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Conserved domains on  [gi|333470745|ref|NP_001193969|]
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transcription factor ETV7 isoform 7 [Homo sapiens]

Protein Classification

erythroblast transformation specific family transcription factor( domain architecture ID 10337522)

erythroblast transformation specific (ETS) family transcription factor may be involved in the regulation of immunoglobulin heavy-chain gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 142-227 1.93e-41

erythroblast transformation specific domain; variation of the helix-turn-helix motif


:

Pssm-ID: 197710  Cd Length: 87  Bit Score: 137.01  E-value: 1.93e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333470745   142 CRLLWDYVYQLLLDTRYEPYIKWEDKDAKIFRVVDPNGLARLWGNHKNRVNMTYEKMSRALRHYYKLNIIKKEPGQKLLF 221
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVY 80


                   ....*.
gi 333470745   222 RFLKTP 227
Cdd:smart00413  81 KFVKNP 86
SAM_superfamily super family cl15755
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 1-35 4.15e-17

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


The actual alignment was detected with superfamily member cd08535:

Pssm-ID: 472832  Cd Length: 68  Bit Score: 73.58  E-value: 4.15e-17
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 333470745   1 MNGRALCILTKDDFRHRAPSSGDVLYELLQYIKTQ 35
Cdd:cd08535   34 MNGKALCLLTKEDFRYRCPHAGDVLYNLLQHLLKQ 68
 
Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 142-227 1.93e-41

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 137.01  E-value: 1.93e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333470745   142 CRLLWDYVYQLLLDTRYEPYIKWEDKDAKIFRVVDPNGLARLWGNHKNRVNMTYEKMSRALRHYYKLNIIKKEPGQKLLF 221
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVY 80


                   ....*.
gi 333470745   222 RFLKTP 227
Cdd:smart00413  81 KFVKNP 86
Ets pfam00178
Ets-domain;
145-223 8.70e-37

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 124.92  E-value: 8.70e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 333470745  145 LWDYVYQLLLDTRYEPYIKWEDKDAKIFRVVDPNGLARLWGNHKNRVNMTYEKMSRALRHYYKLNIIKKEPGQKLLFRF 223
Cdd:pfam00178   2 LWQFLLDLLTDPEYSDIIKWTDKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
SAM_PNT-Tel_Yan cd08535
Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; SAM Pointed domain of Tel ...
 1-35 4.15e-17

Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; SAM Pointed domain of Tel (Translocation, Ets, Leukemia)/Yan subfamily of ETS transcriptional repressors is a protein-protein interaction domain. SAM Pointed domains of this type of regulators can interact with each other, forming head-to-tail homodimers or homooligomers, and/or interact with SAM Pointed domains of another subfamily of ETS factors forming heterodimers. The oligomeric form is able to block transcription of target genes and is involved in MAPK signaling. They participate in regulation of different processes during embryoniv development including hematopoietic differentiation and eye development. Tel/Yan transcriptional factors are frequent targets of chromosomal translocations resulting in fusions of SAM domain with new neighboring genes. Such chimeric proteins were found in different tumors. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 176085  Cd Length: 68  Bit Score: 73.58  E-value: 4.15e-17
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 333470745   1 MNGRALCILTKDDFRHRAPSSGDVLYELLQYIKTQ 35
Cdd:cd08535   34 MNGKALCLLTKEDFRYRCPHAGDVLYNLLQHLLKQ 68
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
1-35 7.49e-11

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 56.91  E-value: 7.49e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 333470745    1 MNGRALCILTKDDFRHRAPSSGDVLYELLQYIKTQ 35
Cdd:pfam02198  48 MNGKALCSLGKEEFLQRAPGPGDILWSHLQILRKA 82
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 1-35 1.69e-10

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 56.12  E-value: 1.69e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 333470745     1 MNGRALCILTKDDFRHRAPSSGDVLYELLQYIKTQ 35
Cdd:smart00251  48 MSGKELCSMSKEEFLERAPFGGDILWSHLQILRKA 82
 
Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 142-227 1.93e-41

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 137.01  E-value: 1.93e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333470745   142 CRLLWDYVYQLLLDTRYEPYIKWEDKDAKIFRVVDPNGLARLWGNHKNRVNMTYEKMSRALRHYYKLNIIKKEPGQKLLF 221
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVY 80


                   ....*.
gi 333470745   222 RFLKTP 227
Cdd:smart00413  81 KFVKNP 86
Ets pfam00178
Ets-domain;
145-223 8.70e-37

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 124.92  E-value: 8.70e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 333470745  145 LWDYVYQLLLDTRYEPYIKWEDKDAKIFRVVDPNGLARLWGNHKNRVNMTYEKMSRALRHYYKLNIIKKEPGQKLLFRF 223
Cdd:pfam00178   2 LWQFLLDLLTDPEYSDIIKWTDKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
SAM_PNT-Tel_Yan cd08535
Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; SAM Pointed domain of Tel ...
 1-35 4.15e-17

Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; SAM Pointed domain of Tel (Translocation, Ets, Leukemia)/Yan subfamily of ETS transcriptional repressors is a protein-protein interaction domain. SAM Pointed domains of this type of regulators can interact with each other, forming head-to-tail homodimers or homooligomers, and/or interact with SAM Pointed domains of another subfamily of ETS factors forming heterodimers. The oligomeric form is able to block transcription of target genes and is involved in MAPK signaling. They participate in regulation of different processes during embryoniv development including hematopoietic differentiation and eye development. Tel/Yan transcriptional factors are frequent targets of chromosomal translocations resulting in fusions of SAM domain with new neighboring genes. Such chimeric proteins were found in different tumors. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 176085  Cd Length: 68  Bit Score: 73.58  E-value: 4.15e-17
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 333470745   1 MNGRALCILTKDDFRHRAPSSGDVLYELLQYIKTQ 35
Cdd:cd08535   34 MNGKALCLLTKEDFRYRCPHAGDVLYNLLQHLLKQ 68
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
1-35 7.49e-11

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 56.91  E-value: 7.49e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 333470745    1 MNGRALCILTKDDFRHRAPSSGDVLYELLQYIKTQ 35
Cdd:pfam02198  48 MNGKALCSLGKEEFLQRAPGPGDILWSHLQILRKA 82
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 1-35 1.69e-10

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 56.12  E-value: 1.69e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 333470745     1 MNGRALCILTKDDFRHRAPSSGDVLYELLQYIKTQ 35
Cdd:smart00251  48 MSGKELCSMSKEEFLERAPFGGDILWSHLQILRKA 82
SAM_PNT cd08203
Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in ...
 1-34 2.70e-08

Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in about 40% of transcriptional regulators of ETS family (initially named for Erythroblastosis virus, E26-E Twenty Six). SAM Pointed domain containing proteins of this family additionally have a C-terminal ETS DNA-binding domain. In a few cases, SAM Pointed domain appears as a single domain protein. Members of this group are mostly involved in regulation of embryonic development and growth control in eukaryotes. SAM Pointed domains mediate protein-protein interactions. Depending on the subgroup, they can interact with other SAM Pointed domains forming homo or hetero dimers/oligomers and/or they can recruit a protein kinase to its target which can be a SAM Pointed domain containing protein itself or another protein that has no kinase docking site. Thus, SAM Pointed domains participate in transcriptional regulation and signal transduction. Some genes coding ETS family transcriptional regulators are proto-oncogenes. They are prone to chromosomal translocations resulting in gene fusions. Chimeric proteins with SAM Pointed domains were found in a number of different human tumors including myeloid leukemia, lymphoblastic leukemia, Ewing's sarcoma and primitive neuroectodermal tumor. Members of this family are potential targets for cancer therapy.


Pssm-ID: 188876  Cd Length: 67  Bit Score: 49.63  E-value: 2.70e-08
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 333470745   1 MNGRALCILTKDDFRHRAPS-SGDVLYELLQYIKT 34
Cdd:cd08203   33 MNGKELCALSKEDFRERAPSrGGDVLASHLALLRK 67
SAM_PNT-PDEF-like cd08532
Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of ...
 1-34 4.06e-07

Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of PDEF-like (Prostate-Derived ETS Factor) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. In human males this activator is highly expressed in the prostate gland and enhances androgen-mediated activation of the PSA promoter though interaction with the DNA binding domain of androgen receptor. PDEF may play a role in prostate cancer development as well as in goblet cell formation and mucus production in the epithelial lining of respiratory and intestinal tracts.


Pssm-ID: 188878  Cd Length: 81  Bit Score: 46.59  E-value: 4.06e-07
                         10        20        30
                 ....*....|....*....|....*....|....
gi 333470745   1 MNGRALCILTKDDFRHRAPSSGDVLYELLQYIKT 34
Cdd:cd08532   45 MNGKTLCALSEEDFVRRAPQGGDTLHAQLEIWKS 78
SAM_PNT-Mae cd08536
Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the ...
 1-31 2.17e-06

Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the Activity of ETS) subfamily represents a group of SAM Pointed monodomain proteins. SAM Pointed domain is a protein-protein interaction domain. It can interact with other SAM pointed domains forming head-to-tail heterodimers and also provides a kinase docking site. For example, in Drosophila Mae is required for facilitating phosphorylation of the Yan factor and for blocking phosphorylation of the ETS-2 regulator. Mae interacts with the SAM Pointed domains of Yan and ETS-2. Binding enhances access of the kinase to the Yan phosphorylation site by providing a kinase docking site, or inhibits phosphorylation of ETS-2 by blocking its docking site. This type of factors participates in regulation of kinase signaling particularly during embryogenesis.


Pssm-ID: 176086  Cd Length: 66  Bit Score: 44.24  E-value: 2.17e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 333470745   1 MNGRALCILTKDDFRHRAPSSGDVLYELLQY 31
Cdd:cd08536   33 MNGKGLCLMSLEGFLYRVPVGGKLLYEDFQR 63
SAM_PNT_ESE cd08757
Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM ...
 1-34 1.44e-04

Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM Pointed domain of ESE-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. ETS factors are important for cell differentiation. They can be involved in regulation of gene expression in different types of epithelial cells. They are expressed in salivary gland, intestine, stomach, pancreas, lungs, kidneys, colon, mammary gland, and prostate. Members of this group are proto-oncogenes. Expression profiles of these factors are altered in epithelial cancers, which makes them potential targets for cancer therapy.


Pssm-ID: 188885  Cd Length: 69  Bit Score: 39.24  E-value: 1.44e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 333470745   1 MNGRALCILTKDDFRHRAPSSGDVLYELLQYIKT 34
Cdd:cd08757   36 IDGQTLCSMSLEEFIERDGVYGNLLYAELRRLLS 69
SAM_PNT-ETS-1,2 cd08533
Sterile alpha motif (SAM)/Pointed domain of ETS-1,2 family; SAM Pointed domain of ETS-1,2 ...
 1-29 7.71e-04

Sterile alpha motif (SAM)/Pointed domain of ETS-1,2 family; SAM Pointed domain of ETS-1,2 family of transcriptional activators is a protein-protein interaction domain. It carries a kinase docking site and mediates interaction between ETS transcriptional activators and protein kinases. This group of transcriptional factors is involved in the Ras/MAP kinase signaling pathway. MAP kinases phosphorylate the transcription factors. Phosphorylated factors then recruit coactivators and enhance transactivation. Members of this group play a role in regulation of different embryonic developmental processes. ETS-1,2 transcriptional activators are proto-oncogenes involved in malignant transformation and tumor progression. They are potential molecular targets for selective cancer therapy.


Pssm-ID: 188879  Cd Length: 71  Bit Score: 37.35  E-value: 7.71e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 333470745   1 MNGRALCILTKDDFRHRAPS-SGDVLYELL 29
Cdd:cd08533   35 MSGRDMCALGKEAFLSLAPPfVGDILWEHL 64
SAM_PNT-ERG_FLI-1 cd08531
Sterile alpha motif (SAM)/Pointed domain of ERG (Ets related gene) and FLI-1 (Friend leukemia ...
 1-33 8.11e-04

Sterile alpha motif (SAM)/Pointed domain of ERG (Ets related gene) and FLI-1 (Friend leukemia integration 1) transcription factors; SAM Pointed domain of ERG/FLI-1 subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. The ERG and FLI regulators are involved in endothelial cell differentiation, bone morphogenesis and neural crest development. They are proto-oncogenes implicated in cancer development such as myeloid leukemia, Ewing's sarcoma and erythroleukemia. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188877  Cd Length: 75  Bit Score: 37.39  E-value: 8.11e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 333470745   1 MNGRALCILTKDDFRHRAPS-SGDVLYELLQYIK 33
Cdd:cd08531   37 IDGKELCRMTRDDFLRLTSAyNGDVLISHLCYLR 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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