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Conserved domains on  [gi|442633976|ref|NP_001262169|]
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cytochrome c oxidase subunit 8, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_c_Oxidase_VIII super family cl27440
Cytochrome oxidase c subunit VIII. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 26-65 4.84e-12

Cytochrome oxidase c subunit VIII. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIII is the smallest of the nuclear-encoded subunits. It exists in muscle-specific and non-muscle-specific isoforms that are differently expressed in different species, suggesting species-specific regulation of energy metabolism.


The actual alignment was detected with superfamily member pfam02285:

Pssm-ID: 474920  Cd Length: 41  Bit Score: 54.15  E-value: 4.84e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 442633976  26 VSGPPTQRISTAEKVILGGGMCAASLFIPAWVLYHIRDYK 65
Cdd:pfam02285  1 HSKPPREPLSAAEQAIGLTVFFVTFLLPAGWVLSHLESYK 40
 
Name Accession Description Interval E-value
COX8 pfam02285
Cytochrome oxidase c subunit VIII; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
 26-65 4.84e-12

Cytochrome oxidase c subunit VIII; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIII.


Pssm-ID: 460523  Cd Length: 41  Bit Score: 54.15  E-value: 4.84e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 442633976  26 VSGPPTQRISTAEKVILGGGMCAASLFIPAWVLYHIRDYK 65
Cdd:pfam02285  1 HSKPPREPLSAAEQAIGLTVFFVTFLLPAGWVLSHLESYK 40
Cyt_c_Oxidase_VIII cd00930
Cytochrome oxidase c subunit VIII. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 25-66 9.53e-06

Cytochrome oxidase c subunit VIII. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIII is the smallest of the nuclear-encoded subunits. It exists in muscle-specific and non-muscle-specific isoforms that are differently expressed in different species, suggesting species-specific regulation of energy metabolism.


Pssm-ID: 238470  Cd Length: 43  Bit Score: 38.11  E-value: 9.53e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 442633976 25 VVSGPPTQRISTAEKVILGGGMCAASLFIPAWVLYHIRDYKG 66
Cdd:cd00930   1 IHSKPPKTPLSAAESAIGLSVFFTTFLLPAGWVLSHLENYKK 42
 
Name Accession Description Interval E-value
COX8 pfam02285
Cytochrome oxidase c subunit VIII; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
 26-65 4.84e-12

Cytochrome oxidase c subunit VIII; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIII.


Pssm-ID: 460523  Cd Length: 41  Bit Score: 54.15  E-value: 4.84e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 442633976  26 VSGPPTQRISTAEKVILGGGMCAASLFIPAWVLYHIRDYK 65
Cdd:pfam02285  1 HSKPPREPLSAAEQAIGLTVFFVTFLLPAGWVLSHLESYK 40
Cyt_c_Oxidase_VIII cd00930
Cytochrome oxidase c subunit VIII. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 25-66 9.53e-06

Cytochrome oxidase c subunit VIII. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIII is the smallest of the nuclear-encoded subunits. It exists in muscle-specific and non-muscle-specific isoforms that are differently expressed in different species, suggesting species-specific regulation of energy metabolism.


Pssm-ID: 238470  Cd Length: 43  Bit Score: 38.11  E-value: 9.53e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 442633976 25 VVSGPPTQRISTAEKVILGGGMCAASLFIPAWVLYHIRDYKG 66
Cdd:cd00930   1 IHSKPPKTPLSAAESAIGLSVFFTTFLLPAGWVLSHLENYKK 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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