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Conserved domains on  [gi|402793870|ref|NP_001258016|]
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vacuolar protein sorting-associated protein 72 homolog isoform 1 [Homo sapiens]

Protein Classification

Vps72/YL1 family protein( domain architecture ID 12065826)

Vps72/YL1 family protein similar to human Vps72 (vacuolar protein sorting-associated protein 72) homolog, which is a component of the SRCAP complex and mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling; contains YL1 C-terminal domain which is found in proteins that are not YL1 protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YL1 pfam05764
YL1 nuclear protein; The proteins in this family are designated YL1. These proteins have been ...
 7-216 1.96e-40

YL1 nuclear protein; The proteins in this family are designated YL1. These proteins have been shown to be DNA-binding and may be a transcription factor.


:

Pssm-ID: 461734 [Multi-domain]  Cd Length: 245  Bit Score: 142.94  E-value: 1.96e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402793870    7 RAPRKTAGNRLSGLLEAEE-EDEFYQttygGFTEESGDDEYQGDQSDtEDEVDSDFDIDEGDEPSSDGEAE-----EPRR 80
Cdd:pfam05764   1 RARRSTAGNRMKKLLEQELeDDELEL----LFAEEEDDEEFESEEEE-EDESDSDFDSSEDDEDSEEEEDDdegekELQR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402793870   81 KRRVVTKAYKEPLK----SLRPRKVNTPAGSSQKAREEKALLPLELQ--------------DDGSDSRKSMRQSTAEHTR 142
Cdd:pfam05764  76 QERKKRRSKKEKKKrkaqEAILKLFKKAAIKRKKVKIDKPRKAPAPRpkkkseraswlpteEDGPTRRKSSRSSTVQNKE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402793870  143 QTFLRVQER-----------QGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEAD-----KKKQVHKKRK 206
Cdd:pfam05764 156 ATHERLKEAeerrkkqlarmKKKAARKKKKKEEKPLTQEERLAEAAETEEINLKSLNRWEEQEEEkkkeqRAKLAALKRR 235

                         250
                  ....*....|
gi 402793870  207 CPGPIITYHS 216
Cdd:pfam05764 236 KLGPVIRYWS 245
YL1_C pfam08265
YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. ...
 302-330 7.46e-10

YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. These proteins have been shown to be DNA-binding and may be a transcription factor. This domain is found in proteins that are not YL1 proteins.


:

Pssm-ID: 462412  Cd Length: 29  Bit Score: 53.52  E-value: 7.46e-10
                          10        20
                  ....*....|....*....|....*....
gi 402793870  302 VCPVTHRPALYRDPVTDIPYATARAFKII 330
Cdd:pfam08265   1 YCDITGLPAKYRDPKTGLPYANVEAYKVI 29
 
Name Accession Description Interval E-value
YL1 pfam05764
YL1 nuclear protein; The proteins in this family are designated YL1. These proteins have been ...
 7-216 1.96e-40

YL1 nuclear protein; The proteins in this family are designated YL1. These proteins have been shown to be DNA-binding and may be a transcription factor.


Pssm-ID: 461734 [Multi-domain]  Cd Length: 245  Bit Score: 142.94  E-value: 1.96e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402793870    7 RAPRKTAGNRLSGLLEAEE-EDEFYQttygGFTEESGDDEYQGDQSDtEDEVDSDFDIDEGDEPSSDGEAE-----EPRR 80
Cdd:pfam05764   1 RARRSTAGNRMKKLLEQELeDDELEL----LFAEEEDDEEFESEEEE-EDESDSDFDSSEDDEDSEEEEDDdegekELQR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402793870   81 KRRVVTKAYKEPLK----SLRPRKVNTPAGSSQKAREEKALLPLELQ--------------DDGSDSRKSMRQSTAEHTR 142
Cdd:pfam05764  76 QERKKRRSKKEKKKrkaqEAILKLFKKAAIKRKKVKIDKPRKAPAPRpkkkseraswlpteEDGPTRRKSSRSSTVQNKE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402793870  143 QTFLRVQER-----------QGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEAD-----KKKQVHKKRK 206
Cdd:pfam05764 156 ATHERLKEAeerrkkqlarmKKKAARKKKKKEEKPLTQEERLAEAAETEEINLKSLNRWEEQEEEkkkeqRAKLAALKRR 235

                         250
                  ....*....|
gi 402793870  207 CPGPIITYHS 216
Cdd:pfam05764 236 KLGPVIRYWS 245
YL1_C pfam08265
YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. ...
 302-330 7.46e-10

YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. These proteins have been shown to be DNA-binding and may be a transcription factor. This domain is found in proteins that are not YL1 proteins.


Pssm-ID: 462412  Cd Length: 29  Bit Score: 53.52  E-value: 7.46e-10
                          10        20
                  ....*....|....*....|....*....
gi 402793870  302 VCPVTHRPALYRDPVTDIPYATARAFKII 330
Cdd:pfam08265   1 YCDITGLPAKYRDPKTGLPYANVEAYKVI 29
YL1_C smart00993
YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. ...
 301-330 9.52e-09

YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. These proteins have been shown to be DNA-binding and may be a transcription factor. This domain is found in proteins that are not YL1 proteins.


Pssm-ID: 198061 [Multi-domain]  Cd Length: 30  Bit Score: 50.59  E-value: 9.52e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 402793870   301 EVCPVTHRPALYRDPVTDIPYATARAFKII 330
Cdd:smart00993   1 KYCDITGLPARYRDPKTGLRYANAEAYKVI 30
 
Name Accession Description Interval E-value
YL1 pfam05764
YL1 nuclear protein; The proteins in this family are designated YL1. These proteins have been ...
 7-216 1.96e-40

YL1 nuclear protein; The proteins in this family are designated YL1. These proteins have been shown to be DNA-binding and may be a transcription factor.


Pssm-ID: 461734 [Multi-domain]  Cd Length: 245  Bit Score: 142.94  E-value: 1.96e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402793870    7 RAPRKTAGNRLSGLLEAEE-EDEFYQttygGFTEESGDDEYQGDQSDtEDEVDSDFDIDEGDEPSSDGEAE-----EPRR 80
Cdd:pfam05764   1 RARRSTAGNRMKKLLEQELeDDELEL----LFAEEEDDEEFESEEEE-EDESDSDFDSSEDDEDSEEEEDDdegekELQR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402793870   81 KRRVVTKAYKEPLK----SLRPRKVNTPAGSSQKAREEKALLPLELQ--------------DDGSDSRKSMRQSTAEHTR 142
Cdd:pfam05764  76 QERKKRRSKKEKKKrkaqEAILKLFKKAAIKRKKVKIDKPRKAPAPRpkkkseraswlpteEDGPTRRKSSRSSTVQNKE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402793870  143 QTFLRVQER-----------QGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEAD-----KKKQVHKKRK 206
Cdd:pfam05764 156 ATHERLKEAeerrkkqlarmKKKAARKKKKKEEKPLTQEERLAEAAETEEINLKSLNRWEEQEEEkkkeqRAKLAALKRR 235

                         250
                  ....*....|
gi 402793870  207 CPGPIITYHS 216
Cdd:pfam05764 236 KLGPVIRYWS 245
YL1_C pfam08265
YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. ...
 302-330 7.46e-10

YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. These proteins have been shown to be DNA-binding and may be a transcription factor. This domain is found in proteins that are not YL1 proteins.


Pssm-ID: 462412  Cd Length: 29  Bit Score: 53.52  E-value: 7.46e-10
                          10        20
                  ....*....|....*....|....*....
gi 402793870  302 VCPVTHRPALYRDPVTDIPYATARAFKII 330
Cdd:pfam08265   1 YCDITGLPAKYRDPKTGLPYANVEAYKVI 29
YL1_C smart00993
YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. ...
 301-330 9.52e-09

YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. These proteins have been shown to be DNA-binding and may be a transcription factor. This domain is found in proteins that are not YL1 proteins.


Pssm-ID: 198061 [Multi-domain]  Cd Length: 30  Bit Score: 50.59  E-value: 9.52e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 402793870   301 EVCPVTHRPALYRDPVTDIPYATARAFKII 330
Cdd:smart00993   1 KYCDITGLPARYRDPKTGLRYANAEAYKVI 30
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 18-88 4.34e-03

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 39.14  E-value: 4.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402793870   18 SGLLEAEEEDEfyqttyggftEESGDDEYQGDQSDTEDEVDSDF-DIDEGDEPSSDGEAEEPRRKRRVVTKA 88
Cdd:pfam04931 633 QELFEDEDEDE----------EDDDEEEDDDDEDDEDSEEDDDEdDDDEDEEDDDDEDVDEIDELRAKLAEA 694
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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