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Conserved domains on  [gi|385251388|ref|NP_001245255|]
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protein SFI1 homolog isoform d [Homo sapiens]

Protein Classification

Sfi1 domain-containing protein( domain architecture ID 713344)

Sfi1 domain-containing protein similar to Homo sapiens coiled-coil domain-containing protein 191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sfi1 super family cl25835
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 335-759 3.21e-10

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


The actual alignment was detected with superfamily member pfam08457:

Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 64.24  E-value: 3.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   335 LLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELWLQYTQKRRykqLLQARADGHFQQRALPAAFHTWn 412
Cdd:pfam08457   57 LRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAWRRRTLQIR---VREEVAVQVYQENLLKRSFWKW- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   413 rlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQ---- 488
Cdd:pfam08457  119 ---FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEqead 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   489 -------------EWQTVA---------CAHHRHGRLKKAFCLWRESAQGLRtertgrvRAAEFHMAQLLRWAWSQWR-- 544
Cdd:pfam08457  189 sfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKLRARMSR-------QAREVDRARILRNAWTTWNde 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   545 -ECLALRG----------------AERQKLMRAdlHHQHSVLHRALQAWVTyqgRVRSILREVAARESQH----NRQLLR 603
Cdd:pfam08457  262 lRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVLSTWVT---NTRDTRTRLLRHEEEFeehrNRKLLR 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   604 GALRRWKENTMAR---------VDEAKKTFQASTHYR------------------RTICSKVLVQWREAVSVQMYYRQQE 656
Cdd:pfam08457  337 SKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRerhqhvqklekwardarfYFLATRTLKKWRAATEESRRERRQD 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   657 DCA-IWEAQKV-LDRGCLRTWFQRwwdcSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLA 734
Cdd:pfam08457  417 AYAqVRRKVKInLARRALSKWRSK----AAEVADLEQQADQLRQNRLLEDAIELFDRWRERTAKRKQR---AEDADQFYA 489

                          490       500
                   ....*....|....*....|....*.
gi 385251388   735 QRLSRTCFRQWRQQLAA-RRQEQRAT 759
Cdd:pfam08457  490 EQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 854-1047 6.95e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 6.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  854 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 933
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  934 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1013
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 385251388 1014 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1047
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
 
Name Accession Description Interval E-value
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 335-759 3.21e-10

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 64.24  E-value: 3.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   335 LLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELWLQYTQKRRykqLLQARADGHFQQRALPAAFHTWn 412
Cdd:pfam08457   57 LRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAWRRRTLQIR---VREEVAVQVYQENLLKRSFWKW- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   413 rlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQ---- 488
Cdd:pfam08457  119 ---FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEqead 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   489 -------------EWQTVA---------CAHHRHGRLKKAFCLWRESAQGLRtertgrvRAAEFHMAQLLRWAWSQWR-- 544
Cdd:pfam08457  189 sfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKLRARMSR-------QAREVDRARILRNAWTTWNde 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   545 -ECLALRG----------------AERQKLMRAdlHHQHSVLHRALQAWVTyqgRVRSILREVAARESQH----NRQLLR 603
Cdd:pfam08457  262 lRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVLSTWVT---NTRDTRTRLLRHEEEFeehrNRKLLR 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   604 GALRRWKENTMAR---------VDEAKKTFQASTHYR------------------RTICSKVLVQWREAVSVQMYYRQQE 656
Cdd:pfam08457  337 SKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRerhqhvqklekwardarfYFLATRTLKKWRAATEESRRERRQD 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   657 DCA-IWEAQKV-LDRGCLRTWFQRwwdcSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLA 734
Cdd:pfam08457  417 AYAqVRRKVKInLARRALSKWRSK----AAEVADLEQQADQLRQNRLLEDAIELFDRWRERTAKRKQR---AEDADQFYA 489

                          490       500
                   ....*....|....*....|....*.
gi 385251388   735 QRLSRTCFRQWRQQLAA-RRQEQRAT 759
Cdd:pfam08457  490 EQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 PHA03247
large tegument protein UL36; Provisional
 854-1047 6.95e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 6.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  854 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 933
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  934 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1013
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 385251388 1014 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1047
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 838-1064 1.84e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   838 HRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEgPLLNRIAAGAG--------DGTLETKRPQASRPLGALGRLA- 908
Cdd:pfam03154  228 HTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQ-PLPQPSLHGQMppmphslqTGPSHMQHPVPPQPFPLTPQSSq 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   909 AEEPHALELNTAHSARKQPRRPhfllePAQSQ--RPQKPQEHGLgmaqPAAPsLTRPFLAEAPTALVPHSPLPGALS--- 983
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTP-----PSQSQlqSQQPPREQPL----PPAP-LSMPHIKPPPTTPIPQLPNPQSHKhpp 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   984 --SAPGPKQ---------------------PPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPR-DKPPVPSSLASV 1039
Cdd:pfam03154  377 hlSGPSPFQmnsnlppppalkplsslsthhPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPaASHPPTSGLHQV 456

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 385251388  1040 PD-----PHLLLPGD-----------FSATRAGPGLSTAGS 1064
Cdd:pfam03154  457 PSqspfpQHPFVPGGpppitppsgppTSTSSAMPGIQPPSS 497
COG3899 COG3899
Predicted ATPase [General function prediction only];
368-894 2.06e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 42.54  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  368 IALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQK 447
Cdd:COG3899   725 LRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLG 804

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  448 MFQhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVacahhrHGRLKKAFCLWRESAQGLRTERTGRVRA 527
Cdd:COG3899   805 DYE-EAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREA------LELLREALEAGLETGDAALALLALAAAA 877

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  528 AEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALR 607
Cdd:COG3899   878 AAAAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAA 957

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  608 RWKENTMARVDEAKKTFQASTHYRRTICSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSA 687
Cdd:COG3899   958 LALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALL 1037

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  688 QQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWA 767
Cdd:COG3899  1038 AAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALA 1117

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  768 FSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATL 847
Cdd:COG3899  1118 AALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAAAAAAAAALLA 1197

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 385251388  848 WKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKR 894
Cdd:COG3899  1198 ALLALAARLAALLALALLALEAAALLLLLLLAALALAAALLALRLLA 1244
 
Name Accession Description Interval E-value
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 335-759 3.21e-10

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 64.24  E-value: 3.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   335 LLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELWLQYTQKRRykqLLQARADGHFQQRALPAAFHTWn 412
Cdd:pfam08457   57 LRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAWRRRTLQIR---VREEVAVQVYQENLLKRSFWKW- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   413 rlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQ---- 488
Cdd:pfam08457  119 ---FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEqead 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   489 -------------EWQTVA---------CAHHRHGRLKKAFCLWRESAQGLRtertgrvRAAEFHMAQLLRWAWSQWR-- 544
Cdd:pfam08457  189 sfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKLRARMSR-------QAREVDRARILRNAWTTWNde 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   545 -ECLALRG----------------AERQKLMRAdlHHQHSVLHRALQAWVTyqgRVRSILREVAARESQH----NRQLLR 603
Cdd:pfam08457  262 lRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVLSTWVT---NTRDTRTRLLRHEEEFeehrNRKLLR 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   604 GALRRWKENTMAR---------VDEAKKTFQASTHYR------------------RTICSKVLVQWREAVSVQMYYRQQE 656
Cdd:pfam08457  337 SKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRerhqhvqklekwardarfYFLATRTLKKWRAATEESRRERRQD 416

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   657 DCA-IWEAQKV-LDRGCLRTWFQRwwdcSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLA 734
Cdd:pfam08457  417 AYAqVRRKVKInLARRALSKWRSK----AAEVADLEQQADQLRQNRLLEDAIELFDRWRERTAKRKQR---AEDADQFYA 489

                          490       500
                   ....*....|....*....|....*.
gi 385251388   735 QRLSRTCFRQWRQQLAA-RRQEQRAT 759
Cdd:pfam08457  490 EQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 PHA03247
large tegument protein UL36; Provisional
 854-1047 6.95e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 6.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  854 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 933
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  934 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1013
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 385251388 1014 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1047
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 258-748 9.33e-07

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 53.07  E-value: 9.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   258 HAQVEKLARKMALRRAFTHWKhymLLCAEEAAQFEMAEEHHRHSQLYFCFRALKDNvthahlQQIRRnlAHQQHGVTLLH 337
Cdd:pfam08457   69 TAVNELKAQRFALKRPLGAWR---RRTLQIRVREEVAVQVYQENLLKRSFWKWFWE------FCERR--APQWYDFRLKR 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   338 RFWNLWRSQIEQKKEREllpllHAAWDHYRIALLCKCIELWLQytqKRRYKQLLQARADGHFQQRALPAAFHTWnrlwRW 417
Cdd:pfam08457  138 RSLLTWLRKFRTLRERE-----QEAEAKRKRLLLSSALQIWSE---RTEAVQAAEQEADSFRRRKLLRRALDEW----RI 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   418 RHQENVLSARATRFHRETLEKQVFSLWRQKMFQHRENRLAERMAILH---------------AER-------QLLYRsWF 475
Cdd:pfam08457  206 QARLEPALRQVSAKVDRRILRSALSVWKLRARMSRQAREVDRARILRnawttwndelrckalRERiderlklEALYK-WV 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   476 MWHQQAAARHqeqewqtvacaHHRHGRLKKAFCLWRESAQGLRTERTGRVRAAEFHMAQ-LLRWAWSQWRECLALRgaeR 554
Cdd:pfam08457  285 LEERLRLFQR-----------IREQRLKREVLSTWVTNTRDTRTRLLRHEEEFEEHRNRkLLRSKLLKWRDQLAEQ---R 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   555 QKLMRADLHHQHSVLHRALQAWvtyqgrvRSILREVAARESQHNRQ----LLRGALRRWKENTmarVDEAKKTFQASTH- 629
Cdd:pfam08457  351 EREIAANEFYAPRLLQEALDAW-------RERHQHVQKLEKWARDArfyfLATRTLKKWRAAT---EESRRERRQDAYAq 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   630 YRRTI----CSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWfqrwwdcSRRSAQQRLQLERAVQHHHRQLL 705
Cdd:pfam08457  421 VRRKVkinlARRALSKWRSKAAEVADLEQQADQLRQNRLLEDAIELFDRW-------RERTAKRKQRAEDADQFYAEQLL 493

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 385251388   706 LEGLARW-------KTHHLQCVRKRLLHrQSTQLLAQ---------------------------RLSRTCFRQWRQQ 748
Cdd:pfam08457  494 RSYLARWrerlrelRELEQDADAYRREH-TLGQAAAAlrkwslrlfqirsreetadalrernlrKHLRNMLRHWLQK 569
PHA03247 PHA03247
large tegument protein UL36; Provisional
 894-1064 9.90e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 9.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  894 RPQASRPLGAlGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQ-SQRPQKPQEHGLGMAQPAAPSLTRPFLAE----- 967
Cdd:PHA03247 2632 SPAANEPDPH-PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPptpep 2710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  968 APTALVPHSPLP----------GALSSAPGPKQPPTASTGPELLLLPLSSFMPCGA------AAPARVSAQRATPRDKPP 1031
Cdd:PHA03247 2711 APHALVSATPLPpgpaaarqasPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPpapappAAPAAGPPRRLTRPAVAS 2790

                         170       180       190
                  ....*....|....*....|....*....|...
gi 385251388 1032 VPSSLASVPDPHLLLPGDFSATRAGPGLSTAGS 1064
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
PHA03247 PHA03247
large tegument protein UL36; Provisional
 859-1090 1.40e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  859 PQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKRPQASRPLgalgrlAAEEPHALELntahsARKQPRRPH--FLLEP 936
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA------APARPPVRRL-----ARPAVSRSTesFALPP 2902

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  937 AQSQRPQKPQehglgmaqPAAPSLTRPfLAEAPTALVPHSPLPGAlssaPGPKQPPTASTGPELLLLPLSSFMPCGAAAP 1016
Cdd:PHA03247 2903 DQPERPPQPQ--------APPPPQPQP-QPPPPPQPQPPPPPPPR----PQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 385251388 1017 ARVSAQRA-TPRDKPPVPSSLASVPDPHlllpgdfsaTRAGPGLST-AGSLDLEAELEEIQQQLlhyqttKQNLWS 1090
Cdd:PHA03247 2970 GRVAVPRFrVPQPAPSREAPASSTPPLT---------GHSLSRVSSwASSLALHEETDPPPVSL------KQTLWP 3030
PHA03247 PHA03247
large tegument protein UL36; Provisional
 856-1043 3.28e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  856 GGKPQPLAAIAPSrkvtfegpllnriaaGAGDGTLETKRPqASRPLGAlgrlaaeephalelntahSARKQPRRPHFLLE 935
Cdd:PHA03247 2549 GDPPPPLPPAAPP---------------AAPDRSVPPPRP-APRPSEP------------------AVTSRARRPDAPPQ 2594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  936 PAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPH--SPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMpcGA 1013
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAanEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL--GR 2672

                         170       180       190
                  ....*....|....*....|....*....|
gi 385251388 1014 AAPARVSAQRATPRDKPPVPSSLASVPDPH 1043
Cdd:PHA03247 2673 AAQASSPPQRPRRRAARPTVGSLTSLADPP 2702
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 919-1142 3.82e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  919 TAHSARKQPRRPHFLLEPAQSQRPQKPQEH--GLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGAlSSAPGPKQPPTAST 996
Cdd:PRK07764  598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPapAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA-SDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  997 GPELLLLPLSSFMPCGAAAPARvSAQRATPRDKPPVPSSLASVPDPhlllPGDfSATRAGPGLSTAGSLDLEAELEEIQQ 1076
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAP-AQPAPAPAATPPAGQADDPAAQP----PQA-AQGASAPSPAADDPVPLPPEPDDPPD 750

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 385251388 1077 QLLHYQTTKQNLWSCRRQASSLR-RWLELNREEPGPEDQEVEQQVQKELEQVEMQIQLLAEELQAQR 1142
Cdd:PRK07764  751 PAGAPAQPPPPPAPAPAAAPAAApPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEELGAKK 817
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
858-1042 9.88e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 9.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  858 KPQPLAAIAPSRKVTfegPLLNRIAAGAGDGTletkrpQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPA 937
Cdd:PRK07003  411 APKAAAAAAATRAEA---PPAAPAPPATADRG------DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA 481

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  938 QSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTAL-------VPHSPLPGALSSAPGPKQPPTASTGPELLL-------L 1003
Cdd:PRK07003  482 SDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAsredapaAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnagM 561

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 385251388 1004 PLSSFMPCGAAAPARVSAQRATPrDKPPVPSSLASVPDP 1042
Cdd:PRK07003  562 RVSSDRGARAAAAAKPAAAPAAA-PKPAAPRVAVQVPTP 599
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
854-1067 1.12e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  854 GRGGKPQPLAAIAPSRKVTFEGPllnRIAAGAGDGTLETKRPQASRPLGALgRLAAEEPHALELNTAhsarkqprrphfl 933
Cdd:PRK07003  363 TGGGAPGGGVPARVAGAVPAPGA---RAAAAVGASAVPAVTAVTGAAGAAL-APKAAAAAAATRAEA------------- 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  934 lEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLP---GALSSAPGPKQPPTASTGPELLLLPLSSFMP 1010
Cdd:PRK07003  426 -PPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPpadSGSASAPASDAPPDAAFEPAPRAAAPSAATP 504

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 385251388 1011 CGAAAPARVSAQRATPRDKPP-VPSSLASVPDPhlllPGDFSATRAGpglSTAGSLDL 1067
Cdd:PRK07003  505 AAVPDARAPAAASREDAPAAAaPPAPEARPPTP----AAAAPAARAG---GAAAALDV 555
PHA03378 PHA03378
EBNA-3B; Provisional
 886-1061 1.29e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.68  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  886 GDGTLETKRPQASRPLGALGRLAAEEPHALELNTA---HSARKQPRR-PHFLLEPAQSQRPQKPqeHGLGMAQPAAPSLT 961
Cdd:PHA03378  607 EPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPItfnVLVFPTPHQpPQVEITPYKPTWTQIG--HIPYQPSPTGANTM 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  962 RPFLAeAPTALVPHSPLPGALS---SAPGPKQPPTASTGPellllplssfMPCGAAAPARVSAQRATPRDKPPvPSSLAS 1038
Cdd:PHA03378  685 LPIQW-APGTMQPPPRAPTPMRppaAPPGRAQRPAAATGR----------ARPPAAAPGRARPPAAAPGRARP-PAAAPG 752

                         170       180
                  ....*....|....*....|...
gi 385251388 1039 VPDPHLLLPGDFSATRAGPGLST 1061
Cdd:PHA03378  753 RARPPAAAPGRARPPAAAPGAPT 775
PHA03247 PHA03247
large tegument protein UL36; Provisional
 858-1065 2.45e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  858 KPQPLAAIAPSRkVTFEGPLLNRIAAGAGDGTLETKRPQASRP-LGALGRLA---------AEEPHALELNTAHSARKQP 927
Cdd:PHA03247 2649 PERPRDDPAPGR-VSRPRRARRLGRAAQASSPPQRPRRRAARPtVGSLTSLAdpppppptpEPAPHALVSATPLPPGPAA 2727

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  928 RRPHFLLEPAQSQRPQKPQehglGMAQPAAPS--LTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPL 1005
Cdd:PHA03247 2728 ARQASPALPAAPAPPAVPA----GPATPGGPArpARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388 1006 SSFMPcgAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSatragPGLSTAGSL 1065
Cdd:PHA03247 2804 PADPP--AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP-----PSLPLGGSV 2856
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 838-1064 1.84e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   838 HRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEgPLLNRIAAGAG--------DGTLETKRPQASRPLGALGRLA- 908
Cdd:pfam03154  228 HTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQ-PLPQPSLHGQMppmphslqTGPSHMQHPVPPQPFPLTPQSSq 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   909 AEEPHALELNTAHSARKQPRRPhfllePAQSQ--RPQKPQEHGLgmaqPAAPsLTRPFLAEAPTALVPHSPLPGALS--- 983
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTP-----PSQSQlqSQQPPREQPL----PPAP-LSMPHIKPPPTTPIPQLPNPQSHKhpp 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388   984 --SAPGPKQ---------------------PPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPR-DKPPVPSSLASV 1039
Cdd:pfam03154  377 hlSGPSPFQmnsnlppppalkplsslsthhPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPaASHPPTSGLHQV 456

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 385251388  1040 PD-----PHLLLPGD-----------FSATRAGPGLSTAGS 1064
Cdd:pfam03154  457 PSqspfpQHPFVPGGpppitppsgppTSTSSAMPGIQPPSS 497
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
864-1055 7.16e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 7.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  864 AIAPSRKVTFEGPLLNRIA---AGAGDGTleTKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQSQ 940
Cdd:PRK12323  344 ALAPDEYAGFTMTLLRMLAfrpGQSGGGA--GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAA 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  941 RPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAA------ 1014
Cdd:PRK12323  422 APARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppwee 501

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 385251388 1015 APARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRA 1055
Cdd:PRK12323  502 LPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLA 542
COG3899 COG3899
Predicted ATPase [General function prediction only];
368-894 2.06e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 42.54  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  368 IALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQK 447
Cdd:COG3899   725 LRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLG 804

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  448 MFQhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVacahhrHGRLKKAFCLWRESAQGLRTERTGRVRA 527
Cdd:COG3899   805 DYE-EAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREA------LELLREALEAGLETGDAALALLALAAAA 877

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  528 AEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALR 607
Cdd:COG3899   878 AAAAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAA 957

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  608 RWKENTMARVDEAKKTFQASTHYRRTICSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSA 687
Cdd:COG3899   958 LALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALL 1037

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  688 QQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWA 767
Cdd:COG3899  1038 AAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALA 1117

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  768 FSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATL 847
Cdd:COG3899  1118 AALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAAAAAAAAALLA 1197

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 385251388  848 WKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKR 894
Cdd:COG3899  1198 ALLALAARLAALLALALLALEAAALLLLLLLAALALAAALLALRLLA 1244
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
859-1080 3.49e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  859 PQPLAAIAPSRKVTfEGPLLNRIAAGAGDGTLETKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRrPHFLLEPAQ 938
Cdd:PRK12323  383 AQPAPAAAAPAAAA-PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA-PAPAAAPAA 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  939 SQRPQKPQEHGLGMA--------QPAAPSltrpflAEAPTALVPHSPLPGALSSaPGPKQPPTASTGPEllllpLSSFMP 1010
Cdd:PRK12323  461 AARPAAAGPRPVAAAaaaaparaAPAAAP------APADDDPPPWEELPPEFAS-PAPAQPDAAPAGWV-----AESIPD 528

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 385251388 1011 CGAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRAGPgLSTAGSLDLEAEL--EEIQQQLLH 1080
Cdd:PRK12323  529 PATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD-MFDGDWPALAARLpvRGLAQQLAR 599
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 903-1040 6.26e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 6.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  903 ALGRLAAEEPHALELNTAHSARKQPRRPHfLLEPAQSQRPQKpqehglgmAQPAAPSLTRPFLAEAPTALVPHSPlPGAL 982
Cdd:PRK14951  357 VLLRLLAFKPAAAAEAAAPAEKKTPARPE-AAAPAAAPVAQA--------AAAPAPAAAPAAAASAPAAPPAAAP-PAPV 426

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385251388  983 SSAPGPKQPPTASTGPELLLLPLSSFM---PCGAAAPARVSAQRATPRDKPPVPSSLASVP 1040
Cdd:PRK14951  427 AAPAAAAPAAAPAAAPAAVALAPAPPAqaaPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 953-1065 7.30e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251388  953 AQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPRDKPPV 1032
Cdd:PRK14951  379 KTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPE 458

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 385251388 1033 PSSLA--SVPDPHLLLPGDFSATRAGPGLSTAGSL 1065
Cdd:PRK14951  459 TVAIPvrVAPEPAVASAAPAPAAAPAAARLTPTEE 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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