NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|499137513|ref|NP_001265116|]
View 

probable E3 ubiquitin-protein ligase HERC4 isoform e [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ATS1 super family cl34932
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-67 2.22e-12

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


The actual alignment was detected with superfamily member COG5184:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 61.53  E-value: 2.22e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499137513   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFinKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Cdd:COG5184  272 CWGDNSYGQLGDG--TTTDRSTPVKVPGL--SGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLG 332
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-67 2.22e-12

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 61.53  E-value: 2.22e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499137513   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFinKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Cdd:COG5184  272 CWGDNSYGQLGDG--TTTDRSTPVKVPGL--SGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLG 332
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
36-65 2.54e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.57  E-value: 2.54e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 499137513   36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQ 65
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-67 2.22e-12

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 61.53  E-value: 2.22e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499137513   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFinKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Cdd:COG5184  272 CWGDNSYGQLGDG--TTTDRSTPVKVPGL--SGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLG 332
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-67 8.39e-12

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 59.99  E-value: 8.39e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499137513   3 CWGNASFGQLGLGGIDEEIVlePRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Cdd:COG5184   71 CWGNNSYGQLGDGTTTDRTT--PVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG 131
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-67 1.62e-11

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 58.83  E-value: 1.62e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499137513   3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Cdd:COG5184   21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLG 81
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 1-67 1.92e-11

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 58.83  E-value: 1.92e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 499137513   1 MLCWGNASFGQLGLGGIDEEIVlePRKSDFFINkrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Cdd:COG5184  170 VWCWGANSYGQLGDGTTTDRPT--PVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLG 232
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-67 4.42e-11

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 57.68  E-value: 4.42e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499137513   3 CWGNASFGQLGLGGIDEEIVlePRKSDFFinKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Cdd:COG5184  222 CWGSNSSGQLGDGTTTDRAT--PVQVAGL--TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLG 282
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-67 5.02e-11

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 57.68  E-value: 5.02e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 499137513   3 CWGNASFGQLGLGGIDEEIVlePRKSDFFINKrVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Cdd:COG5184  121 CWGDNSSGQLGDGTTTNRLT--PVQVDAGLSG-VVAIAAGGYHTCALKSDGTVWCWGANSYGQLG 182
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
36-65 2.54e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.57  E-value: 2.54e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 499137513   36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQ 65
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
3-49 9.40e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.51  E-value: 9.40e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 499137513    3 CWGNASFGQLGLGgiDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFV 49
Cdd:pfam00415   6 TWGRNDYGQLGLG--TTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 37-67 3.06e-05

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 41.12  E-value: 3.06e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 499137513  37 RDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG 67
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLG 31
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
52-75 4.10e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 37.88  E-value: 4.10e-05
                          10        20
                  ....*....|....*....|....*.
gi 499137513   52 DGTVYTCGCNDLGQLGH--EKSRKKP 75
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLgtTENVLVP 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH