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Conserved domains on  [gi|353523787|ref|NP_001238784|]
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phosphoinositide 3-kinase regulatory subunit 5 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PI3K_1B_p101 super family cl11126
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
1-494 0e+00

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


The actual alignment was detected with superfamily member pfam10486:

Pssm-ID: 463109  Cd Length: 860  Bit Score: 844.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787    1 MDSGYVEDSEESSSEWPwRRGSQERRGHRRPGQKF-IRIYKLFKSTSQLVLRRdsrslegssdtalplrrAGSLCSPLDE 79
Cdd:pfam10486 382 VDSDYCEDSDESSSSSP-RAEKPREKSKKKSRSRLsQRIYRLFKPKSPLVLRR-----------------AKSLGNPEAK 443
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787   80 PVsPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQ----RRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRL 155
Cdd:pfam10486 444 DL-IPVRSKRSNSLPQQVLLRSLEPPPLPPLSALRhvcfRRRPILSCDEDTKATTLRVVVFGADRIAGKVARAYSNLRRK 522
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  156 ENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPrhaSPGELGTTPWEESTNDISHYLGMLDPWYERN 235
Cdd:pfam10486 523 ESTCPRLTRAFKLQFYFVPVKRSSSTSPGGSSSPLSQSPSPLGSSL---SSADLNLAGWEDSTNDIAHYLGMLDPWYERN 599
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  236 VLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSA 315
Cdd:pfam10486 600 VLSLLNLPSDVLCQQTSKTESESLESSEERLPILADMVLYYCRFAARPVLLQLYQAELTLAGGERRTEVFIHSLELGHTA 679
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  316 ATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVV 395
Cdd:pfam10486 680 GTRAIKAMGAASKRFGIDGDREAVPLTLEIVYNKVAISGRSQWSNEEKVCTSVNLIKACRNPEELDSKMECLQLTMTEVL 759
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  396 KRQNSKSKKGFNQ-ISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQ- 473
Cdd:pfam10486 760 KRQNSKSKKGYNQqISTSEVKVDKVQVIGSNNTTFAVCLDQDEKKILQSVTRCEVSVCYKPDSSSDWRLRKPLSSGQVQp 839
                         490       500
                  ....*....|....*....|.
gi 353523787  474 AAPDLCSLLCLPIMTFSGALP 494
Cdd:pfam10486 840 LQPTFCSLLCLPITTFSGALP 860
 
Name Accession Description Interval E-value
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
1-494 0e+00

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 463109  Cd Length: 860  Bit Score: 844.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787    1 MDSGYVEDSEESSSEWPwRRGSQERRGHRRPGQKF-IRIYKLFKSTSQLVLRRdsrslegssdtalplrrAGSLCSPLDE 79
Cdd:pfam10486 382 VDSDYCEDSDESSSSSP-RAEKPREKSKKKSRSRLsQRIYRLFKPKSPLVLRR-----------------AKSLGNPEAK 443
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787   80 PVsPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQ----RRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRL 155
Cdd:pfam10486 444 DL-IPVRSKRSNSLPQQVLLRSLEPPPLPPLSALRhvcfRRRPILSCDEDTKATTLRVVVFGADRIAGKVARAYSNLRRK 522
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  156 ENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPrhaSPGELGTTPWEESTNDISHYLGMLDPWYERN 235
Cdd:pfam10486 523 ESTCPRLTRAFKLQFYFVPVKRSSSTSPGGSSSPLSQSPSPLGSSL---SSADLNLAGWEDSTNDIAHYLGMLDPWYERN 599
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  236 VLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSA 315
Cdd:pfam10486 600 VLSLLNLPSDVLCQQTSKTESESLESSEERLPILADMVLYYCRFAARPVLLQLYQAELTLAGGERRTEVFIHSLELGHTA 679
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  316 ATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVV 395
Cdd:pfam10486 680 GTRAIKAMGAASKRFGIDGDREAVPLTLEIVYNKVAISGRSQWSNEEKVCTSVNLIKACRNPEELDSKMECLQLTMTEVL 759
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  396 KRQNSKSKKGFNQ-ISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQ- 473
Cdd:pfam10486 760 KRQNSKSKKGYNQqISTSEVKVDKVQVIGSNNTTFAVCLDQDEKKILQSVTRCEVSVCYKPDSSSDWRLRKPLSSGQVQp 839
                         490       500
                  ....*....|....*....|.
gi 353523787  474 AAPDLCSLLCLPIMTFSGALP 494
Cdd:pfam10486 840 LQPTFCSLLCLPITTFSGALP 860
 
Name Accession Description Interval E-value
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
1-494 0e+00

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 463109  Cd Length: 860  Bit Score: 844.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787    1 MDSGYVEDSEESSSEWPwRRGSQERRGHRRPGQKF-IRIYKLFKSTSQLVLRRdsrslegssdtalplrrAGSLCSPLDE 79
Cdd:pfam10486 382 VDSDYCEDSDESSSSSP-RAEKPREKSKKKSRSRLsQRIYRLFKPKSPLVLRR-----------------AKSLGNPEAK 443
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787   80 PVsPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQ----RRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRL 155
Cdd:pfam10486 444 DL-IPVRSKRSNSLPQQVLLRSLEPPPLPPLSALRhvcfRRRPILSCDEDTKATTLRVVVFGADRIAGKVARAYSNLRRK 522
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  156 ENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPrhaSPGELGTTPWEESTNDISHYLGMLDPWYERN 235
Cdd:pfam10486 523 ESTCPRLTRAFKLQFYFVPVKRSSSTSPGGSSSPLSQSPSPLGSSL---SSADLNLAGWEDSTNDIAHYLGMLDPWYERN 599
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  236 VLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSA 315
Cdd:pfam10486 600 VLSLLNLPSDVLCQQTSKTESESLESSEERLPILADMVLYYCRFAARPVLLQLYQAELTLAGGERRTEVFIHSLELGHTA 679
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  316 ATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVV 395
Cdd:pfam10486 680 GTRAIKAMGAASKRFGIDGDREAVPLTLEIVYNKVAISGRSQWSNEEKVCTSVNLIKACRNPEELDSKMECLQLTMTEVL 759
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353523787  396 KRQNSKSKKGFNQ-ISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQ- 473
Cdd:pfam10486 760 KRQNSKSKKGYNQqISTSEVKVDKVQVIGSNNTTFAVCLDQDEKKILQSVTRCEVSVCYKPDSSSDWRLRKPLSSGQVQp 839
                         490       500
                  ....*....|....*....|.
gi 353523787  474 AAPDLCSLLCLPIMTFSGALP 494
Cdd:pfam10486 840 LQPTFCSLLCLPITTFSGALP 860
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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