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Conserved domains on  [gi|471434845|ref|NP_001264212|]
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interleukin-1 receptor-associated kinase 1-binding protein 1 [Rattus norvegicus]

Protein Classification

SIMPL domain-containing protein( domain architecture ID 10516460)

SIMPL domain-containing protein similar to Homo sapiens interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1), a component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival

CATH:  3.30.70.2970|3.30.110.170
PubMed:  11096118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIMPL pfam04402
Protein of unknown function (DUF541); Members of this family have so far been found in ...
 52-196 1.87e-23

Protein of unknown function (DUF541); Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.


:

Pssm-ID: 461292  Cd Length: 159  Bit Score: 92.75  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471434845   52 VHVSGAAEVSASPDRALVTVRVSSTKEVAAEAKKSVCRRLDYITQSLQQQG------VQTENVTVTKDFRRVDNA----- 120
Cdd:pfam04402   1 ITVSGTGEVEVAPDLATVTLGVETEGKDAAEAQAENAERMNAVLAALKKAAgipekdIQTSGYSLYPVYDYKNGKrkitg 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 471434845  121 YHMEAEVCITFTEFGKMQNICNFLVEKldSSVVISPPEFyhTPGSVESLRRQACLAAVENAWRKAQEVCALVGQTL 196
Cdd:pfam04402  81 YRASNSLTVTVRDLDKLGELLDAAVEA--GANRIDGVSF--SLSDEDELRAEARAEAVADARAKAEALAKALGLKL 152
 
Name Accession Description Interval E-value
SIMPL pfam04402
Protein of unknown function (DUF541); Members of this family have so far been found in ...
 52-196 1.87e-23

Protein of unknown function (DUF541); Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.


Pssm-ID: 461292  Cd Length: 159  Bit Score: 92.75  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471434845   52 VHVSGAAEVSASPDRALVTVRVSSTKEVAAEAKKSVCRRLDYITQSLQQQG------VQTENVTVTKDFRRVDNA----- 120
Cdd:pfam04402   1 ITVSGTGEVEVAPDLATVTLGVETEGKDAAEAQAENAERMNAVLAALKKAAgipekdIQTSGYSLYPVYDYKNGKrkitg 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 471434845  121 YHMEAEVCITFTEFGKMQNICNFLVEKldSSVVISPPEFyhTPGSVESLRRQACLAAVENAWRKAQEVCALVGQTL 196
Cdd:pfam04402  81 YRASNSLTVTVRDLDKLGELLDAAVEA--GANRIDGVSF--SLSDEDELRAEARAEAVADARAKAEALAKALGLKL 152
YggE COG2968
Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function ...
 43-205 3.12e-16

Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function unknown];


Pssm-ID: 442208  Cd Length: 234  Bit Score: 75.31  E-value: 3.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471434845  43 AQVHPGAREVHVSGAAEVSASPDRALVTVRVSSTKEVAAEAKKSVCRRLDYITQSLQQQGV-----QTENVTVTKDFRRV 117
Cdd:COG2968   21 QAEAPDEPTITVSGEGEVEVAPDIATVSLGVETEGKTAAEALAENAERMAAVIAALKAAGIaeediQTSNLSVQPEYDYD 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471434845 118 DNA------YHMEAEVCITFTEFGKMQNIcnflvekLDSSV-----VISPPEFYHTPgsVESLRRQACLAAVENAWRKAQ 186
Cdd:COG2968  101 KDGkpkltgYRASNTVTVTVRDLDKLGEV-------LDAAVaaganRINGVSFGLSD--PEALRDEARKAAVADARAKAE 171

                        170
                 ....*....|....*....
gi 471434845 187 EVCALVGQTLERPLLIKEE 205
Cdd:COG2968  172 ALAKALGVKLGRVLSISEG 190
PRK11087 PRK11087
oxidative stress defense protein; Provisional
 53-109 1.80e-05

oxidative stress defense protein; Provisional


Pssm-ID: 236840  Cd Length: 231  Bit Score: 44.53  E-value: 1.80e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 471434845  53 HV--SGAAEVSASPDRALVTVRVSSTKEVAAEAKKSVCRRLDYITQSLQQQGVQTENVT 109
Cdd:PRK11087  24 HIvtSGTASVDAVPDMATLAVEVNVSAKDAATAKKQVDERVAQYLAFLEKNGIAKKDIS 82
 
Name Accession Description Interval E-value
SIMPL pfam04402
Protein of unknown function (DUF541); Members of this family have so far been found in ...
 52-196 1.87e-23

Protein of unknown function (DUF541); Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.


Pssm-ID: 461292  Cd Length: 159  Bit Score: 92.75  E-value: 1.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471434845   52 VHVSGAAEVSASPDRALVTVRVSSTKEVAAEAKKSVCRRLDYITQSLQQQG------VQTENVTVTKDFRRVDNA----- 120
Cdd:pfam04402   1 ITVSGTGEVEVAPDLATVTLGVETEGKDAAEAQAENAERMNAVLAALKKAAgipekdIQTSGYSLYPVYDYKNGKrkitg 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 471434845  121 YHMEAEVCITFTEFGKMQNICNFLVEKldSSVVISPPEFyhTPGSVESLRRQACLAAVENAWRKAQEVCALVGQTL 196
Cdd:pfam04402  81 YRASNSLTVTVRDLDKLGELLDAAVEA--GANRIDGVSF--SLSDEDELRAEARAEAVADARAKAEALAKALGLKL 152
YggE COG2968
Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function ...
 43-205 3.12e-16

Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function unknown];


Pssm-ID: 442208  Cd Length: 234  Bit Score: 75.31  E-value: 3.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471434845  43 AQVHPGAREVHVSGAAEVSASPDRALVTVRVSSTKEVAAEAKKSVCRRLDYITQSLQQQGV-----QTENVTVTKDFRRV 117
Cdd:COG2968   21 QAEAPDEPTITVSGEGEVEVAPDIATVSLGVETEGKTAAEALAENAERMAAVIAALKAAGIaeediQTSNLSVQPEYDYD 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 471434845 118 DNA------YHMEAEVCITFTEFGKMQNIcnflvekLDSSV-----VISPPEFYHTPgsVESLRRQACLAAVENAWRKAQ 186
Cdd:COG2968  101 KDGkpkltgYRASNTVTVTVRDLDKLGEV-------LDAAVaaganRINGVSFGLSD--PEALRDEARKAAVADARAKAE 171

                        170
                 ....*....|....*....
gi 471434845 187 EVCALVGQTLERPLLIKEE 205
Cdd:COG2968  172 ALAKALGVKLGRVLSISEG 190
PRK11087 PRK11087
oxidative stress defense protein; Provisional
 53-109 1.80e-05

oxidative stress defense protein; Provisional


Pssm-ID: 236840  Cd Length: 231  Bit Score: 44.53  E-value: 1.80e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 471434845  53 HV--SGAAEVSASPDRALVTVRVSSTKEVAAEAKKSVCRRLDYITQSLQQQGVQTENVT 109
Cdd:PRK11087  24 HIvtSGTASVDAVPDMATLAVEVNVSAKDAATAKKQVDERVAQYLAFLEKNGIAKKDIS 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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