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Conserved domains on  [gi|391353390|ref|NP_001254651|]
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signal recognition particle subunit SRP72 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP72 pfam08492
SRP72 RNA-binding domain; This region has been identified as the binding site of the SRP72 ...
 471-523 4.67e-17

SRP72 RNA-binding domain; This region has been identified as the binding site of the SRP72 protein to SRP RNA.


:

Pssm-ID: 462494  Cd Length: 53  Bit Score: 75.09  E-value: 4.67e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 391353390  471 KKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERS 523
Cdd:pfam08492   1 KKKSKVSPSTPPKEEVQKKKKKKKRKRKGKLPKNFDPGVTPDPERWLPLRERS 53
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 180-441 9.07e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 9.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 180 YNTACALIGQGQLNQAMKILQKAedlcrrsLSEDTDQ--------NVFDSKKKVKltNAEGVEFKLSKKQLQAIE--FNK 249
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEA-------LELDPETveahlalgNLYRRRGEYD--RAIRIHQKLLERDPDRAEalLEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 250 ALLAMYTNQAEQCRKISASLQSQSPEHLlPVLIQAAQLC-REKQHTKAIELLQEFSDQHPENAaEIKLTMAQLKISQGNI 328
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKLLELDPDDA-EALRLLAEIYeQEGDWEKAIEVLERLLKLGPENA-HAYCELAELYLEQGDY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 329 SKAcliLRSIEE-LKHKPGMVSALVTM---YSHEEDIDSAIEVFTQAIQwyqnhqpKSPAHLSLIREAANFKLKYGRKKE 404
Cdd:COG2956  161 DEA---IEALEKaLKLDPDCARALLLLaelYLEQGDYEEAIAALERALE-------QDPDYLPALPRLAELYEKLGDPEE 230

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 391353390 405 AISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKAL 441
Cdd:COG2956  231 ALELLRKALELDPSDDLLLALADLLERKEGLEAALAL 267
SRP_TPR_like super family cl25252
Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold ...
 51-154 1.40e-09

Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold into a TPR-like structure. Many sequences are annotated as being signal recognition proteins.


The actual alignment was detected with superfamily member pfam17004:

Pssm-ID: 435703 [Multi-domain]  Cd Length: 109  Bit Score: 55.86  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390   51 KVVCLIQNGSFKEALnvinthtKVLANNSlsFEKAYCEYRLNRIENALKTIESANqqTDKLKELYGQVLYRLERYDEcla 130
Cdd:pfam17004  20 KVIALIHLDKYKEAL-------KYAKKGS--FEKAYALYKLKKYKKALKILRKMD--SEGSRVLASQCLYFLGYYNK--- 85

                          90       100
                  ....*....|....*....|....
gi 391353390  131 VYRDLvrnSQDDYDEERKTNLSAV 154
Cdd:pfam17004  86 AYKIL---SECKRDDEIVVNLQAM 106
 
Name Accession Description Interval E-value
SRP72 pfam08492
SRP72 RNA-binding domain; This region has been identified as the binding site of the SRP72 ...
 471-523 4.67e-17

SRP72 RNA-binding domain; This region has been identified as the binding site of the SRP72 protein to SRP RNA.


Pssm-ID: 462494  Cd Length: 53  Bit Score: 75.09  E-value: 4.67e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 391353390  471 KKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERS 523
Cdd:pfam08492   1 KKKSKVSPSTPPKEEVQKKKKKKKRKRKGKLPKNFDPGVTPDPERWLPLRERS 53
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 180-441 9.07e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 9.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 180 YNTACALIGQGQLNQAMKILQKAedlcrrsLSEDTDQ--------NVFDSKKKVKltNAEGVEFKLSKKQLQAIE--FNK 249
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEA-------LELDPETveahlalgNLYRRRGEYD--RAIRIHQKLLERDPDRAEalLEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 250 ALLAMYTNQAEQCRKISASLQSQSPEHLlPVLIQAAQLC-REKQHTKAIELLQEFSDQHPENAaEIKLTMAQLKISQGNI 328
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKLLELDPDDA-EALRLLAEIYeQEGDWEKAIEVLERLLKLGPENA-HAYCELAELYLEQGDY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 329 SKAcliLRSIEE-LKHKPGMVSALVTM---YSHEEDIDSAIEVFTQAIQwyqnhqpKSPAHLSLIREAANFKLKYGRKKE 404
Cdd:COG2956  161 DEA---IEALEKaLKLDPDCARALLLLaelYLEQGDYEEAIAALERALE-------QDPDYLPALPRLAELYEKLGDPEE 230

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 391353390 405 AISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKAL 441
Cdd:COG2956  231 ALELLRKALELDPSDDLLLALADLLERKEGLEAALAL 267
SRP_TPR_like pfam17004
Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold ...
 51-154 1.40e-09

Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold into a TPR-like structure. Many sequences are annotated as being signal recognition proteins.


Pssm-ID: 435703 [Multi-domain]  Cd Length: 109  Bit Score: 55.86  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390   51 KVVCLIQNGSFKEALnvinthtKVLANNSlsFEKAYCEYRLNRIENALKTIESANqqTDKLKELYGQVLYRLERYDEcla 130
Cdd:pfam17004  20 KVIALIHLDKYKEAL-------KYAKKGS--FEKAYALYKLKKYKKALKILRKMD--SEGSRVLASQCLYFLGYYNK--- 85

                          90       100
                  ....*....|....*....|....
gi 391353390  131 VYRDLvrnSQDDYDEERKTNLSAV 154
Cdd:pfam17004  86 AYKIL---SECKRDDEIVVNLQAM 106
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 23-419 1.21e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.17  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390   23 QNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEY-RLNRIENALKTI 101
Cdd:TIGR02917 307 QLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYlALGDFEKAAEYL 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  102 ESANQQTDKLKELYGQV-LYRLERYDECLAVyRDLVRNSQDDYDEE-----------RKTNLSAVVAAQSNWEKVVPENl 169
Cdd:TIGR02917 387 AKATELDPENAAARTQLgISKLSQGDPSEAI-ADLETAAQLDPELGradlllilsylRSGQFDKALAAAKKLEKKQPDN- 464

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  170 glqegthELCYNT-ACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDQNVFDSKKKvkltNAEGVEFKLSK------KQL 242
Cdd:TIGR02917 465 -------ASLHNLlGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEG----NPDDAIQRFEKvltidpKNL 533

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  243 QAIEFNKALLAMYTNQAEQCRKISASLQSqSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLtMAQLK 322
Cdd:TIGR02917 534 RAILALAGLYLRTGNEEEAVAWLEKAAEL-NPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLM-LGRAQ 611

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  323 ISQGNISKACLILRSIEELKHKPGMVSALVT-MYSHEEDIDSAIEVFTQAIQWYqnhqpksPAHLSLIREAANFKLKYGR 401
Cdd:TIGR02917 612 LAAGDLNKAVSSFKKLLALQPDSALALLLLAdAYAVMKNYAKAITSLKRALELK-------PDNTEAQIGLAQLLLAAKR 684

                         410
                  ....*....|....*...
gi 391353390  402 KKEAISDLQQLWKQNPKD 419
Cdd:TIGR02917 685 TESAKKIAKSLQKQHPKA 702
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 21-142 6.59e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 6.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  21 YGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNS-LSFEKAYCEYRLNRIENALK 99
Cdd:COG4783   14 LLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPeARLNLGLALLKAGDYDEALA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 391353390 100 TIESANQQTDKLKELY---GQVLYRLERYDECLAVYRDLVRNSQDD 142
Cdd:COG4783   94 LLEKALKLDPEHPEAYlrlARAYRALGRPDEAIAALEKALELDPDD 139
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 292-449 9.22e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 42.38  E-value: 9.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  292 QHTKAIELLQEFSDQHPENAAeIKLTMAQLKISQGNISKACLILRSI---------------EELKHKP---GMVSAL-- 351
Cdd:PRK11447  162 QRPEAINQLQRLNADYPGNTG-LRNTLALLLFSSGRRDEGFAVLEQMakspagrdaaaqlwyGQIKDMPvsdASVAALqk 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  352 -VTMYSHEEDIDSAIEVFTQaiqwyQNHQPKSPAHLSLIREAAnfKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAY 430
Cdd:PRK11447  241 yLQVFSDGDSVAAARSQLAE-----QQKQLADPAFRARAQGLA--AVDSGQGGKAIPELQQAVRANPKDSEALGALGQAY 313

                         170       180
                  ....*....|....*....|....*..
gi 391353390  431 S--------LVDPEKAKALSKHLPSSD 449
Cdd:PRK11447  314 SqqgdraraVAQFEKALALDPHSSNRD 340
TPR_19 pfam14559
Tetratricopeptide repeat;
290-353 2.06e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 36.79  E-value: 2.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 391353390  290 EKQHTKAIELLQEFSDQHPENAaEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVT 353
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNA-EARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
 
Name Accession Description Interval E-value
SRP72 pfam08492
SRP72 RNA-binding domain; This region has been identified as the binding site of the SRP72 ...
 471-523 4.67e-17

SRP72 RNA-binding domain; This region has been identified as the binding site of the SRP72 protein to SRP RNA.


Pssm-ID: 462494  Cd Length: 53  Bit Score: 75.09  E-value: 4.67e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 391353390  471 KKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERS 523
Cdd:pfam08492   1 KKKSKVSPSTPPKEEVQKKKKKKKRKRKGKLPKNFDPGVTPDPERWLPLRERS 53
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 180-441 9.07e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 9.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 180 YNTACALIGQGQLNQAMKILQKAedlcrrsLSEDTDQ--------NVFDSKKKVKltNAEGVEFKLSKKQLQAIE--FNK 249
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEA-------LELDPETveahlalgNLYRRRGEYD--RAIRIHQKLLERDPDRAEalLEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 250 ALLAMYTNQAEQCRKISASLQSQSPEHLlPVLIQAAQLC-REKQHTKAIELLQEFSDQHPENAaEIKLTMAQLKISQGNI 328
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKLLELDPDDA-EALRLLAEIYeQEGDWEKAIEVLERLLKLGPENA-HAYCELAELYLEQGDY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 329 SKAcliLRSIEE-LKHKPGMVSALVTM---YSHEEDIDSAIEVFTQAIQwyqnhqpKSPAHLSLIREAANFKLKYGRKKE 404
Cdd:COG2956  161 DEA---IEALEKaLKLDPDCARALLLLaelYLEQGDYEEAIAALERALE-------QDPDYLPALPRLAELYEKLGDPEE 230

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 391353390 405 AISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKAL 441
Cdd:COG2956  231 ALELLRKALELDPSDDLLLALADLLERKEGLEAALAL 267
SRP_TPR_like pfam17004
Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold ...
 51-154 1.40e-09

Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold into a TPR-like structure. Many sequences are annotated as being signal recognition proteins.


Pssm-ID: 435703 [Multi-domain]  Cd Length: 109  Bit Score: 55.86  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390   51 KVVCLIQNGSFKEALnvinthtKVLANNSlsFEKAYCEYRLNRIENALKTIESANqqTDKLKELYGQVLYRLERYDEcla 130
Cdd:pfam17004  20 KVIALIHLDKYKEAL-------KYAKKGS--FEKAYALYKLKKYKKALKILRKMD--SEGSRVLASQCLYFLGYYNK--- 85

                          90       100
                  ....*....|....*....|....
gi 391353390  131 VYRDLvrnSQDDYDEERKTNLSAV 154
Cdd:pfam17004  86 AYKIL---SECKRDDEIVVNLQAM 106
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 23-419 1.21e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.17  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390   23 QNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEY-RLNRIENALKTI 101
Cdd:TIGR02917 307 QLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYlALGDFEKAAEYL 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  102 ESANQQTDKLKELYGQV-LYRLERYDECLAVyRDLVRNSQDDYDEE-----------RKTNLSAVVAAQSNWEKVVPENl 169
Cdd:TIGR02917 387 AKATELDPENAAARTQLgISKLSQGDPSEAI-ADLETAAQLDPELGradlllilsylRSGQFDKALAAAKKLEKKQPDN- 464

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  170 glqegthELCYNT-ACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDQNVFDSKKKvkltNAEGVEFKLSK------KQL 242
Cdd:TIGR02917 465 -------ASLHNLlGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEG----NPDDAIQRFEKvltidpKNL 533

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  243 QAIEFNKALLAMYTNQAEQCRKISASLQSqSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLtMAQLK 322
Cdd:TIGR02917 534 RAILALAGLYLRTGNEEEAVAWLEKAAEL-NPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLM-LGRAQ 611

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  323 ISQGNISKACLILRSIEELKHKPGMVSALVT-MYSHEEDIDSAIEVFTQAIQWYqnhqpksPAHLSLIREAANFKLKYGR 401
Cdd:TIGR02917 612 LAAGDLNKAVSSFKKLLALQPDSALALLLLAdAYAVMKNYAKAITSLKRALELK-------PDNTEAQIGLAQLLLAAKR 684

                         410
                  ....*....|....*...
gi 391353390  402 KKEAISDLQQLWKQNPKD 419
Cdd:TIGR02917 685 TESAKKIAKSLQKQHPKA 702
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 25-442 2.42e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.02  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390   25 GDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVlANNSLS--FEKAYCEYRLNRIENALKTIE 102
Cdd:TIGR02917 207 GNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKK-APNSPLahYLKALVDFQKKNYEDARETLQ 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  103 SANQQ-TDKLKELY--GQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELC 179
Cdd:TIGR02917 286 DALKSaPEYLPALLlaGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAA 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  180 YNTA-CALIGQGQLNQAMKILQKAEDLCRRSLSEDTDQNVF-----DSKKKVK-LTNAEGVEFKLSKkqlqaIEFNKALL 252
Cdd:TIGR02917 366 LSLLgEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISklsqgDPSEAIAdLETAAQLDPELGR-----ADLLLILS 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  253 AMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEfsdqhpenaaeikltmaQLKISQGNISKAc 332
Cdd:TIGR02917 441 YLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEK-----------------ALSIEPDFFPAA- 502

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  333 lilrsieelkhkpgmvSALVTMYSHEEDIDSAIEVFTQAIQWYqnhqpksPAHLSLIREAANFKLKYGRKKEAISDLQQL 412
Cdd:TIGR02917 503 ----------------ANLARIDIQEGNPDDAIQRFEKVLTID-------PKNLRAILALAGLYLRTGNEEEAVAWLEKA 559

                         410       420       430
                  ....*....|....*....|....*....|
gi 391353390  413 WKQNPKDIHTLAQLISAYsLVDPEKAKALS 442
Cdd:TIGR02917 560 AELNPQEIEPALALAQYY-LGKGQLKKALA 588
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 283-419 1.50e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.96  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 283 QAAQLCREKQHTKAIELLQEFSDQHPENAaEIKLTMAQLKISQGNISKACLILRSIEELKHK-PGMVSALVTMYSHEEDI 361
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALELDPDNP-EAFALLGEILLQLGDLDEAIVLLHEALELDPDePEARLNLGLALLKAGDY 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 391353390 362 DSAIEVFTQAIQwyqnhqpKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKD 419
Cdd:COG4783   89 DEALALLEKALK-------LDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 242-430 2.08e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.84  E-value: 2.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 242 LQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAaEIKLTMAQL 321
Cdd:COG3914   43 LALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNA-EALFNLGNL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 322 KISQGNISKACLILRSIeeLKHKPGMVSALVTM---YSHEEDIDSAIEVFTQAIQwyqnHQPKSPAHLSLIreaANFKLK 398
Cdd:COG3914  122 LLALGRLEEALAALRRA--LALNPDFAEAYLNLgeaLRRLGRLEEAIAALRRALE----LDPDNAEALNNL---GNALQD 192

                        170       180       190
                 ....*....|....*....|....*....|..
gi 391353390 399 YGRKKEAISDLQQLWKQNPKDIHTLAQLISAY 430
Cdd:COG3914  193 LGRLEEAIAAYRRALELDPDNADAHSNLLFAL 224
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 21-373 3.24e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 3.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  21 YGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEAlnvINTHTKVLANNslsfekayceyrlnrienalkt 100
Cdd:COG2956   18 YLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRA---IRIHQKLLERD---------------------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 101 iesaNQQTDKLKELyGQVLYRLERYDECLAVYRDLVrnSQDDYDEERKTNLSAVVAAQSNWEK---VVPENLGLQEGTHE 177
Cdd:COG2956   73 ----PDRAEALLEL-AQDYLKAGLLDRAEELLEKLL--ELDPDDAEALRLLAEIYEQEGDWEKaieVLERLLKLGPENAH 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 178 LCYNTACALIGQGQLNQAMKILQKAedlcrrsLSEDtdqnvfdskkkvkltnaegvefklskkqlqaiefnkallamytn 257
Cdd:COG2956  146 AYCELAELYLEQGDYDEAIEALEKA-------LKLD-------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 258 qaeqcrkisaslqsqsPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLtMAQLKISQGNISKACLILRS 337
Cdd:COG2956  175 ----------------PDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPR-LAELYEKLGDPEEALELLRK 237

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 391353390 338 IEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQ 373
Cdd:COG2956  238 ALELDPSDDLLLALADLLERKEGLEAALALLERQLR 273
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 21-142 6.59e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 6.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  21 YGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNS-LSFEKAYCEYRLNRIENALK 99
Cdd:COG4783   14 LLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPeARLNLGLALLKAGDYDEALA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 391353390 100 TIESANQQTDKLKELY---GQVLYRLERYDECLAVYRDLVRNSQDD 142
Cdd:COG4783   94 LLEKALKLDPEHPEAYlrlARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
21-144 5.69e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  21 YGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEAlnvINTHTKVLANNSLSFE----KAYCEYRLNRIEN 96
Cdd:COG0457   18 YRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEA---LADYEQALELDPDDAEalnnLGLALQALGRYEE 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 391353390  97 ALKTIESANQQTDKLKELY---GQVLYRLERYDECLAVYRDLVRNSQDDYD 144
Cdd:COG0457   95 ALEDYDKALELDPDDAEALynlGLALLELGRYDEAIEAYERALELDPDDAD 145
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 10-163 2.40e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  10 SVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNS-LSFEKAYCE 88
Cdd:COG2956  109 DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCArALLLLAELY 188

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 391353390  89 YRLNRIENALKTIESANQQTDKLKELY---GQVLYRLERYDECLAVYRDLVRNSQDDYDeerKTNLSAVVAAQSNWEK 163
Cdd:COG2956  189 LEQGDYEEAIAALERALEQDPDYLPALprlAELYEKLGDPEEALELLRKALELDPSDDL---LLALADLLERKEGLEA 263
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 295-419 2.46e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 44.23  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 295 KAIELLQEFSDQHPENAaEIKLTMAQLKISQGNISKACLILRSIEELKHK-PGMVSALVTMYSHEEDIDSAIEVFTQAIQ 373
Cdd:COG4235    1 EAIARLRQALAANPNDA-EGWLLLGRAYLRLGRYDEALAAYEKALRLDPDnADALLDLAEALLAAGDTEEAEELLERALA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 391353390 374 wyqnHQPKSPAHLSLireAANFKLKYGRKKEAISDLQQLWKQNPKD 419
Cdd:COG4235   80 ----LDPDNPEALYL---LGLAAFQQGDYAEAIAAWQKLLALLPAD 118
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 311-440 3.65e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 311 AAEIKLTMAQLKISQGNISKACLILRSIeeLKHKPGMVSALVTM---YSHEEDIDSAIEVFTQAIQwyqnhqpKSPAHLS 387
Cdd:COG4783    3 CAEALYALAQALLLAGDYDEAEALLEKA--LELDPDNPEAFALLgeiLLQLGDLDEAIVLLHEALE-------LDPDEPE 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 391353390 388 LIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLV-DPEKAKA 440
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALgRPDEAIA 127
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
341-461 5.48e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.91  E-value: 5.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 341 LKHKPGMVSALVTM---YSHEEDIDSAIEVFTQAIQWyqnhQPKSP-AHLSliREAANFKLkyGRKKEAISDLQQLWKQN 416
Cdd:COG4785  100 LELDPDLAEAYNNRglaYLLLGDYDAALEDFDRALEL----DPDYAyAYLN--RGIALYYL--GRYELAIADLEKALELD 171

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 391353390 417 PKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALE 461
Cdd:COG4785  172 PNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTEEARE 216
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-204 8.40e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 8.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  38 LQINKDDVTALHCKVVCLIQNGSFKEAlnvINTHTKVLANNSLSFE----KAYCEYRLNRIENALKTIESANQQTDKLKE 113
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEA---IEDYEKALELDPDDAEalynLGLAYLRLGRYEEALADYEQALELDPDDAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 114 LY---GQVLYRLERYDECLAVYRDLVRNSQDDYDEERktNLSAVVAAQSNWEKVVP---ENLGLQEGTHELCYNTACALI 187
Cdd:COG0457   78 ALnnlGLALQALGRYEEALEDYDKALELDPDDAEALY--NLGLALLELGRYDEAIEayeRALELDPDDADALYNLGIALE 155

                        170
                 ....*....|....*..
gi 391353390 188 GQGQLNQAMKILQKAED 204
Cdd:COG0457  156 KLGRYEEALELLEKLEA 172
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
287-441 1.04e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 287 LCREKQHTKAIELLQEFSDQHPENAaEIKLTMAQLKISQGNISKAcliLRSIEE-LKHKPGMVSALVTM---YSHEEDID 362
Cdd:COG0457   18 YRRLGRYEEAIEDYEKALELDPDDA-EALYNLGLAYLRLGRYEEA---LADYEQaLELDPDDAEALNNLglaLQALGRYE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 363 SAIEVFTQAIQwyqnhqpKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAY-SLVDPEKAKAL 441
Cdd:COG0457   94 EALEDYDKALE-------LDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALeKLGRYEEALEL 166
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 247-430 1.29e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 44.52  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 247 FNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLI--QAAQlcREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKIS 324
Cdd:COG3071   20 LLEGLLALAEGRYARAEKLLSKAAEHSEAPLLAYLLaaRAAQ--ALGDYERRDEYLAQALELAPEAELAVLLTRAELLLD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 325 QGNISKAcliLRSIEELK----HKPGMVSALVTMYSHEEDIDSAIEVFTQAiqwyQNHQPKSPAHLSLIREAANFklkyG 400
Cdd:COG3071   98 QGQAEQA---LATLEALRagapRHPQVLRLLLQAYRQLGDWEELLELLPAL----RKHKALSAEEAQALERRAYL----G 166

                        170       180       190
                 ....*....|....*....|....*....|...
gi 391353390 401 RKKEAISD---LQQLWKQNPKDIHTLAQLISAY 430
Cdd:COG3071  167 LLRQAARDaeaLKALWKALPRAERRDPELAAAY 199
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 241-389 1.89e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 241 QLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENaAEIKLTMAQ 320
Cdd:COG3914   76 LLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDF-AEAYLNLGE 154

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 391353390 321 LKISQGNISKACLILRsiEELKHKPGMVSA---LVTMYSHEEDIDSAIEVFTQAIQwyqnHQPKSPAHLSLI 389
Cdd:COG3914  155 ALRRLGRLEEAIAALR--RALELDPDNAEAlnnLGNALQDLGRLEEAIAAYRRALE----LDPDNADAHSNL 220
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
21-111 4.91e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.38  E-value: 4.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  21 YGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVinthTKVLANNSLS----FEKAYCEYRLNRIEN 96
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL----EKALKLDPNNaealLNLAELLLELGDYDE 77

                         90
                 ....*....|....*
gi 391353390  97 ALKTIESANQQTDKL 111
Cdd:COG3063   78 ALAYLERALELDPSA 92
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 292-449 9.22e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 42.38  E-value: 9.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  292 QHTKAIELLQEFSDQHPENAAeIKLTMAQLKISQGNISKACLILRSI---------------EELKHKP---GMVSAL-- 351
Cdd:PRK11447  162 QRPEAINQLQRLNADYPGNTG-LRNTLALLLFSSGRRDEGFAVLEQMakspagrdaaaqlwyGQIKDMPvsdASVAALqk 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  352 -VTMYSHEEDIDSAIEVFTQaiqwyQNHQPKSPAHLSLIREAAnfKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAY 430
Cdd:PRK11447  241 yLQVFSDGDSVAAARSQLAE-----QQKQLADPAFRARAQGLA--AVDSGQGGKAIPELQQAVRANPKDSEALGALGQAY 313

                         170       180
                  ....*....|....*....|....*..
gi 391353390  431 S--------LVDPEKAKALSKHLPSSD 449
Cdd:PRK11447  314 SqqgdraraVAQFEKALALDPHSSNRD 340
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 82-134 1.30e-03

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 38.00  E-value: 1.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 391353390   82 FEKAYCEYRLNRIENALKTIESANQQTDKLK--ELYGQVLYRLERYDECLAVYRD 134
Cdd:pfam12895  27 YLLAQCLFLNGQYKRAYELLRKAKLNGSSLGcrYLFAQCLLKLKKYDEALDALGK 81
TPR_19 pfam14559
Tetratricopeptide repeat;
290-353 2.06e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 36.79  E-value: 2.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 391353390  290 EKQHTKAIELLQEFSDQHPENAaEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVT 353
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNA-EARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 185-443 2.27e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  185 ALIGQGQLNQAMKILQKAEDLCRRSLS-----EDTDQNVFDSKKKVKLTNaegvefKLSKKQLQAIEFNKALLAMYT--- 256
Cdd:TIGR02917 576 YYLGKGQLKKALAILNEAADAAPDSPEawlmlGRAQLAAGDLNKAVSSFK------KLLALQPDSALALLLLADAYAvmk 649

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  257 NQAEQCRKISASLQSQsPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLtMAQLKISQGNISKACLILR 336
Cdd:TIGR02917 650 NYAKAITSLKRALELK-PDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFEL-EGDLYLRQKDYPAAIQAYR 727

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390  337 siEELKHKPgmvSALVTMYSHEedIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQN 416
Cdd:TIGR02917 728 --KALKRAP---SSQNAIKLHR--ALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKA 800

                         250       260
                  ....*....|....*....|....*..
gi 391353390  417 PKDIHTLAQLISAYSLVDPEKAKALSK 443
Cdd:TIGR02917 801 PDNAVVLNNLAWLYLELKDPRALEYAE 827
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
287-445 6.37e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 6.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 287 LCREKQHTKAIELLQEFSDQHPENAaEIKLTMAQLKISQGNISKAcliLRSIEE-LKHKPGMVSALVTM---YSHEEDID 362
Cdd:COG0457   52 YLRLGRYEEALADYEQALELDPDDA-EALNNLGLALQALGRYEEA---LEDYDKaLELDPDDAEALYNLglaLLELGRYD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 363 SAIEVFTQAIQwyqnhqpKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALS 442
Cdd:COG0457  128 EAIEAYERALE-------LDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALL 200


                 ...
gi 391353390 443 KHL 445
Cdd:COG0457  201 LAL 203
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 289-384 8.19e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.51  E-value: 8.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391353390 289 REKQHTKAIELLQEFSDQHPEN--AAEIKLTMAQLKISQGNISKACLILRSIeeLKHKPGMVSALVTMY----SHEE--D 360
Cdd:COG1729    5 KAGDYDEAIAAFKAFLKRYPNSplAPDALYWLGEAYYALGDYDEAAEAFEKL--LKRYPDSPKAPDALLklglSYLElgD 82

                         90       100
                 ....*....|....*....|....
gi 391353390 361 IDSAIEVFTQAIQWYqnhqPKSPA 384
Cdd:COG1729   83 YDKARATLEELIKKY----PDSEA 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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