NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|523498361|ref|NP_001265656|]
View 

DNA-binding protein RFXANK isoform c [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
95-227 1.25e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.46  E-value: 1.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 174
Cdd:COG0666  113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 523498361 175 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKL 227
Cdd:COG0666  193 AAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
95-227 1.25e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.46  E-value: 1.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 174
Cdd:COG0666  113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 523498361 175 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKL 227
Cdd:COG0666  193 AAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
106-196 1.16e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.86  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  106 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERdVDINIYDwNGGTPLLYAVRGNHVKCVE 185
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 523498361  186 ALLARGADLTT 196
Cdd:pfam12796  79 LLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 95-210 3.72e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 3.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASA--FGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI------------------VGLL 154
Cdd:PHA03100  99 VNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYL 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523498361 155 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVA 210
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 167-195 5.06e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 5.06e-04
                           10        20
                   ....*....|....*....|....*....
gi 523498361   167 NGGTPLLYAVRGNHVKCVEALLARGADLT 195
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 104-196 2.51e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 104 TPLIWASAFGEIETVRFLLEW-GADPHILAKERESALSLASTGGYTDIVGLLLERDVD-IN------IYDwnGGTPLLYA 175
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNepmtsdLYQ--GETALHIA 96

                         90       100
                 ....*....|....*....|.
gi 523498361 176 VRGNHVKCVEALLARGADLTT 196
Cdd:cd22192   97 VVNQNLNLVRELIARGADVVS 117
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
95-227 1.25e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.46  E-value: 1.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 174
Cdd:COG0666  113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 523498361 175 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKL 227
Cdd:COG0666  193 AAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-216 1.19e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 1.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  89 LDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 168
Cdd:COG0666   74 LAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG 153

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 523498361 169 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 216
Cdd:COG0666  154 NTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
95-232 5.41e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.43  E-value: 5.41e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 174
Cdd:COG0666  146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 523498361 175 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNL 232
Cdd:COG0666  226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-216 1.25e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.48  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  71 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI 150
Cdd:COG0666   23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523498361 151 VGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 216
Cdd:COG0666  103 VKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168
Ank_2 pfam12796
Ankyrin repeats (3 copies);
106-196 1.16e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.86  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  106 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERdVDINIYDwNGGTPLLYAVRGNHVKCVE 185
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 523498361  186 ALLARGADLTT 196
Cdd:pfam12796  79 LLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
95-205 5.22e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.77  E-value: 5.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 174
Cdd:COG0666  179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                         90       100       110
                 ....*....|....*....|....*....|.
gi 523498361 175 AVRGNHVKCVEALLARGADLTTEADSGYTPM 205
Cdd:COG0666  259 AAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 95-210 3.72e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 3.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASA--FGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI------------------VGLL 154
Cdd:PHA03100  99 VNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYL 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523498361 155 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVA 210
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
Ank_2 pfam12796
Ankyrin repeats (3 copies);
139-224 8.23e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 8.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  139 LSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAdlTTEADSGYTPMDLAVALGYRK-VQ 217
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEiVK 78


                  ....*..
gi 523498361  218 QVIENHI 224
Cdd:pfam12796  79 LLLEKGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 89-222 4.52e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 70.76  E-value: 4.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  89 LDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 168
Cdd:PHA02874 111 LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNG 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 523498361 169 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 222
Cdd:PHA02874 191 ESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINN 244
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
89-216 8.37e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 8.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  89 LDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 168
Cdd:COG0666    8 LLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGG 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 523498361 169 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 216
Cdd:COG0666   88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 114-231 4.58e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 4.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 114 EIETVRFLLEWGADPHILAKERESALSLASTGGYT-----DIVGLLLERDVDINIYDWNGGTPLLYAV--RGNHVKCVEA 186
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEY 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 523498361 187 LLARGADLTTEADSGYTPmdLAVALGYRKvqqvIENHILKLFQSN 231
Cdd:PHA03100 127 LLDNGANVNIKNSDGENL--LHLYLESNK----IDLKILKLLIDK 165
Ank_2 pfam12796
Ankyrin repeats (3 copies);
89-165 1.48e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 1.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361   89 LDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEwgadpHILAKER---ESALSLASTGGYTDIVGLLLERDVDINIYD 165
Cdd:pfam12796  17 LENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----HADVNLKdngRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 100-193 5.07e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.85  E-value: 5.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 100 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 179
Cdd:PHA02875 100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179

                         90
                 ....*....|....
gi 523498361 180 HVKCVEALLARGAD 193
Cdd:PHA02875 180 DIAICKMLLDSGAN 193
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 114-222 2.05e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.90  E-value: 2.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 114 EIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 193
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                         90       100       110
                 ....*....|....*....|....*....|
gi 523498361 194 LTTEADSGYTPMDLAVALG-YRKVQQVIEN 222
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGdYACIKLLIDH 212
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 127-229 7.46e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 55.29  E-value: 7.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 127 DP---HILAKEresALSLASTGgytDIVG--LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 201
Cdd:PTZ00322  75 DPvvaHMLTVE---LCQLAASG---DAVGarILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDG 148

                         90       100
                 ....*....|....*....|....*...
gi 523498361 202 YTPMDLAVALGYRKVQQVIENHILKLFQ 229
Cdd:PTZ00322 149 KTPLELAEENGFREVVQLLSRHSQCHFE 176
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 95-163 1.88e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 1.88e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523498361  95 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 163
Cdd:PHA03100 185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 114-227 2.73e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.73  E-value: 2.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 114 EIETVRFLLEWGADPHILAKER-ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGA 192
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 523498361 193 DLTTEADSGYTPMDLAVAlgyrkvqQVIENHILKL 227
Cdd:PHA02878 226 STDARDKCGNTPLHISVG-------YCKDYDILKL 253
Ank_5 pfam13857
Ankyrin repeats (many copies);
153-208 5.54e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.11  E-value: 5.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 523498361  153 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 208
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 102-223 9.98e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.92  E-value: 9.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 102 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDIN--IYDwNGGTPLLYAVRGN 179
Cdd:PHA02875  35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdvFYK-DGMTPLHLATILK 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 523498361 180 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 223
Cdd:PHA02875 114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDH 157
PHA03095 PHA03095
ankyrin-like protein; Provisional
 118-210 1.51e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.18  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 118 VRFLLEWGADPHILAKERESALSLASTGGYTD--IVGLLLERDVDINIYDWNGGTPLLYA-VRGNHVKCVEaLLARGADL 194
Cdd:PHA03095 205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAaVFNNPRACRR-LIALGADI 283

                         90
                 ....*....|....*.
gi 523498361 195 TTEADSGYTPMDLAVA 210
Cdd:PHA03095 284 NAVSSDGNTPLSLMVR 299
Ank_4 pfam13637
Ankyrin repeats (many copies);
135-188 3.20e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 3.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 523498361  135 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 188
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 95-226 3.39e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASAFGEIETVRFLLEWGAdpHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 174
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNRSAIELLINNASINDQDIDGSTPLHH 260

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 523498361 175 AVRGN-HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK--VQQVIENHILK 226
Cdd:PHA02874 261 AINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDpvIKDIIANAVLI 315
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 95-209 4.94e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 4.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDE-RGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLL 173
Cdd:PHA02878 160 INMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH 239

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 523498361 174 YAV-RGNHVKCVEALLARGADLTTEAD-SGYTPMDLAV 209
Cdd:PHA02878 240 ISVgYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI 277
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 96-155 5.84e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 5.84e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  96 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 155
Cdd:PTZ00322 109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 110-188 6.06e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 6.06e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523498361 110 SAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 188
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 93-209 7.09e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 7.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  93 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL------------------ 154
Cdd:PHA02874  26 NCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLidngvdtsilpipciekd 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 155 -----LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAV 209
Cdd:PHA02874 106 miktiLDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAI 165
PHA03095 PHA03095
ankyrin-like protein; Provisional
 95-206 1.03e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPL-IWASAFGE--IETVRFLLEWGADphILAKER--ESALSLASTGGYT-DIVGLLLERDVDINIYDWNG 168
Cdd:PHA03095  40 VNFRGEYGKTPLhLYLHYSSEkvKDIVRLLLEAGAD--VNAPERcgFTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVG 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 523498361 169 GTPL-LYAVRGN-HVKCVEALLARGADLTTEADSGYTPMD 206
Cdd:PHA03095 118 RTPLhVYLSGFNiNPKVIRLLLRKGADVNALDLYGMTPLA 157
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 85-194 1.08e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.91  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  85 LPATLDCDNLVNKPDERGFTPLIWASAFG-EIETVRFLLEWGADPHILAKERESALSLAST-GGYTDIVGLLLERDVDIN 162
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVN 369

                         90       100       110
                 ....*....|....*....|....*....|..
gi 523498361 163 IYDWNGGTPLLYAVRGNHVKCVEALLARGADL 194
Cdd:PHA02876 370 ARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 65-163 1.25e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.45  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  65 SSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SALSLAS 143
Cdd:PHA02875 131 PNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAI 210

                         90       100
                 ....*....|....*....|
gi 523498361 144 TGGYTDIVGLLLERDVDINI 163
Cdd:PHA02875 211 ENNKIDIVRLFIKRGADCNI 230
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 95-220 1.58e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.06  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERgfTPLIWASAFGEIETVRFLLEWG--ADpHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPL 172
Cdd:PHA02875  63 VKYPDIE--SELHDAVEEGDVKAVEELLDLGkfAD-DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 523498361 173 LYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 220
Cdd:PHA02875 140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 58-213 2.23e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  58 VSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERES 137
Cdd:PHA02876 134 IHYDKINESIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 138 ALSLASTGGYTDIVGLLLERDVDINIYD------------------WNGG-----------TPLLYAVRGNHV-KCVEAL 187
Cdd:PHA02876 214 VLECAVDSKNIDTIKAIIDNRSNINKNDlsllkairnedletslllYDAGfsvnsiddcknTPLHHASQAPSLsRLVPKL 293

                        170       180
                 ....*....|....*....|....*.
gi 523498361 188 LARGADLTTEADSGYTPMDLAVALGY 213
Cdd:PHA02876 294 LERGADVNAKNIKGETPLYLMAKNGY 319
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-233 2.25e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESAL--SLASTGGYTDiVGLLLERDVDINIYDWNGGTPL 172
Cdd:PHA02876 368 VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhfALCGTNPYMS-VKTLIDRGANVNSKNKDLSTPL 446

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523498361 173 LYAVRGN-HVKCVEALLARGADLTTEADSGYTPmdLAVALGYRKVQQVIENHILKLFQSNLV 233
Cdd:PHA02876 447 HYACKKNcKLDVIEMLLDNGADVNAINIQNQYP--LLIALEYHGIVNILLHYGAELRDSRVL 506
Ank_5 pfam13857
Ankyrin repeats (many copies);
121-175 2.89e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 2.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 523498361  121 LLEWG-ADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 175
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
104-155 2.93e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 2.93e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 523498361  104 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 155
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
91-142 4.56e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 4.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 523498361   91 CDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 142
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 67-213 5.57e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 5.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  67 LKHSTTLtnrqRGNEVSALPAtldcDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGG 146
Cdd:PLN03192 498 LQHHKEL----HDLNVGDLLG----DNGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKG 569

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 147 YTDIVGLLLERDVDINIYDWNGGTPL--------------LY-----------------AVRGNHVKCVEALLARGADLT 195
Cdd:PLN03192 570 YEDCVLVLLKHACNVHIRDANGNTALwnaisakhhkifriLYhfasisdphaagdllctAAKRNDLTAMKELLKQGLNVD 649

                        170
                 ....*....|....*...
gi 523498361 196 TEADSGYTPMDLAVALGY 213
Cdd:PLN03192 650 SEDHQGATALQVAMAEDH 667
PHA03095 PHA03095
ankyrin-like protein; Provisional
 95-200 8.73e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 8.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPLIWASAFGEIETVRFLLEWGAdphilakeresalslastggytdivglllerdvDINIYDWNGGTPLLY 174
Cdd:PHA03095 250 INARNRYGQTPLHYAAVFNNPRACRRLIALGA---------------------------------DINAVSSDGNTPLSL 296

                         90       100
                 ....*....|....*....|....*.
gi 523498361 175 AVRGNHVKCVEALLARGADLTTEADS 200
Cdd:PHA03095 297 MVRNNNGRAVRAALAKNPSAETVAAT 322
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 80-215 1.29e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.74  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  80 NEVSALPATLDCDNLVNKPDergfTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLAS-TGGYTDIVGLLLERD 158
Cdd:PHA02876 222 KNIDTIKAIIDNRSNINKND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLERG 297

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 523498361 159 VDINIYDWNGGTPL-LYAVRGNHVKCVEALLARGADLTTeADSGY-TPMDLAVALGYRK 215
Cdd:PHA02876 298 ADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA-ADRLYiTPLHQASTLDRNK 355
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 101-130 2.81e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.81e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 523498361  101 RGFTPLIWASA-FGEIETVRFLLEWGADPHI 130
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNA 31
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 167-195 5.06e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 5.06e-04
                           10        20
                   ....*....|....*....|....*....
gi 523498361   167 NGGTPLLYAVRGNHVKCVEALLARGADLT 195
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 167-194 7.30e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 7.30e-04
                          10        20
                  ....*....|....*....|....*...
gi 523498361  167 NGGTPLLYAVRGNHVKCVEALLARGADL 194
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 167-194 9.85e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 9.85e-04
                          10        20
                  ....*....|....*....|....*....
gi 523498361  167 NGGTPLLYAV-RGNHVKCVEALLARGADL 194
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADV 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
168-216 1.54e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 1.54e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 523498361  168 GGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 216
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEV 49
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 104-196 2.51e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 104 TPLIWASAFGEIETVRFLLEW-GADPHILAKERESALSLASTGGYTDIVGLLLERDVD-IN------IYDwnGGTPLLYA 175
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNepmtsdLYQ--GETALHIA 96

                         90       100
                 ....*....|....*....|.
gi 523498361 176 VRGNHVKCVEALLARGADLTT 196
Cdd:cd22192   97 VVNQNLNLVRELIARGADVVS 117
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 101-130 2.68e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 2.68e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 523498361  101 RGFTPLIWASAFGEIETVRFLLEWGADPHI 130
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02791 PHA02791
ankyrin-like protein; Provisional
 97-202 2.98e-03

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 38.10  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  97 KPDERGFTPLIWASAFGEIETVRFLLEWGADPHILakERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAV 176
Cdd:PHA02791  25 KADVHGHSALYYAIADNNVRLVCTLLNAGALKNLL--ENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAV 102

                         90       100
                 ....*....|....*....|....*.
gi 523498361 177 RGNHVKCVEALLARGADLTTEADSGY 202
Cdd:PHA02791 103 DSGNMQTVKLFVKKNWRLMFYGKTGW 128
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 89-234 3.29e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  89 LDCD-NLVNKPDE----RGFTPLIWASAFGEIETVRFLLEWGAD--------------PHILAKERESALSLASTGGYTD 149
Cdd:cd22192   71 MEAApELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADvvspratgtffrpgPKNLIYYGEHPLSFAACVGNEE 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361 150 IVGLLLERDVDINIYDWNGGTPL-LYAVRGNHVKCVEA---LLARGADLTTEA------DSGYTPMDLAVALGyrkvQQV 219
Cdd:cd22192  151 IVRLLIEHGADIRAQDSLGNTVLhILVLQPNKTFACQMydlILSYDKEDDLQPldlvpnNQGLTPFKLAAKEG----NIV 226

                        170
                 ....*....|....*...
gi 523498361 220 IENHIL---KLFQSNLVP 234
Cdd:cd22192  227 MFQHLVqkrRHIQWTYGP 244
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 95-177 4.17e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.94  E-value: 4.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523498361  95 VNKPDERGFTPL-IWASAFGEIETVRFLLEWGADPHILAKERE-SALSLASTGgyTDIVGLLLERDVDINIYDWNGGTPL 172
Cdd:PHA02878 227 TDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYILGlTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPL 304


                 ....*
gi 523498361 173 LYAVR 177
Cdd:PHA02878 305 SSAVK 309
PHA02792 PHA02792
ankyrin-like protein; Provisional
 160-224 4.72e-03

ankyrin-like protein; Provisional


Pssm-ID: 165155 [Multi-domain]  Cd Length: 631  Bit Score: 38.01  E-value: 4.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523498361 160 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 224
Cdd:PHA02792 402 DINKIDKHGRSILYYCIESHSVSLVEWLIDNGADINITTKYGSTCIGICVILAHACIPEIAELYI 466
PHA03095 PHA03095
ankyrin-like protein; Provisional
 149-207 6.91e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.31  E-value: 6.91e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523498361 149 DIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKC---VEALLARGADLTTEADSGYTPMDL 207
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH