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Conserved domains on  [gi|429836854|ref|NP_001258864|]
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thymidine kinase 2 isoform 6 [Homo sapiens]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 22-121 1.46e-40

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member pfam01712:

Pssm-ID: 450170  Cd Length: 201  Bit Score: 134.37  E-value: 1.46e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429836854   22 ICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNvrghNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRP-QVSSVRL 100
Cdd:pfam01712   1 ISIEGNIGAGKSTLTKILSKRLGFKVFEEPVDRWTN----PYLDKFYKDPSRWSFALQTYFLNSRFKQQLEAfFTGQVVI 76

                          90       100
                  ....*....|....*....|.
gi 429836854  101 MERSIHSARYIFVENLYRRNT 121
Cdd:pfam01712  77 LERSIYSDRYIFAKMLYDKGT 97
 
Name Accession Description Interval E-value
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 22-121 1.46e-40

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 134.37  E-value: 1.46e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429836854   22 ICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNvrghNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRP-QVSSVRL 100
Cdd:pfam01712   1 ISIEGNIGAGKSTLTKILSKRLGFKVFEEPVDRWTN----PYLDKFYKDPSRWSFALQTYFLNSRFKQQLEAfFTGQVVI 76

                          90       100
                  ....*....|....*....|.
gi 429836854  101 MERSIHSARYIFVENLYRRNT 121
Cdd:pfam01712  77 LERSIYSDRYIFAKMLYDKGT 97
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 21-125 5.10e-33

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 115.02  E-value: 5.10e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429836854  21 VICVEGNIASGKTTCLEFFSNATDVEVLTEPVSkwRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSS--- 97
Cdd:cd01673    1 VIVVEGNIGAGKSTLAKELAEHLGYEVVPEPVE--PDVEGNPFLEKFYEDPKRWAFPFQLYFLLSRLKQYKDALEHLstg 78

                         90       100
                 ....*....|....*....|....*....
gi 429836854  98 -VRLMERSIHSARYIFVENLYRRNTWKQF 125
Cdd:cd01673   79 qGVILERSIFSDRVFAEANLKEGGIMKTE 107
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
17-121 2.54e-13

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 64.04  E-value: 2.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429836854  17 EKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSkwrnvrgHNP-LGLMYHDASRWGLTLQTY------VQLTMLDR 89
Cdd:COG1428    1 MKPRYIAVEGNIGAGKTTLARLLAEHLGAELLLEPVE-------DNPfLEDFYEDPKRWAFPLQLFfllsrfKQLKDLRQ 73

                         90       100       110
                 ....*....|....*....|....*....|..
gi 429836854  90 HTRPQVSsvrlmERSIHSARyIFVENLYRRNT 121
Cdd:COG1428   74 FGGNVVS-----DRSIYKDA-IFAKLLHEMGT 99
 
Name Accession Description Interval E-value
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 22-121 1.46e-40

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 134.37  E-value: 1.46e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429836854   22 ICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNvrghNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRP-QVSSVRL 100
Cdd:pfam01712   1 ISIEGNIGAGKSTLTKILSKRLGFKVFEEPVDRWTN----PYLDKFYKDPSRWSFALQTYFLNSRFKQQLEAfFTGQVVI 76

                          90       100
                  ....*....|....*....|.
gi 429836854  101 MERSIHSARYIFVENLYRRNT 121
Cdd:pfam01712  77 LERSIYSDRYIFAKMLYDKGT 97
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 21-125 5.10e-33

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 115.02  E-value: 5.10e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429836854  21 VICVEGNIASGKTTCLEFFSNATDVEVLTEPVSkwRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSS--- 97
Cdd:cd01673    1 VIVVEGNIGAGKSTLAKELAEHLGYEVVPEPVE--PDVEGNPFLEKFYEDPKRWAFPFQLYFLLSRLKQYKDALEHLstg 78

                         90       100
                 ....*....|....*....|....*....
gi 429836854  98 -VRLMERSIHSARYIFVENLYRRNTWKQF 125
Cdd:cd01673   79 qGVILERSIFSDRVFAEANLKEGGIMKTE 107
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
17-121 2.54e-13

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 64.04  E-value: 2.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429836854  17 EKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSkwrnvrgHNP-LGLMYHDASRWGLTLQTY------VQLTMLDR 89
Cdd:COG1428    1 MKPRYIAVEGNIGAGKTTLARLLAEHLGAELLLEPVE-------DNPfLEDFYEDPKRWAFPLQLFfllsrfKQLKDLRQ 73

                         90       100       110
                 ....*....|....*....|....*....|..
gi 429836854  90 HTRPQVSsvrlmERSIHSARyIFVENLYRRNT 121
Cdd:COG1428   74 FGGNVVS-----DRSIYKDA-IFAKLLHEMGT 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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