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Conserved domains on  [gi|508083038|ref|NP_001265246|]
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F-box/LRR-repeat protein 7 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
250-417 9.42e-25

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 101.64  E-value: 9.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 250 CTQLTHLYLRRCVRLtDEGLRYLvIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCS 329
Cdd:cd09293   27 HSGLEWLELYMCPIS-DPPLDQL-SNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCP 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 330 KLRYLN---ARGCEGITDHGVEYLAKNCTKLKSLDIGKCPlVSDTGLECLALNCF-NLKRLSLKSCESITGQGL-QIVAA 404
Cdd:cd09293  105 KLQTINlgrHRNGHLITDVSLSALGKNCTFLQTVGFAGCD-VTDKGVWELASGCSkSLERLSLNNCRNLTDQSIpAILAS 183
                        170
                 ....*....|....
gi 508083038 405 NCF-DLQTLNVQDC 417
Cdd:cd09293  184 NYFpNLSVLEFRGC 197
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
67-110 1.01e-23

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438892  Cd Length: 44  Bit Score: 93.22  E-value: 1.01e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:cd22120    1 FDRLPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWTTI 44
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
138-319 8.52e-15

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 73.52  E-value: 8.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 138 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKvtCISLTreasikl 217
Cdd:cd09293   51 CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRHRN--GHLIT------- 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 218 splhgkqisiryldmtdcfvleDEGLHTIAAHCTQLTHLYLRRCvRLTDEGLRYLVIYCA-SIKELSVSDCRFVSDFGLR 296
Cdd:cd09293  122 ----------------------DVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELASGCSkSLERLSLNNCRNLTDQSIP 178
                        170       180
                 ....*....|....*....|....*
gi 508083038 297 EIAKLES--RLRYLSIAHCGRVTDV 319
Cdd:cd09293  179 AILASNYfpNLSVLEFRGCPLITDF 203
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
250-417 9.42e-25

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 101.64  E-value: 9.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 250 CTQLTHLYLRRCVRLtDEGLRYLvIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCS 329
Cdd:cd09293   27 HSGLEWLELYMCPIS-DPPLDQL-SNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCP 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 330 KLRYLN---ARGCEGITDHGVEYLAKNCTKLKSLDIGKCPlVSDTGLECLALNCF-NLKRLSLKSCESITGQGL-QIVAA 404
Cdd:cd09293  105 KLQTINlgrHRNGHLITDVSLSALGKNCTFLQTVGFAGCD-VTDKGVWELASGCSkSLERLSLNNCRNLTDQSIpAILAS 183
                        170
                 ....*....|....
gi 508083038 405 NCF-DLQTLNVQDC 417
Cdd:cd09293  184 NYFpNLSVLEFRGC 197
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
67-110 1.01e-23

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438892  Cd Length: 44  Bit Score: 93.22  E-value: 1.01e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:cd22120    1 FDRLPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWTTI 44
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
138-319 8.52e-15

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 73.52  E-value: 8.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 138 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKvtCISLTreasikl 217
Cdd:cd09293   51 CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRHRN--GHLIT------- 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 218 splhgkqisiryldmtdcfvleDEGLHTIAAHCTQLTHLYLRRCvRLTDEGLRYLVIYCA-SIKELSVSDCRFVSDFGLR 296
Cdd:cd09293  122 ----------------------DVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELASGCSkSLERLSLNNCRNLTDQSIP 178
                        170       180
                 ....*....|....*....|....*
gi 508083038 297 EIAKLES--RLRYLSIAHCGRVTDV 319
Cdd:cd09293  179 AILASNYfpNLSVLEFRGCPLITDF 203
F-box-like pfam12937
F-box-like; This is an F-box-like family.
67-110 1.12e-14

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 67.89  E-value: 1.12e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 508083038   67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44
FBOX smart00256
A Receptor for Ubiquitination Targets;
70-110 4.91e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.89  E-value: 4.91e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 508083038    70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
166-425 1.08e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 166 ELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTciSLTREASIKLSplhGKQISirylDMTDCFvledeglht 245
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS--NLTNLESLDLS---GNQLT----DLPEEL--------- 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 246 iaAHCTQLTHLYLRRCvRLTD--EGLRYLviycASIKELSVSDCRfVSDFGlREIAKLeSRLRYLSIAHCgRVTDvgIRY 323
Cdd:COG4886  133 --ANLTNLKELDLSNN-QLTDlpEPLGNL----TNLKSLDLSNNQ-LTDLP-EELGNL-TNLKELDLSNN-QITD--LPE 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 324 VAKYCSKLRYLNARGCEgITDHGVEyLAkNCTKLKSLDIGKCPLvsdTGLECLAlNCFNLKRLSLKSCEsITGQGlqiVA 403
Cdd:COG4886  200 PLGNLTNLEELDLSGNQ-LTDLPEP-LA-NLTNLETLDLSNNQL---TDLPELG-NLTNLEELDLSNNQ-LTDLP---PL 268
                        250       260
                 ....*....|....*....|..
gi 508083038 404 ANCFDLQTLNVQDCEVSVEALR 425
Cdd:COG4886  269 ANLTNLKTLDLSNNQLTDLKLK 290
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
328-353 1.48e-04

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 38.54  E-value: 1.48e-04
                           10        20
                   ....*....|....*....|....*.
gi 508083038   328 CSKLRYLNARGCEGITDHGVEYLAKN 353
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
FBXL18_LRR pfam19729
F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from ...
166-221 4.36e-04

F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes.


Pssm-ID: 466163 [Multi-domain]  Cd Length: 594  Bit Score: 42.81  E-value: 4.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 508083038  166 ELRRLEVSGCYNISNEAVfDVVSLCPNLEHLDVSGCsKVTCISLTReasiKLSPLH 221
Cdd:pfam19729  11 EIQQLSLSGCYWLSGSTV-DQVTRCRNLVKLDLSGC-RLTSLRLSK----LLSSLQ 60
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
190-214 4.89e-03

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 34.30  E-value: 4.89e-03
                           10        20
                   ....*....|....*....|....*
gi 508083038   190 CPNLEHLDVSGCSKVTCISLTREAS 214
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAK 25
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
250-417 9.42e-25

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 101.64  E-value: 9.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 250 CTQLTHLYLRRCVRLtDEGLRYLvIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCS 329
Cdd:cd09293   27 HSGLEWLELYMCPIS-DPPLDQL-SNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCP 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 330 KLRYLN---ARGCEGITDHGVEYLAKNCTKLKSLDIGKCPlVSDTGLECLALNCF-NLKRLSLKSCESITGQGL-QIVAA 404
Cdd:cd09293  105 KLQTINlgrHRNGHLITDVSLSALGKNCTFLQTVGFAGCD-VTDKGVWELASGCSkSLERLSLNNCRNLTDQSIpAILAS 183
                        170
                 ....*....|....
gi 508083038 405 NCF-DLQTLNVQDC 417
Cdd:cd09293  184 NYFpNLSVLEFRGC 197
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
67-110 1.01e-23

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438892  Cd Length: 44  Bit Score: 93.22  E-value: 1.01e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:cd22120    1 FDRLPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWTTI 44
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
188-370 5.80e-18

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 82.38  E-value: 5.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 188 SLCPNLEHLDVSGCSKVtcisltreasikLSPLHGKQIS--IRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLT 265
Cdd:cd09293   25 ILHSGLEWLELYMCPIS------------DPPLDQLSNCnkLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENIT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 266 DEGLRYLVIYCASIKELSVSD---CRFVSDFGLREIAKLESRLRYLSIAHCGrVTDVGIRYVAKYCSK-LRYLNARGCEG 341
Cdd:cd09293   93 DSGIVALATNCPKLQTINLGRhrnGHLITDVSLSALGKNCTFLQTVGFAGCD-VTDKGVWELASGCSKsLERLSLNNCRN 171
                        170       180       190
                 ....*....|....*....|....*....|.
gi 508083038 342 ITDHGVEY-LAKN-CTKLKSLDIGKCPLVSD 370
Cdd:cd09293  172 LTDQSIPAiLASNyFPNLSVLEFRGCPLITD 202
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
162-345 1.99e-17

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 80.83  E-value: 1.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 162 QCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTcisltreasiklsplhgkqisiryldmtdcfvleDE 241
Cdd:cd09293   49 SNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENIT----------------------------------DS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 242 GLHTIAAHCTQLTHLYLRR---CVRLTDEGLRYLVIYCASIKELSVSDCrFVSDFGLREIAKLESR-LRYLSIAHCGRVT 317
Cdd:cd09293   95 GIVALATNCPKLQTINLGRhrnGHLITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELASGCSKsLERLSLNNCRNLT 173
                        170       180       190
                 ....*....|....*....|....*....|
gi 508083038 318 DVGIRYV--AKYCSKLRYLNARGCEGITDH 345
Cdd:cd09293  174 DQSIPAIlaSNYFPNLSVLEFRGCPLITDF 203
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
279-424 3.66e-17

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 80.06  E-value: 3.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 279 IKELSVSDCRFVSDFGLREIAKLESRLRYLSIAH---------CGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEY 349
Cdd:cd09293   19 ISQLLRILHSGLEWLELYMCPISDPPLDQLSNCNklkklilpgSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVA 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 350 LAKNCTKLKSLDIG---KCPLVSDTGLECLALNCFNLKRLSLKSCEsITGQGLQIVAANCFD-LQTLNVQDC----EVSV 421
Cdd:cd09293   99 LATNCPKLQTINLGrhrNGHLITDVSLSALGKNCTFLQTVGFAGCD-VTDKGVWELASGCSKsLERLSLNNCrnltDQSI 177

                 ...
gi 508083038 422 EAL 424
Cdd:cd09293  178 PAI 180
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
138-319 8.52e-15

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 73.52  E-value: 8.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 138 CLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKvtCISLTreasikl 217
Cdd:cd09293   51 CNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRHRN--GHLIT------- 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 218 splhgkqisiryldmtdcfvleDEGLHTIAAHCTQLTHLYLRRCvRLTDEGLRYLVIYCA-SIKELSVSDCRFVSDFGLR 296
Cdd:cd09293  122 ----------------------DVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELASGCSkSLERLSLNNCRNLTDQSIP 178
                        170       180
                 ....*....|....*....|....*
gi 508083038 297 EIAKLES--RLRYLSIAHCGRVTDV 319
Cdd:cd09293  179 AILASNYfpNLSVLEFRGCPLITDF 203
F-box-like pfam12937
F-box-like; This is an F-box-like family.
67-110 1.12e-14

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 67.89  E-value: 1.12e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 508083038   67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
67-108 3.63e-11

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 57.75  E-value: 3.63e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22123    1 LDQLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
69-108 7.70e-10

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 53.92  E-value: 7.70e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 508083038  69 RLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22149    3 RLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
67-107 1.81e-09

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 53.11  E-value: 1.81e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22118    1 ISSLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
67-110 7.99e-09

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 51.27  E-value: 7.99e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:cd22091    1 QEELPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
67-108 1.77e-08

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438887  Cd Length: 45  Bit Score: 50.11  E-value: 1.77e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22115    4 NKKLPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALDGSNWQ 45
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
67-109 2.31e-08

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 49.85  E-value: 2.31e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 508083038   67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRT 109
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
68-110 4.18e-08

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 49.24  E-value: 4.18e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 508083038  68 DRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:cd22151    1 RKLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENA 43
F-box_JHDM cd22122
F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; ...
70-109 4.52e-08

F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; The JHDM family includes F-box/LRR-repeat proteins FBXL10, FBXL11 and FBXL19. FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10 (FBL10), JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXL11, also called KDM2A, CXXC8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. FBXL19, also called F-box and leucine-rich repeat protein 19, is the substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It acts as a CpG island-binding protein in mouse embryonic stem (ES) cells and has been shown to associate with the CDK-Mediator complex. It promotes H2Bub1 at the promoters of CpG island-containing genes by interacting with RNF20. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438894  Cd Length: 43  Bit Score: 49.20  E-value: 4.52e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRT 109
Cdd:cd22122    4 LPREVWLPVFQYLSPKDLCVCMRVCKTWNRWCCDPSLWKR 43
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
68-107 6.82e-08

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 48.56  E-value: 6.82e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 508083038  68 DRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22114    2 DSLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
68-101 1.68e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 47.05  E-value: 1.68e-07
                         10        20        30
                 ....*....|....*....|....*....|....
gi 508083038  68 DRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLA 101
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELA 34
F-box_FBXL6 cd22119
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ...
67-108 2.23e-07

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438891  Cd Length: 47  Bit Score: 47.25  E-value: 2.23e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQ-----LCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22119    1 GQRLPPEILVKIFQFAVATEgavplLCRLSRVCRLWREVALDPSLWT 47
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
68-112 2.28e-07

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 47.25  E-value: 2.28e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 508083038  68 DRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRL 112
Cdd:cd22104    2 ANLPSVVLVHIFSYLPPRDRLRASSTCRRWREALFHPSLWRSLRL 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
70-110 4.91e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.89  E-value: 4.91e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 508083038    70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_unchar cd22138
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ...
68-110 5.60e-07

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438910  Cd Length: 45  Bit Score: 46.17  E-value: 5.60e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 508083038  68 DRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:cd22138    2 QSLPVECQLKIFSFLSEVDKCLAATVCRSWSELIRSPRLWRTV 44
F-box_AtSKIP5-like cd22163
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar ...
67-107 7.09e-07

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438934  Cd Length: 46  Bit Score: 45.80  E-value: 7.09e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  67 IDRLPDHSMVQIFSFL-PTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22163    1 INDLDDDCLMHIFSFLtPLPDRFNAARVCKRWRALALDPRSW 42
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
166-425 1.08e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 166 ELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTciSLTREASIKLSplhGKQISirylDMTDCFvledeglht 245
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS--NLTNLESLDLS---GNQLT----DLPEEL--------- 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 246 iaAHCTQLTHLYLRRCvRLTD--EGLRYLviycASIKELSVSDCRfVSDFGlREIAKLeSRLRYLSIAHCgRVTDvgIRY 323
Cdd:COG4886  133 --ANLTNLKELDLSNN-QLTDlpEPLGNL----TNLKSLDLSNNQ-LTDLP-EELGNL-TNLKELDLSNN-QITD--LPE 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 324 VAKYCSKLRYLNARGCEgITDHGVEyLAkNCTKLKSLDIGKCPLvsdTGLECLAlNCFNLKRLSLKSCEsITGQGlqiVA 403
Cdd:COG4886  200 PLGNLTNLEELDLSGNQ-LTDLPEP-LA-NLTNLETLDLSNNQL---TDLPELG-NLTNLEELDLSNNQ-LTDLP---PL 268
                        250       260
                 ....*....|....*....|..
gi 508083038 404 ANCFDLQTLNVQDCEVSVEALR 425
Cdd:COG4886  269 ANLTNLKTLDLSNNQLTDLKLK 290
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
70-109 1.25e-06

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 44.97  E-value: 1.25e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRT 109
Cdd:cd22148    5 LPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWKA 44
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
70-111 1.37e-06

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 44.93  E-value: 1.37e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIR 111
Cdd:cd22139    4 LPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQIC 45
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
67-108 1.53e-06

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 44.61  E-value: 1.53e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22147    2 LSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWK 43
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
70-108 1.84e-06

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 44.52  E-value: 1.84e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22132    4 LPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWK 42
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
65-109 1.88e-06

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 45.74  E-value: 1.88e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 508083038  65 ASIDRLPDHSMVQIFSFLPTNQL-CRCARVCRRWYNLAWDPRLWRT 109
Cdd:cd22168    2 LTISDLPEDVLLEILSLVPARDLiLSCRLVCSRWRDLVDLPTLWKR 47
F-box_FBXO13 cd22092
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ...
66-113 2.56e-06

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438864  Cd Length: 49  Bit Score: 44.33  E-value: 2.56e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 508083038  66 SIDRLPDHSMVQIFSFLPTNQLCRCA-RVCRRWYNLAWDPRLWRTIRLT 113
Cdd:cd22092    1 NINQLPDSILLKIFSYLSLQERCLSAsLVCKYWRDLCLDSQFWKQIDLS 49
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
66-104 6.25e-06

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 43.03  E-value: 6.25e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 508083038  66 SIDRLPDHSMVQIFSFLPTNQLCR-CARVCRRWYNLAWDP 104
Cdd:cd22095    1 HIQQLPEELLRNIFAFLPAEDLYQnISLVCRHWRDIVSDP 40
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
78-111 7.97e-06

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 42.70  E-value: 7.97e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 508083038  78 IFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIR 111
Cdd:cd22109   14 VFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47
F-box_FBXO39 cd22108
F-box domain found in F-box only protein 39 (FBXO39) and similar proteins; FBXO39, also called ...
70-109 8.52e-06

F-box domain found in F-box only protein 39 (FBXO39) and similar proteins; FBXO39, also called FBX39, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a cancer/testis antigen from colon cancer patients by serological analysis of recombinant cDNA expression libraries (SEREX). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438880  Cd Length: 44  Bit Score: 42.79  E-value: 8.52e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRT 109
Cdd:cd22108    4 LPDVCLRHVFRWLGDRDRSRAALVCKRWNQAMYSPALWRS 43
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
69-110 9.28e-06

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 42.37  E-value: 9.28e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  69 RLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:cd22137    2 QLPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNL 43
F-box_FBXL13 cd22124
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ...
67-107 2.01e-05

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438896  Cd Length: 42  Bit Score: 41.55  E-value: 2.01e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22124    1 ISLLPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
67-108 2.82e-05

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 41.09  E-value: 2.82e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22084    1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWK 42
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
70-105 1.01e-04

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 39.37  E-value: 1.01e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPR 105
Cdd:cd22157    3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPS 38
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
328-353 1.48e-04

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 38.54  E-value: 1.48e-04
                           10        20
                   ....*....|....*....|....*.
gi 508083038   328 CSKLRYLNARGCEGITDHGVEYLAKN 353
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
70-107 1.51e-04

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 39.28  E-value: 1.51e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22134    7 LPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLW 44
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
67-108 2.23e-04

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 38.75  E-value: 2.23e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 508083038  67 IDRLPDHSMVQIF----SFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22089    3 ISALPSEILLYILrwvvSDLDLRSLEQLSLVCRKFYLLARDPSIWR 48
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
70-109 2.29e-04

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 38.45  E-value: 2.29e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWD-PRLWRT 109
Cdd:cd22113    4 LPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIENsDYLWRP 44
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
67-100 3.01e-04

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 38.21  E-value: 3.01e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQ-LCRCARVCRRWYNL 100
Cdd:cd22159    1 IDLLPDEILELIFSYLSDPWdRNSCSLVCKRWYRL 35
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
78-108 3.08e-04

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 38.42  E-value: 3.08e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 508083038  78 IFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22172   17 IFSFLDPRSLCRCAQVCWYWKYLTELDQLWM 47
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
69-111 3.84e-04

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 37.96  E-value: 3.84e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 508083038  69 RLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIR 111
Cdd:cd20090    4 DLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRIA 46
F-box_FBXL21 cd22179
F-box domain found in F-box/LRR-repeat protein 21 (FBXL21) and similar proteins; FBXL21, also ...
70-107 3.86e-04

F-box domain found in F-box/LRR-repeat protein 21 (FBXL21) and similar proteins; FBXL21, also called F-box and leucine-rich repeat protein 21, F-box and leucine-rich repeat protein 3B (FBXL3B), or F-box/LRR-repeat protein 3B, is the substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex that mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY protein stabilization, and thus, is involved in circadian rhythm function. It regulates the oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438950  Cd Length: 43  Bit Score: 37.97  E-value: 3.86e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22179    6 LPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPDLW 43
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
67-101 3.88e-04

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 37.70  E-value: 3.88e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 508083038  67 IDRLPDHSMVQIFSFL-PTNQLCRCARVCRRWYNLA 101
Cdd:cd22110    1 INDLPEEILEYILSYLsPYGDLKSAALVCKRWHRII 36
FBXL18_LRR pfam19729
F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from ...
166-221 4.36e-04

F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes.


Pssm-ID: 466163 [Multi-domain]  Cd Length: 594  Bit Score: 42.81  E-value: 4.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 508083038  166 ELRRLEVSGCYNISNEAVfDVVSLCPNLEHLDVSGCsKVTCISLTReasiKLSPLH 221
Cdd:pfam19729  11 EIQQLSLSGCYWLSGSTV-DQVTRCRNLVKLDLSGC-RLTSLRLSK----LLSSLQ 60
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
67-110 4.72e-04

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 37.62  E-value: 4.72e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTI 110
Cdd:cd22093    1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKL 44
F-box_FBXL11 cd22181
F-box domain found in F-box/LRR-repeat protein 11 (FBXL11) and similar proteins; FBXL11, also ...
76-107 5.38e-04

F-box domain found in F-box/LRR-repeat protein 11 (FBXL11) and similar proteins; FBXL11, also called lysine-specific demethylase 2A (KDM2A), CXXC-type zinc finger protein (CXXC8), F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438952  Cd Length: 47  Bit Score: 37.56  E-value: 5.38e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 508083038  76 VQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22181   14 MSVFRYLSRRELCECMRVCKTWYKWCCDKRLW 45
F-box_FBXW1 cd22130
F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; ...
72-108 6.00e-04

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438902  Cd Length: 51  Bit Score: 37.45  E-value: 6.00e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 508083038  72 DHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22130   14 DHIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWK 50
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
250-441 6.24e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 6.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 250 CTQLTHLYLRRC---------------------VRLTDEGL--RYLVIYCASIKELSVSDCRFV------SDFGLREIAK 300
Cdd:cd00116   80 GCGLQELDLSDNalgpdgcgvlesllrssslqeLKLNNNGLgdRGLRLLAKGLKDLPPALEKLVlgrnrlEGASCEALAK 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 301 L---ESRLRYLSIAHcGRVTDVGIRYVA---KYCSKLRYLNARGCeGITDHGVEYLA---KNCTKLKSLDIGKCPLvSDT 371
Cdd:cd00116  160 AlraNRDLKELNLAN-NGIGDAGIRALAeglKANCNLEVLDLNNN-GLTDEGASALAetlASLKSLEVLNLGDNNL-TDA 236
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 508083038 372 GLE--CLALNCFN--LKRLSLkSCESITGQGLQIVAANCFD---LQTLNVQDCEVSVEALRFV--KRHCKRCVIEHTNP 441
Cdd:cd00116  237 GAAalASALLSPNisLLTLSL-SCNDITDDGAKDLAEVLAEkesLLELDLRGNKFGEEGAQLLaeSLLEPGNELESLWV 314
F-box_FBXO22 cd22097
F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called ...
78-101 7.64e-04

F-box domain found in F-box only protein 22 (FBXO22) and similar proteins; FBXO22, also called FBX22, or F-box protein FBX22p44, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. FBXO22 regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438869  Cd Length: 48  Bit Score: 37.34  E-value: 7.64e-04
                         10        20
                 ....*....|....*....|....
gi 508083038  78 IFSFLPTNQLCRCARVCRRWYNLA 101
Cdd:cd22097   11 ILSFLPAKALLRCARVCRLWRDCA 34
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
70-110 8.60e-04

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 37.19  E-value: 8.60e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCAR-VCRRWYNLAWDPRLWRTI 110
Cdd:cd22164    5 LPDDLTASILSRLGAIDILTNAQkVCKLWRRICKDPSMWRVI 46
F-box_FBXL10 cd22180
F-box domain found in F-box/LRR-repeat protein 10 (FBXL10) and similar proteins; FBXL10 is ...
78-107 9.25e-04

F-box domain found in F-box/LRR-repeat protein 10 (FBXL10) and similar proteins; FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10, F-box protein FBL10, JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438951  Cd Length: 45  Bit Score: 36.84  E-value: 9.25e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 508083038  78 IFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22180   14 VFSYLSHRDLCVCMRVCRTWNRWCCDKRLW 43
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
70-107 9.26e-04

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 37.04  E-value: 9.26e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22094    6 LPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELW 43
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
67-112 1.06e-03

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 36.78  E-value: 1.06e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRL 112
Cdd:cd22106    1 LVRLPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEKIYM 46
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
68-100 1.33e-03

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 36.11  E-value: 1.33e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 508083038  68 DRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNL 100
Cdd:cd22111    2 ARLPSRVLEVIFSYLDLPDLRNCSLVCKSWYRL 34
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
354-377 1.64e-03

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 35.84  E-value: 1.64e-03
                           10        20
                   ....*....|....*....|....
gi 508083038   354 CTKLKSLDIGKCPLVSDTGLECLA 377
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALA 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
241-370 2.18e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083038 241 EGLHtiaaHCTQLTHLYL-----------RRCVRLTD-----------EGLRYLViycaSIKELSVS----DCRFVSDFG 294
Cdd:cd21340   40 ENLE----FLTNLTHLYLqnnqiekienlENLVNLKKlylggnrisvvEGLENLT----NLEELHIEnqrlPPGEKLTFD 111
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 508083038 295 LREIAKLESRLRYLSIAHCgrvtdvGIRYVA--KYCSKLRYLNARGCEgITDHG-VEYLAKNCTKLKSLDIGKCPLVSD 370
Cdd:cd21340  112 PRSLAALSNSLRVLNISGN------NIDSLEplAPLRNLEQLDASNNQ-ISDLEeLLDLLSSWPSLRELDLTGNPVCKK 183
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
60-108 2.66e-03

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 35.86  E-value: 2.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 508083038  60 PQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22133   11 PQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
250-275 2.90e-03

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 35.07  E-value: 2.90e-03
                           10        20
                   ....*....|....*....|....*.
gi 508083038   250 CTQLTHLYLRRCVRLTDEGLRYLVIY 275
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
F-box_AtADLO1-like cd22155
F-box domain found in Arabidopsis thaliana protein ARABIDILLO 1 (AtADLO1) and similar proteins; ...
69-107 3.24e-03

F-box domain found in Arabidopsis thaliana protein ARABIDILLO 1 (AtADLO1) and similar proteins; AtADLO1, also called F-box only protein 5 (FBX5), promotes lateral root initiation and development, independently of auxin (IAA) and abscisic acid (ABA). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438926  Cd Length: 42  Bit Score: 35.23  E-value: 3.24e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 508083038  69 RLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22155    4 LLPDDTVLGLFGLLNYRDRASLASVCRAWRALGSSHSLW 42
F-box_FBXW1B cd22183
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ...
72-108 3.27e-03

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438954  Cd Length: 51  Bit Score: 35.65  E-value: 3.27e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 508083038  72 DHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22183   14 DHIAENILSYLDAESLCAAELVCKEWQRVISEGMLWK 50
F-box_AtARP8-like cd22156
F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar ...
66-107 3.34e-03

F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438927  Cd Length: 45  Bit Score: 35.43  E-value: 3.34e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  66 SIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22156    1 AFDQLPEDVLMQILRLLGPKDAAKLCLVCKSWRYLVSDNRLW 42
F-box_FBXO17-like cd22169
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ...
67-108 3.80e-03

F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438940  Cd Length: 48  Bit Score: 35.09  E-value: 3.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLC-RCARVCRRWYNLAWDPRLWR 108
Cdd:cd22169    1 LSLLPEELLLLVLSHVPARTLVtRCRLVCRDWRDLVDGPTLWK 43
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
66-110 3.93e-03

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 35.28  E-value: 3.93e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 508083038  66 SIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAwDPRLWRTI 110
Cdd:cd22143    1 AFDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLA-LPELWRSI 44
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
190-214 4.89e-03

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 34.30  E-value: 4.89e-03
                           10        20
                   ....*....|....*....|....*
gi 508083038   190 CPNLEHLDVSGCSKVTCISLTREAS 214
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAK 25
F-box_FBXO10 cd22090
F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called ...
78-100 4.95e-03

F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438862  Cd Length: 50  Bit Score: 35.02  E-value: 4.95e-03
                         10        20
                 ....*....|....*....|...
gi 508083038  78 IFSFLPTNQLCRCARVCRRWYNL 100
Cdd:cd22090   13 ILAYLPVRDLCRCCQVCRAWYEL 35
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
70-109 5.61e-03

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 34.58  E-value: 5.61e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRT 109
Cdd:cd22087    4 LPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLWRF 43
F-box_FBXL3 cd22178
F-box domain found in F-box/LRR-repeat protein 3 (FBXL3) and similar proteins; FBXL3, also ...
70-107 5.99e-03

F-box domain found in F-box/LRR-repeat protein 3 (FBXL3) and similar proteins; FBXL3, also called F-box and leucine-rich repeat protein 3A, or F-box/LRR-repeat protein 3A, is the substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex that mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2, and thus, is involved in circadian rhythm function. It plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438949  Cd Length: 43  Bit Score: 34.49  E-value: 5.99e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLW 107
Cdd:cd22178    6 LLQDIILQIFQYLPLLDRAHASQVCRNWNQVFHMPDLW 43
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
304-327 6.56e-03

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 33.92  E-value: 6.56e-03
                           10        20
                   ....*....|....*....|....
gi 508083038   304 RLRYLSIAHCGRVTDVGIRYVAKY 327
Cdd:smart00367   3 NLRELDLSGCTNITDEGLQALAKG 26
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
276-301 6.76e-03

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 33.92  E-value: 6.76e-03
                           10        20
                   ....*....|....*....|....*.
gi 508083038   276 CASIKELSVSDCRFVSDFGLREIAKL 301
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
70-109 6.84e-03

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 34.69  E-value: 6.84e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 508083038  70 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRT 109
Cdd:cd22173    6 LPRFLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQDCLWMP 45
F-box_FBXO46 cd22177
F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called ...
70-90 9.10e-03

F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called FBX46, or F-box only protein 34-like, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438948  Cd Length: 47  Bit Score: 34.12  E-value: 9.10e-03
                         10        20
                 ....*....|....*....|....*
gi 508083038  70 LPDHSMVQIFSFLPTNQL----CRC 90
Cdd:cd22177    4 LPDHILVNIFSYLPTRSLaalkCSC 28
F-box_FBXO2 cd22167
F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called ...
67-107 9.36e-03

F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called FBX2, is a neuron-specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It binds specifically to proteins attached with N-linked high-mannose type oligosaccharides, and subsequently contributes to ubiquitination of glycoproteins. FBXO2 regulates amyloid precursor protein (APP) levels and processing in the brain, and may play a role in modulating Alzheimer disease (AD) pathogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438938 [Multi-domain]  Cd Length: 72  Bit Score: 34.72  E-value: 9.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 508083038  67 IDRLPDHSMVQIFSFLPTNQLCR-CARVCRRWYNLAWDPRLW 107
Cdd:cd22167    1 MESLPEAVLVRILAYLPAEELVLvCRLVCSQWKELVDGAALW 42
F-box_FBXO4 cd22085
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ...
66-108 9.48e-03

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438857  Cd Length: 50  Bit Score: 34.31  E-value: 9.48e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 508083038  66 SIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22085    2 LLNHLPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWR 44
F-box_FBXL14 cd22125
F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also ...
75-108 9.51e-03

F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also called F-box and leucine-rich repeat protein 14, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which acts by mediating ubiquitination and subsequent degradation of SNAIL1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438897  Cd Length: 41  Bit Score: 33.99  E-value: 9.51e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 508083038  75 MVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWR 108
Cdd:cd22125    8 LAMIFSYLDVRDKGRAAQVCTAWRDAAYHKSVWR 41
LRR_CC smart00367
Leucine-rich repeat - CC (cysteine-containing) subfamily;
380-405 9.92e-03

Leucine-rich repeat - CC (cysteine-containing) subfamily;


Pssm-ID: 197685 [Multi-domain]  Cd Length: 26  Bit Score: 33.53  E-value: 9.92e-03
                           10        20
                   ....*....|....*....|....*.
gi 508083038   380 CFNLKRLSLKSCESITGQGLQIVAAN 405
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALAKG 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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