|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
813-1138 |
2.04e-84 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
:
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 277.31 E-value: 2.04e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 813 LTRYLKRLKLGTLRAGRLLELLHCaheTQQPGIWEHVAHQlpGHLSFLGTRLTPP--DVYVLGRALETASqdfslDLRQT 890
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 891 GVEPSGLGNLVGLSCVTSFRASLS-DTMALWESLQQ---QGEAQLLQAAEEKfTIEPFKAKSPKDV-EDLDRLVQTQRLR 965
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 966 N--PSEDAAKDLPAIRDLKKLEFALGPIlGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 1043
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 1044 LNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLqKC 1123
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 344217725 1124 PQVETLAMWTPTIPF 1138
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
438-609 |
1.37e-48 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 170.18 E-value: 1.37e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 438 QVVAVLGKAGQGKSHWARTVSHTWACGQLLQY-DFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPD 516
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 517 RVLLILDAFEELEAQDGLLHGpcgslspePCSLRGLLAGIFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 594
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 344217725 595 TKQAKTYMRHYFENS 609
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
737-842 |
3.61e-04 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 41.51 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 737 LQCFLGAVWLAQCNEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAVAAv 805
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 344217725 806 adRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQ 842
Cdd:pfam17776 82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
813-1138 |
2.04e-84 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 277.31 E-value: 2.04e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 813 LTRYLKRLKLGTLRAGRLLELLHCaheTQQPGIWEHVAHQlpGHLSFLGTRLTPP--DVYVLGRALETASqdfslDLRQT 890
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 891 GVEPSGLGNLVGLSCVTSFRASLS-DTMALWESLQQ---QGEAQLLQAAEEKfTIEPFKAKSPKDV-EDLDRLVQTQRLR 965
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 966 N--PSEDAAKDLPAIRDLKKLEFALGPIlGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 1043
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 1044 LNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLqKC 1123
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 344217725 1124 PQVETLAMWTPTIPF 1138
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
438-609 |
1.37e-48 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 170.18 E-value: 1.37e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 438 QVVAVLGKAGQGKSHWARTVSHTWACGQLLQY-DFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPD 516
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 517 RVLLILDAFEELEAQDGLLHGpcgslspePCSLRGLLAGIFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 594
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 344217725 595 TKQAKTYMRHYFENS 609
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1000-1151 |
1.32e-18 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 89.85 E-value: 1.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 1000 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALaKSLLRLSLYNNC 1079
Cdd:COG5238 284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344217725 1080 ICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1151
Cdd:COG5238 360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1068-1094 |
1.87e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.70 E-value: 1.87e-04
10 20
....*....|....*....|....*..
gi 344217725 1068 KSLLRLSLYNNCICDKGAKSLAQVLPD 1094
Cdd:smart00368 2 PSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
737-842 |
3.61e-04 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 41.51 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 737 LQCFLGAVWLAQCNEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAVAAv 805
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 344217725 806 adRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQ 842
Cdd:pfam17776 82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1041-1108 |
9.05e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.58 E-value: 9.05e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344217725 1041 LETLNLSQNNITDVGacklAEALPALaKSLLRLSLYNNCICDKGAKSLAqvlpDMVSLRVMDVQFNKF 1108
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGL-SNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
813-1138 |
2.04e-84 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 277.31 E-value: 2.04e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 813 LTRYLKRLKLGTLRAGRLLELLHCaheTQQPGIWEHVAHQlpGHLSFLGTRLTPP--DVYVLGRALETASqdfslDLRQT 890
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 891 GVEPSGLGNLVGLSCVTSFRASLS-DTMALWESLQQ---QGEAQLLQAAEEKfTIEPFKAKSPKDV-EDLDRLVQTQRLR 965
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 966 N--PSEDAAKDLPAIRDLKKLEFALGPIlGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 1043
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 1044 LNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLqKC 1123
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 344217725 1124 PQVETLAMWTPTIPF 1138
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
438-609 |
1.37e-48 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 170.18 E-value: 1.37e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 438 QVVAVLGKAGQGKSHWARTVSHTWACGQLLQY-DFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPD 516
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 517 RVLLILDAFEELEAQDGLLHGpcgslspePCSLRGLLAGIFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 594
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 344217725 595 TKQAKTYMRHYFENS 609
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1000-1151 |
1.32e-18 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 89.85 E-value: 1.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 1000 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALaKSLLRLSLYNNC 1079
Cdd:COG5238 284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344217725 1080 ICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1151
Cdd:COG5238 360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
992-1129 |
5.20e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 85.23 E-value: 5.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 992 LGPQAFPTLAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALpALAKSLL 1071
Cdd:COG5238 248 IGDEGVIALAEALKNNTTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLH 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 344217725 1072 RLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETL 1129
Cdd:COG5238 324 TLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1011-1146 |
4.45e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 75.98 E-value: 4.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 1011 QHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALpALAKSLLRLSLYNNCICDKGAKSLAQ 1090
Cdd:COG5238 180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAL-KGNKSLTTLDLSNNQIGDEGVIALAE 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 1091 VLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETLAMWTPTIPF----GVQEHLQQ 1146
Cdd:COG5238 259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQG 318
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
945-1129 |
1.59e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 64.57 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 945 KAKSPKDVEDLDRLVQTQRLRNPSEDAAKDLPAIRDLKKLEFAlgpILGPQAFPTLAKILPAFSSLQHLDldsLSENKIG 1024
Cdd:COG4886 76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESL---DLSGNQLTDLPEELANLTNLKELD---LSNNQLT 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 1025 DkgvskLSATFPQLKALETLNLSQNNITDvgackLAEALPALaKSLLRLSLYNNCIcdkgaKSLAQVLPDMVSLRVMDVQ 1104
Cdd:COG4886 150 D-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNL-TNLKELDLSNNQI-----TDLPEPLGNLTNLEELDLS 213
|
170 180
....*....|....*....|....*
gi 344217725 1105 FNKFTAagaqqLASSLQKCPQVETL 1129
Cdd:COG4886 214 GNQLTD-----LPEPLANLTNLETL 233
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
926-1129 |
1.36e-09 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 61.73 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 926 QGEAQLLQAAEEKfTIEPFKAKSPkdVEDLDRLVQTQRLrnPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILP 1005
Cdd:COG5238 68 QGDPGLNPVALEK-AAEAFPTQLL--VVDWEGAEEVSPV--ALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRIN 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 1006 AFSSL--------QHLDLDSLSENKIGDKGVSKlsatFPQLKALETLNLSQNNITDVGACKLAEALPAlAKSLLRLSLYN 1077
Cdd:COG5238 143 LIQVLkdplggnaVHLLGLAARLGLLAAISMAK----ALQNNSVETVYLGCNQIGDEGIEELAEALTQ-NTTVTTLWLKR 217
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 344217725 1078 NCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETL 1129
Cdd:COG5238 218 NPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETL 269
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
973-1121 |
2.25e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.55 E-value: 2.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 973 KDLPA-IRDLKKLEFaLgpILGPQAFPTLAKILPAFSSLQHLDLdslSENKIGDkgvskLSATFPQLKALETLNLSQNNI 1051
Cdd:COG4886 172 TDLPEeLGNLTNLKE-L--DLSNNQITDLPEPLGNLTNLEELDL---SGNQLTD-----LPEPLANLTNLETLDLSNNQL 240
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 344217725 1052 TDvgacklaeaLPALA--KSLLRLSLYNNCICDkgakslaqvLPD---MVSLRVMDVQFNKFTAAGAQQLASSLQ 1121
Cdd:COG4886 241 TD---------LPELGnlTNLEELDLSNNQLTD---------LPPlanLTNLKTLDLSNNQLTDLKLKELELLLG 297
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
436-1019 |
1.44e-05 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 49.42 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 436 ETQVVAVLGKAGQGKS----HWARTVshtWACGQLLQYDFVFYVPCHCLDRPGDtyhLRDLLCPPSLQPLAMDDEVLDYI 511
Cdd:COG5635 179 KKKRLLILGEPGSGKTtllrYLALEL---AERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKRGGEPEDALERL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 512 VRQpDRVLLILDAFEELeaqdgllhgpcgslsPEPCSLRGLLAGI--FQRKlLRGCTLLLTARPRGRLAQSLSKADaIFE 589
Cdd:COG5635 253 LRN-GRLLLLLDGLDEV---------------PDEADRDEVLNQLrrFLER-YPKARVIITSRPEGYDSSELEGFE-VLE 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 590 VPSFSTKQAKTYMRHYFENsgTAGNQDKALGLLEGQPLLCSYSHSPVVCRAVCQLSKalleqgTEAQLPCTLTGLY---V 666
Cdd:COG5635 315 LAPLSDEQIEEFLKKWFEA--TERKAERLLEALEENPELRELARNPLLLTLLALLLR------ERGELPDTRAELYeqfV 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 667 SLL----------GPAAQNSPPGALVELAKLAWELgrrHQStlQETRFSSVEVKTWAVTQGLMQQTLETTEAQLAFSSFL 736
Cdd:COG5635 387 ELLlerwdeqrglTIYRELSREELRELLSELALAM---QEN--GRTEFAREELEEILREYLGRRKDAEALLDELLLRTGL 461
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 737 LQC---------------FLGAVWLAqcneikdkELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHC-----LGA 796
Cdd:COG5635 462 LVErgegrysfahrsfqeYLAARALV--------EELDEELLELLAEHLEDPRWREVLLLLAGLLDDVKQIKelidaLLA 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 797 LVEPAVAAVADRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQPGIWEHVAHQLPGHLSFLGTRLTPPDVYVLGRAL 876
Cdd:COG5635 534 RDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLL 613
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 877 ETASQDFSLDLRQTGVEPSGLGNLVGLSCVTSFRASLSDTMALWESLQQQGEAQLLQAAEEKFTIEPFKAKSPKDVEDLD 956
Cdd:COG5635 614 LLLALALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLL 693
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344217725 957 RLVQTQRLRNPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILPAFSSLQHLDLDSLS 1019
Cdd:COG5635 694 LLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESS 756
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1068-1094 |
1.87e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.70 E-value: 1.87e-04
10 20
....*....|....*....|....*..
gi 344217725 1068 KSLLRLSLYNNCICDKGAKSLAQVLPD 1094
Cdd:smart00368 2 PSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
737-842 |
3.61e-04 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 41.51 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344217725 737 LQCFLGAVWLAQCNEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAVAAv 805
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 344217725 806 adRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQ 842
Cdd:pfam17776 82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1009-1081 |
5.09e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.85 E-value: 5.09e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344217725 1009 SLQHLDLdslSENKIGDkgVSKLSAtfpqLKALETLNLSQNNITDVGAckLAEALPALaKSLLRLSLYNNCIC 1081
Cdd:cd21340 121 SLRVLNI---SGNNIDS--LEPLAP----LRNLEQLDASNNQISDLEE--LLDLLSSW-PSLRELDLTGNPVC 181
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1041-1108 |
9.05e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.58 E-value: 9.05e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344217725 1041 LETLNLSQNNITDVGacklAEALPALaKSLLRLSLYNNCICDKGAKSLAqvlpDMVSLRVMDVQFNKF 1108
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGL-SNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| |
