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Conserved domains on  [gi|327315392|ref|NP_001192155|]
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CCR4-NOT transcription complex subunit 1 isoform 3 [Mus musculus]

Protein Classification

CCR4-NOT transcription complex subunit 1( domain architecture ID 13872477)

CCR4-NOT transcription complex subunit 1 is a scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC39 super family cl34904
Cell division control protein, negative regulator of transcription [Cell division and ...
 833-2362 0e+00

Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription];


The actual alignment was detected with superfamily member COG5103:

Pssm-ID: 227434 [Multi-domain]  Cd Length: 2005  Bit Score: 686.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  833 FSKEIDDEANSYFQRIYNHpphpTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGG 912
Cdd:COG5103   597 KEIDIEEEASSYIQQIYNS----QRGIESSINQLKEFLRSENPRDKELFSCIFHALLEEYGFFYDYPLSALALTAVLFGS 672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  913 IIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASIshfmqfphhlqeyieygqqsr 992
Cdd:COG5103   673 LIKFRLLPKPYLRVAIRYIKGSLKHPENSKMFSFGFQALEVFQEKLPSYPSYCSEVLEI--------------------- 731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  993 dPPVKMQGSITTpgSIALAQAQAQAQVPAKAPlagqvntmvttsttttvaktvtvtkptgvsfkkdVPPSINTTNIDTLL 1072
Cdd:COG5103   732 -PTLNNRILIYK--SIVEMDSNENTEVEKANP----------------------------------THPMLPLEDFVRLI 774

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1073 VATDQTERivEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNP 1152
Cdd:COG5103   775 VKCDANNE--GRATEVVKSILFAINNLLDLNRNDKIHRLKEALTPGYVGWFSIYMVTQRSTAEENCRRLYGKVVERLGSK 852

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1153 EFNKMVLNETYRNIKVLLtsDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQqeLLYVVPFV 1232
Cdd:COG5103   853 DLYLRFSRKTLEFLKMLL--DYRCESPSEKKVLKNLGSWLGRITLAKNKPITSEQFDFKKFLVESVECRR--ILFVVPFV 928

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1233 AKVLESSIRSLVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQlsap 1312
Cdd:COG5103   929 SKFLRQASCSIIFKPPNPWVMGILKLLSELHSCAPRVLRLKFEIEGLLRHLNVELVPIKPSKSLGNHLVLKSRLEK---- 1004

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1313 kkdvKQPEELPAITTTTTSTTPAtsttctatvppqpQYSYHDINVYSLAGLAPHITLNPtiplfqaHPQLKQCVRQAIER 1392
Cdd:COG5103  1005 ----ELPEDVLNAKFPDGTDYLA-------------QYIIEDSSQITVTDLVARHVGSP-------KPAIKNLTQLALDL 1060

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1393 AVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKnSFASALRT 1472
Cdd:COG5103  1061 SVREICGAVVEKSCGIAIQTTMALFKKDFAMEVEKSMLYVAARNMVVNLAKFLALVTAQEPLKACISGNVR-SYAMKLCS 1139

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1473 ASPQQREMMDQAAAQlaqdNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQegRRYCDPVVLTYQAE---RMPEQ 1549
Cdd:COG5103  1140 VLDFSAEKVDKIAME----NQDVACRLIERAGVSKVSESISAEIEHMIVERVRHRK--TTPNLPFVDPAAANlslNLPSS 1213

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1550 IRLKVGGVDPKQLAVYEEFARNVPGFLPTND--------LSQPTGFLAQPMKQAWATDDVAQiyDKCITELEQHLHAIPP 1621
Cdd:COG5103  1214 LELSIGKATPQQFSLYEDFDRLSLSTIMGHIekiainaiDTDSADSTDALNNNLNNTVENEA--NQTALEYQENLLIIKA 1291

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1622 TLAM----NPQA--QALRSLLEVVVLSRNSRDaiaalglLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQdgrayg 1695
Cdd:COG5103  1292 QLVQlskkIPYSskKNVIADEEHGLLKEGKNQ-------FETVFRRILESIASSDDKDLECIQLCRYILGHLSK------ 1358

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1696 SPWCNKQITRCL------------------IECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNyMAVAFAMQ 1757
Cdd:COG5103  1359 SPSKEEVLSRCLekickisfktqkevlgwlIYSNDPRKFNIPLIGSLIEHNLINVVEYDQALSRKIPLADG-NVTDFAIA 1437

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1758 LVKILLVDERSVAhiTEADLfhtIETLMRINAHSRGNAPEGLPQLMEVvrsnyeamidrahggpnfMMHSgISQASEYDd 1837
Cdd:COG5103  1438 LLASLVTAEVPIC--TVYDF---ICTLEMLAGSSDPKVKDFFQKISNT------------------MMHI-VAKGNKQQ- 1492

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1838 ppgLREKAEYLLREWVNLYHSAAAgRDSTKAfsAFVGQMHQQGILKTDDLITRFFRlcteMCVEISYRAQAEqqhnpaAN 1917
Cdd:COG5103  1493 ---LNDQIIIVFSEWVELLRNCRF-NDTVPE--MFLPQLMERGDYSASLDIRSFFK----VSLEHFIRAFHE------RI 1556

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1918 PTmirAKCYHNLDAFVRLIALLVKHSGEATNTVTkiNLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAP 1997
Cdd:COG5103  1557 PT---AYCYLKIDALPSLIKNRLYEEGSTEGTVS--VLFRKIIKDILFVFAEAHRKRAEFVHNYLFFRLFSRILIETLDV 1631

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1998 EHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLaHTPQQKGWPMYAQLLIDLFKYLAPFLRNVEL 2077
Cdd:COG5103  1632 IDEDTSCFVNNRSVVYSIFEALQPSRFPGFTFAWLELLSHKFLLPKVL-LVNNDKINDLFSEGLMSFLKFLDLSEEGVVL 1710

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 2078 TkpMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRI 2157
Cdd:COG5103  1711 V--MEALYCGFLRTILVYLHDFPGFLITQIYQLFRRNPLECVQLRNMMLSAYPSDLTYPCPFAQGLKVQEYPHIKNFPNQ 1788

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 2158 ltnFTGVMPP--QFKKDLDSYLKTRSPV-TFLSDLRSNLQVSNEPGNRYNL---QLINALVLYVGTQAIahihnKGSTPS 2231
Cdd:COG5103  1789 ---FRDRIVPleGQNSFFDLEACLRSALqNRTSVKVTDLYIGKNTPLWVYLidnLNEMDAVSHTVVESI-----KFMIER 1860

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 2232 MSTIthSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLF--AEANTEA--IQEQITRVLLERLIV 2307
Cdd:COG5103  1861 FMHK--SEILTMLWIRMRAGGPPKRYFLLTAILAQLRYPEIHTYDFSRVFLKSFksHGYNPQKllIKEQMTTVLLERIIC 1938

                        1530      1540      1550      1560      1570
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 327315392 2308 NRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQV 2362
Cdd:COG5103  1939 NRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLFDSLHEHVMAPSSANNV 1993
CNOT1_HEAT pfam16418
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ...
 498-654 9.56e-55

CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1.


:

Pssm-ID: 465113  Cd Length: 146  Bit Score: 187.81  E-value: 9.56e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392   498 HELISTLMPIFLGNHPNSAIILHYAWHgqgQSPsirQLIMHAMAEWYMRgeqyDQAKLSRILDVAQDLKALSMLLNGTPF 577
Cdd:pfam16418    1 QELIDELFPLFLQGHPNSDLVLHSLWE---VDP---QLLLKRLVDYYAR----DPLNLSRILDVAQELKILDELLNLLPF 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 327315392   578 AFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEkDQPKSAQLPAETLATMLACLQ 654
Cdd:pfam16418   71 NFALDLAALASRRGYLDLEKWLQDKLKEHGEPFAQALLDFLEIKAKLELEVQANQ-PEPSSVPLSVETVHTLLKVLQ 146
 
Name Accession Description Interval E-value
CDC39 COG5103
Cell division control protein, negative regulator of transcription [Cell division and ...
 833-2362 0e+00

Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription];


Pssm-ID: 227434 [Multi-domain]  Cd Length: 2005  Bit Score: 686.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  833 FSKEIDDEANSYFQRIYNHpphpTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGG 912
Cdd:COG5103   597 KEIDIEEEASSYIQQIYNS----QRGIESSINQLKEFLRSENPRDKELFSCIFHALLEEYGFFYDYPLSALALTAVLFGS 672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  913 IIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASIshfmqfphhlqeyieygqqsr 992
Cdd:COG5103   673 LIKFRLLPKPYLRVAIRYIKGSLKHPENSKMFSFGFQALEVFQEKLPSYPSYCSEVLEI--------------------- 731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  993 dPPVKMQGSITTpgSIALAQAQAQAQVPAKAPlagqvntmvttsttttvaktvtvtkptgvsfkkdVPPSINTTNIDTLL 1072
Cdd:COG5103   732 -PTLNNRILIYK--SIVEMDSNENTEVEKANP----------------------------------THPMLPLEDFVRLI 774

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1073 VATDQTERivEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNP 1152
Cdd:COG5103   775 VKCDANNE--GRATEVVKSILFAINNLLDLNRNDKIHRLKEALTPGYVGWFSIYMVTQRSTAEENCRRLYGKVVERLGSK 852

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1153 EFNKMVLNETYRNIKVLLtsDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQqeLLYVVPFV 1232
Cdd:COG5103   853 DLYLRFSRKTLEFLKMLL--DYRCESPSEKKVLKNLGSWLGRITLAKNKPITSEQFDFKKFLVESVECRR--ILFVVPFV 928

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1233 AKVLESSIRSLVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQlsap 1312
Cdd:COG5103   929 SKFLRQASCSIIFKPPNPWVMGILKLLSELHSCAPRVLRLKFEIEGLLRHLNVELVPIKPSKSLGNHLVLKSRLEK---- 1004

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1313 kkdvKQPEELPAITTTTTSTTPAtsttctatvppqpQYSYHDINVYSLAGLAPHITLNPtiplfqaHPQLKQCVRQAIER 1392
Cdd:COG5103  1005 ----ELPEDVLNAKFPDGTDYLA-------------QYIIEDSSQITVTDLVARHVGSP-------KPAIKNLTQLALDL 1060

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1393 AVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKnSFASALRT 1472
Cdd:COG5103  1061 SVREICGAVVEKSCGIAIQTTMALFKKDFAMEVEKSMLYVAARNMVVNLAKFLALVTAQEPLKACISGNVR-SYAMKLCS 1139

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1473 ASPQQREMMDQAAAQlaqdNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQegRRYCDPVVLTYQAE---RMPEQ 1549
Cdd:COG5103  1140 VLDFSAEKVDKIAME----NQDVACRLIERAGVSKVSESISAEIEHMIVERVRHRK--TTPNLPFVDPAAANlslNLPSS 1213

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1550 IRLKVGGVDPKQLAVYEEFARNVPGFLPTND--------LSQPTGFLAQPMKQAWATDDVAQiyDKCITELEQHLHAIPP 1621
Cdd:COG5103  1214 LELSIGKATPQQFSLYEDFDRLSLSTIMGHIekiainaiDTDSADSTDALNNNLNNTVENEA--NQTALEYQENLLIIKA 1291

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1622 TLAM----NPQA--QALRSLLEVVVLSRNSRDaiaalglLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQdgrayg 1695
Cdd:COG5103  1292 QLVQlskkIPYSskKNVIADEEHGLLKEGKNQ-------FETVFRRILESIASSDDKDLECIQLCRYILGHLSK------ 1358

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1696 SPWCNKQITRCL------------------IECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNyMAVAFAMQ 1757
Cdd:COG5103  1359 SPSKEEVLSRCLekickisfktqkevlgwlIYSNDPRKFNIPLIGSLIEHNLINVVEYDQALSRKIPLADG-NVTDFAIA 1437

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1758 LVKILLVDERSVAhiTEADLfhtIETLMRINAHSRGNAPEGLPQLMEVvrsnyeamidrahggpnfMMHSgISQASEYDd 1837
Cdd:COG5103  1438 LLASLVTAEVPIC--TVYDF---ICTLEMLAGSSDPKVKDFFQKISNT------------------MMHI-VAKGNKQQ- 1492

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1838 ppgLREKAEYLLREWVNLYHSAAAgRDSTKAfsAFVGQMHQQGILKTDDLITRFFRlcteMCVEISYRAQAEqqhnpaAN 1917
Cdd:COG5103  1493 ---LNDQIIIVFSEWVELLRNCRF-NDTVPE--MFLPQLMERGDYSASLDIRSFFK----VSLEHFIRAFHE------RI 1556

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1918 PTmirAKCYHNLDAFVRLIALLVKHSGEATNTVTkiNLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAP 1997
Cdd:COG5103  1557 PT---AYCYLKIDALPSLIKNRLYEEGSTEGTVS--VLFRKIIKDILFVFAEAHRKRAEFVHNYLFFRLFSRILIETLDV 1631

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1998 EHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLaHTPQQKGWPMYAQLLIDLFKYLAPFLRNVEL 2077
Cdd:COG5103  1632 IDEDTSCFVNNRSVVYSIFEALQPSRFPGFTFAWLELLSHKFLLPKVL-LVNNDKINDLFSEGLMSFLKFLDLSEEGVVL 1710

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 2078 TkpMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRI 2157
Cdd:COG5103  1711 V--MEALYCGFLRTILVYLHDFPGFLITQIYQLFRRNPLECVQLRNMMLSAYPSDLTYPCPFAQGLKVQEYPHIKNFPNQ 1788

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 2158 ltnFTGVMPP--QFKKDLDSYLKTRSPV-TFLSDLRSNLQVSNEPGNRYNL---QLINALVLYVGTQAIahihnKGSTPS 2231
Cdd:COG5103  1789 ---FRDRIVPleGQNSFFDLEACLRSALqNRTSVKVTDLYIGKNTPLWVYLidnLNEMDAVSHTVVESI-----KFMIER 1860

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 2232 MSTIthSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLF--AEANTEA--IQEQITRVLLERLIV 2307
Cdd:COG5103  1861 FMHK--SEILTMLWIRMRAGGPPKRYFLLTAILAQLRYPEIHTYDFSRVFLKSFksHGYNPQKllIKEQMTTVLLERIIC 1938

                        1530      1540      1550      1560      1570
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 327315392 2308 NRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQV 2362
Cdd:COG5103  1939 NRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLFDSLHEHVMAPSSANNV 1993
Not1 pfam04054
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
 1991-2346 0e+00

CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


Pssm-ID: 427680  Cd Length: 365  Bit Score: 593.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  1991 LLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAhTPQQKGWPMYAQLLIDLFKYLAP 2070
Cdd:pfam04054    1 LCELNSVEELLEEEDQEFLLAFASALHSLQPIYFPGFTFAWLSLISHRMFLPKLLR-LPDQKGWPLYTKLLIDLLKFLGE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  2071 FLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSE 2150
Cdd:pfam04054   80 YLKKAELSDVIKVLYKGTLRILLVLLHDFPEFLAENHYQLCNAIPPHCIQLRNIILSAFPRNMKLPDPFTPGLKVDRLPE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  2151 INIAPRILTNFTGVM-PPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSN-------EPGNRYNLQLINALVLYVGTQAIAH 2222
Cdd:pfam04054  160 IRQAPKILYDPVADLqEAGLKKPVDNYLRSIPSESLLATILHALYLSEyketgfgFVPISVNVKLINALVLYVGIHAVAE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  2223 IHNKGSTPSMStiTHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEA----IQEQIT 2298
Cdd:pfam04054  240 AQKKGSSAVFN--PKSPHVALLSNLIHELDPEGRYYLLSAIANQLRYPNSHTHYFSCVLLHLFGSDMSDPeeteIQEQIT 317

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 327315392  2299 RVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLF 2346
Cdd:pfam04054  318 RVLLERLIVNRPHPWGLLITFIELLKNPKYNFWELPFIKAAPEIEELF 365
NOT1_connector cd20710
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ...
 1595-1807 1.92e-60

Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown.


Pssm-ID: 411008 [Multi-domain]  Cd Length: 202  Bit Score: 206.73  E-value: 1.92e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1595 AWATDDVAQIYDKCITELEQHLHAIPPT-LAMNPQAQALRSLLEVVVLSRNSRDA--IAALGLLQKAVEGLLDATSgada 1671
Cdd:cd20710     1 ALSPDQLLERFDKLLAELERLLAEAPEEhISDLPPDHEIRSLLRQILQLIISSEQrdELALALAQKIVQLLYESSE---- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1672 dlLLRYRECHLLVLKALQDGraygSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMA 1751
Cdd:cd20710    77 --SQLAREVLVALLEKLCDL----SPKVAKEVTSWLIYSDDERKFNVPVTVALIRSGLLNLAEYDAQLAKLIENGRNPAA 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 327315392 1752 VAFAMQLVKILLVDERSVAhiTEADLFHTIETLMRINAHSRgnAPEGLPQLMEVVR 1807
Cdd:cd20710   151 LEFAAQLLRELLLDDRPVA--LRADFANTLEALAKLAQESP--SPEGLQQLLEKLR 202
CNOT1_HEAT pfam16418
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ...
 498-654 9.56e-55

CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1.


Pssm-ID: 465113  Cd Length: 146  Bit Score: 187.81  E-value: 9.56e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392   498 HELISTLMPIFLGNHPNSAIILHYAWHgqgQSPsirQLIMHAMAEWYMRgeqyDQAKLSRILDVAQDLKALSMLLNGTPF 577
Cdd:pfam16418    1 QELIDELFPLFLQGHPNSDLVLHSLWE---VDP---QLLLKRLVDYYAR----DPLNLSRILDVAQELKILDELLNLLPF 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 327315392   578 AFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEkDQPKSAQLPAETLATMLACLQ 654
Cdd:pfam16418   71 NFALDLAALASRRGYLDLEKWLQDKLKEHGEPFAQALLDFLEIKAKLELEVQANQ-PEPSSVPLSVETVHTLLKVLQ 146
 
Name Accession Description Interval E-value
CDC39 COG5103
Cell division control protein, negative regulator of transcription [Cell division and ...
 833-2362 0e+00

Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription];


Pssm-ID: 227434 [Multi-domain]  Cd Length: 2005  Bit Score: 686.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  833 FSKEIDDEANSYFQRIYNHpphpTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGG 912
Cdd:COG5103   597 KEIDIEEEASSYIQQIYNS----QRGIESSINQLKEFLRSENPRDKELFSCIFHALLEEYGFFYDYPLSALALTAVLFGS 672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  913 IIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASIshfmqfphhlqeyieygqqsr 992
Cdd:COG5103   673 LIKFRLLPKPYLRVAIRYIKGSLKHPENSKMFSFGFQALEVFQEKLPSYPSYCSEVLEI--------------------- 731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  993 dPPVKMQGSITTpgSIALAQAQAQAQVPAKAPlagqvntmvttsttttvaktvtvtkptgvsfkkdVPPSINTTNIDTLL 1072
Cdd:COG5103   732 -PTLNNRILIYK--SIVEMDSNENTEVEKANP----------------------------------THPMLPLEDFVRLI 774

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1073 VATDQTERivEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNP 1152
Cdd:COG5103   775 VKCDANNE--GRATEVVKSILFAINNLLDLNRNDKIHRLKEALTPGYVGWFSIYMVTQRSTAEENCRRLYGKVVERLGSK 852

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1153 EFNKMVLNETYRNIKVLLtsDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQqeLLYVVPFV 1232
Cdd:COG5103   853 DLYLRFSRKTLEFLKMLL--DYRCESPSEKKVLKNLGSWLGRITLAKNKPITSEQFDFKKFLVESVECRR--ILFVVPFV 928

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1233 AKVLESSIRSLVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQlsap 1312
Cdd:COG5103   929 SKFLRQASCSIIFKPPNPWVMGILKLLSELHSCAPRVLRLKFEIEGLLRHLNVELVPIKPSKSLGNHLVLKSRLEK---- 1004

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1313 kkdvKQPEELPAITTTTTSTTPAtsttctatvppqpQYSYHDINVYSLAGLAPHITLNPtiplfqaHPQLKQCVRQAIER 1392
Cdd:COG5103  1005 ----ELPEDVLNAKFPDGTDYLA-------------QYIIEDSSQITVTDLVARHVGSP-------KPAIKNLTQLALDL 1060

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1393 AVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKnSFASALRT 1472
Cdd:COG5103  1061 SVREICGAVVEKSCGIAIQTTMALFKKDFAMEVEKSMLYVAARNMVVNLAKFLALVTAQEPLKACISGNVR-SYAMKLCS 1139

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1473 ASPQQREMMDQAAAQlaqdNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQegRRYCDPVVLTYQAE---RMPEQ 1549
Cdd:COG5103  1140 VLDFSAEKVDKIAME----NQDVACRLIERAGVSKVSESISAEIEHMIVERVRHRK--TTPNLPFVDPAAANlslNLPSS 1213

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1550 IRLKVGGVDPKQLAVYEEFARNVPGFLPTND--------LSQPTGFLAQPMKQAWATDDVAQiyDKCITELEQHLHAIPP 1621
Cdd:COG5103  1214 LELSIGKATPQQFSLYEDFDRLSLSTIMGHIekiainaiDTDSADSTDALNNNLNNTVENEA--NQTALEYQENLLIIKA 1291

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1622 TLAM----NPQA--QALRSLLEVVVLSRNSRDaiaalglLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQdgrayg 1695
Cdd:COG5103  1292 QLVQlskkIPYSskKNVIADEEHGLLKEGKNQ-------FETVFRRILESIASSDDKDLECIQLCRYILGHLSK------ 1358

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1696 SPWCNKQITRCL------------------IECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNyMAVAFAMQ 1757
Cdd:COG5103  1359 SPSKEEVLSRCLekickisfktqkevlgwlIYSNDPRKFNIPLIGSLIEHNLINVVEYDQALSRKIPLADG-NVTDFAIA 1437

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1758 LVKILLVDERSVAhiTEADLfhtIETLMRINAHSRGNAPEGLPQLMEVvrsnyeamidrahggpnfMMHSgISQASEYDd 1837
Cdd:COG5103  1438 LLASLVTAEVPIC--TVYDF---ICTLEMLAGSSDPKVKDFFQKISNT------------------MMHI-VAKGNKQQ- 1492

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1838 ppgLREKAEYLLREWVNLYHSAAAgRDSTKAfsAFVGQMHQQGILKTDDLITRFFRlcteMCVEISYRAQAEqqhnpaAN 1917
Cdd:COG5103  1493 ---LNDQIIIVFSEWVELLRNCRF-NDTVPE--MFLPQLMERGDYSASLDIRSFFK----VSLEHFIRAFHE------RI 1556

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1918 PTmirAKCYHNLDAFVRLIALLVKHSGEATNTVTkiNLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAP 1997
Cdd:COG5103  1557 PT---AYCYLKIDALPSLIKNRLYEEGSTEGTVS--VLFRKIIKDILFVFAEAHRKRAEFVHNYLFFRLFSRILIETLDV 1631

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1998 EHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLaHTPQQKGWPMYAQLLIDLFKYLAPFLRNVEL 2077
Cdd:COG5103  1632 IDEDTSCFVNNRSVVYSIFEALQPSRFPGFTFAWLELLSHKFLLPKVL-LVNNDKINDLFSEGLMSFLKFLDLSEEGVVL 1710

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 2078 TkpMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRI 2157
Cdd:COG5103  1711 V--MEALYCGFLRTILVYLHDFPGFLITQIYQLFRRNPLECVQLRNMMLSAYPSDLTYPCPFAQGLKVQEYPHIKNFPNQ 1788

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 2158 ltnFTGVMPP--QFKKDLDSYLKTRSPV-TFLSDLRSNLQVSNEPGNRYNL---QLINALVLYVGTQAIahihnKGSTPS 2231
Cdd:COG5103  1789 ---FRDRIVPleGQNSFFDLEACLRSALqNRTSVKVTDLYIGKNTPLWVYLidnLNEMDAVSHTVVESI-----KFMIER 1860

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 2232 MSTIthSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLF--AEANTEA--IQEQITRVLLERLIV 2307
Cdd:COG5103  1861 FMHK--SEILTMLWIRMRAGGPPKRYFLLTAILAQLRYPEIHTYDFSRVFLKSFksHGYNPQKllIKEQMTTVLLERIIC 1938

                        1530      1540      1550      1560      1570
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 327315392 2308 NRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQV 2362
Cdd:COG5103  1939 NRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLFDSLHEHVMAPSSANNV 1993
Not1 pfam04054
CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription ...
 1991-2346 0e+00

CCR4-Not complex component, Not1; The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


Pssm-ID: 427680  Cd Length: 365  Bit Score: 593.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  1991 LLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAhTPQQKGWPMYAQLLIDLFKYLAP 2070
Cdd:pfam04054    1 LCELNSVEELLEEEDQEFLLAFASALHSLQPIYFPGFTFAWLSLISHRMFLPKLLR-LPDQKGWPLYTKLLIDLLKFLGE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  2071 FLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSE 2150
Cdd:pfam04054   80 YLKKAELSDVIKVLYKGTLRILLVLLHDFPEFLAENHYQLCNAIPPHCIQLRNIILSAFPRNMKLPDPFTPGLKVDRLPE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  2151 INIAPRILTNFTGVM-PPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSN-------EPGNRYNLQLINALVLYVGTQAIAH 2222
Cdd:pfam04054  160 IRQAPKILYDPVADLqEAGLKKPVDNYLRSIPSESLLATILHALYLSEyketgfgFVPISVNVKLINALVLYVGIHAVAE 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  2223 IHNKGSTPSMStiTHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEA----IQEQIT 2298
Cdd:pfam04054  240 AQKKGSSAVFN--PKSPHVALLSNLIHELDPEGRYYLLSAIANQLRYPNSHTHYFSCVLLHLFGSDMSDPeeteIQEQIT 317

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 327315392  2299 RVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLF 2346
Cdd:pfam04054  318 RVLLERLIVNRPHPWGLLITFIELLKNPKYNFWELPFIKAAPEIEELF 365
CNOT1_CAF1_bind pfam16415
CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain ...
 1081-1305 3.27e-124

CCR4-NOT transcription complex subunit 1 CAF1-binding domain; This is the CAF1-binding domain of CCR4-NOT transcription complex. It adopts a MIF4G (middle portion of eIF4G) fold.


Pssm-ID: 465111  Cd Length: 225  Bit Score: 390.33  E-value: 3.27e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  1081 IVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLN 1160
Cdd:pfam16415    2 QEEPPEEVQDKILFIVNNLSEDNLESKLKELKELLEEEYYPWFAQYLVVKRASIEPNFHKLYLKLLDKLNSPLLYEEVLN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  1161 ETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQqeLLYVVPFVAKVLESSI 1240
Cdd:pfam16415   82 ETYRNIKVLLNSEKTLTSSSERSLLKNLGSWLGSITLARNKPILHKNIAFKELLLEAYDKGR--LIVVIPFVCKVLEQAK 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 327315392  1241 RSLVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNL 1305
Cdd:pfam16415  160 KSKVFKPPNPWTMGILKLLVELYHLADLKLNLKFEIEVLCKNLNLDIKDIEPSTLLRDRDRLEEL 224
CNOT1_TTP_bind pfam16417
CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of ...
 814-997 9.28e-97

CCR4-NOT transcription complex subunit 1 TTP binding domain; This is the TTP binding domain of CCR4-NOT transcription complex subunit 1. It adopts a MIF4G (middle portion of eIF4G) fold.


Pssm-ID: 465112  Cd Length: 183  Bit Score: 309.92  E-value: 9.28e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392   814 QPTFQQTDLSQVWPEANQHFSKEIDDEANSYFQRIYNhpphPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYR 893
Cdd:pfam16417    4 QYKEIIQDFPQLDSSTDQQFSQEVEKEANSYFQRLYN----GEISIEEFIEMLKQFKSSKNKREQEVFACMITNLFDEYK 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392   894 FFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISH 973
Cdd:pfam16417   80 FFPQYPDKELLITGQLFGSIIEHGLVSYKALGIALRYVLEALRKPPGSKMFEFGIKALEQFKSRLKEWPQYCQHLDSIPH 159

                          170       180
                   ....*....|....*....|....
gi 327315392   974 FMQFPHHLQEYIEYGQQSRDPPVK 997
Cdd:pfam16417  160 LREFPPDLVEYIEYGLKQQESPPQ 183
DUF3819 pfam12842
CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized ...
 1380-1526 6.75e-69

CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819; This is an uncharacterized domain that is found on the CCR4-Not complex component Not1. Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID.


Pssm-ID: 463726  Cd Length: 143  Bit Score: 228.17  E-value: 6.75e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392  1380 PQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSIS 1459
Cdd:pfam12842    1 PDLKRLVQAAIERAIREIISPVVERSVTIAVITTEELVLKDFATEPDENKMRKAAHLMVRNLAGSLALVTCKEPLRESIS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 327315392  1460 TNLKNSFASALrtasPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHA 1526
Cdd:pfam12842   81 NNLRSLLSNLL----PNVNEQPEQAIQLAANDNLDLACAFIEKAAMEKAIPEIDERLAPAYELRRRH 143
NOT1_connector cd20710
Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive ...
 1595-1807 1.92e-60

Connector domain of NOT1; This NOT1 connector domain is one of several catalytically inactive subunits of the multisubunit CCR4-NOT complex assembly that plays a central role in post-translational gene regulation in eukaryotes. CCR4-NOT contains the catalytic center formed by two deadenylase subunits CCR4 and CAF1, and the conserved core complex which contains a minimum of four catalytically inactive subunits, NOT1, NOT2, NOT3 and CAF40/NOT9. NOT1 is the largest subunit which functions as a central scaffold for complex assembly in human orthologs. The Chaetomium thermophilum NOT1 connector domain consists of five alpha-helical hairpin repeats of the HEAT type that structurally resemble MIF4G domains, and hence is also called the MIF4G-C domain. However, NOT1 MIF4G-C does not interact with DEAD-box helicases such as DDX6 like MIF4G does. Structural conservation of this domain suggests an important role but its function is as yet unknown.


Pssm-ID: 411008 [Multi-domain]  Cd Length: 202  Bit Score: 206.73  E-value: 1.92e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1595 AWATDDVAQIYDKCITELEQHLHAIPPT-LAMNPQAQALRSLLEVVVLSRNSRDA--IAALGLLQKAVEGLLDATSgada 1671
Cdd:cd20710     1 ALSPDQLLERFDKLLAELERLLAEAPEEhISDLPPDHEIRSLLRQILQLIISSEQrdELALALAQKIVQLLYESSE---- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392 1672 dlLLRYRECHLLVLKALQDGraygSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMA 1751
Cdd:cd20710    77 --SQLAREVLVALLEKLCDL----SPKVAKEVTSWLIYSDDERKFNVPVTVALIRSGLLNLAEYDAQLAKLIENGRNPAA 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 327315392 1752 VAFAMQLVKILLVDERSVAhiTEADLFHTIETLMRINAHSRgnAPEGLPQLMEVVR 1807
Cdd:cd20710   151 LEFAAQLLRELLLDDRPVA--LRADFANTLEALAKLAQESP--SPEGLQQLLEKLR 202
CNOT1_HEAT pfam16418
CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in ...
 498-654 9.56e-55

CCR4-NOT transcription complex subunit 1 HEAT repeat; This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1.


Pssm-ID: 465113  Cd Length: 146  Bit Score: 187.81  E-value: 9.56e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327315392   498 HELISTLMPIFLGNHPNSAIILHYAWHgqgQSPsirQLIMHAMAEWYMRgeqyDQAKLSRILDVAQDLKALSMLLNGTPF 577
Cdd:pfam16418    1 QELIDELFPLFLQGHPNSDLVLHSLWE---VDP---QLLLKRLVDYYAR----DPLNLSRILDVAQELKILDELLNLLPF 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 327315392   578 AFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEkDQPKSAQLPAETLATMLACLQ 654
Cdd:pfam16418   71 NFALDLAALASRRGYLDLEKWLQDKLKEHGEPFAQALLDFLEIKAKLELEVQANQ-PEPSSVPLSVETVHTLLKVLQ 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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