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Conserved domains on  [gi|404351658|ref|NP_001258228|]
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serine palmitoyltransferase small subunit B [Rattus norvegicus]

Protein Classification

serine palmitoyltransferase small subunit family protein( domain architecture ID 10570340)

serine palmitoyltransferase small subunit (SPTSS) family protein such as SPTSS that stimulates the activity of serine palmitoyltransferase (SPT); the composition of the SPT complex determines substrate preference

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPT_ssu-like pfam11779
Small subunit of serine palmitoyltransferase-like; Serine palmitoyltransferase (SPT) catalyzes ...
 7-60 3.19e-13

Small subunit of serine palmitoyltransferase-like; Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In mammals, two small subunits of serine palmitoyltransferase, ssSPTa and ssSPTb, substantially enhance the activity of SPT, conferring full enzyme activity upon it. The 2 ssSPT isoforms share a conserved hydrophobic central domain, which is predicted to reside in the membrane.


:

Pssm-ID: 463347  Cd Length: 54  Bit Score: 57.59  E-value: 3.19e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 404351658   7 KEYFAWLYYQYQIITCCAVMEPWEQSMLNTIILTIVAMVVYTAYVFIPIHIRLA 60
Cdd:pfam11779  1 KRWLSLKYYQYEVTFGLYMLTPWEKFLFNSVLLLLLSLLLYAAYLYLPQHIRTL 54
 
Name Accession Description Interval E-value
SPT_ssu-like pfam11779
Small subunit of serine palmitoyltransferase-like; Serine palmitoyltransferase (SPT) catalyzes ...
 7-60 3.19e-13

Small subunit of serine palmitoyltransferase-like; Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In mammals, two small subunits of serine palmitoyltransferase, ssSPTa and ssSPTb, substantially enhance the activity of SPT, conferring full enzyme activity upon it. The 2 ssSPT isoforms share a conserved hydrophobic central domain, which is predicted to reside in the membrane.


Pssm-ID: 463347  Cd Length: 54  Bit Score: 57.59  E-value: 3.19e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 404351658   7 KEYFAWLYYQYQIITCCAVMEPWEQSMLNTIILTIVAMVVYTAYVFIPIHIRLA 60
Cdd:pfam11779  1 KRWLSLKYYQYEVTFGLYMLTPWEKFLFNSVLLLLLSLLLYAAYLYLPQHIRTL 54
 
Name Accession Description Interval E-value
SPT_ssu-like pfam11779
Small subunit of serine palmitoyltransferase-like; Serine palmitoyltransferase (SPT) catalyzes ...
 7-60 3.19e-13

Small subunit of serine palmitoyltransferase-like; Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In mammals, two small subunits of serine palmitoyltransferase, ssSPTa and ssSPTb, substantially enhance the activity of SPT, conferring full enzyme activity upon it. The 2 ssSPT isoforms share a conserved hydrophobic central domain, which is predicted to reside in the membrane.


Pssm-ID: 463347  Cd Length: 54  Bit Score: 57.59  E-value: 3.19e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 404351658   7 KEYFAWLYYQYQIITCCAVMEPWEQSMLNTIILTIVAMVVYTAYVFIPIHIRLA 60
Cdd:pfam11779  1 KRWLSLKYYQYEVTFGLYMLTPWEKFLFNSVLLLLLSLLLYAAYLYLPQHIRTL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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