEKAPEVSEAAkaPKASGNPKATEVSKAPEASEAAATQASPT---------------------TQLS 90
Cdd:PRK13914 154 VKKETTTQQAaPAAETKTEVKQTT--QATTPAPKVAETKETPVVDQNATTHAVKSgdtiwalsvkygvsvqdimswNNLS 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  91 ETQVL---------ATENKSPAADTKTQKSDLQAMTMP---------TTPTKKVSCGTDPKVNTKAP-ETEAPASQAGTD 151
Cdd:PRK13914 232 SSSIYvgqklaikqTANTATPKAEVKTEAPAAEKQAAPvvkentntnTATTEKKETTTQQQTAPKAPtEAAKPAPAPSTN 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888 152 EPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDGEEDGNSDQSQASEATGGRRVSKALMASMARRASR-------GPIAF 224
Cdd:PRK13914 312 TNANKTNTNTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKayswggnGPTTF 391
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE family; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety ...
286-454 3.82e-27

MAGE family; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 396164  Cd Length: 202  Bit Score: 108.88  E-value: 3.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  286 LVKYLLAKDQTKIPIRRSDMLKDIIKEYTDV-YPEIIERAGYSLEKVFGIQLKEIDKNDHL------------------- 345
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGERGRRlFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaqksqkps 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  346 -----YILLSTLEPT--DAGILGTTK---------DSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGIHhslF 409
Cdd:pfam01454  81 sssksYILVSTLPPEyrVPAILWPSKapsfvldqdEATYTGLLTVILSLILLSGGSISEQKLLRYLRRLGIDTDTP---G 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 312839888  410 GDVKKLItDEFVKQKYLDYARVPNSN-PPEYEFFWGLRSYYETSKM 454
Cdd:pfam01454 158 INTDDLL-KRLVKQGYLVRTKEASDDgEEIIEYRVGPRAKVEFGPE 202
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
32-125 6.90e-05

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 45.50  E-value: 6.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  32 TVTQ--NLEVSETPKAEKAPEVSE----AAKAPKASgNPKATEVSKAPEASEAAATQASPTTQLSETQVLATENKSPAAD 105
Cdd:PRK13335  61 ATTQaaNTRQERTPKLEKAPNTNEektsASKIEKIS-QPKQEEQKSLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTN 139
                         90       100
                 ....*....|....*....|
gi 312839888 106 TKTQKSDLQAMTmPTTPTKK 125
Cdd:PRK13335 140 TPQPMQSTKSDT-PQSPTIK 158
PRK13914 PRK13914
invasion associated endopeptidase;
33-224 4.63e-04

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 42.87  E-value: 4.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  33 VTQNLEVSET-PKAEKAPEVSEAAkaPKASGNPKATEVSKAPEASEAAATQASPT---------------------TQLS 90
Cdd:PRK13914 154 VKKETTTQQAaPAAETKTEVKQTT--QATTPAPKVAETKETPVVDQNATTHAVKSgdtiwalsvkygvsvqdimswNNLS 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  91 ETQVL---------ATENKSPAADTKTQKSDLQAMTMP---------TTPTKKVSCGTDPKVNTKAP-ETEAPASQAGTD 151
Cdd:PRK13914 232 SSSIYvgqklaikqTANTATPKAEVKTEAPAAEKQAAPvvkentntnTATTEKKETTTQQQTAPKAPtEAAKPAPAPSTN 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888 152 EPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDGEEDGNSDQSQASEATGGRRVSKALMASMARRASR-------GPIAF 224
Cdd:PRK13914 312 TNANKTNTNTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKayswggnGPTTF 391
opacity_OapA NF033909
opacity-associated protein OapA; This family consists of full-length homologs to OapA, ...
29-185 6.12e-03

opacity-associated protein OapA; This family consists of full-length homologs to OapA, opacity-associated protein A as described in Haemophilus influenzae. OapA shares a C-terminal homology domain, called the OapA domain, with the Escherichia coli protein YtfB, which is now known to bind peptidoglycan through its OapA domain and to act as a cell division protein.


Pssm-ID: 411470 [Multi-domain]  Cd Length: 421  Bit Score: 39.45  E-value: 6.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  29 DLLTVTQNLEVSETPKAEKAPEVSEAAKApkASGNPKATEVSKAPEASEAAATQASPTtqlSETQVLATENKSPAADT-- 106
Cdd:NF033909 190 DNPPAQNDNAAAQTNQAENAPKAAEPNNA--TAVEPQAENAGSTQQATEQTTTTAAEN---KPEPVKPAQTEPVKAVEvs 264
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312839888 107 KTQKSDLQAMTMPTTPTKKVSCGTDPKVNTKAPEtEAPASQAGtdEPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDG 185
Cdd:NF033909 265 KVQETVKPKVAQEDVKKEEPKVAEKAKPPTKKTE-QTVAKTAK--KAPQEAKPVQAKTEKKVQDIVDAKSATKTASTTS 340
opacity_OapA NF033909
opacity-associated protein OapA; This family consists of full-length homologs to OapA, ...
32-197 8.58e-03

opacity-associated protein OapA; This family consists of full-length homologs to OapA, opacity-associated protein A as described in Haemophilus influenzae. OapA shares a C-terminal homology domain, called the OapA domain, with the Escherichia coli protein YtfB, which is now known to bind peptidoglycan through its OapA domain and to act as a cell division protein.


Pssm-ID: 411470 [Multi-domain]  Cd Length: 421  Bit Score: 38.68  E-value: 8.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  32 TVTQNLevseTPKAEKAPEVSE-AAKAPKASGNPKATEVskAPEAsEAAATQASPTTQLSETQVLATENKSPAADTKTQK 110
Cdd:NF033909 187 TVLDNP----PAQNDNAAAQTNqAENAPKAAEPNNATAV--EPQA-ENAGSTQQATEQTTTTAAENKPEPVKPAQTEPVK 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888 111 SDlqamtMPTTPTKKVSCGTDPKVNTKAPETEAPASQAGTDEPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDGEEDGN 190
Cdd:NF033909 260 AV-----EVSKVQETVKPKVAQEDVKKEEPKVAEKAKPPTKKTEQTVAKTAKKAPQEAKPVQAKTEKKVQDIVDAKSATK 334

                 ....*..
gi 312839888 191 SDQSQAS 197
Cdd:NF033909 335 TASTTSS 341
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE family; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety ...
286-454 3.82e-27

MAGE family; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 396164  Cd Length: 202  Bit Score: 108.88  E-value: 3.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  286 LVKYLLAKDQTKIPIRRSDMLKDIIKEYTDV-YPEIIERAGYSLEKVFGIQLKEIDKNDHL------------------- 345
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGERGRRlFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaqksqkps 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  346 -----YILLSTLEPT--DAGILGTTK---------DSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGIHhslF 409
Cdd:pfam01454  81 sssksYILVSTLPPEyrVPAILWPSKapsfvldqdEATYTGLLTVILSLILLSGGSISEQKLLRYLRRLGIDTDTP---G 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 312839888  410 GDVKKLItDEFVKQKYLDYARVPNSN-PPEYEFFWGLRSYYETSKM 454
Cdd:pfam01454 158 INTDDLL-KRLVKQGYLVRTKEASDDgEEIIEYRVGPRAKVEFGPE 202
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
32-125 6.90e-05

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 45.50  E-value: 6.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  32 TVTQ--NLEVSETPKAEKAPEVSE----AAKAPKASgNPKATEVSKAPEASEAAATQASPTTQLSETQVLATENKSPAAD 105
Cdd:PRK13335  61 ATTQaaNTRQERTPKLEKAPNTNEektsASKIEKIS-QPKQEEQKSLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTN 139
                         90       100
                 ....*....|....*....|
gi 312839888 106 TKTQKSDLQAMTmPTTPTKK 125
Cdd:PRK13335 140 TPQPMQSTKSDT-PQSPTIK 158
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
34-173 1.20e-04

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 44.73  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  34 TQNLEVSETPKAEKAPEVSEAAKAPKASGNPKATEVSKAPEASEAAATQ-----ASPTTQLSETQVLATENKSPAADTKT 108
Cdd:PRK13335  35 STKVDKVPTLKAERLAMINITAGANSATTQAANTRQERTPKLEKAPNTNeektsASKIEKISQPKQEEQKSLNISATPAP 114
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312839888 109 QKSDLQAMTMPTTPTKKVScgTDPKVNtkapeTEAPASQAGTDEPEPEGTAvqvQENQDTRPKVK 173
Cdd:PRK13335 115 KQEQSQTTTESTTPKTKVT--TPPSTN-----TPQPMQSTKSDTPQSPTIK---QAQTDMTPKYE 169
PRK13914 PRK13914
invasion associated endopeptidase;
33-224 4.63e-04

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 42.87  E-value: 4.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  33 VTQNLEVSET-PKAEKAPEVSEAAkaPKASGNPKATEVSKAPEASEAAATQASPT---------------------TQLS 90
Cdd:PRK13914 154 VKKETTTQQAaPAAETKTEVKQTT--QATTPAPKVAETKETPVVDQNATTHAVKSgdtiwalsvkygvsvqdimswNNLS 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  91 ETQVL---------ATENKSPAADTKTQKSDLQAMTMP---------TTPTKKVSCGTDPKVNTKAP-ETEAPASQAGTD 151
Cdd:PRK13914 232 SSSIYvgqklaikqTANTATPKAEVKTEAPAAEKQAAPvvkentntnTATTEKKETTTQQQTAPKAPtEAAKPAPAPSTN 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888 152 EPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDGEEDGNSDQSQASEATGGRRVSKALMASMARRASR-------GPIAF 224
Cdd:PRK13914 312 TNANKTNTNTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKayswggnGPTTF 391
opacity_OapA NF033909
opacity-associated protein OapA; This family consists of full-length homologs to OapA, ...
29-185 6.12e-03

opacity-associated protein OapA; This family consists of full-length homologs to OapA, opacity-associated protein A as described in Haemophilus influenzae. OapA shares a C-terminal homology domain, called the OapA domain, with the Escherichia coli protein YtfB, which is now known to bind peptidoglycan through its OapA domain and to act as a cell division protein.


Pssm-ID: 411470 [Multi-domain]  Cd Length: 421  Bit Score: 39.45  E-value: 6.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  29 DLLTVTQNLEVSETPKAEKAPEVSEAAKApkASGNPKATEVSKAPEASEAAATQASPTtqlSETQVLATENKSPAADT-- 106
Cdd:NF033909 190 DNPPAQNDNAAAQTNQAENAPKAAEPNNA--TAVEPQAENAGSTQQATEQTTTTAAEN---KPEPVKPAQTEPVKAVEvs 264
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312839888 107 KTQKSDLQAMTMPTTPTKKVSCGTDPKVNTKAPEtEAPASQAGtdEPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDG 185
Cdd:NF033909 265 KVQETVKPKVAQEDVKKEEPKVAEKAKPPTKKTE-QTVAKTAK--KAPQEAKPVQAKTEKKVQDIVDAKSATKTASTTS 340
opacity_OapA NF033909
opacity-associated protein OapA; This family consists of full-length homologs to OapA, ...
32-197 8.58e-03

opacity-associated protein OapA; This family consists of full-length homologs to OapA, opacity-associated protein A as described in Haemophilus influenzae. OapA shares a C-terminal homology domain, called the OapA domain, with the Escherichia coli protein YtfB, which is now known to bind peptidoglycan through its OapA domain and to act as a cell division protein.


Pssm-ID: 411470 [Multi-domain]  Cd Length: 421  Bit Score: 38.68  E-value: 8.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  32 TVTQNLevseTPKAEKAPEVSE-AAKAPKASGNPKATEVskAPEAsEAAATQASPTTQLSETQVLATENKSPAADTKTQK 110
Cdd:NF033909 187 TVLDNP----PAQNDNAAAQTNqAENAPKAAEPNNATAV--EPQA-ENAGSTQQATEQTTTTAAENKPEPVKPAQTEPVK 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888 111 SDlqamtMPTTPTKKVSCGTDPKVNTKAPETEAPASQAGTDEPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDGEEDGN 190
Cdd:NF033909 260 AV-----EVSKVQETVKPKVAQEDVKKEEPKVAEKAKPPTKKTEQTVAKTAKKAPQEAKPVQAKTEKKVQDIVDAKSATK 334

                 ....*..
gi 312839888 191 SDQSQAS 197
Cdd:NF033909 335 TASTTSS 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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