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Conserved domains on  [gi|330688397|ref|NP_001193457|]
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cartilage acidic protein 1 isoform B precursor [Homo sapiens]

Protein Classification

UnbV_ASPIC and EGF_CA domain-containing protein( domain architecture ID 10608433)

protein containing domains FG-GAP_3, UnbV_ASPIC, and EGF_CA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UnbV_ASPIC pfam07593
ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...
 460-518 2.18e-14

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.


:

Pssm-ID: 429555  Cd Length: 66  Bit Score: 67.99  E-value: 2.18e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 330688397  460 GAKVVLYTKkSGAHLRIIDGGSGYLCEMEPVAHFGLGK-DEASSVEVTWPDGKM-VSRNVA 518
Cdd:pfam07593   1 GARVTVTTA-GGRQYREVTGGRGYLSSSDPRLHFGLGDaTTIDSLEVRWPDGKVqTLENVA 60
EGF_CA pfam07645
Calcium-binding EGF domain;
559-595 5.51e-10

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 54.55  E-value: 5.51e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 330688397  559 DTNECIQFPFVCPRDkPVCVNTYGSYRCRtnkkCSRG 595
Cdd:pfam07645   1 DVDECATGTHNCPAN-TVCVNTIGSFECR----CPDG 32
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 299-363 1.11e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 46.06  E-value: 1.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 330688397  299 DFNRDGKVDIVYGNWNGPhRLYLQmstHGKVRFRDIASPKFSMPSPVRTVITADFDNDQELEIFF 363
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-RLYLN---NGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 255-309 2.76e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 44.91  E-value: 2.76e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 330688397  255 DIFCdNENGPNFLFHNRGDGTFVDAAASAGVDDPHqhGRGVALADFNRDGKVDIV 309
Cdd:pfam13517   9 DLVV-ANDGGLRLYLNNGDGTFTFITSVSLGGGGG--GLSVAVGDLDGDGRLDLL 60
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 62-132 2.38e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 39.52  E-value: 2.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 330688397   62 DVDHDGDFEIVVAGYNGPNLVLKydRAQKRLVNIAVDERSSPyyalrdrqGNAIGVTACDIDGDGREEIYF 132
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRLYLN--NGDGTFTFITSVSLGGG--------GGGLSVAVGDLDGDGRLDLLV 61
 
Name Accession Description Interval E-value
UnbV_ASPIC pfam07593
ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...
 460-518 2.18e-14

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.


Pssm-ID: 429555  Cd Length: 66  Bit Score: 67.99  E-value: 2.18e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 330688397  460 GAKVVLYTKkSGAHLRIIDGGSGYLCEMEPVAHFGLGK-DEASSVEVTWPDGKM-VSRNVA 518
Cdd:pfam07593   1 GARVTVTTA-GGRQYREVTGGRGYLSSSDPRLHFGLGDaTTIDSLEVRWPDGKVqTLENVA 60
EGF_CA pfam07645
Calcium-binding EGF domain;
559-595 5.51e-10

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 54.55  E-value: 5.51e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 330688397  559 DTNECIQFPFVCPRDkPVCVNTYGSYRCRtnkkCSRG 595
Cdd:pfam07645   1 DVDECATGTHNCPAN-TVCVNTIGSFECR----CPDG 32
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 299-363 1.11e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 46.06  E-value: 1.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 330688397  299 DFNRDGKVDIVYGNWNGPhRLYLQmstHGKVRFRDIASPKFSMPSPVRTVITADFDNDQELEIFF 363
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-RLYLN---NGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 255-309 2.76e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 44.91  E-value: 2.76e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 330688397  255 DIFCdNENGPNFLFHNRGDGTFVDAAASAGVDDPHqhGRGVALADFNRDGKVDIV 309
Cdd:pfam13517   9 DLVV-ANDGGLRLYLNNGDGTFTFITSVSLGGGGG--GLSVAVGDLDGDGRLDLL 60
EGF_CA smart00179
Calcium-binding EGF-like domain;
559-606 1.90e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 1.90e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 330688397   559 DTNECIQFPfVCPRDKpVCVNTYGSYRCRtnkkCSRGYepnEDGTACV 606
Cdd:smart00179   1 DIDECASGN-PCQNGG-TCVNTVGSYRCE----CPPGY---TDGRNCE 39
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 62-132 2.38e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 39.52  E-value: 2.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 330688397   62 DVDHDGDFEIVVAGYNGPNLVLKydRAQKRLVNIAVDERSSPyyalrdrqGNAIGVTACDIDGDGREEIYF 132
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRLYLN--NGDGTFTFITSVSLGGG--------GGGLSVAVGDLDGDGRLDLLV 61
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 559-606 7.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.53  E-value: 7.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 330688397 559 DTNECiQFPFVCPRDKpVCVNTYGSYRCrtnkKCSRGYEpnedGTACV 606
Cdd:cd00054    1 DIDEC-ASGNPCQNGG-TCVNTVGSYRC----SCPPGYT----GRNCE 38
 
Name Accession Description Interval E-value
UnbV_ASPIC pfam07593
ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...
 460-518 2.18e-14

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.


Pssm-ID: 429555  Cd Length: 66  Bit Score: 67.99  E-value: 2.18e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 330688397  460 GAKVVLYTKkSGAHLRIIDGGSGYLCEMEPVAHFGLGK-DEASSVEVTWPDGKM-VSRNVA 518
Cdd:pfam07593   1 GARVTVTTA-GGRQYREVTGGRGYLSSSDPRLHFGLGDaTTIDSLEVRWPDGKVqTLENVA 60
EGF_CA pfam07645
Calcium-binding EGF domain;
559-595 5.51e-10

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 54.55  E-value: 5.51e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 330688397  559 DTNECIQFPFVCPRDkPVCVNTYGSYRCRtnkkCSRG 595
Cdd:pfam07645   1 DVDECATGTHNCPAN-TVCVNTIGSFECR----CPDG 32
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 299-363 1.11e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 46.06  E-value: 1.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 330688397  299 DFNRDGKVDIVYGNWNGPhRLYLQmstHGKVRFRDIASPKFSMPSPVRTVITADFDNDQELEIFF 363
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-RLYLN---NGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 255-309 2.76e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 44.91  E-value: 2.76e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 330688397  255 DIFCdNENGPNFLFHNRGDGTFVDAAASAGVDDPHqhGRGVALADFNRDGKVDIV 309
Cdd:pfam13517   9 DLVV-ANDGGLRLYLNNGDGTFTFITSVSLGGGGG--GLSVAVGDLDGDGRLDLL 60
EGF_CA smart00179
Calcium-binding EGF-like domain;
559-606 1.90e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 1.90e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 330688397   559 DTNECIQFPfVCPRDKpVCVNTYGSYRCRtnkkCSRGYepnEDGTACV 606
Cdd:smart00179   1 DIDECASGN-PCQNGG-TCVNTVGSYRCE----CPPGY---TDGRNCE 39
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 62-132 2.38e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 39.52  E-value: 2.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 330688397   62 DVDHDGDFEIVVAGYNGPNLVLKydRAQKRLVNIAVDERSSPyyalrdrqGNAIGVTACDIDGDGREEIYF 132
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRLYLN--NGDGTFTFITSVSLGGG--------GGGLSVAVGDLDGDGRLDLLV 61
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 559-606 7.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.53  E-value: 7.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 330688397 559 DTNECiQFPFVCPRDKpVCVNTYGSYRCrtnkKCSRGYEpnedGTACV 606
Cdd:cd00054    1 DIDEC-ASGNPCQNGG-TCVNTVGSYRC----SCPPGYT----GRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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