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Conserved domains on  [gi|325651962|ref|NP_001191767|]
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zinc finger protein 568 isoform 5 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
48-102 1.68e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 1.68e-32
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 325651962    48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ 102
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB smart00349
krueppel associated box;
137-197 7.77e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 7.77e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325651962   137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWM 197
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-621 1.40e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 278 LHTGEKSCECRKC---KNAFRYQSCPIQHEIIHNKekepecgecrkifNSGSDLIKHQTLHESKKHSENNKCAFN----- 349
Cdd:COG5048   55 SHTGEKPSQCSYSgcdKSFSRPLELSRHLRTHHNN-------------PSDLNSKSLPLSNSKASSSSLSSSSSNsndnn 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 350 HDSGITQPQSINTGEKP----------HKCKECGKAFR----SSSQISQHQRMHLGEKPYKCRECGK------AFPSTAQ 409
Cdd:COG5048  122 LLSSHSLPPSSRDPQLPdllsisnlrnNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLLIssnvstSIPSSSE 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 410 LNLHQR---------IHTDEKYYESKACGKAFTRPSHLFRHQR---IHTGEKPHKCKECGKAFRYDTQLSLHQIIHTGER 477
Cdd:COG5048  202 NSPLSSsysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSpssLSSSDSSSSASESPRSSLPTASSQSSSPNESDSS 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 478 -------RYECRECGKVYSCASQLSLHQR--IHTGE--KPHECKE--CGKAFISDSHLIRHQSVHTGEKPCKCK--ECGK 542
Cdd:COG5048  282 sekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 543 SFRRGSELTRHQRA--HTGEKPYECKECEKAFTCSTELVRHQ-----KVHTGERPH--KCKECGKAFIRRSELTHHERSH 613
Cdd:COG5048  362 KFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNlslhiITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441


                 ....*...
gi 325651962 614 TGEKPYEC 621
Cdd:COG5048  442 TNHAPLLC 449
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
48-102 1.68e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 1.68e-32
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 325651962    48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ 102
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB smart00349
krueppel associated box;
137-197 7.77e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 7.77e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325651962   137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWM 197
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 48-88 2.10e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 2.10e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 325651962   48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVG 88
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 139-177 2.93e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.93e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 325651962  139 FKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLG 177
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 48-85 7.03e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.98  E-value: 7.03e-20
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 325651962  48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLV 85
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 137-176 5.16e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 5.16e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 325651962 137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLL 176
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-621 1.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 278 LHTGEKSCECRKC---KNAFRYQSCPIQHEIIHNKekepecgecrkifNSGSDLIKHQTLHESKKHSENNKCAFN----- 349
Cdd:COG5048   55 SHTGEKPSQCSYSgcdKSFSRPLELSRHLRTHHNN-------------PSDLNSKSLPLSNSKASSSSLSSSSSNsndnn 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 350 HDSGITQPQSINTGEKP----------HKCKECGKAFR----SSSQISQHQRMHLGEKPYKCRECGK------AFPSTAQ 409
Cdd:COG5048  122 LLSSHSLPPSSRDPQLPdllsisnlrnNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLLIssnvstSIPSSSE 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 410 LNLHQR---------IHTDEKYYESKACGKAFTRPSHLFRHQR---IHTGEKPHKCKECGKAFRYDTQLSLHQIIHTGER 477
Cdd:COG5048  202 NSPLSSsysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSpssLSSSDSSSSASESPRSSLPTASSQSSSPNESDSS 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 478 -------RYECRECGKVYSCASQLSLHQR--IHTGE--KPHECKE--CGKAFISDSHLIRHQSVHTGEKPCKCK--ECGK 542
Cdd:COG5048  282 sekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 543 SFRRGSELTRHQRA--HTGEKPYECKECEKAFTCSTELVRHQ-----KVHTGERPH--KCKECGKAFIRRSELTHHERSH 613
Cdd:COG5048  362 KFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNlslhiITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441


                 ....*...
gi 325651962 614 TGEKPYEC 621
Cdd:COG5048  442 TNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 4.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 325651962  437 HLFRHQRIHTGEKPHKCKECGKAFRY 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
48-102 1.68e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 1.68e-32
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 325651962    48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ 102
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB smart00349
krueppel associated box;
137-197 7.77e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 7.77e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325651962   137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWM 197
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 48-88 2.10e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 2.10e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 325651962   48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVG 88
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 139-177 2.93e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.93e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 325651962  139 FKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLG 177
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 48-85 7.03e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.98  E-value: 7.03e-20
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 325651962  48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLV 85
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 137-176 5.16e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 5.16e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 325651962 137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLL 176
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-621 1.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 278 LHTGEKSCECRKC---KNAFRYQSCPIQHEIIHNKekepecgecrkifNSGSDLIKHQTLHESKKHSENNKCAFN----- 349
Cdd:COG5048   55 SHTGEKPSQCSYSgcdKSFSRPLELSRHLRTHHNN-------------PSDLNSKSLPLSNSKASSSSLSSSSSNsndnn 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 350 HDSGITQPQSINTGEKP----------HKCKECGKAFR----SSSQISQHQRMHLGEKPYKCRECGK------AFPSTAQ 409
Cdd:COG5048  122 LLSSHSLPPSSRDPQLPdllsisnlrnNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLLIssnvstSIPSSSE 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 410 LNLHQR---------IHTDEKYYESKACGKAFTRPSHLFRHQR---IHTGEKPHKCKECGKAFRYDTQLSLHQIIHTGER 477
Cdd:COG5048  202 NSPLSSsysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSpssLSSSDSSSSASESPRSSLPTASSQSSSPNESDSS 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 478 -------RYECRECGKVYSCASQLSLHQR--IHTGE--KPHECKE--CGKAFISDSHLIRHQSVHTGEKPCKCK--ECGK 542
Cdd:COG5048  282 sekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 543 SFRRGSELTRHQRA--HTGEKPYECKECEKAFTCSTELVRHQ-----KVHTGERPH--KCKECGKAFIRRSELTHHERSH 613
Cdd:COG5048  362 KFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNlslhiITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441


                 ....*...
gi 325651962 614 TGEKPYEC 621
Cdd:COG5048  442 TNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
319-610 8.91e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 8.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 319 RKIFNSGSDLIKHQTLHESKKHSENNKCAFNHDSGITQPQSINTGEKPHKCKEcgkafRSSSQISQHQRMHLGEKPYKCR 398
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-----SPSSLSSSDSSSSASESPRSSL 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 399 eCGKAFPSTAQLNLHQRIHTDEKY-YESKACGKAFTRPSHLFRHQR--IHTGE--KPHKCKE--CGKAFRYDTQLSLHQI 471
Cdd:COG5048  266 -PTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 472 IHTGERRYECREC-------GKVYSCASQLSLHQRIHTGEKPHEC--KECGKAFISDSHLIRHQSVHTGEKPCKCKecgk 542
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK---- 420

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325651962 543 sfrrgseltrhqrahtgekpyeCKECEKAFTCSTELVRHQKVHTGERPHKCKECGKAFIRRSELTHHE 610
Cdd:COG5048  421 ----------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 4.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 325651962  437 HLFRHQRIHTGEKPHKCKECGKAFRY 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
505-565 1.15e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325651962 505 KPHECKECGKAFISDSHLIRHQSVHTGEKPCKC--KECGKSFRRGSELTRHQRAHTGEKPYEC 565
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
577-602 3.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 325651962  577 ELVRHQKVHTGERPHKCKECGKAFIR 602
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
494-518 7.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.49e-04
                          10        20
                  ....*....|....*....|....*
gi 325651962  494 LSLHQRIHTGEKPHECKECGKAFIS 518
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
549-574 1.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|....*.
gi 325651962  549 ELTRHQRAHTGEKPYECKECEKAFTC 574
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-404 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|.
gi 325651962  384 QHQRMHLGEKPYKCRECGKAF 404
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
428-470 3.94e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 325651962 428 CGKAFTRPSHLFRHQRIHTGEKPHKCKECGKAFRYDTQLSLHQ 470
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
393-622 4.81e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 393 KPYKCRECGKAFPSTAQLNLHQRIHTDEKYYESKA--CGKAFTRPSHLFRHQRIHTGEKPHKCK---------------- 454
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 455 ECGKAFRYDTQLSLH--------QIIHTGERRYECREC---------------------------GKVYSCASQLSLHQR 499
Cdd:COG5048  112 SSSSNSNDNNLLSSHslppssrdPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 500 IHTGEKPHECKECGKAFISDSHLI----------------------------RHQSVHTGEKPCKCKECGKSFR--RGSE 549
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSsdqnlensssslplttnsqlspksllsqSPSSLSSSDSSSSASESPRSSLptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325651962 550 LTRHQRAHTGE-----KPYECKECEKAFTCSTELVRHQ--KVHTGE--RPHKCKE--CGKAFIRRSELTHHERSHTGEKP 618
Cdd:COG5048  272 SSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351


                 ....
gi 325651962 619 YECK 622
Cdd:COG5048  352 AKEK 355
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 591-613 6.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.21e-03
                          10        20
                  ....*....|....*....|...
gi 325651962  591 HKCKECGKAFIRRSELTHHERSH 613
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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