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Conserved domains on  [gi|335057546|ref|NP_001229401|]
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zinc finger protein 345 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
88-476 5.46e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 5.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546  88 KPYECKECGKAFGSGANLAYHQRIHTGEKPFEC--KECGKAFGSGSNLTHHQRIHTGEKPYEC-KECGKAFSFGSGLIRH 164
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 165 QIIHSGEKPYECKECGKSFSFESALIRHHRIHTGEKPYECIDCGKAF--GSGSNLTQHRRIHTGEKPYEckacgmafSSG 242
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPANSLSKDP--------SSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 243 SALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYVCKECGKAFNSGSDLTQHQRIHTGEKPYECKECEKA 322
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 323 FRS--GSKLIQHQRMHTGE-----KPYECKECGKTFSSGSDLTQH--HRIHTGE--KPYECKE--CGKAFGSGSKLIQHQ 389
Cdd:COG5048  264 SLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 390 LIHTGERPYECKECGKSFSSGSALN-------RHQRIHTGEKPYEC--KECGKAFYSGSSLTQHQRIHTGEKLYECKN-- 458
Cdd:COG5048  344 LLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNpp 423

                        410
                 ....*....|....*...
gi 335057546 459 CGKAYGRDSEFQQHKKSH 476
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
88-476 5.46e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 5.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546  88 KPYECKECGKAFGSGANLAYHQRIHTGEKPFEC--KECGKAFGSGSNLTHHQRIHTGEKPYEC-KECGKAFSFGSGLIRH 164
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 165 QIIHSGEKPYECKECGKSFSFESALIRHHRIHTGEKPYECIDCGKAF--GSGSNLTQHRRIHTGEKPYEckacgmafSSG 242
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPANSLSKDP--------SSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 243 SALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYVCKECGKAFNSGSDLTQHQRIHTGEKPYECKECEKA 322
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 323 FRS--GSKLIQHQRMHTGE-----KPYECKECGKTFSSGSDLTQH--HRIHTGE--KPYECKE--CGKAFGSGSKLIQHQ 389
Cdd:COG5048  264 SLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 390 LIHTGERPYECKECGKSFSSGSALN-------RHQRIHTGEKPYEC--KECGKAFYSGSSLTQHQRIHTGEKLYECKN-- 458
Cdd:COG5048  344 LLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNpp 423

                        410
                 ....*....|....*...
gi 335057546 459 CGKAYGRDSEFQQHKKSH 476
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-435 1.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.45e-04
                          10        20
                  ....*....|....*....|....
gi 335057546  412 ALNRHQRIHTGEKPYECKECGKAF 435
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 312-360 1.62e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 1.62e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 335057546 312 KPYeCKECEKAFRSGSKLIQHQRMHTgekpYECKECGKTFSSGSDLTQH 360
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
88-476 5.46e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 5.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546  88 KPYECKECGKAFGSGANLAYHQRIHTGEKPFEC--KECGKAFGSGSNLTHHQRIHTGEKPYEC-KECGKAFSFGSGLIRH 164
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 165 QIIHSGEKPYECKECGKSFSFESALIRHHRIHTGEKPYECIDCGKAF--GSGSNLTQHRRIHTGEKPYEckacgmafSSG 242
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPANSLSKDP--------SSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 243 SALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYVCKECGKAFNSGSDLTQHQRIHTGEKPYECKECEKA 322
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 323 FRS--GSKLIQHQRMHTGE-----KPYECKECGKTFSSGSDLTQH--HRIHTGE--KPYECKE--CGKAFGSGSKLIQHQ 389
Cdd:COG5048  264 SLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 390 LIHTGERPYECKECGKSFSSGSALN-------RHQRIHTGEKPYEC--KECGKAFYSGSSLTQHQRIHTGEKLYECKN-- 458
Cdd:COG5048  344 LLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNpp 423

                        410
                 ....*....|....*...
gi 335057546 459 CGKAYGRDSEFQQHKKSH 476
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-484 5.77e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 5.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 144 KPYECKECGKAFSFGSGLIRHQIIHSGEKPYEC--KECGKSFSFESALIRHHRIHTGEKPYECIDCGKAFGSGSNLTQHR 221
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 222 RIHTgekpYECKACGMAFSSGSALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYVCKECGKAFNSGSDL 301
Cdd:COG5048  112 SSSS----NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 302 TQHQRIHTGEKPYECKECEKaFRSGSKLIQHQRMHTGEKPYECKECGKTFSSGSDLTQHHRIHTGEKPYECKECGKAFGS 381
Cdd:COG5048  188 ISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 382 GSKLIQHQLIHTGER-------PYECKECGKSFSSGSALNRHQR--IHTGE--KPYECKE--CGKAFYSGSSLTQHQRIH 448
Cdd:COG5048  267 TASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 335057546 449 TGEKLYECK--NCGKAYGRDSE------FQQHKKSHNGKKLCEL 484
Cdd:COG5048  347 TSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETL 390
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
58-417 1.32e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546  58 DEKLLECKECGKDFSFVSVLVRHQRIHTGEKPYEC--KECGKAFGSGANLAYHQRIHTGEKPFECK-------------- 121
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassss 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 122 --ECGKAF-----GSGSNLTHHQR------IHTGEKPYECKE-------------------------CGKAFSFGSGLIR 163
Cdd:COG5048  110 lsSSSSNSndnnlLSSHSLPPSSRdpqlpdLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 164 HQIIHSGEKPYECKEcGKSFSFESALIRHHRIHTGEKPYECIDCGKAFGSGSNLTQHRRIHTGEKPYECKACGMAFSSGS 243
Cdd:COG5048  190 SNVSTSIPSSSENSP-LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 244 ALTRHQRIHTGE-------KPYICNECGKAFSFGSALTRHQR--IHTGE--KPYVCKE--CGKAFNSGSDLTQHQRIHTG 310
Cdd:COG5048  269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 311 EKPYECK--ECEKAFR--SGSKLIQHQRMHTGEKPYECKECGKTFSSGSDLTQH----HRI-HTGEKPYECK--ECGKAF 379
Cdd:COG5048  349 ISPAKEKllNSSSKFSplLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnlslHIItHLSFRPYNCKnpPCSKSF 428

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 335057546 380 GSGSKLIQHQLIHTGERPYECKECGKSFSSGSALNRHQ 417
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-335 3.55e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 172 KPYECKECGKSFSFESALIRH--HRIHTGE--KPYEC--IDCGKAFGSGSNLTQHRRIHTGEKPYECKACGMAFSSGSAL 245
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 246 T-------RHQRIHTGEKPYIC--NECGKAFSFGSALTRHQRIHTGEKPYVCK--ECGKAFNSGSDLTQHQRIHTGEKPY 314
Cdd:COG5048  368 NneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|.
gi 335057546 315 ECkECEKAFRSGSKLIQHQRM 335
Cdd:COG5048  448 LC-SILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-435 1.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.45e-04
                          10        20
                  ....*....|....*....|....
gi 335057546  412 ALNRHQRIHTGEKPYECKECGKAF 435
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-297 1.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.93e-04
                          10        20
                  ....*....|....*....|....*.
gi 335057546  272 ALTRHQRIHTGEKPYVCKECGKAFNS 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
77-99 3.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.34e-04
                          10        20
                  ....*....|....*....|...
gi 335057546   77 LVRHQRIHTGEKPYECKECGKAF 99
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
104-127 4.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.31e-04
                          10        20
                  ....*....|....*....|....
gi 335057546  104 NLAYHQRIHTGEKPFECKECGKAF 127
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-353 6.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.02e-04
                          10        20
                  ....*....|....*....|....*
gi 335057546  329 LIQHQRMHTGEKPYECKECGKTFSS 353
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-325 6.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.14e-04
                          10        20
                  ....*....|....*....|....*.
gi 335057546  300 DLTQHQRIHTGEKPYECKECEKAFRS 325
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-241 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 335057546  216 NLTQHRRIHTGEKPYECKACGMAFSS 241
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-379 1.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.37e-03
                          10        20
                  ....*....|....*....|....
gi 335057546  356 DLTQHHRIHTGEKPYECKECGKAF 379
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-211 1.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|....
gi 335057546  188 ALIRHHRIHTGEKPYECIDCGKAF 211
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 312-360 1.62e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 1.62e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 335057546 312 KPYeCKECEKAFRSGSKLIQHQRMHTgekpYECKECGKTFSSGSDLTQH 360
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
136-156 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|.
gi 335057546  136 HQRIHTGEKPYECKECGKAFS 156
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-184 3.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.10e-03
                          10        20
                  ....*....|....*....|....
gi 335057546  161 LIRHQIIHSGEKPYECKECGKSFS 184
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 114-197 3.21e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 335057546 114 GEKPFECK--ECGKAFGSGSNLTHHqRIHtgekpyecKECGKAFSFGSGLIRHQIIHSGEKPYECKECGKSFSFESALiR 191
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                 ....*.
gi 335057546 192 HHRIHT 197
Cdd:COG5189  416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-409 3.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.49e-03
                          10        20
                  ....*....|....*....|....*
gi 335057546  385 LIQHQLIHTGERPYECKECGKSFSS 409
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-268 5.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.12e-03
                          10        20
                  ....*....|....*....|....*
gi 335057546  244 ALTRHQRIHTGEKPYICNECGKAFS 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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