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Conserved domains on  [gi|396578117|ref|NP_001257514|]
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dynein regulatory complex protein 11 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 551-710 3.80e-102

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 312.54  E-value: 3.80e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 551 DVRQLITLYGIWPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGLQMMLHAVF 630
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 631 KVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKKHLPQILKLLKPDDRILIVGTTRRPFDAELQSFCKVYQKIILV 710
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
 
Name Accession Description Interval E-value
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 551-710 3.80e-102

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 312.54  E-value: 3.80e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 551 DVRQLITLYGIWPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGLQMMLHAVF 630
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 631 KVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKKHLPQILKLLKPDDRILIVGTTRRPFDAELQSFCKVYQKIILV 710
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 551-787 2.43e-20

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 94.21  E-value: 2.43e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 551 DVRQLITLYGIWPLGSAAVHEKA--PLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPG---KNglqmm 625
Cdd:COG0464  164 EVKEELRELVALPLKRPELREEYglPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGeteKN----- 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 626 LHAVFKVARQLQPSVVWI-EdtektFYKKVPNAEKMNEP--KRLkkhLPQILKLL-KPDDRILIVGTTRRPF--DAELQS 699
Cdd:COG0464  239 LREVFDKARGLAPCVLFIdE-----ADALAGKRGEVGDGvgRRV---VNTLLTEMeELRSDVVVIAATNRPDllDPALLR 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 700 -FckvyQKIILVPRPDYASRYVLWKQIIERNGgvLTSALNVSCLAKVTDGFTQGHIVEVVKGVLtdQRIRRQIHKPLTAV 778
Cdd:COG0464  311 rF----DEIIFFPLPDAEERLEIFRIHLRKRP--LDEDVDLEELAEATEGLSGADIRNVVRRAA--LQALRLGREPVTTE 382


                 ....*....
gi 396578117 779 EFITAITSM 787
Cdd:COG0464  383 DLLEALERE 391
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 579-712 2.90e-16

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 76.09  E-value: 2.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  579 LLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKvpNAE 658
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGES--EKRLRELFEAAKKLAPCVIFIDEIDALAGSR--GSG 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 396578117  659 KMNEPKRLKKHL-PQILKLLKPDDRILIVGTTRRP--FDAELQSFCkvyQKIILVPR 712
Cdd:pfam00004  77 GDSESRRVVNQLlTELDGFTSSNSKVIVIAATNRPdkLDPALLGRF---DRIIEFPL 130
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 504-759 2.88e-13

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 73.79  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  504 ESLYKELVEEglliqaLKVNLSDYIGEYSYL-GTTLRQVSIE-------PMPSLLDVRQLITLYGIWPLGSAAVHEKAPL 575
Cdd:TIGR01243 411 EEIPAEVLKE------LKVTMKDFMEALKMVePSAIREVLVEvpnvrwsDIGGLEEVKQELREAVEWPLKHPEIFEKMGI 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  576 V--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFYKK 653
Cdd:TIGR01243 485 RppKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGES--EKAIREIFRKARQAAPAIIFFDEIDAIAPAR 562

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  654 VPNAEKMNEPKRLKKHLPQILKLLKPDDrILIVGTTRRP--FDAELQSFCKvYQKIILVPRPDYASRYVLWKqiIERNGG 731
Cdd:TIGR01243 563 GARFDTSVTDRIVNQLLTEMDGIQELSN-VVVIAATNRPdiLDPALLRPGR-FDRLILVPPPDEEARKEIFK--IHTRSM 638

                         250       260
                  ....*....|....*....|....*...
gi 396578117  732 VLTSALNVSCLAKVTDGFTQGHIVEVVK 759
Cdd:TIGR01243 639 PLAEDVDLEELAEMTEGYTGADIEAVCR 666
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 577-750 4.71e-04

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 43.28  E-value: 4.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 577 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKnGLQmMLHAVFKVARQLQPSVVWIED-----TEKTFY 651
Cdd:PRK03992 166 KGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGE-GAR-LVRELFELAREKAPSIIFIDEidaiaAKRTDS 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 652 KKVPNAEkmnepkrLKKHLPQILKLL---KPDDRILIVGTTRRP------------FDaelqsfckvyqKIILVPRPDYA 716
Cdd:PRK03992 244 GTSGDRE-------VQRTLMQLLAEMdgfDPRGNVKIIAATNRIdildpailrpgrFD-----------RIIEVPLPDEE 305

                        170       180       190
                 ....*....|....*....|....*....|....
gi 396578117 717 SRYVLWKqiIERNGGVLTSALNVSCLAKVTDGFT 750
Cdd:PRK03992 306 GRLEILK--IHTRKMNLADDVDLEELAELTEGAS 337
 
Name Accession Description Interval E-value
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 551-710 3.80e-102

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 312.54  E-value: 3.80e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 551 DVRQLITLYGIWPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGLQMMLHAVF 630
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNGLQMMLHLVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 631 KVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKKHLPQILKLLKPDDRILIVGTTRRPFDAELQSFCKVYQKIILV 710
Cdd:cd19506   81 KVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDPKRLKKDLPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKIILI 160
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 549-709 1.54e-31

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 120.47  E-value: 1.54e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 549 LLDVRQLITLYGIWPLGSAAvheKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGknGLQMMLHA 628
Cdd:cd19481    2 KASLREAVEAPRRGSRLRRY---GLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVG--ESEKNLRK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 629 VFKVARQLQPSVVWIEDTEKTFYKKVPnaekMNEPKRLKKHLPQILKLLKP---DDRILIVGTTRRP--FDAELQSFCKV 703
Cdd:cd19481   77 IFERARRLAPCILFIDEIDAIGRKRDS----SGESGELRRVLNQLLTELDGvnsRSKVLVIAATNRPdlLDPALLRPGRF 152


                 ....*.
gi 396578117 704 YQKIIL 709
Cdd:cd19481  153 DEVIEF 158
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 551-787 2.43e-20

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 94.21  E-value: 2.43e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 551 DVRQLITLYGIWPLGSAAVHEKA--PLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPG---KNglqmm 625
Cdd:COG0464  164 EVKEELRELVALPLKRPELREEYglPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGeteKN----- 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 626 LHAVFKVARQLQPSVVWI-EdtektFYKKVPNAEKMNEP--KRLkkhLPQILKLL-KPDDRILIVGTTRRPF--DAELQS 699
Cdd:COG0464  239 LREVFDKARGLAPCVLFIdE-----ADALAGKRGEVGDGvgRRV---VNTLLTEMeELRSDVVVIAATNRPDllDPALLR 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 700 -FckvyQKIILVPRPDYASRYVLWKQIIERNGgvLTSALNVSCLAKVTDGFTQGHIVEVVKGVLtdQRIRRQIHKPLTAV 778
Cdd:COG0464  311 rF----DEIIFFPLPDAEERLEIFRIHLRKRP--LDEDVDLEELAEATEGLSGADIRNVVRRAA--LQALRLGREPVTTE 382


                 ....*....
gi 396578117 779 EFITAITSM 787
Cdd:COG0464  383 DLLEALERE 391
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 575-710 1.69e-17

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 80.47  E-value: 1.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 575 LVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKV 654
Cdd:cd19509   31 PPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGES--EKIVRALFALARELQPSIIFIDEIDSLLSERG 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 396578117 655 pnAEKMNEPKRLKKhlpQILKLL-----KPDDRILIVGTTRRPFDAElQSFCKVYQKIILV 710
Cdd:cd19509  109 --SGEHEASRRVKT---EFLVQMdgvlnKPEDRVLVLGATNRPWELD-EAFLRRFEKRIYI 163
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 572-702 1.08e-16

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 78.35  E-value: 1.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 572 KAPlVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFY 651
Cdd:cd19524   30 RAP-ARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEG--EKLVRALFAVARELQPSIIFIDEVDSLLS 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 396578117 652 KKVPNAEKMNepKRLKKHLPQILKLLK--PDDRILIVGTTRRPF---DAELQSFCK 702
Cdd:cd19524  107 ERSEGEHEAS--RRLKTEFLIEFDGVQsnGDDRVLVMGATNRPQeldDAVLRRFTK 160
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 561-694 2.87e-16

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 77.08  E-value: 2.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 561 IWPLGSAAVHEKAPLV---KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQ 637
Cdd:cd19520   17 ILPLQRPELFDNSRLLqppKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGES--QKLVAAVFSLASKLQ 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 396578117 638 PSVVWIEDTEkTFYKKvpnaEKMNEPKRLKKHLPQILKLL-----KPDDRILIVGTTRRPFD 694
Cdd:cd19520   95 PSIIFIDEID-SFLRQ----RSSTDHEATAMMKAEFMSLWdglstDGNCRVIVMGATNRPQD 151
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 579-712 2.90e-16

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 76.09  E-value: 2.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  579 LLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKvpNAE 658
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGES--EKRLRELFEAAKKLAPCVIFIDEIDALAGSR--GSG 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 396578117  659 KMNEPKRLKKHL-PQILKLLKPDDRILIVGTTRRP--FDAELQSFCkvyQKIILVPR 712
Cdd:pfam00004  77 GDSESRRVVNQLlTELDGFTSSNSKVIVIAATNRPdkLDPALLGRF---DRIIEFPL 130
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 561-692 2.76e-15

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 75.02  E-value: 2.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 561 IWPLGSAAVHE--KAPlVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQP 638
Cdd:cd19525   39 VWPMLRPDIFTglRGP-PKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEG--EKMVRALFSVARCKQP 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 396578117 639 SVVWIEDTEKTFYKKvpNAEKMNEPKRLKKHLpqILKL----LKPDDRILIVGTTRRP 692
Cdd:cd19525  116 AVIFIDEIDSLLSQR--GEGEHESSRRIKTEF--LVQLdgatTSSEDRILVVGATNRP 169
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 561-692 3.56e-15

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 73.77  E-value: 3.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 561 IWP-LGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPS 639
Cdd:cd19523   17 LWPlLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEG--EKILQASFLAARCRQPS 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 396578117 640 VVWIEDTEKTFYKKVPNAEKMNepkRLKKHLPQILK--LLKPDDRILIVGTTRRP 692
Cdd:cd19523   95 VLFISDLDALLSSQDDEASPVG---RLQVELLAQLDgvLGSGEDGVLVVCTTSKP 146
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 553-692 5.55e-14

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 70.40  E-value: 5.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 553 RQLITLygiwPLGSAAVHEK--APLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVF 630
Cdd:cd19503   13 KELIEL----PLKYPELFRAlgLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGES--EKNLREIF 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 396578117 631 KVARQLQPSVVWIEDTEKTFYKKvpnAEKMNEPKRlkKHLPQILKLL---KPDDRILIVGTTRRP 692
Cdd:cd19503   87 EEARSHAPSIIFIDEIDALAPKR---EEDQREVER--RVVAQLLTLMdgmSSRGKVVVIAATNRP 146
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 504-759 2.88e-13

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 73.79  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  504 ESLYKELVEEglliqaLKVNLSDYIGEYSYL-GTTLRQVSIE-------PMPSLLDVRQLITLYGIWPLGSAAVHEKAPL 575
Cdd:TIGR01243 411 EEIPAEVLKE------LKVTMKDFMEALKMVePSAIREVLVEvpnvrwsDIGGLEEVKQELREAVEWPLKHPEIFEKMGI 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  576 V--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFYKK 653
Cdd:TIGR01243 485 RppKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGES--EKAIREIFRKARQAAPAIIFFDEIDAIAPAR 562

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  654 VPNAEKMNEPKRLKKHLPQILKLLKPDDrILIVGTTRRP--FDAELQSFCKvYQKIILVPRPDYASRYVLWKqiIERNGG 731
Cdd:TIGR01243 563 GARFDTSVTDRIVNQLLTEMDGIQELSN-VVVIAATNRPdiLDPALLRPGR-FDRLILVPPPDEEARKEIFK--IHTRSM 638

                         250       260
                  ....*....|....*....|....*...
gi 396578117  732 VLTSALNVSCLAKVTDGFTQGHIVEVVK 759
Cdd:TIGR01243 639 PLAEDVDLEELAEMTEGYTGADIEAVCR 666
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 577-670 1.16e-11

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 63.85  E-value: 1.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 577 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKVPN 656
Cdd:cd19522   34 KGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGES--EKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTS 111

                         90
                 ....*....|....
gi 396578117 657 AEKmNEPKRLKKHL 670
Cdd:cd19522  112 EEH-EASRRVKSEL 124
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 577-750 1.17e-09

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 61.85  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  577 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKvpn 656
Cdd:TIGR01243 213 KGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGES--EERLREIFKEAEENAPSIIFIDEIDAIAPKR--- 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117  657 AEKMNE-PKRLKKHLPQILKLLKPDDRILIVGTTRRP--FDAELQSFCKVYQKIILVPrPDYASRYVLWKqiIERNGGVL 733
Cdd:TIGR01243 288 EEVTGEvEKRVVAQLLTLMDGLKGRGRVIVIGATNRPdaLDPALRRPGRFDREIVIRV-PDKRARKEILK--VHTRNMPL 364

                         170
                  ....*....|....*..
gi 396578117  734 TSALNVSCLAKVTDGFT 750
Cdd:TIGR01243 365 AEDVDLDKLAEVTHGFV 381
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 577-693 2.55e-09

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 57.18  E-value: 2.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 577 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFYkkvPN 656
Cdd:cd19521   41 SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGES--EKLVKQLFAMARENKPSIIFIDEVDSLCG---TR 115

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 396578117 657 AEKMNEPKRLKKH--LPQILKLLKPDDRILIVGTTRRPF 693
Cdd:cd19521  116 GEGESEASRRIKTelLVQMNGVGNDSQGVLVLGATNIPW 154
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 562-692 2.07e-08

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 54.42  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 562 WPLGSAAVHEKAPLV--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPS 639
Cdd:cd19529   11 WPLLKPEVFKRLGIRppKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGES--EKAIREIFRKARQVAPC 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 396578117 640 VVWIEDTEKTFYKKVPNAEKmNEPKRLKKHLPQILKLLKPDDRILIVGTTRRP 692
Cdd:cd19529   89 VIFFDEIDSIAPRRGTTGDS-GVTERVVNQLLTELDGLEEMNGVVVIAATNRP 140
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 577-692 3.89e-07

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 50.80  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 577 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGlqMMLHAVFKVARQLQPSVVWIEDTEKTFYKKV-P 655
Cdd:cd19502   38 KGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEGA--RLVRELFEMAREKAPSIIFIDEIDAIGAKRFdS 115

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 396578117 656 NAEKMNEPKRLKKHLPQILKLLKPDDRILIVGTTRRP 692
Cdd:cd19502  116 GTGGDREVQRTMLELLNQLDGFDPRGNIKVIMATNRP 152
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 565-650 1.11e-06

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 49.29  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 565 GSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNGLQMmlHAVFKVARQLQPSVVWIE 644
Cdd:cd19507   20 SKQASAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRL--RQMIQTAEAIAPCVLWID 97


                 ....*.
gi 396578117 645 DTEKTF 650
Cdd:cd19507   98 EIEKGF 103
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 579-692 1.70e-06

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 48.94  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 579 LLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKvPNAE 658
Cdd:cd19518   37 VLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGES--EEKIRELFDQAISNAPCIVFIDEIDAITPKR-ESAQ 113

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 396578117 659 KMNEpKRLKKHLPQILKLL--KPDD--RILIVGTTRRP 692
Cdd:cd19518  114 REME-RRIVSQLLTCMDELnnEKTAggPVLVIGATNRP 150
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 577-697 2.91e-06

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 47.91  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 577 KSLLLAGPSGVGKKMLVHAICTET---GANLFNLSSSNIAGKYPGKNGLQM-MLHAVFKVARQLQPSVVWIEDtektfyk 652
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGHfLVRLLFELAEKAKPGVLFIDE------- 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 396578117 653 kvpnAEKMNEPK--RLKKHLPQILKLLKPDDRILIVGTTRRPFDAEL 697
Cdd:cd00009   93 ----IDSLSRGAqnALLRVLETLNDLRIDRENVRVIGATNRPLLGDL 135
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 549-692 6.41e-06

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 47.10  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 549 LLDVRQLITLYGIWPLGSAAVHEKAPLV--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMML 626
Cdd:cd19530    1 LDHVREELTMSILRPIKRPDIYKALGIDlpTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGES--ERAV 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 396578117 627 HAVFKVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEpkRLKKHLPQILKLLKPDDRILIVGTTRRP 692
Cdd:cd19530   79 RQVFQRARASAPCVIFFDEVDALVPKRGDGGSWASE--RVVNQLLTEMDGLEERSNVFVIAATNRP 142
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 577-750 4.71e-04

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 43.28  E-value: 4.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 577 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKnGLQmMLHAVFKVARQLQPSVVWIED-----TEKTFY 651
Cdd:PRK03992 166 KGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGE-GAR-LVRELFELAREKAPSIIFIDEidaiaAKRTDS 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578117 652 KKVPNAEkmnepkrLKKHLPQILKLL---KPDDRILIVGTTRRP------------FDaelqsfckvyqKIILVPRPDYA 716
Cdd:PRK03992 244 GTSGDRE-------VQRTLMQLLAEMdgfDPRGNVKIIAATNRIdildpailrpgrFD-----------RIIEVPLPDEE 305

                        170       180       190
                 ....*....|....*....|....*....|....
gi 396578117 717 SRYVLWKqiIERNGGVLTSALNVSCLAKVTDGFT 750
Cdd:PRK03992 306 GRLEILK--IHTRKMNLADDVDLEELAELTEGAS 337
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 577-645 2.56e-03

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 41.30  E-value: 2.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 396578117 577 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGKNglQMMLHAVFKVARQLQPSVVWIED 645
Cdd:PTZ00361 218 KGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDG--PKLVRELFRVAEENAPSIVFIDE 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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