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Conserved domains on  [gi|525507366|ref|NP_001267483|]
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paired box protein Pax-5 isoform 9 [Homo sapiens]

Protein Classification

paired box protein Pax( domain architecture ID 10646828)

paired box protein Pax functions as a transcription factor, similar to human paired box protein Pax-5 that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
16-140 4.18e-89

Paired Box domain;


:

Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 263.03  E-value: 4.18e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 95
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 525507366    96 VEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIR 140
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
236-347 2.83e-52

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


:

Pssm-ID: 463563  Cd Length: 113  Bit Score: 168.80  E-value: 2.83e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366  236 ANLASP-TPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDS 314
Cdd:pfam12403   1 ASLASFsAFAHLGSSYGQFQSYSLVAGRDMASTTLPGYPPHVPPTGQGSYSTSTLAGMVPGSDYSGNPYSHPQYSSYNEA 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 525507366  315 WRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR 347
Cdd:pfam12403  81 WRFPNPSLLGSPYYYSSASRGSAPPAAAAAYDH 113
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
16-140 4.18e-89

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 263.03  E-value: 4.18e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 95
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 525507366    96 VEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIR 140
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
16-142 2.44e-84

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 251.18  E-value: 2.44e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366  16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 95
Cdd:cd00131    1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 525507366  96 VEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTK 142
Cdd:cd00131   81 VKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX pfam00292
'Paired box' domain;
16-140 4.87e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 247.86  E-value: 4.87e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366   16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 95
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 525507366   96 VEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIR 140
Cdd:pfam00292  81 VTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
236-347 2.83e-52

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


Pssm-ID: 463563  Cd Length: 113  Bit Score: 168.80  E-value: 2.83e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366  236 ANLASP-TPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDS 314
Cdd:pfam12403   1 ASLASFsAFAHLGSSYGQFQSYSLVAGRDMASTTLPGYPPHVPPTGQGSYSTSTLAGMVPGSDYSGNPYSHPQYSSYNEA 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 525507366  315 WRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR 347
Cdd:pfam12403  81 WRFPNPSLLGSPYYYSSASRGSAPPAAAAAYDH 113
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
38-140 9.84e-08

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 52.93  E-value: 9.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366  38 RQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETG--SIKPGVIGGSKPKVaTPKVVEKIAEY-KRQNPTMFA-W- 112
Cdd:COG3415   28 RLRAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSKL-SDEQRERLLELlREKSPDQGSrWt 106
                         90       100       110
                 ....*....|....*....|....*....|
gi 525507366 113 --EIRDRLLAERvcdnDTVPSVSSINRIIR 140
Cdd:COG3415  107 laELAELLEEEF----GVEVSPSTVRRLLK 132
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
16-140 4.18e-89

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 263.03  E-value: 4.18e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 95
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 525507366    96 VEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIR 140
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
16-142 2.44e-84

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 251.18  E-value: 2.44e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366  16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 95
Cdd:cd00131    1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 525507366  96 VEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTK 142
Cdd:cd00131   81 VKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX pfam00292
'Paired box' domain;
16-140 4.87e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 247.86  E-value: 4.87e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366   16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKV 95
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 525507366   96 VEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIR 140
Cdd:pfam00292  81 VTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Pax2_C pfam12403
Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is ...
236-347 2.83e-52

Paired-box protein 2 C terminal; This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with pfam00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.


Pssm-ID: 463563  Cd Length: 113  Bit Score: 168.80  E-value: 2.83e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366  236 ANLASP-TPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDS 314
Cdd:pfam12403   1 ASLASFsAFAHLGSSYGQFQSYSLVAGRDMASTTLPGYPPHVPPTGQGSYSTSTLAGMVPGSDYSGNPYSHPQYSSYNEA 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 525507366  315 WRFPNPGLLGSPYYYSAAARGAAPPAAATAYDR 347
Cdd:pfam12403  81 WRFPNPSLLGSPYYYSSASRGSAPPAAAAAYDH 113
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
38-140 9.84e-08

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 52.93  E-value: 9.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507366  38 RQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETG--SIKPGVIGGSKPKVaTPKVVEKIAEY-KRQNPTMFA-W- 112
Cdd:COG3415   28 RLRAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSKL-SDEQRERLLELlREKSPDQGSrWt 106
                         90       100       110
                 ....*....|....*....|....*....|
gi 525507366 113 --EIRDRLLAERvcdnDTVPSVSSINRIIR 140
Cdd:COG3415  107 laELAELLEEEF----GVEVSPSTVRRLLK 132
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
30-79 8.95e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.66  E-value: 8.95e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 525507366  30 GRPLPDVVRQRIVE-LAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIK 79
Cdd:cd00090    1 LKALSDPTRLRILRlLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVE 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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