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Conserved domains on  [gi|1511289985|ref|NP_001265372|]
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ankyrin repeat and LEM domain-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GIY-YIG_COG3680_Meta cd10454
GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally ...
 413-528 1.93e-67

GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally uncharacterized hypothetical proteins from Metazoa. They have bacterial homologs that display sequence homology with the catalytic GIY-YIG domain of bacterial UvrC DNA repair proteins. However, unlike their bacterial relatives, these Metazoan proteins contain an N-terminal extension that includes the region of approximately 3-4 ankyrin repeats, unique motifs mediating protein-protein interactions. Some of them do have an additional LEM domain located between ankyrin repeats region and GIY-YIG domain. The LEM domain, found in inner nuclear membrane proteins, may be involved in protein- or DNA-binding. The different domains composition suggests members in this subfamily might participate in interactions with multiple partners and imply some important cellular functions.


:

Pssm-ID: 198401  Cd Length: 114  Bit Score: 214.09  E-value: 1.93e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985 413 SFTYLLLDPRETQDLPARAFSLTPAERLQTFIRAIFYVGKGTRARPYVHLWEALGHHGrsRKQPHQACPKVRQILDIWAS 492
Cdd:cd10454     1 SFNYLLLDPRVTRNLPSRARGLTPIETFQTFVSSIFYVGKGKRSRPYAHFYEALKQHN--DKDKKKGSRKLRRILDIWNS 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1511289985 493 GCGVVSLHCFQHVVAVEAYTREACIVEALGIQTLTN 528
Cdd:cd10454    79 GLGVVSLHCFQNVIPVEAYTREAAMIEALGLSNLTN 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-117 3.82e-19

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.09  E-value: 3.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985  11 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRclgALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGAD 90
Cdd:COG0666   102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK---LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                          90       100
                  ....*....|....*....|....*..
gi 1511289985  91 PALRDQDGLRPLDLALQQGHLECARVL 117
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
 
Name Accession Description Interval E-value
GIY-YIG_COG3680_Meta cd10454
GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally ...
 413-528 1.93e-67

GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally uncharacterized hypothetical proteins from Metazoa. They have bacterial homologs that display sequence homology with the catalytic GIY-YIG domain of bacterial UvrC DNA repair proteins. However, unlike their bacterial relatives, these Metazoan proteins contain an N-terminal extension that includes the region of approximately 3-4 ankyrin repeats, unique motifs mediating protein-protein interactions. Some of them do have an additional LEM domain located between ankyrin repeats region and GIY-YIG domain. The LEM domain, found in inner nuclear membrane proteins, may be involved in protein- or DNA-binding. The different domains composition suggests members in this subfamily might participate in interactions with multiple partners and imply some important cellular functions.


Pssm-ID: 198401  Cd Length: 114  Bit Score: 214.09  E-value: 1.93e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985 413 SFTYLLLDPRETQDLPARAFSLTPAERLQTFIRAIFYVGKGTRARPYVHLWEALGHHGrsRKQPHQACPKVRQILDIWAS 492
Cdd:cd10454     1 SFNYLLLDPRVTRNLPSRARGLTPIETFQTFVSSIFYVGKGKRSRPYAHFYEALKQHN--DKDKKKGSRKLRRILDIWNS 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1511289985 493 GCGVVSLHCFQHVVAVEAYTREACIVEALGIQTLTN 528
Cdd:cd10454    79 GLGVVSLHCFQNVIPVEAYTREAAMIEALGLSNLTN 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-117 3.82e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.09  E-value: 3.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985  11 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRclgALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGAD 90
Cdd:COG0666   102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK---LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                          90       100
                  ....*....|....*....|....*..
gi 1511289985  91 PALRDQDGLRPLDLALQQGHLECARVL 117
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-117 2.30e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 2.30e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1511289985  45 LRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQgADPALRDqDGLRPLDLALQQGHLECARVL 117
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLL 80
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-117 2.82e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.83  E-value: 2.82e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1511289985  51 LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 117
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
COG3680 COG3680
Uncharacterized protein, contains GIY-YIG domain [Function unknown];
416-533 6.11e-06

Uncharacterized protein, contains GIY-YIG domain [Function unknown];


Pssm-ID: 442896  Cd Length: 253  Bit Score: 47.81  E-value: 6.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985 416 YLLLDPREtqdlparafsltpaerlqtfiRAIFYVGKGTRARPYVHLWEALghhgrsrKQPHQACPKVRQILDIWASGCG 495
Cdd:COG3680    18 YALIDPRD---------------------NKPFYIGKGKGNRVFAHLREAI-------ASNESESAKLERIREIKKAGLD 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1511289985 496 VVSLHCFQHVVAVEAYTREACIVEALGI--QTLTNQKQGH 533
Cdd:COG3680    70 VEHYILRHGLDEKTAFEVEAALIDLLGIveAKLTNIVRGH 109
 
Name Accession Description Interval E-value
GIY-YIG_COG3680_Meta cd10454
GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally ...
 413-528 1.93e-67

GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally uncharacterized hypothetical proteins from Metazoa. They have bacterial homologs that display sequence homology with the catalytic GIY-YIG domain of bacterial UvrC DNA repair proteins. However, unlike their bacterial relatives, these Metazoan proteins contain an N-terminal extension that includes the region of approximately 3-4 ankyrin repeats, unique motifs mediating protein-protein interactions. Some of them do have an additional LEM domain located between ankyrin repeats region and GIY-YIG domain. The LEM domain, found in inner nuclear membrane proteins, may be involved in protein- or DNA-binding. The different domains composition suggests members in this subfamily might participate in interactions with multiple partners and imply some important cellular functions.


Pssm-ID: 198401  Cd Length: 114  Bit Score: 214.09  E-value: 1.93e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985 413 SFTYLLLDPRETQDLPARAFSLTPAERLQTFIRAIFYVGKGTRARPYVHLWEALGHHGrsRKQPHQACPKVRQILDIWAS 492
Cdd:cd10454     1 SFNYLLLDPRVTRNLPSRARGLTPIETFQTFVSSIFYVGKGKRSRPYAHFYEALKQHN--DKDKKKGSRKLRRILDIWNS 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1511289985 493 GCGVVSLHCFQHVVAVEAYTREACIVEALGIQTLTN 528
Cdd:cd10454    79 GLGVVSLHCFQNVIPVEAYTREAAMIEALGLSNLTN 114
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-117 3.82e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.09  E-value: 3.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985  11 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRclgALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGAD 90
Cdd:COG0666   102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK---LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                          90       100
                  ....*....|....*....|....*..
gi 1511289985  91 PALRDQDGLRPLDLALQQGHLECARVL 117
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
GIY-YIG_COG3680 cd10440
GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; This ...
 416-528 1.30e-18

GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; This family includes a group of functionally uncharacterized proteins from bacteria and their eukaryotic homologs which are present only in metazoa. These proteins might have nuclease activities and possibly be engaged in DNA repair or recombination, since they share sequence homology with the catalytic GIY-YIG domain of bacterial UvrC DNA repair proteins. Distinct from their prokaryotic relatives, the eukaryotic homologs contain an N-terminal extension that includes the region of approximately 3-4 ankyrin repeats, unique motifs mediating protein-protein interactions. Some of eukaryotic homologs do have an additional LEM domain located between ankyrin repeats region and GIY-YIG domain. The LEM domain, found in inner nuclear membrane proteins, may be involved in protein- or DNA-binding. The different domain composition of the eukaryotic homologs suggests that they might participate in interactions with multiple partners and implies important cellular function.


Pssm-ID: 198387 [Multi-domain]  Cd Length: 94  Bit Score: 80.89  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985 416 YLLLDPRETQdlparafsltpaerlqtfiraIFYVGKGTRARPYVHLWEALGHHGRSRKQPhqaCPKVRQILDIWASGCG 495
Cdd:cd10440     4 YALIDPRTGE---------------------VFYVGKGKGNRVFSHVKEALGEYENIKEKL---SAKLQRIREILSAGLE 59

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1511289985 496 VVSLHCFQHVVAVEAYTREACIVEALG--IQTLTN 528
Cdd:cd10440    60 VEHYILRHGLDEVEAFEVEAALIDALGltLPGLTN 94
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-119 1.99e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.00  E-value: 1.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985  11 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRclgALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGAD 90
Cdd:COG0666   135 IVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK---LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                          90       100
                  ....*....|....*....|....*....
gi 1511289985  91 PALRDQDGLRPLDLALQQGHLECARVLQD 119
Cdd:COG0666   212 VNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-134 2.16e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985  11 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRclgALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGAD 90
Cdd:COG0666   168 IVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK---LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1511289985  91 PALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIGAET 134
Cdd:COG0666   245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-117 2.02e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.81  E-value: 2.02e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1511289985  50 ALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 117
Cdd:COG0666    72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-117 2.30e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 2.30e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1511289985  45 LRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQgADPALRDqDGLRPLDLALQQGHLECARVL 117
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLL 80
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-117 2.82e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.83  E-value: 2.82e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1511289985  51 LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 117
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-117 1.67e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 1.67e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1511289985  66 LTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 117
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-117 9.11e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 9.11e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1511289985  69 LHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 117
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-119 2.37e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.45  E-value: 2.37e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1511289985  45 LRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 119
Cdd:PHA02876  158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232
COG3680 COG3680
Uncharacterized protein, contains GIY-YIG domain [Function unknown];
416-533 6.11e-06

Uncharacterized protein, contains GIY-YIG domain [Function unknown];


Pssm-ID: 442896  Cd Length: 253  Bit Score: 47.81  E-value: 6.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985 416 YLLLDPREtqdlparafsltpaerlqtfiRAIFYVGKGTRARPYVHLWEALghhgrsrKQPHQACPKVRQILDIWASGCG 495
Cdd:COG3680    18 YALIDPRD---------------------NKPFYIGKGKGNRVFAHLREAI-------ASNESESAKLERIREIKKAGLD 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1511289985 496 VVSLHCFQHVVAVEAYTREACIVEALGI--QTLTNQKQGH 533
Cdd:COG3680    70 VEHYILRHGLDEKTAFEVEAALIDLLGIveAKLTNIVRGH 109
PHA03095 PHA03095
ankyrin-like protein; Provisional
 10-110 8.21e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.48  E-value: 8.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985  10 RAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRcLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGA 89
Cdd:PHA03095  203 RIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSL-VLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281

                          90       100
                  ....*....|....*....|.
gi 1511289985  90 DPALRDQDGLRPLDLALQQGH 110
Cdd:PHA03095  282 DINAVSSDGNTPLSLMVRNNN 302
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 10-119 8.75e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.45  E-value: 8.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985  10 RAVEELLRCGADPNLVL-EDGAAAVHLAAGARHprgLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQG 88
Cdd:PHA02875   82 KAVEELLDLGKFADDVFyKDGMTPLHLATILKK---LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK 158

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1511289985  89 ADPALRDQDGLRPLDLALQQGHLECARVLQD 119
Cdd:PHA02875  159 ACLDIEDCCGCTPLIIAMAKGDIAICKMLLD 189
Ank_5 pfam13857
Ankyrin repeats (many copies);
51-105 4.45e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 4.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1511289985  51 LLRQGG-DPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLA 105
Cdd:pfam13857   1 LLEHGPiDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
11-95 5.24e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 5.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1511289985  11 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRclgaLLRQGGDPNARSvEALTPLHVAAAWGCRRGLELLLSQGAD 90
Cdd:pfam12796  12 LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVK----LLLEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGAD 86


                  ....*
gi 1511289985  91 PALRD 95
Cdd:pfam12796  87 INVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 73-117 2.52e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 2.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1511289985  73 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 117
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVL 134
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 48-117 4.05e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.86  E-value: 4.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1511289985  48 LGALLRQGGDPNARS-VEALTPLHVAAAwgCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH-LECARVL 117
Cdd:PHA02878  251 LKLLLEHGVDVNAKSyILGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLcINIGRIL 320
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 51-107 5.18e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 39.20  E-value: 5.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1511289985  51 LLRQGGDPNARSVEA-LTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQ 107
Cdd:PHA02884   89 LIRYGADVNRYAEEAkITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALM 146
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 67-95 6.71e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 6.71e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1511289985  67 TPLHVAAA-WGCRRGLELLLSQGADPALRD 95
Cdd:pfam00023   4 TPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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