NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|384871666|ref|NP_001245197|]
View 

histone demethylase UTY isoform 23 [Homo sapiens]

Protein Classification

KDM6 family histone demethylase( domain architecture ID 11421451)

KDM6 family histone demethylase, similar to lysine-specific demethylase 6A (KDM6A), also called UTX (ubiquitously-transcribed TPR protein on the X chromosome) that specifically demethylates 'Lys-27' of histone H3, and UTY (ubiquitously-transcribed TPR protein on the Y chromosome) that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
1001-1109 4.78e-37

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.


:

Pssm-ID: 396791  Cd Length: 114  Bit Score: 135.12  E-value: 4.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  1001 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 1073
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 384871666  1074 PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNV 1109
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
103-375 1.73e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 84.51  E-value: 1.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  103 LEDYSKALSAYqrYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHlRLGLMFKVNTDYKS 182
Cdd:COG0457     1 LKDLLLALAIL--LEALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGLLL-LLALALLKLGRLEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  183 SLKHFQLALIdcNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKAtvLQQLGWMHHNMDLvgdkatk 262
Cdd:COG0457    78 ALELLEKALE--LELLPNLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLAEA--LLALGALYELGDY------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  263 eSYAIQYLQKSLEADP---NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKS-EASADTWCSIGVLYQQQNQPMDALQAY 338
Cdd:COG0457   147 -EEALELYEKALELDPelnELAEALLALGALLEALGRYEEALELLEKALKLNpDDDAEALLNLGLLYLKLGKYEEALEYY 225
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 384871666  339 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
Cdd:COG0457   226 EKALELDPDNAEALYNLALLLLELGRYEEALEALEKA 262
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
967-1031 6.37e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


:

Pssm-ID: 214721  Cd Length: 58  Bit Score: 50.33  E-value: 6.37e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384871666    967 QLHELTKLPafarvvSAGNLLTHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 1031
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
1001-1109 4.78e-37

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 135.12  E-value: 4.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  1001 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 1073
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 384871666  1074 PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNV 1109
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
103-375 1.73e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 84.51  E-value: 1.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  103 LEDYSKALSAYqrYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHlRLGLMFKVNTDYKS 182
Cdd:COG0457     1 LKDLLLALAIL--LEALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGLLL-LLALALLKLGRLEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  183 SLKHFQLALIdcNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKAtvLQQLGWMHHNMDLvgdkatk 262
Cdd:COG0457    78 ALELLEKALE--LELLPNLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLAEA--LLALGALYELGDY------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  263 eSYAIQYLQKSLEADP---NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKS-EASADTWCSIGVLYQQQNQPMDALQAY 338
Cdd:COG0457   147 -EEALELYEKALELDPelnELAEALLALGALLEALGRYEEALELLEKALKLNpDDDAEALLNLGLLYLKLGKYEEALEYY 225
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 384871666  339 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
Cdd:COG0457   226 EKALELDPDNAEALYNLALLLLELGRYEEALEALEKA 262
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
84-419 6.30e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.02  E-value: 6.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666    84 AEGKVESD--FFCQLGHFNLLLEDYSKALSAYQRYYSLQAdywKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFC 161
Cdd:TIGR02917  355 ALGLDPDDpaALSLLGEAYLALGDFEKAAEYLAKATELDP---ENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELG 431
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   162 RAKEI----HLRLGLMFKVNTDYKSSLKHfqlalidcnpcTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQ 237
Cdd:TIGR02917  432 RADLLlilsYLRSGQFDKALAAAKKLEKK-----------QPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIE--PDF 498
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   238 VKATVLQQlgwmhhNMDLVGDKATKesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02917  499 FPAAANLA------RIDIQEGNPDD---AIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEP 569
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   318 WCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAArsKRCSNTSTLAARIKFLQAq 397
Cdd:TIGR02917  570 ALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLL--ALQPDSALALLLLADAYA- 646
                          330       340
                   ....*....|....*....|..
gi 384871666   398 lcnlpqsSLQNKTKLLPSIEEA 419
Cdd:TIGR02917  647 -------VMKNYAKAITSLKRA 661
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
967-1031 6.37e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 50.33  E-value: 6.37e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384871666    967 QLHELTKLPafarvvSAGNLLTHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 1031
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
TPR_1 pfam00515
Tetratricopeptide repeat;
127-160 7.01e-03

Tetratricopeptide repeat;


Pssm-ID: 425728 [Multi-domain]  Cd Length: 34  Bit Score: 35.48  E-value: 7.01e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 384871666   127 AAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
1001-1109 4.78e-37

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 135.12  E-value: 4.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  1001 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 1073
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 384871666  1074 PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNV 1109
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
103-375 1.73e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 84.51  E-value: 1.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  103 LEDYSKALSAYqrYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHlRLGLMFKVNTDYKS 182
Cdd:COG0457     1 LKDLLLALAIL--LEALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGLLL-LLALALLKLGRLEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  183 SLKHFQLALIdcNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKAtvLQQLGWMHHNMDLvgdkatk 262
Cdd:COG0457    78 ALELLEKALE--LELLPNLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLAEA--LLALGALYELGDY------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  263 eSYAIQYLQKSLEADP---NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKS-EASADTWCSIGVLYQQQNQPMDALQAY 338
Cdd:COG0457   147 -EEALELYEKALELDPelnELAEALLALGALLEALGRYEEALELLEKALKLNpDDDAEALLNLGLLYLKLGKYEEALEYY 225
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 384871666  339 ICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 375
Cdd:COG0457   226 EKALELDPDNAEALYNLALLLLELGRYEEALEALEKA 262
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
44-312 2.91e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 83.74  E-value: 2.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   44 EALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQADY 123
Cdd:COG0457    13 EALAKLLAEALALLEAGLALLELLGELAEALELLEEALELLPNSDLAGLLLLLALALLKLGRLEEALELLEKALELELLP 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  124 wKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAkEIHLRLGLMFKVNtDYKSSLKHFQLALiDCNPCTLSNAE 203
Cdd:COG0457    93 -NLAEALLNLGLLLEALGKYEEALELLEKALALDPDPDLA-EALLALGALYELG-DYEEALELYEKAL-ELDPELNELAE 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  204 IQFHIAHLYETQRKYHSAKEAYEQLLQtenLPAQVKATVLQQLGWMHHNMDLVGDkatkesyAIQYLQKSLEADPNSGQS 283
Cdd:COG0457   169 ALLALGALLEALGRYEEALELLEKALK---LNPDDDAEALLNLGLLYLKLGKYEE-------ALEYYEKALELDPDNAEA 238
                         250       260
                  ....*....|....*....|....*....
gi 384871666  284 WYFLGRCYSSIGKVQDAFISYRQSIDKSE 312
Cdd:COG0457   239 LYNLALLLLELGRYEEALEALEKALELDP 267
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
162-415 1.57e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 223533 [Multi-domain]  Cd Length: 291  Bit Score: 72.57  E-value: 1.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  162 RAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPctLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKAt 241
Cdd:COG0457    21 EALALLEAGLALLELLGELAEALELLEEALELLPN--SDLAGLLLLLALALLKLGRLEEALELLEKALELELLPNLAEA- 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  242 vlqqlgwmHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR-CYSSIGKVQDAFISYRQSIDKSEAS---ADT 317
Cdd:COG0457    98 --------LLNLGLLLEALGKYEEALELLEKALALDPDPDLAEALLALgALYELGDYEEALELYEKALELDPELnelAEA 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  318 WCSIGVLYQQQNQPMDALQAYICAVQLDHGHAA-AWMDLGTLYESCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQA 396
Cdd:COG0457   170 LLALGALLEALGRYEEALELLEKALKLNPDDDAeALLNLGLLYLKLGKYEEALEYYEKALELDPDNAEALYNLALLLLEL 249
                         250
                  ....*....|....*....
gi 384871666  397 QLCNLPQSSLQNKTKLLPS 415
Cdd:COG0457   250 GRYEEALEALEKALELDPD 268
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
266-369 9.79e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 226687 [Multi-domain]  Cd Length: 287  Bit Score: 61.24  E-value: 9.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIG-VLYQQQNQPMDAL--QAYICAV 342
Cdd:COG4235   141 LIARLETHLQQNPGDAEGWDLLGRAYMALGRASDALLAYRNALRLAGDNPEILLGLAeALYYQAGQQMTAKarALLRQAL 220
                          90       100
                  ....*....|....*....|....*..
gi 384871666  343 QLDHGHAAAWMDLGTLYESCNQPQDAI 369
Cdd:COG4235   221 ALDPANIRALSLLAFAAFEQGDYAEAA 247
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
84-419 6.30e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.02  E-value: 6.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666    84 AEGKVESD--FFCQLGHFNLLLEDYSKALSAYQRYYSLQAdywKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFC 161
Cdd:TIGR02917  355 ALGLDPDDpaALSLLGEAYLALGDFEKAAEYLAKATELDP---ENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELG 431
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   162 RAKEI----HLRLGLMFKVNTDYKSSLKHfqlalidcnpcTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTEnlPAQ 237
Cdd:TIGR02917  432 RADLLlilsYLRSGQFDKALAAAKKLEKK-----------QPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIE--PDF 498
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   238 VKATVLQQlgwmhhNMDLVGDKATKesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02917  499 FPAAANLA------RIDIQEGNPDD---AIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEP 569
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   318 WCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAArsKRCSNTSTLAARIKFLQAq 397
Cdd:TIGR02917  570 ALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLL--ALQPDSALALLLLADAYA- 646
                          330       340
                   ....*....|....*....|..
gi 384871666   398 lcnlpqsSLQNKTKLLPSIEEA 419
Cdd:TIGR02917  647 -------VMKNYAKAITSLKRA 661
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
967-1031 6.37e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 50.33  E-value: 6.37e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384871666    967 QLHELTKLPafarvvSAGNLLTHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 1031
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
162-372 2.00e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 2.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   162 RAKEIHLRLGLMFKVNTDYKSSLKHFQlALIDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTE--NLPAQVk 239
Cdd:TIGR02917  599 DSPEAWLMLGRAQLAAGDLNKAVSSFK-KLLALQP---DSALALLLLADAYAVMKNYAKAITSLKRALELKpdNTEAQI- 673
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   240 atVLQQLgwmhhnmdLVGDKATKESYAI-QYLQKsleADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIdKSEASADTW 318
Cdd:TIGR02917  674 --GLAQL--------LLAAKRTESAKKIaKSLQK---QHPKAALGFELEGDLYLRQKDYPAAIQAYRKAL-KRAPSSQNA 739
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 384871666   319 CSIGVLYQQQNQPMDALQAYIcAVQLDH-GHAAAWMDLGTLYESCNQPQDAIKCY 372
Cdd:TIGR02917  740 IKLHRALLASGNTAEAVKTLE-AWLKTHpNDAVLRTALAELYLAQKDYDKAIKHY 793
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
82-317 6.28e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.39  E-value: 6.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666    82 LKAEGKVESDFF-CQLGHFNLLLEDySKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
Cdd:TIGR02917  658 LKRALELKPDNTeAQIGLAQLLLAA-KRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSS 736
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   161 CRAKEIHLRLGLmfkvNTDYKSSLKHFQLALIDcNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTenlpAQVKA 240
Cdd:TIGR02917  737 QNAIKLHRALLA----SGNTAEAVKTLEAWLKT-HP---NDAVLRTALAELYLAQKDYDKAIKHYQTVVKK----APDNA 804
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 384871666   241 TVLQQLGWMHHNMdlvgdkatKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02917  805 VVLNNLAWLYLEL--------KDPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAI 873
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
105-372 6.39e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.39  E-value: 6.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   105 DYSKALSAYQRYYSLQADYWkNAAFLygLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKE----IHLRLGLMfkvnTDY 180
Cdd:TIGR02917  276 NYEDARETLQDALKSAPEYL-PALLL--AGASEYQLGNLEQAYQYLNQILKYAPNSHQARRllasIQLRLGRV----DEA 348
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   181 KSSLKHFqLALIDCNPCTLSNAEIqfhiAHLyeTQRKYHSAKEAYEQLlqTENLPAQVKATVLQQLGWMHHNmdlvgdka 260
Cdd:TIGR02917  349 IATLSPA-LGLDPDDPAALSLLGE----AYL--ALGDFEKAAEYLAKA--TELDPENAAARTQLGISKLSQG-------- 411
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   261 tKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYIC 340
Cdd:TIGR02917  412 -DPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEK 490
                          250       260       270
                   ....*....|....*....|....*....|..
gi 384871666   341 AVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 372
Cdd:TIGR02917  491 ALSIEPDFFPAAANLARIDIQEGNPDDAIQRF 522
YfgC COG4783
Putative Zn-dependent protease, contains TPR repeats [General function prediction only];
179-338 1.51e-03

Putative Zn-dependent protease, contains TPR repeats [General function prediction only];


Pssm-ID: 227122 [Multi-domain]  Cd Length: 484  Bit Score: 42.77  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  179 DYKSSLKHFQlALIDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLL-QTENLPAqvkatvlqqLGWMHHNMDLVG 257
Cdd:COG4783   321 QYDEALKLLQ-PLIAAQP---DNPYYLELAGDILLEANKAKEAIERLKKALaLDPNSPL---------LQLNLAQALLKG 387
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  258 DKATKesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAfisyrqsidkSEASADTWCSIGVLYQQQNQPMDALQA 337
Cdd:COG4783   388 GKPQE---AIRILNRYLFNDPEDPNGWDLLAQAYAELGNRAEA----------LLARAEGYALAGRLEQAIIFLMRASQQ 454

                  .
gi 384871666  338 Y 338
Cdd:COG4783   455 V 455
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
133-317 3.21e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 40.78  E-value: 3.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   133 LGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAkeiHLRLGLMFKVNTDYKSSLKHFQLALidcnpcTLSNAEIQFHI---A 209
Cdd:TIGR02521   37 LALGYLEQGDLEVAKENLDKALEHDPDDYLA---YLALALYYQQLGELEKAEDSFRRAL------TLNPNNGDVLNnygT 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666   210 HLYEtQRKYHSAKEAYEQLLQTENLPAQVKAtvlqqlgwmHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGR 289
Cdd:TIGR02521  108 FLCQ-QGKYEQAMQQFEQAIEDPLYPQPARS---------LENAGLCALKAGDFDKAEKYLTRALQIDPQRPESLLELAE 177
                          170       180
                   ....*....|....*....|....*...
gi 384871666   290 CYSSIGKVQDAFISYRQSIDKSEASADT 317
Cdd:TIGR02521  178 LYYLRGQYKDARAYLERYQQTYNQTAES 205
PilF COG3063
Tfp pilus assembly protein PilF [Cell motility, Extracellular structures];
266-356 4.95e-03

Tfp pilus assembly protein PilF [Cell motility, Extracellular structures];


Pssm-ID: 225605 [Multi-domain]  Cd Length: 250  Bit Score: 40.10  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384871666  266 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 345
Cdd:COG3063    54 AKKNLEKALEHDPSYYLAHLVRAHYYQKLGENDLADESYRKALSLAPNNGDVLNNYGAFLCAQGRPEEAMQQFERALADP 133
                          90
                  ....*....|...
gi 384871666  346 H--GHAAAWMDLG 356
Cdd:COG3063   134 AygEPSDTLENLG 146
TPR_1 pfam00515
Tetratricopeptide repeat;
127-160 7.01e-03

Tetratricopeptide repeat;


Pssm-ID: 425728 [Multi-domain]  Cd Length: 34  Bit Score: 35.48  E-value: 7.01e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 384871666   127 AAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSF 160
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH