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Conserved domains on  [gi|377520125|ref|NP_001243684|]
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PEX5-related protein isoform 7 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 1000094)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
223-453 1.93e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 66.65  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  223 EEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQ 302
Cdd:TIGR02917  27 EAAKSYLQKNKYKAAIIQLKNALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKF 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  303 QDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMskspvdssvLEGVKELYLEAAHQNGDmiDPDLQTGLGVLFHLSGEF 382
Cdd:TIGR02917 107 QQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQ---------LELAQKSYEQALAIDPR--SLYAKLGLAQLALAENRF 175
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 377520125  383 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREA 453
Cdd:TIGR02917 176 DEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246
 
Name Accession Description Interval E-value
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
223-453 1.93e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 66.65  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  223 EEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQ 302
Cdd:TIGR02917  27 EAAKSYLQKNKYKAAIIQLKNALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKF 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  303 QDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMskspvdssvLEGVKELYLEAAHQNGDmiDPDLQTGLGVLFHLSGEF 382
Cdd:TIGR02917 107 QQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQ---------LELAQKSYEQALAIDPR--SLYAKLGLAQLALAENRF 175
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 377520125  383 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREA 453
Cdd:TIGR02917 176 DEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
158-431 8.92e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 56.78  E-value: 8.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 158 FERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWpgAFEEGLKRLKEGDLPVT 237
Cdd:COG0457    1 LKDLLLALAILLEALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGL--LLLLALALLKLGRLEEA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 238 ILFMEAAI--LQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALA-VSYTNTGHQQDACDALKNWIK 314
Cdd:COG0457   79 LELLEKALelELLPNLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLAEALLAlGALYELGDYEEALELYEKALE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 315 QNPKYKYLVKSKKGSPGLTRRMSKspvdssvLEGVKELYLEAAHQNGDmIDPDLQTGLGVLFHLSGEFNRAIDAFNAALT 394
Cdd:COG0457  159 LDPELNELAEALLALGALLEALGR-------YEEALELLEKALKLNPD-DDAEALLNLGLLYLKLGKYEEALEYYEKALE 230
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 377520125 395 VRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQP 431
Cdd:COG0457  231 LDPDNAEALYNLALLLLELGRYEEALEALEKALELDP 267
TPR_12 pfam13424
Tetratricopeptide repeat;
401-466 4.75e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.60  E-value: 4.75e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 377520125  401 SLWNRLGATLANGDRSEEAVEAYTRALEIQ--------PGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRK 466
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
PRK11189 PRK11189
lipoprotein NlpI; Provisional
372-421 1.38e-03

lipoprotein NlpI; Provisional


Pssm-ID: 236875 [Multi-domain]  Cd Length: 296  Bit Score: 40.64  E-value: 1.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 377520125 372 LGVLFHLSGEFNRAIDAFNAALTVRPE-DYSLWNRlGATLANGDRSEEAVE 421
Cdd:PRK11189 104 LGIYLTQAGNFDAAYEAFDSVLELDPTyNYAYLNR-GIALYYGGRYELAQD 153
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
252-285 8.82e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 33.96  E-value: 8.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 377520125   252 AEAWQFLGITQAENENEQAAIVALQRCLELQPNN 285
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
223-453 1.93e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 66.65  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  223 EEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQ 302
Cdd:TIGR02917  27 EAAKSYLQKNKYKAAIIQLKNALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKF 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  303 QDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMskspvdssvLEGVKELYLEAAHQNGDmiDPDLQTGLGVLFHLSGEF 382
Cdd:TIGR02917 107 QQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQ---------LELAQKSYEQALAIDPR--SLYAKLGLAQLALAENRF 175
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 377520125  383 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREA 453
Cdd:TIGR02917 176 DEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
220-440 2.36e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 63.18  E-value: 2.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  220 GAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNT 299
Cdd:TIGR02917 263 AHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRL 342
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  300 GHQQDACDALKNWIKQNP-----------KY----------KYLVKSKKGSPGL----TRR-MSK-SPVDSSvlEGVKEL 352
Cdd:TIGR02917 343 GRVDEAIATLSPALGLDPddpaalsllgeAYlalgdfekaaEYLAKATELDPENaaarTQLgISKlSQGDPS--EAIADL 420
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  353 yLEAAHQNGDMIDPDLqtgLGVLFHL-SGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQP 431
Cdd:TIGR02917 421 -ETAAQLDPELGRADL---LLILSYLrSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEP 496

                  ....*....
gi 377520125  432 GFIRSRYNL 440
Cdd:TIGR02917 497 DFFPAAANL 505
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
229-466 1.56e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 60.48  E-value: 1.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  229 LKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAvsytntghqqDACDA 308
Cdd:TIGR02917 578 LGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLA----------DAYAV 647
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  309 LKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELY--LEAAHQNgdmiDPDLQTGLGVLFHLSGEFNRAI 386
Cdd:TIGR02917 648 MKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAksLQKQHPK----AALGFELEGDLYLRQKDYPAAI 723
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  387 DAFNAALTVRPEDYSLWNRLGATLANGDRSeEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRK 466
Cdd:TIGR02917 724 QAYRKALKRAPSSQNAIKLHRALLASGNTA-EAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPD 802
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
225-463 8.68e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.17  E-value: 8.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  225 GLKRLK--EGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQ 302
Cdd:TIGR02917 164 GLAQLAlaENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEF 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  303 QDA---CDALKNWIKQNPK---YKYLVKSKKG-----SPGLTRRMSKSP--VDSSVLEGVKELYL---EAAHQNGDMI-- 364
Cdd:TIGR02917 244 EEAekhADALLKKAPNSPLahyLKALVDFQKKnyedaRETLQDALKSAPeyLPALLLAGASEYQLgnlEQAYQYLNQIlk 323
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  365 -DPDLQTG---LGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGAT-LANGDrSEEAVEAYTRALEIQPGFIRSRYN 439
Cdd:TIGR02917 324 yAPNSHQArrlLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAyLALGD-FEKAAEYLAKATELDPENAAARTQ 402
                         250       260
                  ....*....|....*....|....
gi 377520125  440 LGISCINLGAYREAVSNFLTALSL 463
Cdd:TIGR02917 403 LGISKLSQGDPSEAIADLETAAQL 426
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
158-431 8.92e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 56.78  E-value: 8.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 158 FERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWpgAFEEGLKRLKEGDLPVT 237
Cdd:COG0457    1 LKDLLLALAILLEALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGL--LLLLALALLKLGRLEEA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 238 ILFMEAAI--LQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALA-VSYTNTGHQQDACDALKNWIK 314
Cdd:COG0457   79 LELLEKALelELLPNLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLAEALLAlGALYELGDYEEALELYEKALE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 315 QNPKYKYLVKSKKGSPGLTRRMSKspvdssvLEGVKELYLEAAHQNGDmIDPDLQTGLGVLFHLSGEFNRAIDAFNAALT 394
Cdd:COG0457  159 LDPELNELAEALLALGALLEALGR-------YEEALELLEKALKLNPD-DDAEALLNLGLLYLKLGKYEEALEYYEKALE 230
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 377520125 395 VRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQP 431
Cdd:COG0457  231 LDPDNAEALYNLALLLLELGRYEEALEALEKALELDP 267
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
332-466 2.66e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 227343 [Multi-domain]  Cd Length: 257  Bit Score: 54.75  E-value: 2.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 332 LTRRMSKSPVDSSVLEGVKELYLEA-AHQ---------NGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYS 401
Cdd:COG5010   56 LGAAVLRNPEDLSIAKLATALYLRGdADSslavlqksaIAYPKDRELLAAQGKNQIRNGNFGEAVSVLRKAARLAPTDWE 135
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 377520125 402 LWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRK 466
Cdd:COG5010  136 AWNLLGAALDQLGRFDEARRAYRQALELAPNEPSIANNLGMSLLLRGDLEDAETLLLPAYLSPAA 200
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
247-431 1.86e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.85  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  247 QDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYkylVKSK 326
Cdd:TIGR02917 460 KQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKN---LRAI 536
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  327 KGSPGLTRRMSKSpvdssvlEGVKELYLEAAHQNGDMIDPDLQtgLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRL 406
Cdd:TIGR02917 537 LALAGLYLRTGNE-------EEAVAWLEKAAELNPQEIEPALA--LAQYYLGKGQLKKALAILNEAADAAPDSPEAWLML 607
                         170       180
                  ....*....|....*....|....*.
gi 377520125  407 GAT-LANGDrSEEAVEAYTRALEIQP 431
Cdd:TIGR02917 608 GRAqLAAGD-LNKAVSSFKKLLALQP 632
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
200-466 2.16e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 49.46  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 200 ISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCL 279
Cdd:COG0457    7 ALAILLEALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGLLLLLALALLKLGRLEEALELLEKAL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 280 ELQ--PNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGspGLTRRMSKspvdssvLEGVKELYLEAA 357
Cdd:COG0457   87 ELEllPNLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLAEALLAL--GALYELGD-------YEEALELYEKAL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 358 HQNGDMID-PDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPE-DYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIR 435
Cdd:COG0457  158 ELDPELNElAEALLALGALLEALGRYEEALELLEKALKLNPDdDAEALLNLGLLYLKLGKYEEALEYYEKALELDPDNAE 237
                        250       260       270
                 ....*....|....*....|....*....|.
gi 377520125 436 SRYNLGISCINLGAYREAVSNFLTALSLQRK 466
Cdd:COG0457  238 ALYNLALLLLELGRYEEALEALEKALELDPD 268
YfgC COG4783
Putative Zn-dependent protease, contains TPR repeats [General function prediction only];
318-469 6.65e-06

Putative Zn-dependent protease, contains TPR repeats [General function prediction only];


Pssm-ID: 227122 [Multi-domain]  Cd Length: 484  Bit Score: 48.55  E-value: 6.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 318 KYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGdmidPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRP 397
Cdd:COG4783  262 QSPPYNKLDSPDFQLARARIRAKYEALPNQQAADLLAKRSKRGG----LAAQYGRALQTYLAGQYDEALKLLQPLIAAQP 337
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 377520125 398 EDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSnfltalSLQRKSRN 469
Cdd:COG4783  338 DNPYYLELAGDILLEANKAKEAIERLKKALALDPNSPLLQLNLAQALLKGGKPQEAIR------ILNRYLFN 403
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
247-419 4.27e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.23  E-value: 4.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  247 QDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLkALMALAVSYTNTGHQQDACDALKNWIKQNPK-------- 318
Cdd:TIGR02917 698 QHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQ-NAIKLHRALLASGNTAEAVKTLEAWLKTHPNdavlrtal 776
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  319 ---YKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYL-----------EAAHQNGDMIDPDLQTgLGVLFHLSGEFNR 384
Cdd:TIGR02917 777 aelYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLelkdpraleyaERALKLAPNIPAILDT-LGWLLVEKGEADR 855
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 377520125  385 AIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEA 419
Cdd:TIGR02917 856 ALPLLRKAVNIAPEAAAIRYHLALALLATGRKAEA 890
TPR_12 pfam13424
Tetratricopeptide repeat;
401-466 4.75e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.60  E-value: 4.75e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 377520125  401 SLWNRLGATLANGDRSEEAVEAYTRALEIQ--------PGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRK 466
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
346-467 7.39e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 44.84  E-value: 7.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 346 LEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLsGEFNRAIDAFNAALTVRPEDYSL---WNRLGATLANGDRSEEAVEA 422
Cdd:COG0457  111 YEEALELLEKALALDPDPDLAEALLALGALYEL-GDYEEALELYEKALELDPELNELaeaLLALGALLEALGRYEEALEL 189
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 377520125 423 YTRALEIQPG-FIRSRYNLGISCINLGAYREAVSNFLTALSLQRKS 467
Cdd:COG0457  190 LEKALKLNPDdDAEALLNLGLLYLKLGKYEEALEYYEKALELDPDN 235
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
372-474 1.10e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.97  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  372 LGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRsEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYR 451
Cdd:TIGR00990 133 KGNKAYRNKDFNKAIKLYSKAIECKPDPVYYSNRAACHNALGDW-EKVVEDTTAALELDPDYSKALNRRANAYDGLGKYA 211
                          90       100
                  ....*....|....*....|...
gi 377520125  452 EAVSNFlTALSLQRKSRNQQQVP 474
Cdd:TIGR00990 212 DALLDL-TASCIIDGFRNEQSAQ 233
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
238-317 2.35e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 226687 [Multi-domain]  Cd Length: 287  Bit Score: 43.13  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125 238 ILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQD---ACDALKNWIK 314
Cdd:COG4235  142 IARLETHLQQNPGDAEGWDLLGRAYMALGRASDALLAYRNALRLAGDNPEILLGLAEALYYQAGQQMtakARALLRQALA 221

                 ...
gi 377520125 315 QNP 317
Cdd:COG4235  222 LDP 224
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
241-305 5.08e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 227343 [Multi-domain]  Cd Length: 257  Bit Score: 42.04  E-value: 5.08e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 377520125 241 MEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDA 305
Cdd:COG5010   89 LQKSAIAYPKDRELLAAQGKNQIRNGNFGEAVSVLRKAARLAPTDWEAWNLLGAALDQLGRFDEA 153
TPR_1 pfam00515
Tetratricopeptide repeat;
403-433 8.12e-04

Tetratricopeptide repeat;


Pssm-ID: 425728 [Multi-domain]  Cd Length: 34  Bit Score: 37.02  E-value: 8.12e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 377520125  403 WNRLGATLANGDRSEEAVEAYTRALEIQPGF 433
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PRK11189 PRK11189
lipoprotein NlpI; Provisional
372-421 1.38e-03

lipoprotein NlpI; Provisional


Pssm-ID: 236875 [Multi-domain]  Cd Length: 296  Bit Score: 40.64  E-value: 1.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 377520125 372 LGVLFHLSGEFNRAIDAFNAALTVRPE-DYSLWNRlGATLANGDRSEEAVE 421
Cdd:PRK11189 104 LGIYLTQAGNFDAAYEAFDSVLELDPTyNYAYLNR-GIALYYGGRYELAQD 153
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
380-432 3.77e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 36.16  E-value: 3.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 377520125  380 GEFNRAIDAFNAALTVR---PEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 432
Cdd:pfam13432  11 GDYDDAAAALEAALARFpesPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPG 66
TPR_1 pfam00515
Tetratricopeptide repeat;
252-285 4.37e-03

Tetratricopeptide repeat;


Pssm-ID: 425728 [Multi-domain]  Cd Length: 34  Bit Score: 34.71  E-value: 4.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 377520125  252 AEAWQFLGITQAENENEQAAIVALQRCLELQPNN 285
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR_12 pfam13424
Tetratricopeptide repeat;
368-429 7.81e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.44  E-value: 7.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377520125  368 LQTGLGVLFHLSGEFNRAIDAFNAALTV--------RPEDYSLWNRLGATLANGDRSEEAVEAYTRALEI 429
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIarrllgpdHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
252-285 8.82e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 33.96  E-value: 8.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 377520125   252 AEAWQFLGITQAENENEQAAIVALQRCLELQPNN 285
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
403-433 9.73e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 33.96  E-value: 9.73e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 377520125   403 WNRLGATLANGDRSEEAVEAYTRALEIQPGF 433
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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